2,078 research outputs found
Total synthesis of the cyclic monoterpenoid pyrano[3,2-a]carbazole alkaloids derived from 2-hydroxy-6-methylcarbazole
The synthesis of seven pyrano[3,2-a]carbazole alkaloids has been achieved using their putative biogenetic precursor 2-hydroxy-6-methylcarbazole as key intermediate
The dynamical evolution of the circumstellar gas around low-and intermediate-mass stars I: the AGB
We have investigated the dynamical interaction of low- and-intermediate mass
stars (from 1 to 5 Msun) with their interstellar medium (ISM). In this first
paper, we examine the structures generated by the stellar winds during the
Asymptotic Giant Branch (AGB) phase, using a numerical code and the wind
history predicted by stellar evolution. The influence of the external ISM is
also taken into account. We find that the wind variations associated with the
thermal pulses lead to the formation of transient shells with an average
lifetime of 20,000 yr, and consequently do not remain recorded in the density
or velocity structure of the gas. The formation of shells that survive at the
end of the AGB occurs via two main processes: shocks between the shells formed
by two consecutive enhancements of the mass-loss or via continuous accumulation
of the material ejected by the star in the interaction region with the ISM. Our
models show that the mass of the circumstellar envelope increases appreciably
due to the ISM material swept up by the wind (up to 70 % for the 1 Msun stellar
model). We also point out the importance of the ISM on the deceleration and
compression of the external shells. According to our simulations, large regions
(up to 2.5 pc) of neutral gas surrounding the molecular envelopes of AGB stars
are expected. These large regions of gas are formed from the mass-loss
experienced by the star during the AGB evolution.Comment: 43 pages, 15 figures. Accepted for publication in the Astrophysical
Journa
Quasi-free Photoproduction from the Bound Nucleon
Differential cross-sections for quasi-free photoproduction from the
proton and neutron bound in the deuteron have been measured for MeV at usind the Glasgow photon
tagger at MAMI, the Mainz 48 cm 64 cm NaI(Tl) photon
detector and the G\"ottingen SENECA recoil detector. For the proton
measurements made with both liquid deuterium and liquid hydrogen targets allow
direct comparison of "free" photoproduction cross-sections as extracted
from the bound proton data with experimental free cross sections which are
found to be in reasonable agreement below 320 MeV. At higher energies the
"free" cross sections extracted from quasifree data are significantly smaller
than the experimental free cross sections and theoretical predictions based on
multipole analysis. For the first time, "free" neutron cross sections have been
extracted in the -region. They are also in agreement with the
predictions from multipole analysis up to 320 MeV and significantly smaller at
higher photon energies
The high-precision, charge-dependent Bonn nucleon-nucleon potential (CD-Bonn)
We present a charge-dependent nucleon-nucleon (NN) potential that fits the
world proton-proton data below 350 MeV available in the year of 2000 with a
chi^2 per datum of 1.01 for 2932 data and the corresponding neutron-proton data
with chi^2/datum = 1.02 for 3058 data. This reproduction of the NN data is more
accurate than by any phase-shift analysis and any other NN potential. The
charge-dependence of the present potential (that has been dubbed `CD-Bonn') is
based upon the predictions by the Bonn Full Model for charge-symmetry and
charge-independence breaking in all partial waves with J <= 4. The potential is
represented in terms of the covariant Feynman amplitudes for one-boson exchange
which are nonlocal. Therefore, the off-shell behavior of the CD-Bonn potential
differs in a characteristic and well-founded way from commonly used local
potentials and leads to larger binding energies in nuclear few- and many-body
systems, where underbinding is a persistent problem.Comment: 69 pages (RevTex) including 20 tables and 9 figures (ps files
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Sozialstaatliche Kürzungspolitik in Deutschland: Nur eine Mär? Eine quantitative Gesetzgebungsanalyse 1974–2014
Quantitative analyses on welfare state dynamics have to cope with the “dependent variable problem”, as studies on social spending reach different conclusions than analyses of replacement rate data. This article suggests a way around this problem by presenting results from a fine-grained analysis of welfare state legislation in Germany between 1974 and 2014.
