KNEE POWER IN LOW BACK PAIN SUBJECTS DURING RUNNING

The purpose of this study was to examine lower extremity shock absorption between runners with and without low back pain. We compared data from three groups based on low back pain status: current low back pain, resolved pain after a single bout of low back pain and runners who never had low back pain (CTRL). All subjects ran at least 20 km per week and ran on a force treadmill at 3.8 m•s-1 while kinematic and kinetic data were collected. Work was determined from joint power histories during the shock attenuation portion of the stance phase. Individuals with a history of low back pain exhibited less peak knee negative power and negative work suggesting that they exhibited decreased eccentric muscle activity during foot-ground impact. The results of this study suggest that decreased eccentric activity of the muscles crossing the knee joint is associated with individuals who have low back pain and, to a lesser extent, with those who have residual low back pain. We suggest that the decreased eccentric activity can result in the footground impact shock wave moving through the lower extremity with little attenuation to the low back region

Implementation of a Subset of Modes in an Algol 68 Compiler

This thesis is a description .of the mode facilities which have been added to the Oklahoma State University ALGOL 68 Compiler. Also included is a description of the changes that were required to update the language accepted by the compiler in accordance with the newest definition.Computing and Information Science

Direct Manipulation on the Virtual Workbench: Two Hands Aren't Always Better Than One

This paper reports on the investigation of the differential levels of effectiveness of various interaction techniques on a simple rotation and translation task on the virtual workbench. Manipulation time and number of collisions were measured for subjects using four device sets (unimanual glove, bimanual glove, unimanual stick, and bimanual stick). Participants were also asked to subjectively judge each device's effectiveness. Performance results indicated a main effect for device (better performance for users of the stick(s)), but not for number of hands. Subjective results supported these findings, as users expressed a preference for the stick(s)

Rumen and Serum Metabolomes in Response to Endophyte-Infected Tall Fescue Seed and Isoflavone Supplementation in Beef Steers

Fescue toxicosis impacts beef cattle production via reductions in weight gain and muscle development. Isoflavone supplementation has displayed potential for mitigating these effects. The objective of the current study was to evaluate isoflavone supplementation with fescue seed consumption on rumen and serum metabolomes. Angus steers (n = 36) were allocated randomly in a 2 × 2 factorial arrangement of treatments including endophyte-infected (E+) or endophyte-free (E−) tall fescue seed, with (P+) or without (P−) isoflavones. Steers were provided a basal diet with fescue seed for 21 days, while isoflavones were orally administered daily. Following the trial, blood and rumen fluid were collected for metabolite analysis. Metabolites were extracted and then analyzed by UPLC-MS. The MAVEN program was implemented to identify metabolites for MetaboAnalyst 4.0 and SAS 9.4 statistical analysis. Seven differentially abundant metabolites were identified in serum by isoflavone treatment, and eleven metabolites in the rumen due to seed type (p \u3c 0.05). Pathways affected by treatments were related to amino acid and nucleic acid metabolism in both rumen fluid and serum (p \u3c 0.05). Therefore, metabolism was altered by fescue seed in the rumen; however, isoflavones altered metabolism systemically to potentially mitigate detrimental effects of seed and improve animal performance

Considerations and best practices in animal science 16S ribosomal RNA gene sequencing microbiome studies

Microbiome studies in animal science using 16S rRNA gene sequencing have become increasingly common in recent years as sequencing costs continue to fall and bioinformatic tools become more powerful and user-friendly. The combination of molecular biology, microbiology, microbial ecology, computer science, and bioinformatics—in addition to the traditional considerations when conducting an animal science study—makes microbiome studies sometimes intimidating due to the intersection of different fields. The objective of this review is to serve as a jumping-off point for those animal scientists less familiar with 16S rRNA gene sequencing and analyses and to bring up common issues and concerns that arise when planning an animal microbiome study from design through analysis. This review includes an overview of 16S rRNA gene sequencing, its advantages, and its limitations; experimental design considerations such as study design, sample size, sample pooling, and sample locations; wet lab considerations such as field handing, microbial cell lysis, low biomass samples, library preparation, and sequencing controls; and computational considerations such as identification of contamination, accounting for uneven sequencing depth, constructing diversity metrics, assigning taxonomy, differential abundance testing, and, finally, data availability. In addition to general considerations, we highlight some special considerations by species and sample type

Development of a Performance-Related Test for Designing Seal Coats [Project Title from Cover]

