BaSysBio: Towards an understanding of dynamic transcriptional regulation at global scale in bacteria: a systems biology approach

9th International Conference on Systems Biology, ICSB 2008, 22-28 August, Goteborg, SwedenBaSysBio adopts a systems biology approach in which quantitative experimental data will be generated for each step of the information flow and will fuel computational modelling. High throughput technologies (living cell arrays, tiling DNA microarrays, MDLC proteomics and quantitative metabolomics) will be developed in conjunction with new computational modelling concepts to facilitate the understanding of biological complexity. Models will simulate the cellular transcriptional responses to environmental changes and their impact on metabolism and proteome dynamics. The iterative process of simulations and model-driven targeted experiments will generate novel hypotheses about the mechanistic nature of dynamic cellular responses, unravel emerging systems properties and ultimately provide an efficient roadmap to tackle novel, pathogenic organismsN

Les légumes et les fruits. Aidez votre enfant à les aimer. Un guide pour les parents de jeunes enfants

Livret à vocation pédagogiquelivret Projet HabEatLe Projet HabEat a rassemblé des chercheurs de 11 groupes, répartis dans 6 pays européens. Une approche multidisciplinaire a été utilisée pour étudier comment les habitudes alimentaires essentielles se formaient chez les nourrissons et les jeunes enfants (de 0 à 6 ans). Différentes stratégies pouvant permettre de modifier de mauvaises habitudes alimentaires déjà établies ont également été étudiées. Le projet a reposé sur des études épidémiologiques, à partir de cohortes existantes dans 4 pays, et sur des travaux expérimentaux conduits dans 6 pays. Ce livret s’appuie sur les principaux résultats de ce projet et les données antérieures de la littérature

Le Verbe

Les contributions proposées dans ce volume, par leur diversité, apportent un nouvel éclairage sur des questions centrales relatives à l’enseignement / apprentissage du verbe. Elles permettent de mettre en évidence le lien étroit entre recherche linguistique et application didactique dans ce domaine et de réfléchir sur les conditions d’une transposition didactique, en vérifiant la pertinence des propositions faites dans le cadre d’expérimentations menées en classe. En proposant une réflexion sur les critères identificatoires de cette unité ou sur l’organisation du système verbal, en portant une attention particulière sur les manuels scolaires ou encore sur les constructions syntaxiques dépendant du verbe, les études proposées ici ébauchent aussi des pistes qui pourraient être envisagées utilement dans le cadre de la formation des enseignants

Le verbe pour exprimer le temps

Ce numéro de la revue Lidil a pour objectif de revisiter le concept de verbe dans la perspective de sa transposition didactique centrée sur les usages effectifs de la langue. Alors que les programmes scolaires tendent à réduire la situation temporelle à la chronologie et à assimiler le temps linguistique à la conjugaison, les contributions proposées ici prennent le parti d'une approche centrée sur le statut du verbe dans la construction et l'expression du temps envisagée du point de vue de la chronologie et de l’aspect. Elles contribuent à établir une liste des « outils grammaticaux » en jeu dans l’expression du temps, envisagent la manière dont les élèves appréhendent ces concepts et décrivent les problèmes soulevés par leur transposition en classe. Sont ainsi abordées les questions de l’apport des formes non fléchies à l’expression du temps, de l’auxiliarisation des verbes à l’infinitif dans l’expression du futur, de l’interprétation des formes périphrastiques par des élèves de l’école élémentaire, des normes qui régissent l’usage du verbe dans des textes argumentatifs en français et narratifs en espagnol

MetaboHUB and RFMF : two tools at the service of metabolomics and fluxomics in France

International audienceMetaboHUB and RFMF are two tools developed in France to serve the scientific community in Metabolomics and Fluxomics (M&F). The French Metabolomics and Fluxomics Network (RFMF, https://www.bordeaux.inra.fr/ifr103/reseau_metabolome/) is a scientific society which contributes to the development of M&F and more broadly to the overall analysis of metabolism in France through various actions:• Foster relationships between French researchers working in the world of M&F (public and private sectors);• Promote and structure education and training in M&F;• Organize and support the organization of conferences in France and abroad;• Encourage the participation of young researchers to national and international conferences through grants;• Allocate funds mission or prizes for accomplished work in M&F.MetaboHUB project (http://www.metabohub.fr/en/) aims at creating a national infrastructure that will place France among the European leaders for advanced research services in M&F. MetaboHUB provides equipment and services to academic research and industrial partners in nutrition, health, agriculture, environment and biotechnology. MetaboHUB is the merging of 4 existing facilities (Bordeaux, Paris-Saclay, Toulouse and Clermont-Ferrand) into a unique infrastructure sharing common regulations and complementary M&F tools. Besides providing state-of-the-art services and support to national and international projects, a major ambition of MetaboHUB is to develop innovative tools and methods to address critical biological questions. MetaboHUB will provide custom solutions for (i) high-throughput, quantitative technologies for biochemical phenotyping of large sets of samples and for systems biology through standardization and combination of state–of-art technologies, (ii) identification of metabolites in human biofluids, plants, microorganisms and animal cell extracts, through the implementation and maintenance of centralized and open spectral repositories for metabolome annotations, (iii) large-scale flux profiling and sub-cellular fluxomics through integration of analytical data from multiple analytical devices, (iv) access to high-impact services to the national scientific community and industrial actors and, (v) attracting and training a new generation of scientists and students

MetaboHUB and RFMF : two tools at the service of metabolomics and fluxomics in France

MetaboHUB and RFMF are two tools developed in France to serve the scientific community in Metabolomics and Fluxomics (M&F). The French Metabolomics and Fluxomics Network (RFMF, https://www.bordeaux.inra.fr/ifr103/reseau_metabolome/) is a scientific society which contributes to the development of M&F and more broadly to the overall analysis of metabolism in France through various actions:• Foster relationships between French researchers working in the world of M&F (public and private sectors);• Promote and structure education and training in M&F;• Organize and support the organization of conferences in France and abroad;• Encourage the participation of young researchers to national and international conferences through grants;• Allocate funds mission or prizes for accomplished work in M&F.MetaboHUB project (http://www.metabohub.fr/en/) aims at creating a national infrastructure that will place France among the European leaders for advanced research services in M&F. MetaboHUB provides equipment and services to academic research and industrial partners in nutrition, health, agriculture, environment and biotechnology. MetaboHUB is the merging of 4 existing facilities (Bordeaux, Paris-Saclay, Toulouse and Clermont-Ferrand) into a unique infrastructure sharing common regulations and complementary M&F tools. Besides providing state-of-the-art services and support to national and international projects, a major ambition of MetaboHUB is to develop innovative tools and methods to address critical biological questions. MetaboHUB will provide custom solutions for (i) high-throughput, quantitative technologies for biochemical phenotyping of large sets of samples and for systems biology through standardization and combination of state–of-art technologies, (ii) identification of metabolites in human biofluids, plants, microorganisms and animal cell extracts, through the implementation and maintenance of centralized and open spectral repositories for metabolome annotations, (iii) large-scale flux profiling and sub-cellular fluxomics through integration of analytical data from multiple analytical devices, (iv) access to high-impact services to the national scientific community and industrial actors and, (v) attracting and training a new generation of scientists and students

MetaboHUB and RFMF : two tools at the service of metabolomics and fluxomics in France

International audienc