INOVAÇÃO E TRANSFORMAÇÃO DIGITAL EM GESTÃO DE PESSOAS NO GOVERNO FEDERAL: CASO SOUGOV.BR

Esta pesquisa tem como objetivo investigar os efeitos percebidos pelos usuários do SouGov.br no uso da plataforma. Para o aprimoramento dos serviços prestados à sociedade, o Governo Federal estabeleceu a Inovação e a Transformação Digital em Gestão de Pessoas como uma política estratégica do Ministério da Economia, materializada em instrumentos de governança voltados aos servidores públicos federais. Desta maneira, foi formulada a pergunta de pesquisa: Com a implantação do SouGov.br, quais foram os efeitos e o ganho de valor à sociedade identificados a partir da percepção dos usuários, sejam eles gestores de pessoas ou usuários finais? O estudo foi do tipo exploratório e qualitativo, utilizando-se do estudo de caso como forma de detalhamento das temáticas, em dois módulos do SouGov.br: o Atestado em Saúde, utilizado por servidores efetivos, e o Prova de Vida, voltado aos aposentados e pensionistas. A pesquisa indicou os parâmetros necessários à aplicação das entrevistas aos gestores da Secretaria de Gestão e Desempenho de Pessoal (SGP) e do questionário aos usuários gestores das unidades vinculadas à SGP. Os resultados revelaram que existem vários ganhos, que é necessário constante aprimoramento nessas políticas e que é primordial a atenção às pessoas, gerando real valor público e bem-estar à sociedade

Green-algal photobiont diversity (Trebouxia spp.) in representatives of Teloschistaceae (Lecanoromycetes, lichen-forming ascomycetes)

The green algal photobionts of 12 Xanthoria, seven Xanthomendoza, two Teloschistes species and Josefpoeltia parva (all Teloschistaceae) were analyzed. Xanthoria parietina was sampled on four continents. More than 300 photobiont isolates were brought into sterile culture. The nuclear ribosomal internal transcribed spacer region (nrITS; 101 sequences) and the large subunit of the RuBiSco gene (rbcL; 54 sequences) of either whole lichen DNA or photobiont isolates were phylogenetically analyzed. ITS and rbcL phylogenies were congruent, although some subclades had low bootstrap support. Trebouxia arboricola, T. decolorans and closely related, unnamed Trebouxia species, all belonging to clade A, were found as photobionts of Xanthoria species. Xanthomendoza species associated with either T. decolorans (clade A), T. impressa, T. gelatinosa (clade I) or with an unnamed Trebouxia species. Trebouxia gelatinosa genotypes (clade I) were the photobionts of Teloschistes chrysophthalmus, T. hosseusianus and Josefpoeltia parva. Only weak correlations between distribution patterns of algal genotypes and environmental conditions or geographical location were observe

Efeito do óxido de cálcio na longevidade de gérberas cv. Gibsy

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Influência de 1-MCP, solução de sacarose e presença de bactérias na longevidade de boca-de-leão

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Long-term leukocyte reconstitution in NSG mice transplanted with human cord blood hematopoietic stem and progenitor cells

Abstract Background Humanized mice (hu mice) are based on the transplantation of hematopoietic stem and progenitor cells into immunodeficient mice and have become important pre-clinical models for biomedical research. However, data about their hematopoiesis over time are scarce. We therefore characterized leukocyte reconstitution in NSG mice, which were sublethally irradiated and transplanted with human cord blood-derived CD34+ cells at newborn age, longitudinally in peripheral blood and, for more detailed analyses, cross-sectionally in peripheral blood, spleen and bone marrow at different time points. Results Human cell chimerism and absolute human cell count decreased between week 16 and 24 in the peripheral blood of hu mice, but were stable thereafter as assessed up to 32 weeks. Human cell chimerism in spleen and bone marrow was maintained over time. Notably, human cell chimerism in peripheral blood and spleen as well as bone marrow positively correlated with each other. Percentage of B cells decreased between week 16 and 24, whereas percentage of T cells increased; subsequently, they levelled off with T cells clearly predominating at week 32. Natural killer cells, monocytes and plasmacytoid dendritic cells (DCs) as well as CD1c + and CD141+ myeloid DCs were all present in hu mice. Proliferative responses of splenic T cells to stimulation were preserved over time. Importantly, the percentage of more primitive hematopoietic stem cells (HSCs) in bone marrow was maintained over time. Conclusions Overall, leukocyte reconstitution was maintained up to 32 weeks post-transplantation in our hu NSG model, possibly explained by the maintenance of HSCs in the bone marrow. Notably, we observed great variation in multi-lineage hematopoietic reconstitution in hu mice that needs to be taken into account for the experimental design with hu mice

