Smart Footwear Insole for Recognition of Foot Pronation and Supination Using Neural Networks

Abnormal foot postures during gait are common sources of pain and pathologies of the lower limbs. Measurements of foot plantar pressures in both dynamic and static conditions can detect these abnormal foot postures and prevent possible pathologies. In this work, a plantar pressure measurement system is developed to identify areas with higher or lower pressure load. This system is composed of an embedded system placed in the insole and a user application. The instrumented insole consists of a low-power microcontroller, seven pressure sensors and a low-energy bluetooth module. The user application receives and shows the insole pressure information in real-time and, finally, provides information about the foot posture. In order to identify the different pressure states and obtain the final information of the study with greater accuracy, a Deep Learning neural network system has been integrated into the user application. The neural network can be trained using a stored dataset in order to obtain the classification results in real-time. Results prove that this system provides an accuracy over 90% using a training dataset of 3000+ steps from 6 different users.Ministerio de Economía y Competitividad TEC2016-77785-

Efficacy and safety clinical trial with efavirenz in patients diagnosed with adult Niemann-pick type C with cognitive impairment

Background:Niemann-Pick disease Type C (NPC) is a genetic, incurable, neurodegenerative disorder. This orphan disease is most frequently caused by mutations in the NPC1 protein, resulting in intralysossomal cholesterol accumulation. NPC1 is found in neuronal cell bodies, axon terminals and synaptosomes, suggesting it plays a role in lysosomal degradation pathway and in synaptic transmission. Neuronal function is especially vulnerable to NPC1 deficiency and synaptic changes seem a key element in disease development. Currently, Miglustat (Zavesca (R)) is the only approved treatment for NPC. However, preclinical evidence showed that low-dose Efavirenz reverted synaptic defects through pharmacological activation of the enzyme CYP46. Methods:This is a single-center, phase II clinical trial to evaluate the efficacy and safety of Efavirenz in addition to standard of care in patients diagnosed with adult or late juvenile-onset NPC with cognitive impairment. All enrolled patients will be treated orally with 25 mg/d of Efavirenz for 52 weeks (1 year). Secondary objectives include evaluating clinical (neurological and neuropsychological questionnaires) and biological (imaging and biochemical biomarkers) parameters. Discussion:NPC is still an unmet medical need. Although different therapeutic approaches are under study, this is the first clinical trial (to the best of our knowledge) studying the effects of Efavirenz in adult- and late-juvenile-onset NPC. Despite the small sample size and the single-arm design, we expect the results to show Efavirenz's capacity of activating the CYP46 enzyme to compensate for NPC1 deficiency and correct synaptic changes, therefore compensating cognitive and psychiatric changes in these patients. This study may provide direct benefit to enrolled patients in terms of slowing down the disease progression

Qué necesitan los estudiantes de Periodismo para su inserción laboral. Análisis de la demanda del mercado laboral de las empresas de comunicación.

PIMCD nº 176, realizado por el grupo Research and Learning of Media and Communications Management. Investigación y Enseñanza de la Gestión de los Medios y la Comunicación (MediaCom UCM) www.ccinf.es/mediacom/Primera fase de trabajo para fijar descriptores que identifiquen comportamientos formativos de entrada en el mercado laboral. En esta fase se han encontrado 442 oferentes de contratos en prácticas para estudiantes de Periodismo. Los datos obtenidos se articulan de acuerdo a dos subsecciones: sectores empresariales y empresas; a su vez, cada subsector, atendiendo al índice de recepción de alumnos y la descripción cualitativa de los puestos.Depto. de Periodismo y Comunicación GlobalFac. de Ciencias de la InformaciónFALSEsubmitte

