Microtransit in Latin America and the Caribbean: Governance, operations, and regulation for socially inclusive and sustainable urban mobility

This document provides an overview of the current landscape of app-based collective transportation in Latin America and the Caribbean from the perspective of its contributions to social inclusion and environmental sustainability. The research builds on a review of the recent academic literature and a review of available secondary evidence from technical reports and policy documents. The analysis of secondary evidence is expanded upon through primary evidence from a stakeholder survey and semi-structured interviews with a select group of stakeholders in the transportation sector in the region. The manuscript shows the current situation in what remains an emerging industry in Latin America and the Caribbean, spanning from the terminology used by practitioners in different sectors to refer to app-based collective transportation, such as vanpooling, microtransit or micro transport, to the overview of different business approaches and regulatory responses in various contexts. The paper finalizes by presenting an evidence-based reflection of the prospects and expectations from different perspectives about the contribution of technology-enabled collective transportation to social and environmental challenges for transport in the region

Vorschlag zur Überarbeitung der Transferimpedanzanforderungen in CISPR 25 und CISPR 16-1-2

[no abstract available

Educating planners in Europe: A review of 21st century study programmes

A  Education for urban, regional and spatial planning has become a regular subject throughout most European nations; this can be attributed in part to European policies promoting planning and spatially balanced development, but also to the recognition that planning can support sustainability. Nevertheless, there is lingering and justifiable concern about the status, profile and recognition of planning as a profession in its own right with the result that planning and planning education remain contested territories in academia. Conceptions of planning differ between countries and over time. The array of different planning cultures and associated educational models and pedagogies that traditionally have coexisted in Europe mean that education for planning can be either very visible or leading a shadow existence being embedded in programmes of other disciplines. While planning education provision customarily has been shaped by changes in planning practice paradigms and the profession, in 21st century Europe the provision is also influenced by European integration policies, the Bologna process and powerful transformations affecting the higher education sector writ large. This review seeks to advance our understanding of the complex dynamics at work, which to date have been only partially explored in the literature, by taking stock of the current state-of-play of planning education provision in Europe. Aside from examining the factors influencing planning education in Europe, an inventory of planning education programmes available throughout the member states of the Council of Europe was developed to quantify the provision as a critical first step. Figures indicate a substantial increase in the number of programmes when compared to limited historical data. Data also suggest an underdeveloped provision for education in planning in about ten per cent of European countries. Country case studies with historically differing planning cultures and education provision, i.e., Spain, Portugal, Finland, Poland, Slovakia, the United Kingdom and Switzerland are used to compare and explore trends and developments (e.g., in respect to programme structure, curriculum content and focus, professional conceptions, specialisms) in detail. Findings demonstrate, both, an enduring power of national preferences and traditions but also some emerging commonalities. Overall a picture of increasing pluralism and diversity of education models transpires in the aftermath of Bologna which may contravene efforts to establish cross-national professional recognition and standards. Education for planning seems to embrace trends to provide increasingly international learning experiences and degrees while the provision of flexible recognised (online) degree programmes remains sparse. Recommendations for future actions and strategies to further develop and strengthen the field which is at present complex and little coordinated conclude the contribution

Employment status, psychological needs, and mental health: Meta-analytic findings concerning the latent deprivation model

Marie Jahoda’s latent deprivation model proposes that unemployed people have a worse mental health compared to employed people. This is because they suffer not only from a lack of the manifest function of employment (earning money), but also from a lack of five so-called latent functions of employment: Time structure, social contact, collective purpose (i.e., the sense of being useful to other people), status, and activity. In order to test the basic assumptions of this theory, a study based on meta-analytic methods was conducted. Results showed that employed people reported higher levels on all five latent functions, as well as on the manifest function, compared to unemployed people. They also report more latent functions than people who are out of the labor force (OLF). Moreover, OLF-people reported more manifest and latent functions than unemployed people. Specific analyses for three OLF-subgroups found retired people to be almost as deprived of the latent functions (but not the manifest function) as unemployed people, while students were more similar to employed people but still experienced some manifest and latent deprivation. For homemakers, the effect sizes pointed in the expected direction, but they were not significant. Thus, the proposition that employment is the best provider of the latent functions was generally endorsed, although homemakers need further scrutiny in future studies. All latent functions, as well as the manifest function, emerged as significant independent predictors of mental health, when the influence of the other manifest and latent functions was controlled. Together, the dimensions in the model explained 19% of variation in mental health

A New Multilocus Sequence Typing Scheme and Its Application for the Characterization of Photobacterium damselae subsp. damselae Associated with Mortality in Cetaceans

Photobacterium damselae subsp. damselae (PDD) is a known pathogen of fish, humans and marine mammals. In this study, a Multilocus Sequence Typing (MLST) scheme based on six housekeeping genes (glp, gyrB, metG, pnt, pyrC and toxR) was developed to better understand the PDD population structure and used to type 73 PDD isolates from cetaceans, mainly striped dolphins (Stenella coeruleoalba) involved in mortality episodes, and from a few marine chelonians. Five reference ATCC strains were also included in the study. Typing allowed the discrimination of groups of PDD strains isolated from different host species, at different times and from different geographic areas, suggesting that a clonal PDD group may have spread in the Tyrrhenian sea at the time of an Unusual Mortality Event (UME) among cetaceans, mainly striped dolphins, occurred in early 2013 along the Italian western coasts

Lymphotropic viruses EBV, KSHV and HTLV in Latin America: Epidemiology and associated malignancies. A literature-based study by the RIAL-CYTED