0-7058TxDOT\u2019s seal coat program is critical to preserving its existing roadway infrastructure and ensuring roadways retain adequate skid resistance. However, sometimes seal coats fail prematurely due to factors such as incompatibility between aggregate and binder and/or binder that has poor durability while meeting other specification requirements. Seal coat design methods focus on the application rates and volumetric approaches to ensure that they are optimal. However, these methods typically do not address the compatibility of and adhesion between binder and aggregate. The overall goal of this project was to identify and develop a laboratory test(s) that can be used to evaluate the expected binder-aggregate adhesion performance and as a screening tool for any seal coat project based on its specific materials (aggregate and asphalt binder or emulsion). The study used modifications of a Sweep Test and Vialit Test to measure seal coat aggregate adhesion and performed these tests in multiple experiments to investigate the effects of binder type, dust, certain types of binder modifiers, and liquid antistrip agents on adhesion characteristics using four different aggregates mineralogies. The lab testing program and a field section evaluation indicated that the Sweep Test best evaluates the binder-aggregate adhesion. The testing also lead to recommended limits for aggregate loss

The Solenoidal Large Intensity Device (SoLID) for JLab 12 GeV

The Solenoidal Large Intensity Device (SoLID) is a new experimental apparatus planned for Hall A at the Thomas Jefferson National Accelerator Facility (JLab). SoLID will combine large angular and momentum acceptance with the capability to handle very high data rates at high luminosity. With a slate of approved high-impact physics experiments, SoLID will push JLab to a new limit at the QCD intensity frontier that will exploit the full potential of its 12 GeV electron beam. In this paper, we present an overview of the rich physics program that can be realized with SoLID, which encompasses the tomography of the nucleon in 3-D momentum space from Semi-Inclusive Deep Inelastic Scattering (SIDIS), expanding the phase space in the search for new physics and novel hadronic effects in parity-violating DIS (PVDIS), a precision measurement of $J/\psi$ production at threshold that probes the gluon field and its contribution to the proton mass, tomography of the nucleon in combined coordinate and momentum space with deep exclusive reactions, and more. To meet the challenging requirements, the design of SoLID described here takes full advantage of recent progress in detector, data acquisition and computing technologies. In addition, we outline potential experiments beyond the currently approved program and discuss the physics that could be explored should upgrades of CEBAF become a reality in the future.Comment: This white paper for the SoLID program at Jefferson Lab was prepared in part as an input to the 2023 NSAC Long Range Planning exercise. To be submitted to J. Phys.

Physician Awareness of Drug Cost: A Systematic Review

From a review of data from 24 studies, Michael Allan and colleagues conclude that doctors often underestimate the price of expensive drugs and overestimate the price of those that are inexpensive

Optimal Social Insurance and Health Inequality

This paper integrates into public economics a biologically founded, stochastic process of individual ageing. The novel approach enables us to quantitatively characterize the optimal joint design of health and retirement policy behind the veil of ignorance for today and in response to future medical progress. Calibrating our model to Germany, we find that future progress in medical technology calls for a potentially drastic increase in health spending that typically should be accompanied by a lower pension savings rate and a higher retirement age. Interestingly, medical progress and higher health spending are in conflict with the goal to reduce health inequality

Density and Dichotomous Family History Measures of Alcohol Use Disorder as Predictors of Behavioral and Neural Phenotypes: A Comparative Study Across Gender and Race/Ethnicity

Background: Family history (FH) is an important risk factor for the development of alcohol use disorder (AUD). A variety of dichotomous and density measures of FH have been used to predict alcohol outcomes; yet, a systematic comparison of these FH measures is lacking. We compared 4 density and 4 commonly used dichotomous FH measures and examined variations by gender and race/ethnicity in their associations with age of onset of regular drinking, parietal P3 amplitude to visual target, and likelihood of developing AUD. Methods: Data from the Collaborative Study on the Genetics of Alcoholism (COGA) were utilized to compute the density and dichotomous measures. Only subjects and their family members with DSM-5 AUD diagnostic information obtained through direct interviews using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) were included in the study. Area under receiver operating characteristic curves were used to compare the diagnostic accuracy of FH measures at classifying DSM-5 AUD diagnosis. Logistic and linear regression models were used to examine associations of FH measures with alcohol outcomes. Results: Density measures had greater diagnostic accuracy at classifying AUD diagnosis, whereas dichotomous measures presented diagnostic accuracy closer to random chance. Both dichotomous and density measures were significantly associated with likelihood of AUD, early onset of regular drinking, and low parietal P3 amplitude, but density measures presented consistently more robust associations. Further, variations in these associations were observed such that among males (vs. females) and Whites (vs. Blacks), associations of alcohol outcomes with density (vs. dichotomous) measures were greater in magnitude. Conclusions: Density (vs. dichotomous) measures seem to present more robust associations with alcohol outcomes. However, associations of dichotomous and density FH measures with different alcohol outcomes (behavioral vs. neural) varied across gender and race/ethnicity. These findings have great applicability for alcohol research examining FH of AUD