Proyectos de emprendimiento para la empleabilidad de titulados en periodismo

Objetivo principal: poner a disposición de los alumnos de segundo ciclo del Grado de Periodismo un espacio de coworking en condiciones adecuadas así como docentes que les tutelen para que puedan afrontar sus ideas y proyectarlas hacia el mercado de la Comunicación, en el que puedan desarrollar sus proyectos periodísticos y lograr la creación de una micro-pyme informativa y/o de comunicación. Objetivos específicos: a) Diseñar un marco integral de conocimientos a partir de las competencias periodísticas aprendidos en la titulación de periodismo: la empresa informativa, la estructura, la tecnología, la dirección y gestión periodística y de medios, para acercar a los estudiantes al mundo empresarial. b) Facilitar la salida al mercado laboral, empresarial y en Comunicación a cuantas ideas de negocio se valoren como posibles y se puedan gestionar desde estos espacios de trabajo colaborativo, mediante la tutorización y la mentoría. En cuanto a la metodología aplicada, se trata de evaluar y proyectar ideas creativas previas a su lanzamiento al mercado, a partir de una personalidad jurídica concreta y presumible (viabilidad societaria), durante el cuatrimestre de trabajo (fase de recuperación de datos) a partir de dos grupos (muestra total de unos 132 alumnos) divididos en 18 equipos (17 presenciales y uno virtual) organizados a partir de un proyecto de innovación docente. Se les explica el contenido del proyecto y las razones de llevarlo a cabo, tras lo cual sólo 16 alumnos han decidido no participar, por lo que el total de alumnos participantes ha sido de 116. Los espacios de desarrollo metodológico se sitúan en el marco de las clases de 4º curso del Grado de Periodismo, asignatura de “Dirección y Gestión de Empresas Periodísticas”, grupos A y C, durante el 2ª Cuatrimestre del curso 2017-2018 (enero-mayo) y termina con una presentación de cada proyecto a la finalización del periodo lectivo. Destacar como resultados más notables que de los 18 equipos que todos son proyectos nativos digitales y que internet es la red por excelencia que les acoge y les permite distribuir sus productos a partir de contenidos periodísticos de información, bien generalista o de diferentes temáticas que a su vez se van especializando. Seis de estos proyectos se basan en la información general y otros cuatro establecen la información cultural como el valor fundamental sobre el que descansa su idea emprendedora. Ocho proyectos se distinguen por ser considerados temáticos con especializaciones muy diversas: el fútbol sala y la hípica (en el marco deportivo); la arquitectura; la información universitaria; videojuegos y tecnología; los productos lácteos (alimentación); sobre la tercera edad, y sobre el negocio de las “bodas… y divorcios”. Se observa una clara tendencia para su oportunidad de negocio y encuentran razones de mercado para un lanzamiento a corto – medio plazo. Uno de estos proyectos está residente en Tetuán Valley

Tools for cooperative learning in food and health sciences in university education and vocational training

El presente proyecto ha pretendido la realización de prácticas docentes por parte de alumnos de 4º curso del Grado de Ciencia y Tecnología de los Alimentos, basadas en conocimientos sobre alimentación y nutrición, en colaboración con los estudiantes de un Ciclo Formativo de Grado Superior de la Familia Profesional Sanitaria en el Instituto de Educación Secundaria Fuensanta de la ciudad de Córdoba. La toma de decisiones y realización de las mismas se ha llevado a cabo en todo momento por parte del alumnado de ambos centros educativos, actuando el profesorado como meros orientadores del proceso. Con dicho proyecto se ha pretendido, además de la puesta en práctica de los conocimientos teóricos, adquiridos durante su formación, la puesta en común de una misma actividad que permita el conocimiento entre ambos niveles educativos así como el enriquecimiento profesional y personal.The object of the present project has been the realization of teaching practices by students of 4th year of Degree in Food Science and Technology of the University of Cordoba in collaboration with vocational training students. They have made decision-making at all times and professors has been mere counselors. With this project it has been tried, in addition to the putting into practice of the theoretical knowledge, acquired during its formation. Moreover it has been keep in touch, students belonging to different educational stages

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies

Individual Shrink Wrapping of Zucchini Fruit Improves Postharvest Chilling Tolerance Associated with a Reduction in Ethylene Production and Oxidative Stress Metabolites

