La transmisión de la música tradicional: el patrimonio cultural inmaterial en los museos de Navarra

Por medio de este trabajo se pretende indagar la manera en que los museos de la Comunidad Foral de Navarra transmiten el patrimonio cultural inmaterial, y más concretamente aquellas categorías relacionadas con la música, en particular la considerada o catalogada como tradicionalMáster Universitario en Desarrollo de las Capacidades MusicalesUnibertsitate Masterra Musika Gaitasunen Garapenea

La conciliación de la vida laboral, familiar y personal: ¿un asunto de mujeres?

Conciliar la vida familiar y laboral sigue constituyendo en la actualidad un reto pendiente de resolver en nuestra sociedad. El reparto de roles establecidos en función del sexo continúa inmerso en nuestra sociedad y es éste el que presupone que las tareas relacionadas con el trabajo doméstico y las responsabilidades familiares le corresponden a la mujer, mientras que las tareas productivas (objeto de remuneración) le corresponden al hombre. Según estudios de la UGT (Unión General de Trabajadores), la existencia de estos estereotipos se traduce en una situación de discriminación para la mujer que se puede ver reflejada en una mayor tasa de desempleo; mayores dificultades para encontrar empleo, la promoción y el acceso a puestos de responsabilidad; así como recibir retribuciones inferiores por trabajos de igual valor, entre otras consecuencias. Mientras que esta situación para los hombres supone una menor participación en la vida familiar y en las responsabilidades familiares, y a su vez, la ausencia de problemas en el empleo derivados del cuidado y asistencia a la familia, una mayor eficiencia en el desarrollo de su trabajo y, en consecuencia, un desarrollo profesional muy superior al de sus homónimas femeninas. Por tanto, conciliar la vida familiar y laboral se percibe generalmente como un problema de las mujeres, cuando, en realidad, se trata de un conflicto de carácter social, cuya solución depende de la sociedad en su conjunto.Facultad de Ciencias de la EmpresaUniversidad Politécnica de Cartagen

El azar y la intuición como medio de producción pictórica

[ES] En el presente trabajo se exploran las posibilidades del azar y la intuición como forma de producción pictórica a través de la técnica del pouring, color field y dripping. En la parte teórica se aborda la abstracción pictórica en la segunda mitad del siglo XX, haciendo hincapié en estas técnicas, su evolución y los usos que han tenido por parte de artistas como Morris Louis o Hellen Frankenthaler. De esta misma manera, se exploran las posibilidades del dorado y sus diversas aplicaciones pictóricas, desde el arte medieval hasta la contemporaneidad. En la obra presentada empleamos una gama cromática basada en azules y el color dorado como elemento unificador que veremos reflejada en la obra final. Los vertidos se hacen de manera casi automática generando patrones espontáneos y dinámicos. Hacemos uso del dorado para recuperar el control sobre nuestra obra y darle un sentido estético personal. Con todos estos elementos buscamos crear un lenguaje pictórico propio que refleje nuestros intereses personales, así como nuestro mundo interior.[EN] In this work we explore the possibilities of chance and intuition as a form of pictorial production through the technique of pouring, color field and dripping. The theoretical part deals with pictorial abstraction in the second half of the twentieth century, emphasizing these techniques, their evolution and the uses they have had by artists like Morris Louis or Hellen Frankenthaler. In the same way, the possibilities of the gold and its various pictorial applications from medieval art to contemporary art are explored. In the presented work we use a colour range based on blues and the golden colour as a unifying element that we will see reflected in the final work. The fluids are made almost automatically generating spontaneous and dynamic patterns. We use gol to regain control over our artwork and give it a personal aesthertic sense. With all these elements we seek to create our own pictorial language that reflects our personal interests as well as our inner world.Saura Perez, C. (2020). El azar y la intuición como medio de producción pictórica. http://hdl.handle.net/10251/148845TFG

The change of paradigm in the treatment of HER2-positive breast cancer with the development of new generation antibody-drug conjugates

