A system level comparison of drive topologies for high speed electrical machines

This paper presents a comprehensive comparative study among five different converter topologies all designed to drive a 8.5kW-120krpm surface permanent magnet synchronous machine. The study aims at comparing the considered systems in terms of converter complexity, control complexity and overall efficiency. The assessment of the subsystems’ efficiencies is based on a set of decoupled converter-electrical machine simulations. First the designed converters are simulated in Matlab-Simulink environment in order to estimate the converter losses and the current waveforms. Then the latter are used to supply the FE model of the electrical machine so to estimate all the loss components present in the real scenario. The results of the carried out study gives a wide understanding of the interaction between the two subsystems and some general design considerations needed to select the converter topology

Femtocore: An Application Specific Processor for Vertically Integrated High Performance Real-Time Controls

In applications that require a high availability and high performance (for example aerospace),modular power electronics and multi-phase machines represent an advantageous choice. In this framework, a control system able to handle a high number of PWM signals and communication interfaces as well as featuring a high computational power is required. This paper proposes a novel HDL plus soft-core approach to be implemented on System-on-Chip hardware which allows for the efficient and modular implementation of the modern control techniques with strong guarantees in terms of determinism. The proposal lies in the adoption of a very simplified and optimized floating-point soft-core, the femtocore (fCore) and its tool-chain, which allows C-like implementation of complex algorithms in a HDL-design power electronics control framework. Several fCore units can be arranged for parallel processing to handle the time requirements of a complex modular system even with low sampling time (100 kHz or more). The proposed architecture is experimentally validated in a proof-of-concept, six-phase electric machine including a comparison against a traditional method

High-Speed Electric Drives: A Step Towards System Design

Electric drives applications have been worldwide adopted for the transportation electrification. An electric drive system is constituted by two main components: the power electronics converter and the electrical machine. Traditionally the design workflow consisted in the separate realization of these two parts, by different teams or even organizations. This requires strong assumptions regarding operating conditions and may lead to actual performance at system level far from the one expected. In this article, a unified design methodology of the two sub-systems is presented considering the true operating conditions, allowing a more accurate assessment of power losses at system level and identifying the influence of the converter design choices on the electric machine performance. As a case study, this article presents a comparative analysis among three different converter topologies designed to drive a 8.5 kW-120 krpm surface PMSM. The study aims at comparing the considered systems in terms of overall efficiency, losses distribution and system complexity. At first converters are simulated in Matlab-Simulink to estimate the losses and the current waveforms, that are then used in the Finite Element model of the electrical machine to estimate the loss components in a real scenario. The models developed are then validated by means of experimental measurements. This article highlights the new understanding that can be gained by considering the interactions between sub-systems, allowing a more conscious choice of the converter topology to achieve optimal overall performance

Frovatriptan versus almotriptan for acute treatment of menstrual migraine: analysis of a double-blind, randomized, cross-over, multicenter, Italian, comparative study

The objective of the study was to compare the efficacy and safety of frovatriptan and almotriptan in women with menstrually related migraine (IHS Classification of Headache disorders) enrolled in a multicenter, randomized, double-blind, cross-over study. Patients received frovatriptan 2.5 mg or almotriptan 12.5 mg in a randomized sequence: after treating 3 episodes of migraine in no more than 3 months with the first treatment, the patient was switched to the other treatment. 67 of the 96 female patients of the intention-to-treat population of the main study had regular menstrual cycles and were thus included in this subgroup analysis. 77 migraine attacks classified as related to menses were treated with frovatriptan and 78 with almotriptan. Rate of pain relief at 2 and 4 h was 36 and 53 % for frovatriptan and 41 and 50 % for almotriptan (p = NS between treatments). Rate of pain free at 2 and 4 h was 19 and 47 % with frovatriptan and 29 and 54 % for almotriptan (p = NS). At 24 h, 62 % of frovatriptan-treated and 67 % of almotriptan-treated patients had pain relief, while 60 versus 67 % were pain free (p = NS). Recurrence at 24 h was significantly (p < 0.05) lower with frovatriptan (8 vs. 21 % almotriptan). This was the case also at 48 h (9 vs. 24 %, p < 0.05). Frovatriptan was as effective as almotriptan in the immediate treatment of menstrually related migraine attacks. However, it showed a more favorable sustained effect, as shown by a lower rate of migraine recurrence

