Dermatoprotective activity of a combination of enoxifol with rexod in a reduced form the blood circulation in the skin in diabetes mellitus and hypercholesterinemia

Experiments in rats showed that the 9-diethylaminoethyl-2-(3,4-dioxyphenyl)-imidazo- [1,2-a]-benzimidazole dihydrobromide with the provisional name of enoxifol (0.94 - 15 mg/kg), rexod (recombinant human superoxide dismutase; 0.002 mg/kg) and especially their combination in intravenous administration in a reduced blood circulation in the skin against the background of the normoglycemia and hyperglycemia induced by experimental (alloxanic) diabetes mellitus complicated by exogenous hypercholesterinemia have a pronounced dose-dependent dermatoprotective effect, which may be due to the activation of energy processes and increase the reserve capacity of the antioxidant support network and normalization of carbohydrate and lipid metabolis

Dermatoprotective activity of a combination of enoxifol with rexod in a reduced form the blood circulation in the skin in diabetes mellitus and hypercholesterinemia

Experiments in rats showed that the 9-diethylaminoethyl-2-(3,4-dioxyphenyl)-imidazo- [1,2-a]-benzimidazole dihydrobromide with the provisional name of enoxifol (0.94 - 15 mg/kg), rexod (recombinant human superoxide dismutase; 0.002 mg/kg) and especially their combination in intravenous administration in a reduced blood circulation in the skin against the background of the normoglycemia and hyperglycemia induced by experimental (alloxanic) diabetes mellitus complicated by exogenous hypercholesterinemia have a pronounced dose-dependent dermatoprotective effect, which may be due to the activation of energy processes and increase the reserve capacity of the antioxidant support network and normalization of carbohydrate and lipid metabolis

Comparison of markers of skin inflammation after injections of polylactic acid and threads based on polylactic acid

Aging processes lead to the tremendous changes in every tissues of human and skin is not an exception. Externally observable aging changes of the skin are caused by involutionary processes, which are happening on all levels, from skin to bones. The development of methods of prevention and treatment, which are aimed at fighting age-related changes in the skin and activating regenerative processes, is a live issue and has great scientific and practical significance.One of the important factors of skin aging is involutional changes occurring in the dermis. Currently, injections, based on polylactic acid are actively used as collagen stimulants in aesthetic medicine. Polylactic acid is a hydrophobic, biodegradable polymer derived from lactic acid. However, the mechanism of effect of polylactic acid on the components of the dermis, as well as the morphohistochemical status of the implant itself and the effect on markers of skin inflammation remains insufficiently understood and are actively discussed in the literature.We carried out biochemical studies of rat skin in order to study the effect of polylactic acid on markers of skin inflammation. To assess the condition of the skin of rats, after the administration of the studied drugs, the following was determined:• marker of inflammation - the activity of neutrophilic elastase;• factor of the state of cell membranes - the activity of lysosomal acid phosphatase;• the state of nonspecific antimicrobial protection - the activity of lysozyme.The conducted study allows us to conclude about the relative safety of preparations based on polylactic acid, the subdermal administration of which after 60 days shows minor signs of inflammation and practically does not affect the nonspecific antimicrobial protection of the skin of laboratory rats.</p

The use of author's electronic resources in the teaching of children at the 1st level of general secondary education in the conditions of inclusive education

В статье раскрываются возможности использования авторских электронных средств обучения в условиях инклюзивного образования. Эти работы могут использоваться при обучении учащихся с тяжёлыми нарушениями речи, нарушениями психического развития, трудностями в обучении, слабослышащими и слабовидящими учащимися. The article reveals the possibilities of using copyright electronic teaching aids in an inclusive education. These works can be used for teaching students with severe speech impairments, mental development disorders, learning difficulties, hearing impaired and visually impaired students

Rat skin inflammation markers change in response to calcium hydroxyapatite and hyaluronic acid administration

In the research, the level of some markers of skin inflammation in Wistar rats was examined after injection of calcium hydroxyapatite and hyaluronic acid drugs of various concentrations, where the nature, degree, extent of tissue damage and the general condition of the animals in general were close to humans’. Each drug was evaluated according to several indicators (MDA content, activity of neutrophil elastase, acid phosphatase, and catalase) to understand the measure of the adequacy of the body's response to the intensity of the stimulus. A biochemical analysis of the skin of laboratory rats after the injection of the studied drugs showed that the safest drugs contain nonstabilized 4% hyaluronic acid. Either in pure form or in a 1: 1 mixture with calcium hydroxyapatite at a concentration of 55.7%, since in 2 months after their injection in the skin of experimental animals, markers of inflammation (elastase, acid phosphatase and MDA levels), catalase and API activity were found at the normal level. The injection of drugs containing stabilized 2% hyaluronic acid and calcium hydroxyapatite 55.7%, as well as stabilized 2.6% hyaluronic acid and calcium hydroxyapatite at a concentration of 1% caused prolonged LPO activation, increased level of inflammation markers and decreased API. The injection of calcium hydroxyapatite drugs without hyaluronic acid, even at a 1: 1 dilution with saline, also caused prolonged LPO activation, an increased level of inflammation markers and a decreased API, and, in addition, revealed a significant increase in acid phosphatase activity, which is an indicator of the integrity of cell membranes. The obtained results made it possible to analyze the features of the molecular response and regulation of inflammation upon injection of calcium hydroxyapatite and hyaluronic acid drugs of different concentrations, which will help in prescribing of treatment

Construction of precision wire readout planes for the Short-Baseline Near Detector (SBND)

The Short-Baseline Near Detector time projection chamber is unique in the design of its charge readout planes. These anode plane assemblies (APAs) have been fabricated and assembled to meet strict accuracy and precision requirements: wire spacing of 3 mm +/- 0.5 mm and wire tension of 7 N +/- 1 N across 3,964 wires per APA, and flatness within 0.5 mm over the 4 m +/- 2.5 m extent of each APA. This paper describes the design, manufacture and assembly of these key detector components, with a focus on the quality assurance at each stage