Rural banks and their communities: a matter of survival

Rural development ; Banking market

Pattern and Potential Causes of White-faced Ibis, Plegadis chihi, Establishment in the Northern Prairie and Parkland Region of North America

The Northern Prairie and Parkland Waterbird Conservation Plan calls for renewed attention to determining the current status of waterbird populations, their distributions, and conservation needs. It highlights the need for baseline information on the White-faced Ibis (Plegadis chihi). In response, we examined the historical and current distribution of the ibis in North Dakota and summarized first sightings and nest records for the provinces and other states composing the northern prairie and parkland region. The establishment of breeding colonies of White-faced Ibis here may be due to climate and precipitation patterns, invasion and spread of Narrowleaf Cattail (Typha angustifolia), changes in agricultural practices, habitat loss and range expansion in the southern and western portions of the species’ range, and increases in ibis populations in the Intermountain West. We placed special emphasis on North Dakota, a state for which there is scant published information concerning the current status of this species. In recent decades, the ibis has become a regular breeding-season resident in North Dakota and in other areas of the northern prairie and parkland region. From 1882 to 2002, there were 145 reports of one or more Whitefaced Ibis in North Dakota, including 93 reports during the breeding season (15 May to 31 August), 49 during the nonbreeding season (1 September to 14 May), and three for which the season of occurrence was not reported. Prior to the 1960s, there were only three records of the species in North Dakota. Observations of White-faced Ibises in North Dakota increased dramatically between the 1960s and the early 21st century, and the species has been observed nearly annually since 1971. The first White-faced Ibis nesting activity in the state was recorded in 1978, and to date, there have been 21 known records of nesting activity in the state. The species nested in large (>300 ha) semipermanent or permanent wetlands within mixed-species colonies ranging in areal extent from small (0.1 ha) to fairly large (27 ha), and colonies were located in patches of emergent vegetation dominated by cattails (Typha) and bulrushes (Scirpus). We classify the White-faced Ibis as a fairly common migrant and a locally uncommon breeder east of the Missouri River and a casual migrant west of the Missouri River

Kennedy Space Center (KSC) Launch Pad Avian Abatement Efforts Including Related KSC Road Kill Reduction Effort

While birds might seem harmless, there's a good reason for the concern. During the July 2005 launch of Discovery on mission STS-1 14, a vulture soaring around the launch pad impacted the shuttle's external tank just after liftoff. With a vulture's average weight ranging from 3 to 5 pounds. a strike at a critical point on the Shuttle -- like the nose or wing leading thermal protection panels -- could cause catastrophic damage to the vehicle. The foam chunk that fatefully struck Columbia's wing in 2003 weighed only 1.7 pounds. (Cheryl L. Mansfield "Bye Bye Birdies" 2006) To address this issue, NASA formed an "Avian Abatement Team". The team goal is to have safer Shuttle missions by reducing the vulture population at KSC near the pad area thereby reducing the probability of another vulture strike during a Shuttle launch

Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways

Scope: To investigate the effect of sulforaphane (SFN) on the abnormal lipid metabolism and underlying mechanisms.  Methods and results: Models with abnormal lipid metabolism were established both in rats and human hepatocytes. Hepatic steatosis was detected by H&E and oil red O staining. The structure of endoplasmic reticulum was visualized by transmission electron microscopy. The expressions of X-box binding protein 1 (XBP1), protein kinase-like ER kinase (PERK), sterol regulatory element binding protein-1c (SREBP1c) and lipogenic enzymes were determined by real-time PCR and western blot analysis. SFN lowered the content of triglyceride and cholesterol. SFN alleviated the swelling of endoplasmic reticulum (ER) and decreased the perimeter of ER. SFN significantly decreased the expressions of acetyl CoA carboxylase 1 (ACC1), stearoyl-CoA desaturase 1 (SCD1) and fatty acid synthase. SFN inhibited SREBP1c by blocking the PERK. Meanwhile, SFN suppressed ACC1 and SCD1 via blocking the formation of splicing-type XBP1. The key roles of XBP1 and SREBP1c in SFN-reduced lipid droplets were confirmed by a timed sequence of measurement according to time points.  Conclusion: SFN improved abnormal lipid metabolism via both ER stress -dependent and -independent pathways