Breast cancer; HER2-positive; New drugsCàncer de mama; HER2-positiu; Nous medicamentsCáncer de mama; HER2 positivo; Nuevos fármacosHER2-positive breast cancer is an aggressive disease. As a result of the development of specific HER2-targeted therapies, such as trastuzumab, more than 20 years ago, the prognosis of these patients has improved. Metastatic HER2-positive breast cancer patients are achieving better survival rates upon treatment with anti-HER2 therapies than patients with HER2-negative disease. Double HER2 blockade with trastuzumab and pertuzumab combined with a taxane achieved an unprecedented survival of over 57 months in first-line patients. Trastuzumab emtansine, the first antibody-drug conjugate approved for patients in second-line treatment was a potent cytotoxic agent bound to trastuzumab and is currently a standard therapeutic strategy. Despite the progress in treatment development, most patients develop resistance and eventually relapse. Advances in the design of antibody-drug conjugates have led to the development of new generation drugs with enhanced properties, such as trastuzumab deruxtecan and trastuzumab duocarmazine, which are significantly changing the paradigm in the treatment of HER2-positive metastatic breast cancer

Modelización de la riqueza de aves mediante redes neuronales para la gestión forestal a escala de paisaje

For preserving biodiversity of European-Mediterranean forest ecosystems in current and future scenarios of global change by means of sustainable forest management it is necessary to determine how environment and forest characteristics correlate with biodiversity. For this purpose, neural networks were used to model forest bird species richness as a function of environment and forest structure and composition at the 1x1 km scale in Catalonia (NE Spain). Univariate and multivariate models respectively allowed exploring individual variable response and obtaining a parsimonious (ecologically meaningful) and accurate neural network. Forest area (with a canopy cover above 5%), mean forest canopy cover, mean annual temperature and summer precipitation were the best predictors of forest bird species richness. The resultant multivariate network had a good generalization capacity that failed however in the locations with highest species richness. Additionally, those forests with different degrees of canopy closure that were more mature and presented a more diverse tree species composition were also associated with higher bird species richness. This allowed us to provide management guidelines for forest planning in order to promote avian diversity in this European-Mediterranean region.Para preservar la biodiversidad de los ecosistemas forestales de la Europa mediterránea en escenarios actuales y futuros de cambio global mediante una gestión forestal sostenible es necesario determinar cómo influye el medio ambiente y las propias características de los bosques sobre la biodiversidad que éstos albergan. Con este propósito, se analizó la influencia de diferentes factores ambientales y de estructura y composición del bosque sobre la riqueza de aves forestales a escala 1x1 km en Cataluña (NE de España). Se construyeron modelos univariantes y multivariantes de redes neuronales para respectivamente explorar la respuesta individual a las variables y obtener un modelo parsimonioso (ecológicamente interpretable) y preciso. La superficie de bosque (con una fracción de cabida cubierta superior a 5%), la fracción de cabida cubierta media, la temperatura anual y la precipitación estival medias fueron los mejores predictores de la riqueza de aves forestales. La red neuronal multivariante obtenida tuvo una buena capacidad de generalización salvo en las localidades con una mayor riqueza. Además, los bosques con diferentes grados de apertura del dosel arbóreo, más maduros y más diversos en cuanto a su composición de especies arbóreas se asociaron de forma positiva con una mayor riqueza de aves forestales. Finalmente, se proporcionan directrices de gestión para la planificación forestal que permitan promover la diversidad ornítica en esta región de la Europa mediterránea

War and Deforestation : Using Remote Sensing and Machine Learning to Identify the War-Induced Deforestation in Syria 2010-2019

