56 research outputs found
First LIGO search for gravitational wave bursts from cosmic (super)strings
We report on a matched-filter search for gravitational wave bursts from
cosmic string cusps using LIGO data from the fourth science run (S4) which took
place in February and March 2005. No gravitational waves were detected in 14.9
days of data from times when all three LIGO detectors were operating. We
interpret the result in terms of a frequentist upper limit on the rate of
gravitational wave bursts and use the limits on the rate to constrain the
parameter space (string tension, reconnection probability, and loop sizes) of
cosmic string models.Comment: 11 pages, 3 figures. Replaced with version submitted to PR
Stacked Search for Gravitational Waves from the 2006 SGR 1900+14 Storm
We present the results of a LIGO search for short-duration gravitational
waves (GWs) associated with the 2006 March 29 SGR 1900+14 storm. A new search
method is used, "stacking'' the GW data around the times of individual
soft-gamma bursts in the storm to enhance sensitivity for models in which
multiple bursts are accompanied by GW emission. We assume that variation in the
time difference between burst electromagnetic emission and potential burst GW
emission is small relative to the GW signal duration, and we time-align GW
excess power time-frequency tilings containing individual burst triggers to
their corresponding electromagnetic emissions. We use two GW emission models in
our search: a fluence-weighted model and a flat (unweighted) model for the most
electromagnetically energetic bursts. We find no evidence of GWs associated
with either model. Model-dependent GW strain, isotropic GW emission energy
E_GW, and \gamma = E_GW / E_EM upper limits are estimated using a variety of
assumed waveforms. The stacking method allows us to set the most stringent
model-dependent limits on transient GW strain published to date. We find E_GW
upper limit estimates (at a nominal distance of 10 kpc) of between 2x10^45 erg
and 6x10^50 erg depending on waveform type. These limits are an order of
magnitude lower than upper limits published previously for this storm and
overlap with the range of electromagnetic energies emitted in SGR giant flares.Comment: 7 pages, 3 figure
Serotonin Antagonism Improves Platelet Inhibition in Clopidogrel Low-Responders after Coronary Stent Placement: An In Vitro Pilot Study
Increased residual platelet reactivity remains a burden for coronary artery disease (CAD) patients who received a coronary stent and do not respond sufficiently to treatment with acetylsalicylic acid and clopidogrel. We hypothesized that serotonin antagonism reduces high on-treatment platelet reactivity. Whole blood impedance aggregometry was performed with arachidonic acid (AA, 0.5 mM) and adenosine diphosphate (ADP, 6.5 µM) in addition to different concentrations of serotonin (1–100 µM) in whole blood from 42 CAD patients after coronary stent placement and 10 healthy subjects. Serotonin increased aggregation dose-dependently in CAD patients who responded to clopidogrel treatment: After activation with ADP, aggregation increased from 33.7±1.3% to 40.9±2.0% in the presence of 50 µM serotonin (p<0.05) and to 48.2±2.0% with 100 µM serotonin (p<0.001). The platelet serotonin receptor antagonist ketanserin decreased ADP-induced aggregation significantly in clopidogrel low-responders (from 59.9±3.1% to 37.4±3.5, p<0.01), but not in clopidogrel responders. These results were confirmed with light transmission aggregometry in platelet-rich plasma in a subset of patients. Serotonin hence increased residual platelet reactivity in patients who respond to clopidogrel after coronary stent placement. In clopidogrel low-responders, serotonin receptor antagonism improved platelet inhibition, almost reaching responder levels. This may justify further investigation of triple antiplatelet therapy with anti-serotonergic agents
The Inflammatory Kinase MAP4K4 Promotes Reactivation of Kaposi's Sarcoma Herpesvirus and Enhances the Invasiveness of Infected Endothelial Cells
Kaposi's sarcoma (KS) is a mesenchymal tumour, which is caused by Kaposi's sarcoma herpesvirus (KSHV) and develops under inflammatory conditions. KSHV-infected endothelial spindle cells, the neoplastic cells in KS, show increased invasiveness, attributed to the elevated expression of metalloproteinases (MMPs) and cyclooxygenase-2 (COX-2). The majority of these spindle cells harbour latent KSHV genomes, while a minority undergoes lytic reactivation with subsequent production of new virions and viral or cellular chemo- and cytokines, which may promote tumour invasion and dissemination. In order to better understand KSHV pathogenesis, we investigated cellular mechanisms underlying the lytic reactivation of KSHV. Using a combination of small molecule library screening and siRNA silencing we found a STE20 kinase family member, MAP4K4, to be involved in KSHV reactivation from latency and to contribute to the invasive phenotype of KSHV-infected endothelial cells by regulating COX-2, MMP-7, and MMP-13 expression. This kinase is also highly expressed in KS spindle cells in vivo. These findings suggest that MAP4K4, a known mediator of inflammation, is involved in KS aetiology by regulating KSHV lytic reactivation, expression of MMPs and COX-2, and, thereby modulating invasiveness of KSHV-infected endothelial cells. © 2013 Haas et al
Search for gravitational-wave bursts in the first year of the fifth LIGO science run
We present the results obtained from an all-sky search for gravitational-wave
(GW) bursts in the 64-2000 Hz frequency range in data collected by the LIGO
detectors during the first year (November 2005 - November 2006) of their fifth
science run. The total analyzed livetime was 268.6 days. Multiple hierarchical
data analysis methods were invoked in this search. The overall sensitivity
expressed in terms of the root-sum-square (rss) strain amplitude h_{rss} for
gravitational-wave bursts with various morphologies was in the range of 6 times
10^{-22} Hz^{-1/2} to a few times 10^{-21} Hz^{-1/2}. No GW signals were
observed and a frequentist upper limit of 3.6 events per year on the rate of
strong GW bursts was placed at the 90% confidence level. As in our previous
searches, we also combined this rate limit with the detection efficiency for
selected waveform morphologies to obtain event rate versus strength exclusion
curves. In sensitivity, these exclusion curves are the most stringent to date.Comment: v3: various figure and text edits; submitted to PRD; 26 page
Search for gravitational wave ringdowns from perturbed black holes in LIGO S4 data
According to general relativity a perturbed black hole will settle to a
stationary configuration by the emission of gravitational radiation. Such a
perturbation will occur, for example, in the coalescence of a black hole
binary, following their inspiral and subsequent merger. At late times the
waveform is a superposition of quasi-normal modes, which we refer to as the
ringdown. The dominant mode is expected to be the fundamental mode, l=m=2.
