Evaluation of a sub-kilometre NWP system in an Arctic fjord-valley system in winter

Terrain challenges the prediction of near-surface atmospheric conditions, even in kilometre-scale numerical weather prediction (NWP) models. In this study, the ALADIN-HIRLAM NWP system with 0.5 km horizontal grid spacing and an increased number of vertical levels is compared to the 2.5-km model system similar to the currently operational NWP system at the Norwegian Meteorological Institute. The impact of the increased resolution on the forecasts’ ability to represent boundary-layer processes is investigated for the period from 12 to 16 February 2018 in an Arctic fjord-valley system in the Svalbard archipelago. Model simulations are compared to a wide range of observations conducted during a field campaign. The model configuration with sub-kilometre grid spacing improves both the spatial structure and overall verification scores for the near-surface temperature and wind forecasts compared to the 2.5-km experiment. The subkilometre experiment successfully captures the wind channelling through the valley and the temperature field associated with it. In a situation of a cold-air pool development, the sub-kilometre experiment has a particularly high near-surface temperature bias at low elevations. The use of measurement campaign data, however, reveals some encouraging results, e.g. the sub-kilometre system has a more realistic vertical profile of temperature and wind speed, and the surface temperature sensitivity to the net surface energy is closer to the observations. This work demonstrates the potential of sub-kilometre NWP systems for forecasting weather in complex Arctic terrain, and also suggests that the increase in resolution needs to be accompanied with further development of other parts of the model system

Gravitationally lensed QSOs in the ISSIS/WSO-UV era

Gravitationally lensed QSOs (GLQs) at redshift z = 1-2 play a key role in understanding the cosmic evolution of the innermost parts of active galaxies (black holes, accretion disks, coronas and internal jets), as well as the structure of galaxies at intermediate redshifts. With respect to studies of normal QSOs, GLQ programmes have several advantages. For example, a monitoring of GLQs may lead to unambiguous detections of intrinsic and extrinsic variations. Both kinds of variations can be used to discuss central engines in distant QSOs, and mass distributions and compositions of lensing galaxies. In this context, UV data are of particular interest, since they correspond to emissions from the immediate surroundings of the supermassive black hole. We describe some observation strategies to analyse optically bright GLQs at z of about 1.5, using ISSIS (CfS) on board World Space Observatory-Ultraviolet.Comment: 7 pages, 4 figures, Accepted for publication in Astrophysics & Space Scienc

The new IOC and IAAF policies on female eligibility: old Emperor, new clothes?

The Caster Semenya debacle touched off by the 2009 Berlin World Athletics Championships resulted finally in IOC and IAAF abandonment of sex testing, which gave way to procedures that make female competition eligibility dependent upon the level of serum testosterone, which must be below the male range or instrumentally countered by androgen resistance. We argue that the new policy is unsustainable because (i) the testosterone-performance connection it posits is uncompelling; (ii) testosterone-induced female advantage is not ipso facto unfair advantage; (iii) the new policy reflects the gender policing impulses endemic to sport as well as the broader cultural impulses to monstrify women and to doctor women who have nothing wrong with them; (iv) female–male performance disparities are not the only reason for sex-segregated sport, but co-exist with respectable cultural and practical reasons, which (v) provide a powerful case for allowing athletes to compete in the sex category congruent with their gender identity

Catalytically inactive carbonic anhydrase-related proteins enhance the transport of lactate by MCT1

Carbonic anhydrases (CA) catalyze the reversible hydration of CO2 to protons and bicarbonate and thereby play a fundamental role in the epithelial acid/base transport mechanisms serving fluid secretion and absorption for whole‐body acid/base regulation. The three carbonic anhydrase‐related proteins (CARPs) VIII, X, and XI, however, are catalytically inactive. Previous work has shown that some CA isoforms noncatalytically enhance lactate transport through various monocarboxylate transporters (MCT). Therefore, we examined whether the catalytically inactive CARPs play a role in lactate transport. Here, we report that CARP VIII, X, and XI enhance transport activity of the MCT MCT1 when coexpressed in Xenopus oocytes, as evidenced by the rate of rise in intracellular H+ concentration detected using ion‐sensitive microelectrodes. Based on previous studies, we suggest that CARPs may function as a ‘proton antenna’ for MCT1, to drive proton‐coupled lactate transport across the cell membrane

