Elaborations on Thought Process and Practice

An extended statement describing the thought process and practice behind the sculptural work of artist George A. Schwab. Includes short descriptions and documentation of work installed during the Fall 2015 Thesis exhibition at CUNY Hunter\u27s 205 Hudson Street Gallery

Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody.

Breast cancers enduring treatment with chemotherapy may be enriched for cancer stem cells or tumor-initiating cells, which have an enhanced capacity for self-renewal, tumor initiation, and/or metastasis. Breast cancer cells that express the type I tyrosine kinaselike orphan receptor ROR1 also may have such features. Here we find that the expression of ROR1 increased in breast cancer cells following treatment with chemotherapy, which also enhanced expression of genes induced by the activation of Rho-GTPases, Hippo-YAP/TAZ, or B lymphoma Mo-MLV insertion region 1 homolog (BMI1). Expression of ROR1 also enhanced the capacity of breast cancer cells to invade Matrigel, form spheroids, engraft in Rag2-/-[Formula: see text] mice, or survive treatment with paclitaxel. Treatment of mice bearing breast cancer patient-derived xenografts (PDXs) with the humanized anti-ROR1 monoclonal antibody cirmtuzumab repressed expression of genes associated with breast cancer stemness, reduced activation of Rho-GTPases, Hippo-YAP/TAZ, or BMI1, and impaired the capacity of breast cancer PDXs to metastasize or reengraft Rag2-/-[Formula: see text] mice. Finally, treatment of PDX-bearing mice with cirmtuzumab and paclitaxel was more effective than treatment with either alone in eradicating breast cancer PDXs. These results indicate that targeting ROR1 may improve the response to chemotherapy of patients with breast cancer

Holocene sediment distribution on the inner continental shelf of northeastern South Carolina : implications for the regional sediment budget and long-term shoreline response

This paper is not subject to U.S. copyright. The definitive version was published in Continental Shelf Research 56 (2013): 56-70, doi:10.1016/j.csr.2013.02.004.High-resolution geophysical and sediment sampling surveys were conducted offshore of the Grand Strand, South Carolina to define the shallow geologic framework of the inner shelf. Results are used to identify and map Holocene sediment deposits, infer sediment transport pathways, and discuss implications for the regional coastal sediment budget. The thickest deposits of Holocene sediment observed on the inner shelf form shoal complexes composed of moderately sorted fine sand, which are primarily located offshore of modern tidal inlets. These shoal deposits contain ∼67 M m3 of sediment, approximately 96% of Holocene sediment stored on the inner shelf. Due to the lack of any significant modern fluvial input of sand to the region, the Holocene deposits are likely derived from reworking of relict Pleistocene and older inner-shelf deposits during the Holocene marine transgression. The Holocene sediments are concentrated in the southern part of the study area, due to a combination of ancestral drainage patterns, a regional shift in sediment supply from the northeast to the southwest in the late Pleistocene, and proximity to modern inlet systems. Where sediment is limited, only small, low relief ridges have formed and Pleistocene and older deposits are exposed on the seafloor. The low-relief ridges are likely the result of a thin, mobile veneer of sediment being transported across an irregular, erosional surface formed during the last transgression. Sediment textural trends and seafloor morphology indicate a long-term net transport of sediment to the southwest. This is supported by oceanographic studies that suggest the long-term sediment transport direction is controlled by the frequency and intensity of storms that pass through the region, where low pressure systems yield net along-shore flow to the southwest and a weak onshore component. Current sediment budget estimates for the Grand Strand yield a deficit for the region. Volume calculations of Holocene deposits on the inner shelf suggest that there is sufficient sediment to balance the sediment budget and provide a source of sediment to the shoreline. Although the processes controlling cross-shelf sediment transport are not fully understood, in sediment-limited environments such as the Grand Strand, erosion of the inner shelf likely contributes significant sediment to the beach system

Arthrobots

This paper describes a class of robots—“arthrobots”— inspired, in part, by the musculoskeletal system of arthropods (spiders and insects, inter alia). An exoskeleton, constructed from thin organic polymeric tubes, provides lightweight structural support. Pneumatic joints modeled after the hydrostatic joints of spiders provide actuation and inherent mechanical compliance to external forces. An inflatable elastomeric tube (a “balloon”) enables active extension of a limb; an opposing elastic tendon enables passive retraction. A variety of robots constructed from these structural elements demonstrate i) crawling with one or two limbs, ii) walking with four or six limbs (including an insect-like triangular gait), iii) walking with eight limbs, or iv) floating and rowing on the surface of water. Arthrobots are simple to fabricate, inexpensive, light-weight, and able to operate safely in contact with humans.Chemistry and Chemical Biolog

Deep Low-Frequency Radio Observations of the NOAO Bootes Field: I. Data Reduction and Catalog Construction