Since this is a well-known waveform, matched filtering can be implemented to
search for this signal using LIGO data. We present a search for gravitational
waves from black hole ringdowns in the fourth LIGO science run S4, during which
LIGO was sensitive to the dominant mode of perturbed black holes with masses in
the range of 10 Msun to 500 Msun, the regime of intermediate-mass black holes,
to distances up to 300 Mpc. We present a search for gravitational waves from
black hole ringdowns using data from S4. No gravitational wave candidates were
found; we place a 90%-confidence upper limit on the rate of ringdowns from
black holes with mass between 85 Msun and 390 Msun in the local universe,
assuming a uniform distribution of sources, of 3.2 x 10^{-5} yr^{-1} Mpc^{-3} =
1.6 x 10^{-3}yr^{-1} L_{10}^{-1}, where L_{10} is 10^{10} times the solar
blue-light luminosity.Comment: 8 pages, 6 figure
Search for High Frequency Gravitational Wave Bursts in the First Calendar Year of LIGO's Fifth Science Run
We present an all-sky search for gravitational waves in the frequency range 1
to 6 kHz during the first calendar year of LIGO's fifth science run. This is
the first untriggered LIGO burst analysis to be conducted above 3 kHz. We
discuss the unique properties of interferometric data in this regime. 161.3
days of triple-coincident data were analyzed. No gravitational events above
threshold were observed and a frequentist upper limit of 5.4 events per year on
the rate of strong gravitational wave bursts was placed at a 90% confidence
level. Implications for specific theoretical models of gravitational wave
emission are also discussed.Comment: 13 pages, accepted for publication in Physical Review
The present gravitational wave detection effort
Gravitational radiation offers a new non-electromagnetic window through which to observe the universe. The LIGO and Virgo Collaborations have completed a first joint data run with unprecedented sensitivities to gravitational waves. Results from searches in the data for a variety of astrophysical sources are presented. A second joint data run with improved detector sensitivities is underway, and soon major upgrades will be carried out to build Advanced LIGO and Advanced Virgo with expected improvements in event rates of more than 1000. In parallel there is a vigorous effort in the radio pulsar community to detect nHz gravitational waves via the timing residuals in an array of pulsars at different locations in the sky.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/85430/1/jpconf10_203_012002.pd
Search for gravitational waves from low mass compact binary coalescence in 186 days of LIGO's fifth science run
We report on a search for gravitational waves from coalescing compact binaries, of total mass between 2 and 35M_☉, using LIGO observations between November 14, 2006 and May 18, 2007. No gravitational-wave signals were detected. We report upper limits on the rate of compact binary coalescence as a function of total mass. The LIGO cumulative 90%-confidence rate upper limits of the binary coalescence of neutron stars, black holes and black hole-neutron star systems are 1.4 × 10^(-2), 7.3 × 10(-4) and 3.6 × 10(-3) yr(-1) L_10^(-1), respectively, where L_(10_ is 10^(10) times the blue solar luminosit
Dental caries in rats associated with Candida albicans
In addition to occasional opportunistic colonization of the oral mucosa, Candida albicans is frequently found in carious dentin. The yeast's potential to induce dental caries as a consequence of its pronounced ability to produce and tolerate acids was investigated. Eighty caries-active Osborne-Mendel rats were raised on an ampicillin-supplemented diet and exposed to C. albicans and/or Streptococcus mutans, except for controls. Throughout the 28-day test period, the animals were offered the modified cariogenic diet 2000a, containing 40% various sugars. Subsequently, maxillary molars were scored for plaque extent. After dissection, the mandibular molars were evaluated for smooth surface and fissure caries. Test animals exposed to C. albicans displayed considerably more advanced fissure lesions (p < 0.001) than non-exposed controls. While S. mutans yielded similar results, a combined association of C. albicans and S. mutans had no effect on occlusal caries incidence. Substituting dietary sucrose by glucose did not modify caries induction by C. albicans. However, animals fed a diet containing 20% of both sugars showed no differences to non-infected controls. Smooth surface caries was not generated by the yeast. This study provides experimental evidence that C. albicans is capable of causing occlusal caries in rats at a high rate
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