Armed conflicts and other types of violence are key drivers of human-induced landscape change. Since March 2011, Syria has been embroiled in a prolonged and devastating armed conflict causing immense human suffering and extensive destruction. As a result, over five million people have been forced to seek refuge outside the country's borders, while more than six million have been internally displaced. This study focuses on examining the impact of this conflict on forest cover by identifying the drivers of forest change. To assess this change, Landsat and PALSAR imagery were used to differentiate between forested and non-forested areas. Spectral information was synthetized using the Tasseled Cap transformation and the time series data was simplified and despiked using the LandTrendr algorithm. Our results show that between 2010 and 2019 there was a substantial decrease of 19.3% in forest cover, predominantly concentrated in the northwestern region of Syria. This decline was induced by the armed conflict, with several key drivers contributing to the decline, such as illegal logging activities conducted by both locals and refugees living in nearby forest areas. Drivers such as proximity to refugee camps, roads, and settlements played an important role in producing this change by facilitating access to forests. In addition, the occurrence of explosive events such as bombings and shelling near forests also contributed to this decline by causing forest fires. To mitigate further deforestation and reduce dependence on forests for fuel, it is crucial for local governments in the post-conflict period to offer sustainable alternatives for heating and cooking to both the local populations and refugees. Additionally, governments are recommended to enforce strict laws and regulations to protect forests and combat illegal logging activities. These measures are essential for preserving and restoring forests, promoting environmental sustainability, and ensuring the well-being of both displaced populations and local communities

Inteligencia emocional rasgo como amortiguador del estado de ánimo en docentes de educación infantil y primaria durante el impacto de la COVID-19

Background: Trait Emotional Intelligence (EI) is a personal characteristic that can act as a buffer factor against vital challenging circumstances and be a predictor of mood in a variety of natural situations such as those derived from the social context of the COVID-19 pandemic. The general aim of this research was to study the relationship between trait EI and teacher moods during confinement. Method: The study included 478 participants, 316 Preschool teachers and Elementary teachers from public centers in the Region of Murcia and 162 university students of Preschool and Elementary education degrees. The instrument used to assess trait EI was the TEIQue-SF; to assess the moods experienced during the impact of COVID-19, a short version of the POMS was used.Results: Teachers with high trait EI were perceived to be more energized and kinder, as well as less nervous, moody, sad and tired, just the opposite pattern of teachers with a low trait EI profile. In addition, female teachers obtained higher scores in negative mood states. Conclusions: Although the study is correla-tional, the results support the idea of trait EI as a protective factor against stress, which reinforces its role as a promoter of teacher well-being.Antecedentes: La Inteligencia Emocional (IE) rasgo es una característica personal que puede actuar como factor protector contra circunstancias vitales desafiantes y ser un predictor del estado de ánimo en situaciones naturales como las derivadas del contexto social de la pandemia COVID-19. El objetivo general fue estudiar la relación entre IE rasgo y los estados anímicos docentes durante el confinamiento. Método: Se contó con 478 participantes, 316 docentes de Educación Infantil (EI) y Primaria (EP) de centros públicos de la Región de Murcia y 162 estudiantes de los Grados de EI y EP. Los instrumentos empleados fueron: para evaluar la IE rasgo, el TEIQue-SF; para evaluar los estados de ánimo vividos durante el impacto de la COVID-19 se utilizó una versión breve del POMS. Resultados: Los docentes con IE elevada se percibieron más enérgicos y considerados con los demás; así como menos nerviosos, malhumorados, tristes y cansados, justo el patrón contrario al de docentes con perfil de IE baja. Además, las maestras obtienen puntuaciones mayores en los estados emocionales negativos. Conclusiones: Si bien el estudio es correlacional, los resultados avalan la idea de la IE rasgo como factor protector frente al estrés, lo que refuerza su papel como promotor del bienestar docente

Trastuzumab deruxtecan in previously treated patients with HER2-positive metastatic breast cancer: updated survival results from a phase II trial (DESTINY-Breast01)

