Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Withdrawal Is Associated with Higher Mortality in Hospitalized Patients with COVID-19

Our main aim was to describe the effect on the severity of ACEI (angiotensin-converting enzyme inhibitor) and ARB (angiotensin II receptor blocker) during COVID-19 hospitalization. A retrospective, observational, multicenter study evaluating hospitalized patients with COVID-19 treated with ACEI/ARB. The primary endpoint was the incidence of the composite outcome of prognosis (IMV (invasive mechanical ventilation), NIMV (non-invasive mechanical ventilation), ICU admission (intensive care unit), and/or all-cause mortality). We evaluated both outcomes in patients whose treatment with ACEI/ARB was continued or withdrawn. Between February and June 2020, 11,205 patients were included, mean age 67 years (SD = 16.3) and 43.1% female; 2162 patients received ACEI/ARB treatment. ACEI/ARB treatment showed lower all-cause mortality (p < 0.0001). Hypertensive patients in the ACEI/ARB group had better results in IMV, ICU admission, and the composite outcome of prognosis (p < 0.0001 for all). No differences were found in the incidence of major adverse cardiovascular events. Patients previously treated with ACEI/ARB continuing treatment during hospitalization had a lower incidence of the composite outcome of prognosis than those whose treatment was withdrawn (RR 0.67, 95%CI 0.63-0.76). ARB was associated with better survival than ACEI (HR 0.77, 95%CI 0.62-0.96). ACEI/ARB treatment during COVID-19 hospitalization was associated with protection on mortality. The benefits were greater in hypertensive, those who continue

“Viceversos SocioArquitectónicos”: líneas de transversalidad entre Sociología, Geografía y Arquitectura

Introduciendo en los espacios de discusión al Departamento de Geografía Humana, el objetivo de la Red para retro-alimentar prácticas docentes mediante la aplicación de metodologías aparentemente exclusivas se mantiene, como también que dichas metodologías compartidas se aplican en acciones participadas por estudiantes y que acaban constituyendo prácticas para ser presentadas como TFGs o PFCs. El balance en cuanto a materiales producidos cuya visibilidad es ahora pública es: una comunicación presentada y leída; otra comunicación presentada y prevista su lectura en Noviembre; dos resúmenes presentados, una comunicación y organización de la Jornada “Competencias Cívicas”; y el inicio de otros campos de trabajo que se apuntan para el curso próximo. El último formato de debate y expositivo tuvo lugar fuera de la Universidad, con una jornada de investigación abierta al público y que actuó como motor de iniciativas de contenidos o metodologías sobre desarrollo local, técnicas de diseño compartido, patrimonio, medición de impactos en proyectos, fabricación digital y virtualización

Clinical Characteristics and Risk Factors of Respiratory Failure in a Cohort of Young Patients Requiring Hospital Admission with SARS-CoV2 Infection in Spain: Results of the Multicenter SEMI-COVID-19 Registry.

Age is a risk factor for COVID severity. Most studies performed in hospitalized patients with SARS-CoV2 infection have shown an over-representation of older patients and consequently few have properly defined COVID-19 in younger patients who require hospital admission. The aim of the present study was to analyze the clinical characteristics and risk factors for the development of respiratory failure among young (18 to 50 years) hospitalized patients with COVID-19. This retrospective nationwide cohort study included hospitalized patients from 18 to 50 years old with confirmed COVID-19 between March 1, 2020, and July 2, 2020. All patient data were obtained from the SEMI-COVID Registry. Respiratory failure was defined as the ratio of partial pressure of arterial oxygen to fraction of inspired oxygen (PaO2/FiO2 ratio) ≤200 mmHg or the need for mechanical ventilation and/or high-flow nasal cannula or the presence of acute respiratory distress syndrome. During the recruitment period, 15,034 patients were included in the SEMI-COVID-19 Registry, of whom 2327 (15.4%) were younger than 50 years. Respiratory failure developed in 343 (14.7%), while mortality occurred in 2.3%. Patients with respiratory failure showed a higher incidence of major adverse cardiac events (44 (13%) vs 14 (0.8%), p320 U/I (OR, 1.69; 95% CI, 1.18 to 2.42; p=0.0039), AST >35 mg/dL (OR, 1.74; 95% CI, 1.2 to 2.52; p=0.003), sodium 35 mg/dL (OR, 1.74; 95% CI, 1.2 to 2.52; p=0.003), sodium 8 mg/dL (OR, 2.42; 95% CI, 1.72 to 3.41; p Young patients with COVID-19 requiring hospital admission showed a notable incidence of respiratory failure. Obesity, SAHS, alcohol abuse, and certain laboratory parameters were independently associated with the development of this complication. Patients who suffered respiratory failure had a higher mortality and a higher incidence of major cardiac events, venous thrombosis, and hospital stay

“Viceversos SocioArquitectónicos”: líneas de transversalidad entre Sociología, Geografía y Arquitectura

Introduciendo en los espacios de discusión al Departamento de Geografía Humana, el objetivo de la Red para retro-alimentar prácticas docentes mediante la aplicación de metodologías aparentemente exclusivas se mantiene, como también que dichas metodologías compartidas se aplican en acciones participadas por estudiantes y que acaban constituyendo prácticas para ser presentadas como TFGs o PFCs. El balance en cuanto a materiales producidos cuya visibilidad es ahora pública es: una comunicación presentada y leída; otra comunicación presentada y prevista su lectura en Noviembre; dos resúmenes presentados, una comunicación y organización de la Jornada “Competencias Cívicas”; y el inicio de otros campos de trabajo que se apuntan para el curso próximo. El último formato de debate y expositivo tuvo lugar fuera de la Universidad, con una jornada de investigación abierta al público y que actuó como motor de iniciativas de contenidos o metodologías sobre desarrollo local, técnicas de diseño compartido, patrimonio, medición de impactos en proyectos, fabricación digital y virtualización