Challenging sex segregation: A philosophical evaluation of the football association’s rules on mixed football

The Football Association (FA) has been under pressure to allow girls to play in mixed teams since 1978, following 12-year old Theresa Bennett’s application to play with boys in a local league. In 1991, over a decade after Bennett’s legal challenge, the FA agreed to remove its ban on mixed football and introduced Rule C4 in order to permit males and females to play together in competitive matches under the age of 11. More recently, following a campaign by parents, coaches, local Members of Parliament and the Women’s Sport Foundation, the FA agreed to trial mixed football for the under-12 to under-15 age categories in order to establish, among other things, the risk of injury to players in sex-integrated competitions. A series of exponential changes ensued: between 2010 and 2014, the age at which mixed football was permitted increased from U11 to U16. In 2015, the FA announced the decision to raise the age limit on mixed football from U16 to U18 for the forthcoming 2015–2016 season. We critically examine the reasons given by the FA for enforcing segregated participation beyond the age of 18, namely that males have an unfair advantage and that females face an unacceptable risk of injury. We also discuss the argument that removing the ban might harm the women’s game. In conclusion, we suggest that the FA ought to abandon the ban on mixed football over the age of 18

Off-label use of aducanumab for cerebral amyloid angiopathy

Neuro Imaging Researc

Cosmological distance indicators

We review three distance measurement techniques beyond the local universe: (1) gravitational lens time delays, (2) baryon acoustic oscillation (BAO), and (3) HI intensity mapping. We describe the principles and theory behind each method, the ingredients needed for measuring such distances, the current observational results, and future prospects. Time delays from strongly lensed quasars currently provide constraints on $H_0$ with < 4% uncertainty, and with 1% within reach from ongoing surveys and efforts. Recent exciting discoveries of strongly lensed supernovae hold great promise for time-delay cosmography. BAO features have been detected in redshift surveys up to z <~ 0.8 with galaxies and z ~ 2 with Ly-$\alpha$ forest, providing precise distance measurements and $H_0$ with < 2% uncertainty in flat $\Lambda$CDM. Future BAO surveys will probe the distance scale with percent-level precision. HI intensity mapping has great potential to map BAO distances at z ~ 0.8 and beyond with precisions of a few percent. The next years ahead will be exciting as various cosmological probes reach 1% uncertainty in determining $H_0$, to assess the current tension in $H_0$ measurements that could indicate new physics.Comment: Review article accepted for publication in Space Science Reviews (Springer), 45 pages, 10 figures. Chapter of a special collection resulting from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in the Space Ag

Toward an internally consistent astronomical distance scale

Accurate astronomical distance determination is crucial for all fields in astrophysics, from Galactic to cosmological scales. Despite, or perhaps because of, significant efforts to determine accurate distances, using a wide range of methods, tracers, and techniques, an internally consistent astronomical distance framework has not yet been established. We review current efforts to homogenize the Local Group's distance framework, with particular emphasis on the potential of RR Lyrae stars as distance indicators, and attempt to extend this in an internally consistent manner to cosmological distances. Calibration based on Type Ia supernovae and distance determinations based on gravitational lensing represent particularly promising approaches. We provide a positive outlook to improvements to the status quo expected from future surveys, missions, and facilities. Astronomical distance determination has clearly reached maturity and near-consistency.Comment: Review article, 59 pages (4 figures); Space Science Reviews, in press (chapter 8 of a special collection resulting from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in the Space Age

Forward pi^0 Production and Associated Transverse Energy Flow in Deep-Inelastic Scattering at HERA

Deep-inelastic positron-proton interactions at low values of Bjorken-x down to x \approx 4.10^-5 which give rise to high transverse momentum pi^0 mesons are studied with the H1 experiment at HERA. The inclusive cross section for pi^0 mesons produced at small angles with respect to the proton remnant (the forward region) is presented as a function of the transverse momentum and energy of the pi^0 and of the four-momentum transfer Q^2 and Bjorken-x. Measurements are also presented of the transverse energy flow in events containing a forward pi^0 meson. Hadronic final state calculations based on QCD models implementing different parton evolution schemes are confronted with the data.Comment: 27 pages, 8 figures and 3 table