Equity, Diversity, and Inclusion in Alberta Accredited International Schools: Bridging Modern and Traditional Societal Perspectives in Educational Practice

International schools accredited by Western-based educational paradigms encounter specific challenges within the theoretical framework of equity, diversity, and inclusion (EDI), as perceived through the lens of social justice in education. This Organizational Improvement Plan (OIP) considers, from the context of modern and traditional societies, the change readiness of the Alberta Accredited International Schools program (AAIS) surrounding the practice of EDI. Generalized expectations of universal application present with factors that may provide educational leaders with the framework to deliberate critical theory motivating practice. Modernist and traditionalist societal views of EDI, and the translation of pedagogical frameworks through educational reform, are considered. My agency as an external educational psychologist and EDI consultant provides a practical, site-based context of change with a worldview of transformative leadership. As an external consultant, I proposed a blended change model, including Cawsey et al.’s (2016) Change Path Model through the lens of Capper’s (2019) critical theory for organizational improvement. The proposal of an EDI policy analyst change driver to inform a transformative worldview and associated theoretical resolutions is presented. Solutions are offered to influence current and future alignment within varied contexts between the provincial agency and the AAIS program sites. Informed by social justice in educational leadership, this OIP accepts a theoretically based challenge to apply a transformative leadership model of EDI practice to AAIS leaders. The outcome includes an alternative conceptualization of EDI practice demands within schools existing in a traditional society aligned with a Western-based educational pedagogy

The Molecular Clockwork of the Fire Ant Solenopsis invicta

This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

In silico toxicology protocols

The present publication surveys several applications of in silico (i.e., computational) toxicology approaches across different industries and institutions. It highlights the need to develop standardized protocols when conducting toxicity-related predictions. This contribution articulates the information needed for protocols to support in silico predictions for major toxicological endpoints of concern (e.g., genetic toxicity, carcinogenicity, acute toxicity, reproductive toxicity, developmental toxicity) across several industries and regulatory bodies. Such novel in silico toxicology (IST) protocols, when fully developed and implemented, will ensure in silico toxicological assessments are performed and evaluated in a consistent, reproducible, and well-documented manner across industries and regulatory bodies to support wider uptake and acceptance of the approaches. The development of IST protocols is an initiative developed through a collaboration among an international consortium to reflect the state-of-the-art in in silico toxicology for hazard identification and characterization. A general outline for describing the development of such protocols is included and it is based on in silico predictions and/or available experimental data for a defined series of relevant toxicological effects or mechanisms. The publication presents a novel approach for determining the reliability of in silico predictions alongside experimental data. In addition, we discuss how to determine the level of confidence in the assessment based on the relevance and reliability of the information

Wakota Bridge Thermal Monitoring Program Part I: Analysis and Monitoring Plan

In this work, a common refined design method is evaluated with respect to a recently constructed bridge. Two finite element models of the Wakota Bridge in South St. Paul, Minnesota, were produced, one using a design level program (SAP2000) and the other using a research level program (ABAQUS). These models were verified with respect to each other using linearly elastic materials and were found to behave similarly. After this verification, an arbitrary temperature load was applied to each model and the refined design method was evaluated for accuracy of reduced section properties with respect to the more descriptive progressive cracking solution simulated by ABAQUS. The refined design method was employed using two, four, and six stiffness segments at which stiffness is evaluated along the height of the pier walls. It was seen that accuracy increased as the number of stiffness segments increased and that four segments seemed to balance accuracy and time-commitment by the engineer adequately. A staged construction model of the Wakota Bridge was also built, using the design level program, which incorporates all time-dependent effects of the construction sequence as well as locked-in forces. A pile analysis was performed and appropriate rotational springs were found for Foundations 2 and 3. A simplified method for the determination of the rotational springs is discussed, and a range of effective lengths was found for use with this procedure. The staged construction model is used for field data correlation in Part two of this report. The staged construction model was also used to evaluate the different design options as described in the AASHTO LRFD. The two options given for accounting for reduced section properties were evaluated and compared. The refined analysis option and gross section option were compared for the Wakota Bridge and are shown to correlate to within about 10%. The two temperature application methods (Procedure A and B in the AASHTO LRFD) were also compared. As expected, Procedure B produced much larger design moments than that of Procedure A.Minnesota Department of Transportatio

Functional connectivity in autosomal dominant and late-onset Alzheimer disease

IMPORTANCE: Autosomal dominant Alzheimer disease (ADAD) is caused by rare genetic mutations in 3 specific genes in contrast to late-onset Alzheimer disease (LOAD), which has a more polygenetic risk profile. OBJECTIVE: To assess the similarities and differences in functional connectivity changes owing to ADAD and LOAD. DESIGN, SETTING, AND PARTICIPANTS: We analyzed functional connectivity in multiple brain resting state networks (RSNs) in a cross-sectional cohort of participants with ADAD (n = 79) and LOAD (n = 444), using resting-state functional connectivitymagnetic resonance imaging at multiple international academic sites. MAIN OUTCOMES AND MEASURES: For both types of AD, we quantified and compared functional connectivity changes in RSNs as a function of dementia severity measured by the Clinical Dementia Rating Scale. In ADAD, we qualitatively investigated functional connectivity changes with respect to estimated years from onset of symptoms within 5 RSNs. RESULTS: A decrease in functional connectivity with increasing Clinical Dementia Rating scores were similar for both LOAD and ADAD in multiple RSNs. Ordinal logistic regression models constructed in one type of Alzheimer disease accurately predicted clinical dementia rating scores in the other, further demonstrating the similarity of functional connectivity loss in each disease type. Among participants with ADAD, functional connectivity in multiple RSNs appeared qualitatively lower in asymptomatic mutation carriers near their anticipated age of symptom onset compared with asymptomatic mutation noncarriers. CONCLUSIONS AND RELEVANCE: Resting-state functional connectivity magnetic resonance imaging changes with progressing AD severity are similar between ADAD and LOAD. Resting-state functional connectivitymagnetic resonance imagingmay be a useful end point for LOAD and ADAD therapy trials. Moreover, the disease process of ADAD may be an effective model for the LOAD disease process