We have studied the effect of individual shrink wrapping (ISW) on the postharvest performance of refrigerated fruit from two zucchini cultivars that differ in their sensitivity to cold storage: Sinatra (more sensitive) and Natura (more tolerant). The fruit was individually shrink wrapped before storing at 4°C for 0, 7 and 14 days. Quality parameters, ethylene and CO2 productions, ethylene gene expression, and oxidative stress metabolites were assessed in shrink wrapped and non-wrapped fruit after conditioning the fruit for 6 hours at 20°C. ISW decreased significantly the postharvest deterioration of chilled zucchini in both cultivars. Weight loss was reduced to less than 1%, pitting symptoms were completely absent in ISW fruit at 7 days, and were less than 25% those of control fruits at 14 days of cold storage, and firmness loss was significantly reduced in the cultivar Sinatra. These enhancements in quality of ISW fruit were associated with a significant reduction in cold-induced ethylene production, in the respiration rate, and in the level of oxidative stress metabolites such as hydrogen peroxide and malonyldialdehyde (MDA). A detailed expression analysis of ethylene biosynthesis, perception and signaling genes demonstrated a downregulation of CpACS1 and CpACO1 genes in response to ISW, two genes that are upregulated by cold storage. However, the expression patterns of six other ethylene biosynthesis genes (CpACS2 to CpACS7) and five ethylene signal transduction pathway genes (CpCTR1, CpETR1, CpERS1, CpEIN3.1 and CpEN3.2), suggest that they do not play a major role in response to cold storage and ISW packaging. In conclusion, ISW zucchini packaging resulted in improved tolerance to chilling concomitantly with a reduction in oxidative stress, respiration rate and ethylene production, as well as in the expression of ethylene biosynthesis genes, but not of those involved in ethylene perception and sensitivity.This work was supported by grants AGL2011-30568-C02/ALI from the Spanish Ministry of Science and Innovation, and AGR1423 from the Consejería de Economía, Innovación y Ciencia, Junta de Andalucía, Spain. Z.M. acknowledges FPU program scholarships from MEC, Spain. S.M. is funded by grant PTA2011-479-I from the Spanish Ministry of Science and Innovation

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Evaluación de la calidad asistencial de una unidad de hospitalización psiquiátrica mediante el uso de la escala de verona adaptada

Treball de Final de Universitari en Rehabilitació Psicosocial en Salut Mental Comunitària. Codi: SAX014. Curs universitari 2014-2015En el presente estudio se aplicó un cuestionario a 45 pacientes ingresados en una Unidad de Agudos de Psiquiatría, utilizando la Escala de Verona adaptada. Con el objetivo de conocer el grado de satisfacción con los servicios y atención recibida durante su ingreso. Asimismo se realiza un perfil sociodemográfico del paciente ingresado en nuestro servicio. En general, y coincidiendo con la mayoría de estudios revisados, la mayor parte de los pacientes encuestados aportan alto grado de satisfacción. Incluso siendo la “satisfacción” un concepto a día de hoy difícil de medir debido al alto nivel intrínseco de subjetividad que tiene, los profesionales no debemos dejar de preguntarnos qué tipo de atención reciben los pacientes a los que nos debemos, y sobretodo sería más interesante preguntar ¿qué no hacemos bien?, así también incluimos al paciente como agente activo de su propio proceso, haciéndole partícipe de los cambios y poder plantearnos mejoras en nuestra atención.In the present study, a questionnaire to 45 patients admitted to Acute Psychiatric Unit was applied, using the scale adapted Verona, in order to know the degree of satisfaction with the services and care provided during hospitalization. A socio-demographic profile of patients admitted to our service is also performed. Overall, coinciding with most studies reviewed, most of the patients surveyed provide high level of satisfaction. Even is the "satisfaction" concept today difficult to measure due to the high intrinsic level of subjectivity, that is, professionals should not help wondering what kind of care received by patients who should we?, and most would be more interesting ask ¿ what do we well? . Also we include the patient as an active agent in his own process, taking him into the changes and enhancements to ask our attentio