RODIN: Connectionist Techniques in a CAD-System

In future CAD systems the reuse of already existing design objects becomes a key functionality. Typically, in many design domains solutions for new problems are derived from successful cases. Thus, time consuming and expensive design development from scratch needs not to be done. The paper presents RODIN, a connectionist application supporting the reuse of manufacturing information for CAD objects. In RODIN two different problems in reusing of design objects are studied. At first, we present our work how to retrieve appropriate reference cases from a database. In the retrieval process multiple attributes are taken into account. Secondly, we show how information between structurally similar designs can be exchanged. The transformation step is performed by backprop nets. The work of the designer is supported by relieving him/her of routine matters. As a consequence both the time-to-market and the quality of the products are optimized

A detailed study of the diastereoselective catalytic hydrogenation of 6-hydroxytetrahydroisoquinoline-(3R)-carboxylic ester intermediates

A key step towards a highly-selective antagonist of ionotropic glutamate receptors entails the diastereoselective arene hydrogenation of an enantiopure tetrahydroisoquinoline. An extensive screen using parallel reactors was conducted and led to the discovery of several Pd/C catalysts giving high yield and improved diastereoselectivity from 75 : 25 to 95 : 5. A detailed kinetic study of the best system was performed and supports the reduction occuring in two-steps.

Cupulin Is a Zona Pellucida-Like Domain Protein and Major Component of the Cupula from the Inner Ear

The extracellular membranes of the inner ear are essential constituents to maintain sensory functions, the cupula for sensing torsional movements of the head, the otoconial membrane for sensing linear movements and accelerations like gravity, and the tectorial membrane in the cochlea for hearing. So far a number of structural proteins have been described, but for the gelatinous cupula precise data are missing. Here, we describe for the first time a major proteinogenic component of the cupula structure with an apparent molecular mass of 45 kDa from salmon. Analyses of respective peptides revealed highly conserved amino-acid sequences with identity to zona pellucida-like domain proteins. Immunohistochemistry studies localized the protein in the ampulla of the inner ear from salmon and according to its anatomical appearance we identified this glycoprotein as Cupulin. Future research on structure and function of zona pellucida-like domain proteins will enhance our knowledge of inner ear diseases, like sudden loss of vestibular function and other disturbances

Approximate quantum cloning and the impossibility of superluminal information transfer

We show that nonlocality of quantum mechanics cannot lead to superluminal transmission of information, even if most general local operations are allowed, as long as they are linear and trace preserving. In particular, any quantum mechanical approximate cloning transformation does not allow signalling. On the other hand, the no-signalling constraint on its own is not sufficient to prevent a transformation from surpassing the known cloning bounds. We illustrate these concepts on the basis of some examples.Comment: 4 pages, 1eps figur

Quantum optical time-of-arrival model in three dimensions

We investigate the three-dimensional formulation of a recently proposed operational arrival-time model. It is shown that within typical conditions for optical transitions the results of the simple one-dimensional version are generally valid. Differences that may occur are consequences of Doppler and momentum-transfer effects. Ways to minimize these are discussed.Comment: 14 pages, 5 figure

Designing forest biodiversity experiments : general considerations illustrated by a new large experiment in subtropical China

Funded by German Research Foundation. Grant Number: DFG FOR 891/1 and 2 National Natural Science Foundation of China. Grant Numbers: NSFC 30710103907, 30930005, 31170457 , 31210103910 Swiss National Science Foundation (SNSF) Sino-German Centre for Research Promotion in BeijingPeer reviewedPublisher PD

The experience and management of neck pain in general practice: the patients’ perspective

The objective of this study is to investigate the perspective and expectation of patients presenting with neck pain in general practice. The study design is a qualitative analysis of patient interviews and was conducted in a primary care setting in Germany. Twenty patients aged 20–78, according to theoretical sampling were included in the study. Patients tried to cope autonomously with the situation and consulted GPs only if their self-help had failed. When patients asked for external help, they usually focused on somatic treatment options such as massage, physiotherapy or injections. Most patients reported to have experiences with somatic therapies; however, they felt that some or all of these treatments were inefficient or led only to short-time improvements. Patients often avoided psychosocial themes when talking to doctors for fear of being branded as ‘neurotic’. Although neck pain is difficult to manage and a burden for patients, they have obviously found a way of both living with their pain and a pragmatic approach of talking about their symptoms with their doctor. According to the patients’ statements, the interaction between doctor and patient seems to be rather distant, ensuring that both sides avoid any issues that might touch upon psychological aspects of neck pain

Parton-Hadron-String Dynamics: an off-shell transport approach for relativistic energies

The dynamics of partons, hadrons and strings in relativistic nucleus-nucleus collisions is analyzed within the novel Parton-Hadron-String Dynamics (PHSD) transport approach, which is applied to Pb+Pb collisions from 20 to 160 A GeV in order to explore the space-time regions of 'partonic matter'. We find that even central collisions at the top-SPS energy of 158 A GeV show a large fraction of non-partonic, i.e. hadronic or string-like matter, which can be viewed as a hadronic corona. Furthermore, we observe that the partonic phase has a very low impact on rapidity distributions of hadrons but a sizeable influence on the transverse mass distribution of final kaons due to the repulsive partonic mean fields. We also find a significant effect on the production of multi-strange antibaryons due to a slightly enhanced $s{\bar s}$ pair production in the partonic phase from massive time-like gluon decay and a larger formation of antibaryons in the hadronization process. All differential hadron spectra are analyzed in comparison to the data of experimental collaborations.Comment: 33 pages, 23 figures, submitted to Nulc. Phys.

Towards a methodical framework for comprehensively assessing forest multifunctionality

Funded by Deutsche Forschungsgemeinschaft. Grant Number: DFG FOR 891/1-3 National Natural Science Foundation of China. Grant Numbers: 30710103907, 30930005, 31170457, 31210103910 Swiss National Science Foundation (SNSF) Sino-German Centre for Research Promotion in Beijing. Grant Number: GZ 986Peer reviewedPublisher PD