141 research outputs found
Rapid separation of bovine whey proteins by membrane convective liquid chromatography, perfusion chromatography, continuous bed chromatography, and capillary electrophoresis
Associations of microvascular complications with all-cause death in patients with diabetes and COVID-19:the CORONADO, ABCD Covid-19 audit and AMERICADO study groups
AIM: To provide a detailled analysis of the microvascular burden in patients with diabetes hopitalized for COVDâ19. MATERIALS AND METHODS: We analysed data from the French CORONADO initiative and the UK Association of British Clinical Diabetologists (ABCD) COVIDâ19 audit, two nationwide multicentre studies, and the AMERICADO, a multicentre study conducted in New York area. We assessed the association between risk of allâcause death during hospital stay and the following microvascular complications in patients with diabetes hospitalized for COVIDâ19: diabetic retinopathy and/or diabetic kidney disease and/or history of diabetic foot ulcer. RESULTS: Among 2951 CORONADO, 3387 ABCD COVIDâ19 audit and 9327 AMERICADO participants, microvascular diabetic complications status was ascertained for 1314 (44.5%), 1809 (53.4%) and 7367 (79.0%) patients, respectively: 1010, 1059 and 1800, respectively, had â„1 severe microvascular complication(s) and 304, 750 and 5567, respectively, were free of any complications. The patients with isolated diabetic kidney disease had an increased risk of allâcause death during hospital stay: odds ratio [OR] 2.53 (95% confidence interval [CI] 1.66â3.83), OR 1.24 (95% CI 1.00â1.56) and OR 1.66 (95% CI 1.40â1.95) in the CORONADO, the ABCD COVIDâ19 national audit and the AMERICADO studies, respectively. After adjustment for age, sex, hypertension and cardiovascular disease (CVD), compared to those without microvascular complications, patients with microvascular complications had an increased risk of allâcause death during hospital stay in the CORONADO, the ABCD COVIDâ19 diabetes national audit and the AMERICADO studies: adjusted OR ((adj)OR) 2.57 (95% CI 1.69â3.92), (adj)OR 1.22 (95% CI 1.00â1.52) and (adj)OR 1.33 (95% CI 1.15â1.53), respectively. In metaâanalysis of the three studies, compared to patients free of complications, those with microvascular complications had an unadjusted OR for allâcause death during hospital stay of 2.05 (95% CI 1.42â2.97), which decreased to 1.62 (95% CI 1.19â2.119) after adjustment for age and sex, and to 1.50 (1.12â2.02) after hypertension and CVD were further added to the model. CONCLUSION: Microvascular burden is associated with an increased risk of death in patients hospitalized for COVIDâ19
Potamia-Agios Sozomenos (Chypre): La constitution des paysages dans l'Orient médiéval
International audienceCompte-rendu de prospection sur la constitution des paysages dans l'Orient médiéval à Potamia-Agios Sozomenos (Chypre)
Recommended from our members
The catastrophic flash-flood event of 8â9 September 2002 in the Gard region, France: a first case study for the CĂ©vennesâVivarais Mediterranean Hydrometeorological Observatory
The CĂ©vennesâVivarais Mediterranean Hydrometeorological Observatory (OHM-CV) is a research initiative aimed at improving the understanding and modeling of the Mediterranean intense rain events that frequently result in devastating flash floods in southern France. A primary objective is to bring together the skills of meteorologists and hydrologists, modelers and instrumentalists, researchers and practitioners, to cope with these rather unpredictable events. In line with previously published flash-flood monographs, the present paper aims at documenting the 8â9 September 2002 catastrophic event, which resulted in 24 casualties and an economic damage evaluated at 1.2 billion euros (i.e., about 1 billion U.S. dollars) in the Gard region, France. A description of the synoptic meteorological situation is first given and shows that no particular precursor indicated the imminence of such an extreme event. Then, radar and rain gauge analyses are used to assess the magnitude of the rain event, which was particularly remarkable for its spatial extent with rain amounts greater than 200 mm in 24 h over 5500 km2. The maximum values of 600â700 mm observed locally are among the highest daily records in the region. The preliminary results of the postevent hydrological investigation show that the hydrologic response of the upstream watersheds of the Gard and Vidourle Rivers is consistent with the marked spaceâtime structure of the rain event. It is noteworthy that peak specific discharges were very high over most of the affected areas (5â10 m3 sâ1 kmâ2) and reached locally extraordinary values of more than 20 m3 sâ1 kmâ2. A preliminary analysis indicates contrasting hydrological behaviors that seem to be related to geomorphological factors, notably the influence of karst in part of the region. An overview of the ongoing meteorological and hydrological research projects devoted to this case study within the OHM-CV is finally presented
A cryptotephra from the Upper Pleistocene volcanism of the Bas-Vivarais in the sedimentary infilling of the Chauvet-Pont dâArc cave (ArdĂšche, France)
Prebiotics from Marine Macroalgae for Human and Animal Health Applications
The marine environment is an untapped source of bioactive compounds. Specifically, marine macroalgae (seaweeds) are rich in polysaccharides that could potentially be exploited as prebiotic functional ingredients for both human and animal health applications. Prebiotics are non-digestible, selectively fermented compounds that stimulate the growth and/or activity of beneficial gut microbiota which, in turn, confer health benefits on the host. This review will introduce the concept and potential applications of prebiotics, followed by an outline of the chemistry of seaweed polysaccharides. Their potential for use as prebiotics for both humans and animals will be highlighted by reviewing data from both in vitro and in vivo studies conducted to date
Michel Saulnier
Saulnier indicates connections between recent sculptural works (1992-1994) which draw on animal shapes and references to childhood and the body. Biographical notes. 4 bibl. ref
- âŠ