The Growing Regulation of Conversion Therapy.

Conversion therapies are any treatments, including individual talk therapy, behavioral (e.g. aversive stimuli), group therapy or milieu (e.g. "retreats or inpatient treatments" relying on all of the above methods) treatments, which attempt to change an individual's sexual orientation from homosexual to heterosexual. However these practices have been repudiated by major mental health organizations because of increasing evidence that they are ineffective and may cause harm to patients and their families who fail to change. At present, California, New Jersey, Oregon, Illinois, Washington, DC, and the Canadian Province of Ontario have passed legislation banning conversion therapy for minors and an increasing number of US States are considering similar bans. In April 2015, the Obama administration also called for a ban on conversion therapies for minors. The growing trend toward banning conversion therapies creates challenges for licensing boards and ethics committees, most of which are unfamiliar with the issues raised by complaints against conversion therapists. This paper reviews the history of conversion therapy practices as well as clinical, ethical and research issues they raise. With this information, state licensing boards, ethics committees and other regulatory bodies will be better able to adjudicate complaints from members of the public who have been exposed to conversion therapies

Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder

The dopamine D4 receptor (D4R), a G protein-coupled receptor, is predominantly expressed in brain regions that control cognition, attention, and decision making. Previous studies have indicated that D4R-targeted ligands could be promising therapeutic targets for the treatment of several neuropsychiatric conditions, including substance use disorders (SUDs). There are currently no FDA-approved medications that selectively target D4Rs. New ligands may facilitate better understanding of the role of D4R-mediated signaling in drug-taking and drug-seeking behaviors. The present study focuses on the synthesis and evaluation of a novel series of benzothiazole analogues designed to target D4R. We identified several compounds with high D4R binding affinity (Ki ≤ 6.87 nM) and >91-fold selectivity over other D2-like receptors (D2R, D3R) with diverse partial agonist and antagonist profiles. Based on receptor affinity and functional analyses, 5f was identified as a potent low-efficacy partial agonist of the D4R and selected for further investigation. 5f was metabolically stable in rat and human liver microsome assays and displayed excellent brain penetration in rats. Using a within-session multidosing procedure, 5f (5, 15 and 30 mg/kg, i.p.) dose-dependently decreased i.v. infusions of three-unit doses of cocaine under a fixed-ratio (FR) FR3 schedule of reinforcement. These results are consistent with previous results produced by D4R-selective antagonists in SUD models, however off-target antagonism of 5-HT2A or 5-HT2B receptors may also contribute to these effects. Results with compound 5f support further efforts to target D4R in the treatment of SUDs. Further development of the benzothiazole scaffold may engineer out any serotonergic activity

The ATLAS(3D) project - XVII. Linking photometric and kinematic signatures of stellar discs in early-type galaxies

<p>We analyse the morphological structures in galaxies of the ATLAS(3D) sample by fitting a single Sersic profile and decomposing all non-barred objects (180 of 260 objects) in two components parametrized by an exponential and a general Sersic function. The aim of this analysis is to look for signatures of discs in light distributions of nearby early-type galaxies and compare them to kinematic properties. Using Sersic index from single-component fits for a distinction between slow and fast rotators, or even late- and early-type galaxies, is not recommended. Assuming that objects with n > 3 are slow rotators (or ellipticals), there is only a 22 per cent probability to correctly classify objects as slow rotators (or 37 per cent of previously classified as ellipticals). We show that exponential sub-components, as well as light profiles fitted with only a single component of a low Sersic index, can be linked with the kinematic evidence for discs in early-type galaxies. The median disc-to-total light ratio for fast and slow rotators is 0.41 and 0.0, respectively. Similarly, the median Sersic indices of the bulge (general Sersic component) are 1.7 and 4.8 for fast and slow rotators, respectively. Overall, discs or disc-like structures are present in 83 per cent of early-type galaxies which do not have bars, and they show a full range of disc-to-total light ratios. Discs in early-type galaxies contribute with about 40 per cent to the total mass of the analysed (non-barred) objects. The decomposition into discs and bulges can be used as a rough approximation for the separation between fast and slow rotators, but it is not a substitute, as there is only a 59 per cent probability to correctly recognize slow rotators. We find trends between the angular momentum and the disc-to-total light ratios and the Sersic index of the bulge, in the sense that high angular momentum galaxies have large disc-to-total light ratios and small bulge indices, but there is none between the angular momentum and the global Sersic index. We investigate the inclination effects on the decomposition results and confirm that strong exponential profiles can be distinguished even at low inclinations, but medium-size discs are difficult to quantify using photometry alone at inclinations lower than similar to 50 degrees. Kinematics (i.e. projected angular momentum) remains the best approach to mitigate the influence of the inclination effects. We also find weak trends with mass and environmental density, where disc-dominated galaxies are typically less massive and found at all densities, including the densest region sampled by the ATLAS(3D) sample.</p>

ILC Reference Design Report Volume 1 - Executive Summary

The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radio-frequency (SCRF) accelerating cavities. The ILC has a total footprint of about 31 km and is designed for a peak luminosity of 2x10^34 cm^-2s^-1. This report is the Executive Summary (Volume I) of the four volume Reference Design Report. It gives an overview of the physics at the ILC, the accelerator design and value estimate, the detector concepts, and the next steps towards project realization.The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radio-frequency (SCRF) accelerating cavities. The ILC has a total footprint of about 31 km and is designed for a peak luminosity of 2x10^34 cm^-2s^-1. This report is the Executive Summary (Volume I) of the four volume Reference Design Report. It gives an overview of the physics at the ILC, the accelerator design and value estimate, the detector concepts, and the next steps towards project realization

ILC Reference Design Report Volume 4 - Detectors

This report, Volume IV of the International Linear Collider Reference Design Report, describes the detectors which will record and measure the charged and neutral particles produced in the ILC's high energy e+e- collisions. The physics of the ILC, and the environment of the machine-detector interface, pose new challenges for detector design. Several conceptual designs for the detector promise the needed performance, and ongoing detector R&D is addressing the outstanding technological issues. Two such detectors, operating in push-pull mode, perfectly instrument the ILC interaction region, and access the full potential of ILC physics.This report, Volume IV of the International Linear Collider Reference Design Report, describes the detectors which will record and measure the charged and neutral particles produced in the ILC's high energy e+e- collisions. The physics of the ILC, and the environment of the machine-detector interface, pose new challenges for detector design. Several conceptual designs for the detector promise the needed performance, and ongoing detector R&D is addressing the outstanding technological issues. Two such detectors, operating in push-pull mode, perfectly instrument the ILC interaction region, and access the full potential of ILC physics