The Primacy Of Painting: The Institutional Structures of the Singapore Art World from 1935 to 1972

Master'sMASTER OF ART

Evaluating the ESL Reading Texts for Intermediate Learners of English from the Perspective of Students

In order to provide an evaluation of the suitability of reading texts from the perspective of students in university-based intensive English programme this study examined 53 international ESL intermediate learners perceptions of reading texts for a period of 14 weeks reading proficiency lessons Features evaluated include content readability exploitability and authenticity of the reading texts The participants responded to a textbook evaluation questionnaire to express their perceptions with reference to the features of the reading texts Results indicated the extent of appropriateness of the reading texts incorporated in the programme s reading textbook used by intermediate learners of English Further consideration must be given to text selection by including the aspect of authentic text presentatio

COGNITIVE GRAMMAR ON “SMASH”: PERSPECTIVES FROM LANGACKER’S FRAMEWORK

The language system allows us to express perceived events indifferent ways using different linguistic resources. Ability toperform this task goes beyond the notion of prescriptivegrammar, which makes no connection between language and thecognitive mind. Cognitive grammar focuses on the way weconstruct our ideas. Meaning is equated with conceptualization.Semantic structures are characterized Based on the ideas andtheses posited by Langacker with regards to Cognitive Grammar,we seek to illustrate how our cognitive minds help us manipulatethe use of language, especially the grammatical items.Keywords: Cognitive Grammar, Langacker, Pedagogy, Smas

The Impact of PowerPoint on Undergraduates’ Technical Communication Achievement

AbstractPowerPoint, one of the most well known ICT tools, plays a vital role in our society nowadays as it has been utilized widely and actively in facilitating the process of teaching and learning, especially in the educational domain. The study examined the effect of PowerPoint lecturing on undergraduates’ Technical Communication final examination grade. The experimental group was taught in a PowerPoint lecture format while the control group in a traditional whiteboard lecture format. The results revealed that the experimental group grades were significantly higher than the control group at p = 0.00

Educating Effervescent Women Scientists through Lucy Maud Montgomery's Anne of Green Gables

The series Anne of the Green Gables is sequential children books that focus on Anne Shirley, the story's protagonist. The series of books explore Anne's life from a girl to a charming pretty young lady. In the story, Anne is portrayed as an inquisitive young girl. She explores her life philosophically. She also explores many aspects of nature and its relation to science. Her inquisitiveness is extremely sharp, that the skill helps her in learning the science of everyday life. The paper discusses Anne of the Green Gables' use in educating female students to enjoy STEM education. At present, the proportion of women engineers in Malaysia is disproportionate, and the Ministry of Education is working on inculcating female students' effervescence in STEM subjects. The methodological framework utilised in this study adhered to the approach of the phenomenological case study's paradigm. Interviews were conducted, and qualitative data were gathered and analysed using Atlas.ti, a qualitative data analysis software. The findings indicated that female students could draw links between themselves and Anne, the protagonist in the novels. The protagonist's various occupational explorations helped female students understand that they can excel in STEM and arouse their interests to become scientists or engineers. In conclusion, the use of literary texts written by female authors such as Anne of Green Gables could draw attention from female students towards STEM. This study fills the gap in the existing literature where no scholars have used the classic Anne of Green Gables to illicit interests among young female students

Documents, The $100,000 gallery of art

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OPCML Is a Broad Tumor Suppressor for Multiple Carcinomas and Lymphomas with Frequently Epigenetic Inactivation

Background: Identification of tumor suppressor genes (TSGs) silenced by CpG methylation uncovers the molecular mechanism of tumorigenesis and potential tumor biomarkers. Loss of heterozygosity at 11q25 is common multiple tumors including nasopharyngeal carcinoma (NPC). OPCML, located at 11q25, is one of the downregulated genes we identified through digital expression subtraction. Methodology/Principal Findings: Semi-quantitative RT-PCR showed frequent OPCML silencing in NPC and other common tumors, with no homozygous deletion detected by multiplex differential DNA-PCR. Instead, promoter methylation of OPCML was frequently detected in multiple carcinoma cell lines (nasopharyngeal, esophageal, lung, gastric, colon, liver, breast, cervix, prostate), lymphoma cell lines (non-Hodgkin and Hodgkin lymphoma, nasal NK/T-cell lymphoma) and primary tumors, but not in any non-tumor cell line and seldom weakly methylated in normal epithelial tissues. Pharmacological and genetic demethylation restored OPCML expression, indicating a direct epigenetic silencing. We further found that OPCML is stress-responsive, but this response is epigenetically impaired when its promoter becomes methylated. Ecotopic expression of OPCML led to significant inhibition of both anchorage-dependent and -indendent growth of carcinoma cells with endogenous silencing. Conlusions/Significance: Thus, through functional epigenetics, we identified OPCML as a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies. © 2008 Cui et al.published_or_final_versio

Baseline characteristics of participants in the Pre-Diabetes Interventions and Continued Tracking to Ease-out Diabetes (Pre-DICTED) Program

OBJECTIVE: The Pre-Diabetes Interventions and Continued Tracking to Ease-out Diabetes (Pre-DICTED) Program is a diabetes prevention trial comparing the diabetes conversion rate at 3 years between the intervention group, which receives the incentivized lifestyle intervention program with stepwise addition of metformin, and the control group, which receives the standard of care. We describe the baseline characteristics and compare Pre-DICTED participants with other diabetes prevention trials cohort. RESEARCH DESIGN AND METHODS: Participants were aged between 21 and 64 years, overweight (body mass index (BMI) ≥23.0 kg/m2), and had pre-diabetes (impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT)). RESULTS: A total of 751 participants (53.1% women) were randomized. At baseline, mean (SD) age was 52.5 (8.5) years and mean BMI (SD) was 29.0 (4.6) kg/m2. Twenty-three per cent had both IFG and IGT, 63.9% had isolated IGT, and 13.3% had isolated IFG. Ethnic Asian Indian participants were more likely to report a family history of diabetes and had a higher waist circumference, compared with Chinese and Malay participants. Women were less likely than men to meet the physical activity recommendations (≥150 min of moderate-intensity physical activity per week), and dietary intake varied with both sex and ethnicity. Compared with other Asian diabetes prevention studies, the Pre-DICTED cohort had a higher mean age and BMI. CONCLUSION: The Pre-DICTED cohort represents subjects at high risk of diabetes conversion. The study will evaluate the effectiveness of a community-based incentivized lifestyle intervention program in an urban Asian context.Peer reviewe

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process

Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of vertical cup-disc ratio (VCDR), an important disease-related optic nerve parameter. In 21,094 individuals of European ancestry and 6,784 individuals of Asian ancestry, we identify 10 new loci associated with variation in VCDR. In a separate risk-score analysis of five case-control studies, Caucasians in the highest quintile have a 2.5-fold increased risk of primary open-angle glaucoma as compared with those in the lowest quintile. This study has more than doubled the known loci associated with optic disc cupping and will allow greater understanding of mechanisms involved in this common blinding condition

The genetic architecture of type 2 diabetes

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing in 2,657 Europeans with and without diabetes, and exome sequencing in a total of 12,940 subjects from five ancestral groups. To increase statistical power, we expanded sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support a major role for lower-frequency variants in predisposition to type 2 diabetes