640 research outputs found
Report and Assessment of Impact and Policy Outcomes Using Community Level Indicators:H2020 Making Sense Report
Towards Intercultural Philosophy of Education
In this paper, we propose an understanding of philosophy of education as cultural and intercultural work and philosophers of education as cultural and intercultural workers. In our view, the discipline of philosophy of education in North America is currently suffering from measures of insularity and singularity. It is vital that we justly and respectfully engage with and expand our knowledge and understanding of sets of conceptual and life-practice resources, and honor and learn from diverse histories, cultures, and traditions. Such honoring provides responsive conditions for our coming together in and across differences in order that we may productively and creatively address and overturn grammars of violence, destruction, and dis-ease in these complexly troubled times. Committing ourselves to deconstructing historical and contemporary beliefs, values, and practices that are compromising human and planetary flourishing, we undertake responsibilities to go cross-cultural and intercultural
Stop the Noise!:Enhancing Meaningfulness in Participatory Sensing with Community Level Indicators
Report on the Making Sense Framework and Assessment of Participatory Strategies:H2020 Making Sense Report
A systematic review of the risk factors for cervical artery dissection
BACKGROUND AND PURPOSE: Cervical artery dissection (CAD) is a recognized cause of ischemic stroke among young and middle-aged individuals. The pathogenesis of dissections is unknown, although numerous constitutional and environmental risk factors have been postulated. To better understand the quality and nature of the research on the pathogenesis of CAD, we performed a systematic review of its risk factors. METHODS: PubMed [MEDLINE (1966 to February 22, 2005)] and Embase (1980 to February 22, 2005) were searched to identify studies fulfilling the inclusion criteria. Two reviewers independently assessed methodological quality of the primary studies. Relevant data were extracted, including the risk factor(s) investigated, characteristics of the study population, and strength of the association(s). RESULTS: Thirty-one case-control studies were included for analysis. Selection bias, lack of control for confounding, and inadequate method of data analysis were the most common identified methodological shortcomings. Strong associations were reported from individual studies for the following risk factors: aortic root diameter >34 mm (odds ratio [OR=14.2; 95% confidence interval [CI], 3.2 to 63.6), migraine (ORadj, 3.6; 95% CI, 1.5 to 8.6), relative diameter change (>11.8%) during the cardiac cycle of the common carotid artery (ORadj, 10.0; 95% CI, 1.8 to 54.2), and trivial trauma (in the form of manipulative therapy of the neck) (ORadj, 3.8; 95% CI, 1.3 to 11). A weak association was found for homocysteine (2 studies: ORcrude, unknown; 95% CI, 1.05 to 1.52; ORcrude, 1.3; 95% CI, 1.0 to 1.7), and recent infection (ORadj, 1.60; 95% CI, 0.67 to 3.80). Two studies had conflicting findings for low levels of alpha1-antitrypsin, with the methodologically stronger study suggesting no association with CAD. CONCLUSIONS: CAD is a multi-factorial disease. Many of the reviewed studies contained 2 or more major sources of bias commonly found in case-control studies. Only one study (of homocysteine) used healthy controls, a robust sample size, and had a low risk of biased results. The relationship between atherosclerosis and CAD has been insufficiently examine
Making sense framework and assessment of participatory strategies
This report is a combined effort of Dundee University and the Joint Research Centre, based on the integration of D5.2 (Report and evaluation of the pilot approaches to âMaking Sense campaignsâ) and D4.3 (Report on assessment of participatory methods in the pilots and final recommendations). The document is structured as follows: Section 1 articulates the Making Sense approach to pilots and covers our campaign rationale, stakeholders and summarises the Making Sense pilots; Section 2 describes the design and iteration of the Making Sense Framework; Section 3 shows how the Making Sense Framework has been exemplified through the pilots and describes and illustrates each phase of the Framework with an example from a pilot; Section 4 focuses on ten key topics where we observed how citizen engagement and community building were addressed inside Making Sense and how the project participatory strategies developed from there on; Section 5 puts forward a new augmented version of previously devised recommendations for participatory or community driven sensing projects, with lessons learned from and for Making Sense.JRC.I.2-Foresight, Behavioural Insights and Design for Polic
Ten-year evolution of a massive transfusion protocol in a level 1 trauma centre : have outcomes improved?
