Prevalence of and risk factors for degenerative mitral valve disease in dogs attending primary-care veterinary practices in england

Background To date, epidemiological studies on degenerative mitral valve disease (DMVD) in dogs have largely reported referral caseloads or been limited to predisposed breeds. Analysis of primary‐care data to identify factors associated with DMVD would help clinicians identify high‐risk individuals and improve understanding. Objectives To estimate the prevalence of and identify risk factors for DMVD in dogs attending primary‐care veterinary practices in England. Animals Cases were identified within the electronic patient records of 111,967 dogs attending 93 practices. Four hundred and 5 dogs were diagnosed with DMVD (diagnosed cases) and a further 3,557 dogs had a heart murmur (HM) consistent with DMVD (possible cases). Methods Retrospective cross‐sectional study design. Prevalence was adjusted for the sampling approach. Mixed effects logistic regression models identified factors associated with DMVD. Results Prevalence estimates of diagnosed DMVD and HMs consistent with DMVD (both diagnosed and possible cases) were 0.36% (95% confidence interval [CI]: 0.29–0.45) and 3.54% (95% CI: 3.26–3.84) respectively. In the multivariable analysis, males had higher odds of diagnosed DMVD than did females (odds ratio [OR] 1.40, 95% CI: 1.12–1.74). Insured dogs had increased odds of DMVD compared with noninsured dogs (OR 3.56, 95% CI: 2.79–4.55) and dogs ≥20 kg had approximately half the odds of DMVD diagnosis compared with dogs(OR 0.51, 95% CI: 0.36–0.74). Strong associations between a DMVD diagnosis and individual breeds and age were identified. Conclusions and Clinical Importance Degenerative mitral valve disease was a common disorder in practice‐attending dogs. Knowledge of identified risk factors for DMVD could improve clinical diagnosis and direct future research

Monte Carlo Comparisons to a Cryogenic Dark Matter Search Detector with low Transition-Edge-Sensor Transition Temperature

We present results on phonon quasidiffusion and Transition Edge Sensor (TES) studies in a large, 3 inch diameter, 1 inch thick [100] high purity germanium crystal, cooled to 50 mK in the vacuum of a dilution refrigerator, and exposed with 59.5 keV gamma-rays from an Am-241 calibration source. We compare calibration data with results from a Monte Carlo which includes phonon quasidiffusion and the generation of phonons created by charge carriers as they are drifted across the detector by ionization readout channels. The phonon energy is then parsed into TES based phonon readout channels and input into a TES simulator

Experimental Characterization of Space Charge in IZIP Detectors

Interleaved ionization electrode geometries offer the possibility of efficient rejection of near-surface events. The CDMS collaboration has implemented this interleaved approach for the charge and phonon readout for our germanium detectors. During a recent engineering run with negligible ambient radiation, the detectors were found to lose ionization stability more quickly than expected. This paper summarizes studies done in order to determine the underlying cause of the instability, as well as possible running modes that maintain stability without unacceptable loss of livetime. Additionally, first results are shown for the new version IZIP mask which attempts to improve the overall stability of the detectors.United States. Dept. of Energy (Grant DE-AC02-76SF00515)National Science Foundation (U.S.) (Awards 0705052, 0902182, 1004714, and 0802575

Senior Classics Seminar

This document testifies to the determination, dedication, and resilience of the eleven seniors who took CLAS 471: Senior Seminar in Classics during the most challenging crisis many of us are likely to face. It is the attendance sheet for the course. It shows that, in spite of it all, seven of the eleven students had perfect attendance, making it to all 28 class meetings. In the second half of the course, when we met synchronously by Zoom, ten of the eleven students attended every single session; the one outlier missed but a single class. Regarding the document itself. I have always used orange paper for my attendance sheets. The dates on which the course met run across the x-axis (e.g., 1a = week 1 of the semester, first session of the week); the students\u27 last names run along the y-axis. A squiggle to the left of a student\u27s last name indicates perfect attendance. When we were meeting in Gambier, students initialed the appropriate box to record their presence; when we met remotely, I filled out the form, checking the box when students were present and penciling in a circle when the one student was absent. Other symbols include X, which represents an unexcused absence; E an excused one; T means tardy. There are not many Xs, Es, or Ts, and, of course, just one circle. The eleven students in the course know that I am submitting this document to the archive and have given their permission to do so.https://digital.kenyon.edu/covid19words/1000/thumbnail.jp

Baking Class Plan

Born from a conversation with a friend about two months into the shutdown, I began offering a virtual baking class for tweens starting at the beginning of May 2020. In the end, I hosted 13 baking classes for six girls aged 11-13 from May through August. This submission is a PDF containing recipes, scripts, and photos.https://digital.kenyon.edu/covid19words/1065/thumbnail.jp

The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols

It has been previously proposed that nitric oxide (NO) is the only biologically relevant nitrogen oxide capable of activating the enzyme soluble guanylate cyclase (sGC). However, recent reports implicate HNO as another possible activator of sGC. Herein, we examine the affect of HNO donors on the activity of purified bovine lung sGC and find that, indeed, HNO is capable of activating this enzyme. Like NO, HNO activation appears to occur via interaction with the regulatory ferrous heme on sGC. Somewhat unexpectedly, HNO does not activate the ferric form of the enzyme. Finally, HNO-mediated cysteine thiol modification appears to also affect enzyme activity leading to inhibition. Thus, sGC activity can be regulated by HNO via interactions at both the regulatory heme and cysteine thiols

CDMS, Supersymmetry and Extra Dimensions

The CDMS experiment aims to directly detect massive, cold dark matter particles originating from the Milky Way halo. Charge and lattice excitations are detected after a particle scatters in a Ge or Si crystal kept at ~30 mK, allowing to separate nuclear recoils from the dominating electromagnetic background. The operation of 12 detectors in the Soudan mine for 75 live days in 2004 delivered no evidence for a signal, yielding stringent limits on dark matter candidates from supersymmetry and universal extra dimensions. Thirty Ge and Si detectors are presently installed in the Soudan cryostat, and operating at base temperature. The run scheduled to start in 2006 is expected to yield a one order of magnitude increase in dark matter sensitivity.Comment: To be published in the proceedings of the 7th UCLA symposium on sources and detection of dark matter and dark energy in the universe, Marina del Rey, Feb 22-24, 200

Analysis of the low-energy electron-recoil spectrum of the CDMS experiment

We report on the analysis of the low-energy electron-recoil spectrum from the CDMS II experiment using data with an exposure of 443.2 kg-days. The analysis provides details on the observed counting rate and possible background sources in the energy range of 2 - 8.5 keV. We find no significant excess in the counting rate above background, and compare this observation to the recent DAMA results. In the framework of a conversion of a dark matter particle into electromagnetic energy, our 90% confidence level upper limit of 0.246 events/kg/day at 3.15 keV is lower than the total rate above background observed by DAMA by 8.9$\sigma$. In absence of any specific particle physics model to provide the scaling in cross section between NaI and Ge, we assume a Z^2 scaling. With this assumption the observed rate in DAMA differs from the upper limit in CDMS by 6.8$\sigma$. Under the conservative assumption that the modulation amplitude is 6% of the total rate we obtain upper limits on the modulation amplitude a factor of ~2 less than observed by DAMA, constraining some possible interpretations of this modulation.Comment: 4 pages, 3 figure