In this article we present deep, high-resolution radio interferometric observations at 153 MHz to complement the extensively studied NOAO Bootes field. We provide a description of the observations, data reduction and source catalog construction. From our single pointing GMRT observation of ~12 hours we obtain a high-resolution (26" x 22") image of ~11.3 square degrees, fully covering the Bootes field region and beyond. The image has a central noise level of ~1.0 mJy/beam, which rises to 2.0-2.5 mJy/beam at the field edge, placing it amongst the deepest ~150 MHz surveys to date. The catalog of 598 extracted sources is estimated to be ~92 percent complete for >10 mJy sources, while the estimated contamination with false detections is <1 percent. The low RMS position uncertainty of 1.24" facilitates accurate matching against catalogs at optical, infrared and other wavelengths. Differential source counts are determined down to <~10 mJy. There is no evidence for flattening of the counts towards lower flux densities as observed in deep radio surveys at higher frequencies, suggesting that our catalog is dominated by the classical radio-loud AGN population that explains the counts at higher flux densities. Combination with available deep 1.4 GHz observations yields an accurate determination of spectral indices for 417 sources down to the lowest 153 MHz flux densities, of which 16 have ultra-steep spectra with spectral indices below -1.3. We confirm that flattening of the median spectral index towards low flux densities also occurs at this frequency. The detection fraction of the radio sources in NIR Ks-band is found to drop with radio spectral index, which is in agreement with the known correlation between spectral index and redshift for brighter radio sources.Comment: 14 pages, 7 figures. Accepted for publication by A&A. Source catalog will be available from CDS soo

Nitrite binding to globins: linkage isomerism, EPR silence and reductive chemistry

The nitrite adducts of globins can potentially bind via O- or N- linkage to the heme iron. We have used EPR (electron paramagnetic resonance) and DFT (density functional theory) to explore these binding modes to myoglobin and hemoglobin. We demonstrate that the nitrite adducts of both globins have detectable EPR signals; we provide an explanation for the difficulty in detecting these EPR features, based on uniaxial state considerations. The EPR and DFT data show that both nitrite linkage isomers can be present at the same time and that the two isomers are readily interconvertible in solution. The millisecond-scale process of nitrite reduction by Hb is investigated in search of the elusive Fe(II)-nitrite adduct

T-RaMiSu : The Two-meter Radio Mini Survey I. The Bootes Field

W. L. Williams, H. T. Intema, and H. J. A. Röttgering, 'T-RaMiSu: the Two-meter Radio Mini Survey: I. The Boötes Field', Astronomy & Astrophysics, Vol. 549, A55, (2013). The version of record is available at DOI: 10.1051/0004-6361/201220235. Published by EDP Sciences. © ESO 2012.We present wide area, deep, high-resolution 153 MHz GMRT observations of the NOAO Bootes field, adding to the extensive, multi-wavelength data of this region. The observations, data reduction, and catalogue construction and description are described here. The seven pointings produced a final mosaic covering 30 square degrees with a resolution of 25". The rms noise is 2 mJy/beam in the centre of the image, rising to 4-5 mJy/beam on the edges, with an average of 3 mJy/beam. Seventy-five per cent of the area has an rmsPeer reviewe

Craniectomy for Malignant Cerebral Infarction: Prevalence and Outcomes in US Hospitals

Randomized trials have demonstrated the efficacy of craniectomy for the treatment of malignant cerebral edema following ischemic stroke. We sought to determine the prevalence and outcomes related to this by using a national database.Patient discharges with ischemic stroke as the primary diagnosis undergoing craniectomy were queried from the US Nationwide Inpatient Sample from 1999 to 2008. A subpopulation of patients was identified that underwent thrombolysis. Two primary end points were examined: in-hospital mortality and discharge to home/routine care. To facilitate interpretations, adjusted prevalence was calculated from the overall prevalence and two age-specific logistic regression models. The predictive margin was then generated using a multivariate logistic regression model to estimate the probability of in-hospital mortality after adjustment for admission type, admission source, length of stay, total hospital charges, chronic comorbidities, and medical complications.After excluding 71,996 patients with the diagnosis of intracranial hemorrhage and posterior intracranial circulation occlusion, we identified 4,248,955 adult hospitalizations with ischemic stroke as a primary diagnosis. The estimated rates of hospitalizations in craniectomy per 10,000 hospitalizations with ischemic stroke increased from 3.9 in 1999-2000 to 14.46 in 2007-2008 (p for linear trend<0.001). Patients 60+ years of age had in-hospital mortality of 44% while the 18-59 year old group was found to be 24% (p = 0.14). Outcomes were comparable if recombinant tissue plasminogen activator had been administered.Craniectomy is being increasingly performed for malignant cerebral edema following large territory cerebral ischemia. We suspect that the increase in the annual incidence of DC for malignant cerebral edema is directly related to the expanding collection of evidence in randomized trials that the operation is efficacious when performed in the correct patient population. In hospital mortality is high for all patients undergoing this procedure