A Case of Granulocyte-Colony Stimulating Factor-Producing Hepatocellular Carcinoma Confirmed by Immunohistochemistry

Granulocyte-colony stimulating factor (G-CSF) is a naturally occurring glycoprotein that stimulates the proliferation and maturation of precursor cells in the bone marrow into fully differentiated neutrophils. Several reports of G-CSF-producing malignant tumors have been published, but scarcely any in the hepatobiliary system, such as in hepatocellular carcinoma (HCC). Here, we encountered a 69-yr-old man with a hepatic tumor who had received right hepatic resection. He showed leukocytosis of 25,450/µL along with elevated serum G-CSF. Histological examination of surgical samples demonstrated immunohistochemical staining for G-CSF, but not for G-CSF receptor. The patient survived without recurrence for four years, but ultimately passed away with multiple bone metastases. In light of the above, clinicians may consider G-CSF-producing HCC when encountering patients with leukocytosis and a hepatic tumor. More cases are needed to clarify the clinical picture of G-CSF-producing HCC

CO Multi-line Imaging of Nearby Galaxies (COMING) IV. Overview of the Project

Observations of the molecular gas in galaxies are vital to understanding the evolution and star-forming histories of galaxies. However, galaxies with molecular gas maps of their whole discs having sufficient resolution to distinguish galactic structures are severely lacking. Millimeter wavelength studies at a high angular resolution across multiple lines and transitions are particularly needed, severely limiting our ability to infer the universal properties of molecular gas in galaxies. Hence, we conducted a legacy project with the 45 m telescope of the Nobeyama Radio Observatory, called the CO Multi-line Imaging of Nearby Galaxies (COMING), which simultaneously observed 147 galaxies with high far-infrared flux in $^{12}$CO, $^{13}$CO, and C$^{18}$O $J=1-0$ lines. The total molecular gas mass was derived using the standard CO-to-H$_2$ conversion factor and found to be positively correlated with the total stellar mass derived from the WISE $3.4 \mu$m band data. The fraction of the total molecular gas mass to the total stellar mass in galaxies does not depend on their Hubble types nor the existence of a galactic bar, although when galaxies in individual morphological types are investigated separately, the fraction seems to decrease with the total stellar mass in early-type galaxies and vice versa in late-type galaxies. No differences in the distribution of the total molecular gas mass, stellar mass, and the total molecular gas to stellar mass ratio was observed between barred and non-barred galaxies, which is likely the result of our sample selection criteria, in that we prioritized observing FIR bright (and thus molecular gas-rich) galaxies.Comment: Accepted for publication in PASJ; 47 pages, 5 tables, 29 figures. On-line supplementary images are available at this URL (https://astro3.sci.hokudai.ac.jp/~radio/coming/publications/). CO data is available at the Japanese Virtual Observatory (JVO) website (https://jvo.nao.ac.jp/portal/nobeyama/coming.do) and the project website (https://astro3.sci.hokudai.ac.jp/~radio/coming/data/

Japanese glaciological activities at NEEM, Greenland

第2回極域科学シンポジウム　氷床コアセッション 11月16日（水） 国立極地研究所 2階大会議室前フロ

Regional Financial CGE Model for Infrastructure Investment Policy

In this paper, regional financial computable general equilibrium (RFCGE) model was developed. The RFCGE model is a useful tool in the evaluation of regional fiscal policies. So far, computable general equilibrium (CGE) models have often been used to evaluate regional infrastructure investment policies. However, conventional CGE models do not consider financial assets, such as deposits, equities, and government bonds and decision-making mechanism of government. Therefore, applying CGE models might overestimate the benefit incidence of policies on the rural society. To confirm this theory, the RFCGE model was applied to regional infrastructure investment policy

Calibration and control of in-plane Mg doping distribution in Mg_xZn_(1−x)O/ZnO heterostructures grown by molecular beam epitaxy

The in-plane Mg doping distribution in molecular beam epitaxy grown Mg_xZn_(1−x)O/ZnO heterostructures is mapped by low-temperature photoluminescence measurements in an effort to evaluate and control the resultant inhomogeneity formed during the growth process. In an unrotated sample, the independent configuration effects of the O₃ and Mg source cells are clearly demonstrated in a composition spread due to flux gradients, while this inhomogeneity is suppressed by sample rotation during the growth. The present mapping results provide an important means for investigating improved doping regimes with the aim of enhancing the quality of quantum transport observable at the Mg_xZn_(1−x)O/ZnO heterointerface

Calibration and control of in-plane Mg doping distribution in Mg_xZn_(1−x)O/ZnO heterostructures grown by molecular beam epitaxy

The in-plane Mg doping distribution in molecular beam epitaxy grown Mg_xZn_(1−x)O/ZnO heterostructures is mapped by low-temperature photoluminescence measurements in an effort to evaluate and control the resultant inhomogeneity formed during the growth process. In an unrotated sample, the independent configuration effects of the O₃ and Mg source cells are clearly demonstrated in a composition spread due to flux gradients, while this inhomogeneity is suppressed by sample rotation during the growth. The present mapping results provide an important means for investigating improved doping regimes with the aim of enhancing the quality of quantum transport observable at the Mg_xZn_(1−x)O/ZnO heterointerface