We show that the German welfare state has seen both cuts and expansions occur in all decades. Moreover, we show by means of a regression analysis that partisan politics play a role. Supporting the “Nixon-in-China”-thesis, social democratic governments are associated with a higher probability of cutbacks – especially in times of budgetary pressure – whereas expansions are more likely under Christian democratic governments
CS23D: a web server for rapid protein structure generation using NMR chemical shifts and sequence data
CS23D (chemical shift to 3D structure) is a web server for rapidly generating accurate 3D protein structures using only assigned nuclear magnetic resonance (NMR) chemical shifts and sequence data as input. Unlike conventional NMR methods, CS23D requires no NOE and/or J-coupling data to perform its calculations. CS23D accepts chemical shift files in either SHIFTY or BMRB formats, and produces a set of PDB coordinates for the protein in about 10–15 min. CS23D uses a pipeline of several preexisting programs or servers to calculate the actual protein structure. Depending on the sequence similarity (or lack thereof) CS23D uses either (i) maximal subfragment assembly (a form of homology modeling), (ii) chemical shift threading or (iii) shift-aided de novo structure prediction (via Rosetta) followed by chemical shift refinement to generate and/or refine protein coordinates. Tests conducted on more than 100 proteins from the BioMagResBank indicate that CS23D converges (i.e. finds a solution) for >95% of protein queries. These chemical shift generated structures were found to be within 0.2–2.8 Å RMSD of the NMR structure generated using conventional NOE-base NMR methods or conventional X-ray methods. The performance of CS23D is dependent on the completeness of the chemical shift assignments and the similarity of the query protein to known 3D folds. CS23D is accessible at http://www.cs23d.ca
Phase Diagram of the Heisenberg Spin Ladder with Ring Exchange
We investigate the phase diagram of a generalized spin-1/2 quantum
antiferromagnet on a ladder with rung, leg, diagonal, and ring-exchange
interactions. We consider the exactly soluble models associated with the
problem, obtain the exact ground states which exist for certain parameter
regimes, and apply a variety of perturbative techniques in the regime of strong
ring-exchange coupling. By combining these approaches with considerations
related to the discrete Z_4 symmetry of the model, we present the complete
phase diagram.Comment: 17 pages, 10 figure
Superconductivity in Ce- and U-based "122" heavy-fermion compounds
This review discusses the heavy-fermion superconductivity in Ce- and U-based
compounds crystallizing in the body-centered tetragonal ThCr2Si2 structure.
Special attention will be paid to the theoretical background of these systems
which are located close to a magnetic instability.Comment: 12 pages, 9 figures. Invited topical review (special issue on "Recent
Developments in Superconductivity") Metadata and references update
FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium
Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.
Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.
Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95 confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.
Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2. © 2014 Cancer Research UK
Pairing in nuclear systems: from neutron stars to finite nuclei
We discuss several pairing-related phenomena in nuclear systems, ranging from
superfluidity in neutron stars to the gradual breaking of pairs in finite
nuclei. We focus on the links between many-body pairing as it evolves from the
underlying nucleon-nucleon interaction and the eventual experimental and
theoretical manifestations of superfluidity in infinite nuclear matter and of
pairing in finite nuclei. We analyse the nature of pair correlations in nuclei
and their potential impact on nuclear structure experiments. We also describe
recent experimental evidence that points to a relation between pairing and
phase transitions (or transformations) in finite nuclear systems. Finally, we
discuss recent investigations of ground-state properties of random two-body
interactions where pairing plays little role although the interactions yield
interesting nuclear properties such as 0+ ground states in even-even nuclei.Comment: 74 pages, 33 figs, uses revtex4. Submitted to Reviews of Modern
Physic
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