UAVSAR: A new NASA airborne SAR system for science and technology research

NASA’s Jet Propulsion Laboratory is currently building a reconfigurable, polarimetric L-band synthetic aperture radar (SAR), specifically designed to acquire airborne repeat track SAR data for differential interferometric measurements. Differential interferometry can provide key deformation measurements, important for studies of earthquakes, volcanoes and other dynamically changing phenomena. Using precision real-time GPS and a sensor controlled flight management system, the system will be able to fly predefined paths with great precision. The expected performance of the flight control system will constrain the flight path to be within a 10 m diameter tube about the desired flight track. The radar will be designed to be operable on a UAV (Unpiloted Arial Vehicle) but will initially be demonstrated on a on a NASA Gulfstream III. The radar will be fully polarimetric, with a range bandwidth of 80 MHz (2 m range resolution), and will support a 16 km range swath. The antenna will be electronically steered along track to assure that the antenna beam can be directed independently, regardless of the wind direction and speed. Other features supported by the antenna include elevation monopulse and pulse-to-pulse re-steering capabilities that will enable some novel modes of operation. The system will nominally operate at 45,000 ft (13800 m). The program began as an Instrument Incubator Project (IIP) funded by NASA Earth Science and Technology Office (ESTO)

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response

Increasing the size of the ER by lipid synthesis helps the cell deal with ER stress

Physiological IRE-1-XBP-1 and PEK-1 Signaling in Caenorhabditis elegans Larval Development and Immunity

Endoplasmic reticulum (ER) stress activates the Unfolded Protein Response, a compensatory signaling response that is mediated by the IRE-1, PERK/PEK-1, and ATF-6 pathways in metazoans. Genetic studies have implicated roles for UPR signaling in animal development and disease, but the function of the UPR under physiological conditions, in the absence of chemical agents administered to induce ER stress, is not well understood. Here, we show that in Caenorhabditis elegans XBP-1 deficiency results in constitutive ER stress, reflected by increased basal levels of IRE-1 and PEK-1 activity under physiological conditions. We define a dynamic, temperature-dependent requirement for XBP-1 and PEK-1 activities that increases with immune activation and at elevated physiological temperatures in C. elegans. Our data suggest that the negative feedback loops involving the activation of IRE-1-XBP-1 and PEK-1 pathways serve essential roles, not only at the extremes of ER stress, but also in the maintenance of ER homeostasis under physiological conditions.National Institutes of Health (U.S.) (grant R01-GM084477

Multiplex ligation-dependent probe amplification versus karyotyping in prenatal diagnosis: the M.A.K.E. study

Abstract BACKGROUND: In the past 30 years karyotyping was the gold standard for prenatal diagnosis of chromosomal aberrations in the fetus. Traditional karyotyping (TKT) has a high accuracy and reliability. However, it is labor intensive, the results take 14-21 days, the costs are high and unwanted findings such as abnormalities with unknown clinical relevance are not uncommon. These disadvantages challenged the practice of karyotyping. Multiplex ligation-dependent probe amplification (MLPA) is a new molecular genetic technique in prenatal diagnosis. Previous preclinical evidence suggests equivalence of MLPA and traditional karyotyping (TKT) regarding test performance. METHODS/DESIGN: The proposed study is a multicentre diagnostic substitute study among pregnant women, who choose to have amniocentesis for the indication advanced maternal age and/or increased risk following prenatal screening test. In all subjects, both MLPA and karyotyping will be performed on the amniotic fluid sample. The primary outcome is diagnostic accuracy. Secondary outcomes will be maternal quality of life, women's preferences and costs. Analysis will be intention to treat and per protocol analysis. Quality of life analysis will be carried out within the study population. The study aims to include 4500 women. DISCUSSION: The study results are expected to help decide whether MLPA can replace traditional karyotyping for 'low-risk' pregnancies in terms of diagnostic accuracy, quality of life and women's preferences. This will be the first clinical study to report on all relevant aspects of the potential replacement

Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response

The protein folding capacity of the endoplasmic reticulum (ER) is regulated by the unfolded protein response (UPR). The UPR senses unfolded proteins in the ER lumen and transmits that information to the cell nucleus, where it drives a transcriptional program that is tailored to re-establish homeostasis. Using thin section electron microscopy, we found that yeast cells expand their ER volume at least 5-fold under UPR-inducing conditions. Surprisingly, we discovered that ER proliferation is accompanied by the formation of autophagosome-like structures that are densely and selectively packed with membrane stacks derived from the UPR-expanded ER. In analogy to pexophagy and mitophagy, which are autophagic processes that selectively sequester and degrade peroxisomes and mitochondria, the ER-specific autophagic process described utilizes several autophagy genes: they are induced by the UPR and are essential for the survival of cells subjected to severe ER stress. Intriguingly, cell survival does not require vacuolar proteases, indicating that ER sequestration into autophagosome-like structures, rather than their degradation, is the important step. Selective ER sequestration may help cells to maintain a new steady-state level of ER abundance even in the face of continuously accumulating unfolded proteins

Skunk River Fall 1998

https://openspace.dmacc.edu/skunkriver/1019/thumbnail.jp