HER2 positive; Metastatic breast cancer; Overall survivalHER2 positivo; Cáncer de mama metastásico; Supervivencia globalHER2 positiu; Càncer de mama metastàtic; Supervivència globalBackground Primary analysis of the multicenter, open-label, single-arm, phase II DESTINY-Breast01 trial (median follow-up 11.1 months) demonstrated durable antitumor activity with trastuzumab deruxtecan (T-DXd) in patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (mBC) previously treated with trastuzumab emtansine (T-DM1). We report updated cumulative survival outcomes with a median follow-up of 26.5 months (data cut-off 26 March 2021). Patients and methods Patients with HER2-positive mBC resistant or refractory to T-DM1 received T-DXd 5.4 mg/kg intravenously every 3 weeks until disease progression, unacceptable adverse events, or withdrawal of consent. The primary endpoint was confirmed objective response rate (ORR) by independent central review (ICR). Secondary endpoints included overall survival (OS), duration of response (DoR), progression-free survival (PFS), and safety. Results The ORR by ICR was 62.0% [95% confidence interval (CI) 54.5% to 69.0%] in patients who received T-DXd 5.4 mg/kg every 3 weeks (n = 184). Median OS was 29.1 months (95% CI 24.6-36.1 months). Median PFS and DoR were 19.4 months (95% CI 14.1-25.0 months) and 18.2 months (95% CI 15.0 months-not evaluable), respectively. Drug-related treatment-emergent adverse events (TEAEs) were observed in 183 patients (99.5%), and 99 patients (53.8%) had one or more grade ≥3 TEAEs. Adjudicated drug-related interstitial lung disease/pneumonitis occurred in 15.8% of patients (n = 29), of which 2.7% (n = 5) were grade 5. Conclusions These updated results provide further evidence of sustained antitumor activity of T-DXd with a consistent safety profile in heavily pretreated patients with HER2-positive mBC.This work was supported by Daiichi Sankyo Co, Ltd. and AstraZeneca (no grant number)

Modelling Neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents

Neuron-microglia co-cultures treated with pro-inflammatory agents are a useful tool to study neuroinflammation in vitro, where to test the potential neuroprotective effect of anti-inflammatory compounds. However, a great diversity of experimental conditions can be found in the literature, making difficult to select the working conditions when considering this approach for the first time. We compared the use of neuron-primary microglia and neuron-BV2 cells (a microglial cell line) co-cultures, using different neuron:microglia ratios, treatments and time post-treatment to induce glial activation and derived neurotoxicity. We show that each model requires different experimental conditions, but that both neuron-BV2 and neuron-primary microglia LPS/IFN-γ-treated co-cultures are good to study the potential neuroprotective effect of anti-inflammatory agents. The contribution of different pro-inflammatory parameters in the neurotoxicity induced by reactive microglial cells was determined. IL-10 pre-treatment completely inhibited LPS/IFN-γ-induced TNF-α and IL-6 release, and COX-2 expression both in BV2 and primary microglial cultures, but not NO production and iNOS expression. However, LPS/IFN-γ induced neurotoxicity was not inhibited in IL-10 pre-treated co-cultures. The inhibition of NO production using the specific iNOS inhibitor 1400 W totally abolished the neurotoxic effect of LPS/IFN-γ, suggesting a major role for NO in the neurotoxic effect of activated microglia. Consequently, among the anti-inflammatory agents, special attention should be paid to compounds that inhibit NO production

[T.T.T.] TERROR IN TERUEL TOWN: EL PRIMER LARGOMETRAJE DE FICCIÓN / COMEDIA NEGRA RODADO ÍNTEGRAMENTE EN LA PROPIA CIUDAD DE TERUEL

El propósito de este presente proyecto de investigación es explicar la creación del primer largometraje de ficción en categoría de comedia negra, rodado íntegramente en la ciudad de Teruel de manera completamente independiente; y con una limitación extrema de medios puramente vinculados con el manifiesto cinematográfico: Dogma 95, El Cine de serie B y El subgénero cinematográfico italiano conocido como Giallo: “TERROR IN TERUEL TOWN” (T.T.T.)A raíz de una serie de antecedentes situamos la concepción del proyecto y su vinculación e interés con una serie de objetivos que nos dan paso a la metodología y desarrollo del marco de trabajo, analizamos el proceso de realización del largometraje, desde la preproducción hasta la postproducción, barajamos hipótesis y ponemos en contexto a la obra mediante varios Referentes e Intercesores así como la propia estética de la película inclusive.<br /