Background: We aimed to evaluate the evolution and implementation of the massive transfusion protocol (MTP) in an urban level 1 trauma centre. Most data on this topic comes from trauma centres with high exposure to lifeâthreatening haemorrhage. This study examines the effect of the introduction of an MTP in an Australian level 1 trauma centre. Methods: A retrospective study of prospectively collected data was performed over a 14âyear period. Three groups of trauma patients, who received more than 10 units of packed red blood cells (PRBC), were compared: a preâMTP group (2002â2006), an MTPâI group (2006â2010) and an MTPâII group (2010â2016) when the protocol was updated. Key outcomes were mortality, complications and number of blood products transfused. Results: A total of 168 patients were included: 54 preâMTP patients were compared to 47 MTPâI and 67 MTPâII patients. In the MTPâII group, fewer units of PRBC and platelets were administered within the first 24âh: 17 versus 14 (P = 0.01) and 12 versus 8 (Pâ<â0.001), respectively. Less infections were noted in the MTPâI group: 51.9% versus 31.9% (P = 0.04). No significant differences were found regarding mortality, ventilator days, intensive care unit and total hospital lengths of stay. Conclusion: Introduction of an MTPâII in our level 1 civilian trauma centre significantly reduced the amount of PRBC and platelets used during damage control resuscitation. Introduction of the MTP did not directly impact survival or the incidence of complications. Nevertheless, this study reflects the complexity of realâlife medical care in a level 1 civilian trauma centre
Revised Stellar Properties of Kepler Targets for the Quarter 1-16 Transit Detection Run
We present revised properties for 196,468 stars observed by the NASA Kepler
Mission and used in the analysis of Quarter 1-16 (Q1-Q16) data to detect and
characterize transiting exoplanets. The catalog is based on a compilation of
literature values for atmospheric properties (temperature, surface gravity, and
metallicity) derived from different observational techniques (photometry,
spectroscopy, asteroseismology, and exoplanet transits), which were then
homogeneously fitted to a grid of Dartmouth stellar isochrones. We use
broadband photometry and asteroseismology to characterize 11,532 Kepler targets
which were previously unclassified in the Kepler Input Catalog (KIC). We report
the detection of oscillations in 2,762 of these targets, classifying them as
giant stars and increasing the number of known oscillating giant stars observed
by Kepler by ~20% to a total of ~15,500 stars. Typical uncertainties in derived
radii and masses are ~40% and ~20%, respectively, for stars with photometric
constraints only, and 5-15% and ~10% for stars based on spectroscopy and/or
asteroseismology, although these uncertainties vary strongly with spectral type
and luminosity class. A comparison with the Q1-Q12 catalog shows a systematic
decrease in radii for M dwarfs, while radii for K dwarfs decrease or increase
depending on the Q1-Q12 provenance (KIC or Yonsei-Yale isochrones). Radii of
F-G dwarfs are on average unchanged, with the exception of newly identified
giants. The Q1-Q16 star properties catalog is a first step towards an improved
characterization of all Kepler targets to support planet occurrence studies.Comment: 20 pages, 14 figures, 5 tables; accepted for publication in ApJS;
electronic versions of Tables 4 and 5 are available as ancillary files (see
sidebar on the right), and an interactive version of Table 5 is available at
the NASA Exoplanet Archive (http://exoplanetarchive.ipac.caltech.edu/
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-resident Kupffer cells to generate niche availability and show that circulating monocytes engraft in the liver, gradually adopt the transcriptional profile of their depleted counterparts and become long-lived self-renewing cells. Underlining the physiological relevance of our findings, circulating monocytes also contribute to the expanding pool of macrophages in the liver shortly after birth, when macrophage niches become available during normal organ growth. Thus, like embryonic precursors, monocytes can and do give rise to self-renewing tissue-resident macrophages if the niche is available to them
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