Self-organisation in LTE networks : an investigation

Mobile telecommunications networks based on Long Term Evolution (LTE) technology promise faster throughput to their users. LTE networks are however susceptible to a phenomenon known as inter-cell interference which can greatly reduce the throughput of the network causing unacceptable degradation of performance for cell edge users. A number of approaches to mitigating or minimising inter-cell interference have been presented in the literature such as randomisation, cancellation and coordination. The possibility of coordination between network nodes in an LTE network is made possible through the introduction of the X2 network link. This thesis explores approaches to reducing the effect of inter-cell interference on the throughput of LTE networks by using the X2 link to coordinate the scheduling of radio resources. Three approaches to the reduction of inter-cell interference were developed. Localised organisation is a centralised scheme in which a scheduler is optimised by a Genetic Algorithm (GA) to reduce interference. Networked organisation makes use of the X2 communications link to enable the network nodes to exchange scheduling information in a way that lowers the level of interference across the whole network. Finally a more distributed and de-centralised approach is taken in which each of the network nodes optimises its own scheduling in coordination with its neighbours. An LTE network simulator was built to allow for experimental comparison between these techniques and a number of existing approaches and to serve as a test bed for future algorithm development. These approaches were found to significantly improve the throughput of the cell edge users who were most affected by intereference. In particular the networked aspect of these approaches yielded the best initial results showing clear improvement over the existing state of the art. The distributed approach shows significant promise given further development.EPSR

Time to Switch to Second-line Antiretroviral Therapy in Children With Human Immunodeficiency Virus in Europe and Thailand.

Background: Data on durability of first-line antiretroviral therapy (ART) in children with human immunodeficiency virus (HIV) are limited. We assessed time to switch to second-line therapy in 16 European countries and Thailand. Methods: Children aged <18 years initiating combination ART (≥2 nucleoside reverse transcriptase inhibitors [NRTIs] plus nonnucleoside reverse transcriptase inhibitor [NNRTI] or boosted protease inhibitor [PI]) were included. Switch to second-line was defined as (i) change across drug class (PI to NNRTI or vice versa) or within PI class plus change of ≥1 NRTI; (ii) change from single to dual PI; or (iii) addition of a new drug class. Cumulative incidence of switch was calculated with death and loss to follow-up as competing risks. Results: Of 3668 children included, median age at ART initiation was 6.1 (interquartile range (IQR), 1.7-10.5) years. Initial regimens were 32% PI based, 34% nevirapine (NVP) based, and 33% efavirenz based. Median duration of follow-up was 5.4 (IQR, 2.9-8.3) years. Cumulative incidence of switch at 5 years was 21% (95% confidence interval, 20%-23%), with significant regional variations. Median time to switch was 30 (IQR, 16-58) months; two-thirds of switches were related to treatment failure. In multivariable analysis, older age, severe immunosuppression and higher viral load (VL) at ART start, and NVP-based initial regimens were associated with increased risk of switch. Conclusions: One in 5 children switched to a second-line regimen by 5 years of ART, with two-thirds failure related. Advanced HIV, older age, and NVP-based regimens were associated with increased risk of switch