A double-blind, randomized, multicenter, Italian study of frovatriptan versus almotriptan for the acute treatment of migraine

The objective of this study was to evaluate patients’ satisfaction with acute treatment of migraine with frovatriptan or almotriptan by preference questionnaire. One hundred and thirty three subjects with a history of migraine with or without aura (IHS 2004 criteria), with at least one migraine attack in the preceding 6 months, were enrolled and randomized to frovatriptan 2.5 mg or almotriptan 12.5 mg, treating 1–3 attacks. The study had a multicenter, randomized, double blind, cross-over design, with treatment periods lasting <3 months. At study end patients assigned preference to one of the treatments using a questionnaire with a score from 0 to 5 (primary endpoint). Secondary endpoints were pain free and pain relief episodes at 2 and 4 h, and recurrent and sustained pain free episodes within 48 h. Of the 133 patients (86%, intention-to-treat population) 114 of them expressed a preference for a triptan. The average preference score was not significantly different between frovatriptan (3.1 ± 1.3) and almotriptan (3.4 ± 1.3). The rates of pain free (30% frovatriptan vs. 32% almotriptan) and pain relief (54% vs. 56%) episodes at 2 h did not significantly differ between treatments. This was the case also at 4 h (pain free: 56% vs. 59%; pain relief: 75% vs. 72%). Recurrent episodes were significantly (P < 0.05) less frequent under frovatriptan (30% vs. 44%), also for the attacks treated within 30 min. No significant differences were observed in sustained pain free episodes (21% vs. 18%). The tolerability profile was similar between the two drugs. In conclusion, our study suggests that frovatriptan has a similar efficacy of almotriptan in the short-term, while some advantages are observed during long-term treatment

Allergic sensitization to common pets (cats/dogs) according to different possible modalities of exposure: an Italian Multicenter Study

Background: The query "are there animals at home?" is usually administered for collecting information on anamnesis. This modality to consider exposure to pet allergens constitutes a potential bias in epidemiological studies and in clinical practice. The aim of our study was to evaluate/quantify different modalities of exposure to cat/dog in inducing allergic sensitization. Methods: Thirty Italian Allergy units participated in this study. Each centre was required to collect the data of at least 20 consecutive outpatients sensitized to cat/dog allergens. A standardized form reported all demographic data and a particular attention was paid in relieving possible modalities of exposure to cat/dog. Results: A total 723 patients sensitized to cat/dog were recorded, 359 (49.65%) reported direct pet contact, 213 patients (29.46%) were pet owners, and 146 subjects (20.19%) were exposed to pets in other settings. Other patients were sensitized by previous pet ownership (150-20.75%) or indirect contact (103-14.25%), in 111 subjects (15.35%) any contact was reported. Conclusions: Only 213 patients (29.46%) would be classified as "exposed to animals" and 510 (70.54%) as "not exposed" according to usual query. Our classification has shown that many "not-exposed" subjects (399-55.19%) were "really exposed". The magnitude of exposure to pet allergens at home is not related exclusively to pet ownership. These considerations should be taken into account during the planning of epidemiological studies and in clinical practice for the management of pet allergic individuals

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity

Numerical Robustness Evaluation of Floating-Point Closed-Loop Control Based on Interval Analysis

Power-electronics-based systems have penetrated into several critical sectors, such as the industry, power generation, energy transmission and distribution, and transportation. In this context, the system’s control, often implemented in real-time processing units, has to meet stringent requirements in terms of safety and repeatability. Given the growing complexity of the implemented algorithms, floating-point arithmetic is being increasingly adopted for high-performance systems. This paper proposes to assess the numerical stability of the control algorithms by means of an interval analysis. The case study of an electric drive is considered, given the wide adoption of such systems and the importance they hold for the safety of the applications. In particular, two different control strategies—the resonant control and the vector space decomposition—are examined, and a sensitivity analysis based on the proposed technique highlights the different characteristics of the two with respect to numerical stability. The proposed method shows how the resonant control is more robust to variations of the controller gain coefficients with respect to the numerical stability, which could make it the preferred choice for mission-critical electric drive control