Local stress anomaly in the Bavarian Molasse Basin

Background: The characterization of fault zones in the Bavarian Molasse Basin plays a major role for further geothermal reservoir development. Hence, their identification, geological origin, and hydraulic characterization are discussed extensively. Methods: Stress indicators and fractures are interpreted from image and caliper logs of three highly deviated wells at the Sauerlach site. We transform the identified stress field into the borehole coordinate system and compare the observed orientation to the modeled stress field which assumes a homogeneous borehole surrounding. Results: High breakout occurrence, cross-cutting fractures, and a fracture orientation from N-S to NNE-SSW are observed in Sauerlach Th1. In Sauerlach Th2 and Th3, fractures strike primarily ENE-WSW and N-S to NNE-SSW. Drilling-enhanced natural fractures and drilling-induced tensile fractures are observed in all three wells and indicate the orientation of tensile stress at the borehole wall. In Sauerlach Th2 and Th3, stress transformation indicates a S$_{H}$-dir. ~ N 10°E in a strike-slip stress regime. The modeled stress orientations match the observed orientations within the well Sauerlach Th1 if either S$_{H}$-dir. is N 320°E in a strike-slip regime or S$_{H}$-dir. is N 10°E in a normal faulting regime. Conclusion: This approach improves the detection of the local stress field especially for non-vertical wells, which has, in combination with the facture pattern, a major impact on the hydraulic system of the geothermal reservoir

Predictive Maintenance – Analysis of Seasonal Dependence of Vehicle Engine Faults

This paper presents methods and results for the analysis of interrelationships between the occurrence of specific engine faults according to seasons. The issue of maintenance is substantial for the automotive industry and improvements are requested due to the enhancement of profitability. Findings of this paper are based on logged-vehicle data from 760.976 vehicles provided by the company Geotab. Utilization of such data gains importance for the automotive service sector with special regard of increasing importance of predictive maintenance. The visualization of the data of three different engine faults was realized with the free graphic and statistics program “Tableau Desktop 2018.1” as well as “IBM SPSS Statistics Subscription Trial for Mac OS”. The result is that the tested interrelations are significant, leading to the conclusion that the engine faults of “vehicle battery has low voltage”, “low priority warning light on” and “general warning light on” are dependent of seasons. This finding can be used to help car manufacturers and car service providers to reduce maintenance costs. Keywords: automotive, big data, predictive maintenance, seasonal engine faults, vehicle error code

Uptake/Efflux Transport of Tramadol Enantiomers and O-Desmethyl-Tramadol: Focus on P-Glycoprotein

Abstract: The analgesic effect of tramadol (TMD) results from the monoaminergic effect of its two enantiomers, (+)-TMD and ())-TMD as well as its opioid metabolite (+)-O-desmethyl-tramadol (M1). P-glycoprotein (P-gp) might be of importance in the analgesic and tolerability profile variability of TMD. Our study investigated the involvement of P-gp in the transepithelial transport of (+)-TMD, ())-TMD and M1, using a Caco-2 cell monolayer model. The bidirectional transport of racemic TMD and M1 (1–100 lM) across the monolayers was investigated at two pH conditions (pH 6.8/7.4 and 7.4/7.4) in the presence and absence of P-gp inhibitor cyclosporine A (10 lM) and assessed with the more potent and specific P-gp inhibitor GF120918 (4 lM). Analytical quantification was performed by liquid chromatography coupled to the fluorescence detector. A net secretion of (+)-TMD, ())-TMD and M1 was observed when a pH gradient was applied (TR: Papp(B) A)/Papp(A) B): 1.8–2.7; P < 0.05). However, the bidirectional transport of all compounds was equal in the non-gradient system. In the presence of P-gp inhibitors, a slight but significant increase of secretory flux was observed (up to 26%; P < 0.05) at both pH conditions. In conclusion, (+)-TMD, ())-TMD and M1 are not P-gp substrates. However, proton-based efflux pumps may be involved in limiting the gastrointestinal absorption of TMD enantiomers as well as enhancing TMD enantiomers and M1 renal excretion. A possible involvement of uptake carriers in the transepithelial transport of TMD enantiomers and M1 is suggested. Tramadol hydrochloride (TMD) is a centrally acting analgesi

Uptake/Efflux Transport of Tramadol Enantiomers and O-Desmethyl-Tramadol: Focus on P-Glycoprotein

The analgesic effect of tramadol (TMD) results from the monoaminergic effect of its two enantiomers, (+)-TMD and (-)-TMD as well as its opioid metabolite (+)-O-desmethyl-tramadol (M1). P-glycoprotein (P-gp) might be of importance in the analgesic and tolerability profile variability of TMD. Our study investigated the involvement of P-gp in the transepithelial transport of (+)-TMD, (-)-TMD and M1, using a Caco-2 cell monolayer model. The bidirectional transport of racemic TMD and M1 (1-100 microM) across the monolayers was investigated at two pH conditions (pH 6.8/7.4 and 7.4/7.4) in the presence and absence of P-gp inhibitor cyclosporine A (10 microM) and assessed with the more potent and specific P-gp inhibitor GF120918 (4 microM). Analytical quantification was performed by liquid chromatography coupled to the fluorescence detector. A net secretion of (+)-TMD, (-)-TMD and M1 was observed when a pH gradient was applied (TR: P(app)(B - A)/P(app)(A - B): 1.8-2.7; P < 0.05). However, the bidirectional transport of all compounds was equal in the non-gradient system. In the presence of P-gp inhibitors, a slight but significant increase of secretory flux was observed (up to 26%; P < 0.05) at both pH conditions. In conclusion, (+)-TMD, (-)-TMD and M1 are not P-gp substrates. However, proton-based efflux pumps may be involved in limiting the gastrointestinal absorption of TMD enantiomers as well as enhancing TMD enantiomers and M1 renal excretion. A possible involvement of uptake carriers in the transepithelial transport of TMD enantiomers and M1 is suggested

Theatre and Chemistry Buildings

The walkway between the Science (now Chemistry) Building on the right of the photo and Theater Building (formerly the Science Auditorium), on the left, shortly after construction. The second Theater tent can be seen in the background.https://stars.library.ucf.edu/univphotocollection/1785/thumbnail.jp

Ferrell Commons courtyard and palm

A view of the Ferrell Commons courtyard in 1970, with a palm tree in the foreground. Written on back Folder-Buildings, Description-Village Center, Date Sept. 1970, Photographer-Seithel . Stamped on back Chuck .https://stars.library.ucf.edu/univphotocollection/1733/thumbnail.jp