Digitizing the linguistic atlas of German-speaking Switzerland

In this paper, we report on recent digitization efforts of the linguistic atlas of German-speaking Switzerland (Sprachatlas der deutschen Schweiz, henceforth SDS). The SDS project was initiated in the 1930s, its data collection (in 557 locations) took place in the 1940s and 1950s, and the publication of the resulting eight volumes (totalling about 1500 hand-drawn maps) occurred between 1962 and 1997. While the SDS is often considered to have pioneered the concept of small-scale linguistic atlas (Kleinraumatlas), its achievement before the digital era prevented it from being used for quantitative analyses and computational work, and no digitization efforts had been undertaken until recently. Here, we would like to report on the advancement of our SDS digitization project and of some potential uses of the resulting dataset. Because of time and resource constraints, we had to restrict the SDS data in three ways: (1) selection of a subset of the maps, (2) removal of 8 inquiry points located on Italian territory, (3) removal of rarely used variants in each map. We will discuss the linguistic and dialectological reasonings behind these choices. We will also present the technical process of map digitization that we found to be most productive. In the first phase, 216 maps were digitized by one of the co-authors. In the second phase, some of the 216 existing maps were refined and 20 additional maps were digitized by one of the co-authors. The digitized maps are made available on an interactive web site, and can be downloaded freely as ArcGIS shapefiles for research purposes. We will also briefly present briefly some of our application of this material, such as a multi-dialectal morphological generator, a machine translation system into the various Swiss German dialects, as well as dialectometrical analyses

Dialektometrische Analyse von schweizerdeutschen Dialektdaten

Obwohl die Dialekte der Deutschschweiz im internationalen Vergleich sehr gut erforscht sind, ist die seit den Neunzigerjahren aufgekommene Welle der dialektometrischen Forschung (in der Folge von Goebl 1982), mit Ausnahme von Kelle (2001), an der Deutschschweiz recht spurlos vorbeigegangen. Der Hauptgrund dafür liegt in der fehlenden digitalen Verfügbarkeit von Dialektkarten: der SDS (Hotzenköcherle et al. 1962-1997) besteht gänzlich aus handgezeichneten Karten. Seither wurden einerseits im Rahmen des SADS-Projekts (Bucheli & Glaser 2002) Syntaxdaten elektronisch erfasst und andererseits in unterschiedlichen Projekten SDS-Karten digitalisiert, so dass nun die Voraussetzungen für weiterführende dialektometrische Studien gegeben sind. Zu Beginn des Vortrags soll daher ein aktuelles Bild der verschiedenen digital verfügbaren Datensätze gezeichnet werden. Der Hauptteil des Vortrages wird sich aber mit den Resultaten verschiedener dialektometrischer Experimente beschäftigen, die in den letzten paar Jahren in interdisziplinärer Zusammenarbeit entstanden sind und in naher Zukunft fortgesetzt werden sollen. Dabei werden wir auf die folgenden Fragestellungen eingehen: Welche dialektometrischen Analysemethoden gibt es und was ist deren Aussagekraft in Bezug auf Dialektklassifizierung und Sprachdynamik? Wir benutzen dabei einerseits das in Salzburg entwickelte VDM-Programm und andererseits das in Groningen entstandene Softwarepaket RuG/L04 (Nerbonne & Heeringa 2001). Wie unterscheidet sich die räumliche Verteilung der aggregierten Daten aus verschiedenen linguistischen Analyseebenen? Dabei berufen wir uns auf Phonetik-, Morphologie- und Lexikon-Daten aus dem SDS sowie auf Syntaxdaten aus dem SADS. Gibt es linguistische Analyseebenen, oder gar Einzelphänomene, die die schweizerdeutsche Sprachlandschaft besonders gut beschreiben? Wie gross ist der Einfluss der Fragemethode auf die resultierenden Analysen? In einem Ausblick werden wir die Grenzen der Dialektometrie bezüglich der aktuellen Datenlage erörtern und einige Vorschläge für die weiterführende Forschung auf diesem Gebiet nennen