The Epstein-Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, as such, we systematically analyzed the literature to better understand our risk for virus-induced lymphoma. We observed that high endemicity regions for certain lymphomas, e.g., Mexico and Peru, have a high incidence of EBV-positive lymphomas of T/NK cell origin. Peru also carries the highest frequency of EBV-positive classical Hodgkin lymphoma (HL) and EBV-positive diffuse large B cell lymphoma, not otherwise specified (NOS), than any other LA country. Adult T cell lymphoma is endemic to the North of Brazil and Chile. While only few cases of KSHV-positive lymphomas were found, in spite of the close correlation of Kaposi sarcoma and the prevalence of pathogenic types of KSHV. Both EBV-associated HL and Burkitt lymphoma mainly affect young children, unlike in developed countries, in which adolescents and young adults are the most affected, correlating with an early EBV seroconversion for LA population despite of lack of infectious mononucleosis symptoms. High endemicity of KSHV and HTLV infection was observed among Amerindian populations, with differences between Amazonian and Andean populations.Fil: Chabay, Paola Andrea. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Lens, Daniela. Universidad de la Republica. Facultad de Medicina. Hospital de Clínicas "dr. Manuel Quintela".; UruguayFil: Hassan, Rocio. National Cancer Institute “José Alencar Gomes da Silva”; BrasilFil: Rodríguez Pinilla, Socorro María. University Hospital, Fundación Jiménez Díaz; EspañaFil: Valvert Gamboa, Fabiola. Cancer Institute and National League against Cancer; GuatemalaFil: Rivera, Iris. Salvadoran Institute of Social Security; El SalvadorFil: Huamán Garaicoa, Fuad. Santiago de Guayaquil Catholic University; EcuadorFil: Ranuncolo, Stella Maris. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barrionuevo, Carlos. National University of San Marcos; PerúFil: Morales Sánchez, Abigail. Children’s Hospital of Mexico Federico Gómez; MéxicoFil: Scholl, Vanesa. No especifíca;Fil: de Matteo, Elena Noemí. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Fuentes Pananá, Ezequiel M.. Children’s Hospital of Mexico Federico Gómez; Méxic

Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection

Arginase 1 (Arg1), the enzyme catalyzing the conversion of arginine to ornithine, is a hallmark of IL-10-producing immunoregulatory M2 macrophages. However, its expression in T cells is disputed. Here, we demonstrate that induction of Arg1 expression is a key feature of lung CD4+ T cells during mouse in vivo influenza infection. Conditional ablation of Arg1 in CD4+ T cells accelerated both virus-specific T helper 1 (Th1) effector responses and its resolution, resulting in efficient viral clearance and reduced lung pathology. Using unbiased transcriptomics and metabolomics, we found that Arg1-deficiency was distinct from Arg2-deficiency and caused altered glutamine metabolism. Rebalancing this perturbed glutamine flux normalized the cellular Th1 response. CD4+ T cells from rare ARG1-deficient patients or CRISPR-Cas9-mediated ARG1-deletion in healthy donor cells phenocopied the murine cellular phenotype. Collectively, CD4+ T cell-intrinsic Arg1 functions as an unexpected rheostat regulating the kinetics of the mammalian Th1 lifecycle with implications for Th1-associated tissue pathologies

Ridge subduction at an erosive margin - the collision zone of the Nazca Ridge in southern Peru

The 1.5-km-high, obliquely subducting Nazca Ridge and its collision zone with the Peruvian margin have been imaged by wide-angle and reflection seismic profiles, swath bathymetry, and gravity surveying. These data reveal that the crust of the ridge at its northeastern tip is 17 km thick and exhibits seismic velocities and densities similar to layers 2 and 3 of typical oceanic crust. The lowermost layer contributes 10–12 km to the total crustal thickness of the ridge. The sedimentary cover is 300–400 m thick on most parts of the ridge but less than 100 m thick on seamounts and small volcanic ridges. At the collision zone of ridge and margin, the following observations indicate intense tectonic erosion related to the passage of the ridge. The thin sediment layer on the ridge is completely subducted. The lower continental slope is steep, dipping at ∼9°, and the continental wedge has a high taper of 18°. Tentative correlation of model layers with stratigraphy derived from Ocean Drilling Program Leg 112 cores suggests the presence of Eocene shelf deposits near the trench. Continental basement is located <15 km landward of the trench. Normal faults on the upper slope and shelf indicate extension. A comparison with the Peruvian and northern Chilean forearc systems, currently not affected by ridge subduction, suggests that the passage of the Nazca Ridge along the continental margin induces a temporarily limited phase of enhanced tectonic erosion superposed on a long-term erosive regime

Heat Stress Enhances the Accumulation of Polyadenylated Mitochondrial Transcripts in Arabidopsis thaliana

Background: Polyadenylation of RNA has a decisive influence on RNA stability. Depending on the organisms or subcellular compartment, it either enhances transcript stability or targets RNAs for degradation. In plant mitochondria, polyadenylation promotes RNA degradation, and polyadenylated mitochondrial transcripts are therefore widely considered to be rare and unstable. We followed up a surprising observation that a large number of mitochondrial transcripts are detectable in microarray experiments that used poly(A)-specific RNA probes, and that these transcript levels are significantly enhanced after heat treatment. Methodology/Principal Findings: As the Columbia genome contains a complete set of mitochondrial genes, we had to identify polymorphisms to differentiate between nuclear and mitochondrial copies of a mitochondrial transcript. We found that the affected transcripts were uncapped transcripts of mitochondrial origin, which were polyadenylated at multiple sites within their 39region. Heat-induced enhancement of these transcripts was quickly restored during a short recovery period. Conclusions/Significance: Our results show that polyadenylated transcripts of mitochondrial origin are more stable than previously suggested, and that their steady-state levels can even be significantly enhanced under certain conditions. As many microarrays contain mitochondrial probes, due to the frequent transfer of mitochondrial genes into the genome