Verificación de las propiedades psicométricas de la lista de verificación de inclusión

Trabajo Fin de Máster curso 2022/2023[ES] La falta de un instrumento que evalúe la inclusión de estudiantes con discapacidad en Portugal llevó al equipo del Centro de Recursos de Inclusión (CRI) de ASSOL a construir un instrumento denominado Lista de verificación de inclusión (LVI), que es una parte integral del libro Pertenecer y participar para aprender (Pereira, 2017). En 2021 se realizó un primer estudio exploratorio (Saraiva et al, 2022), que concluyó que la versión final de la escala tenía buenas propiedades psicométricas y sugirió la necesidad de realizar otros estudios replicativos y confirmatorios de los resultados encontrados. A partir de los datos recogidos en la aplicación del LVI, en el curso escolar 2021-2022 se desarrolló un nuevo estudio cuantitativo, no experimental y exploratorio con el objetivo de confirmar los datos del estudio anterior. Este estudio se llevó a cabo con una muestra de 176 estudiantes de ocho grupos de escuelas en el distrito de Viseu, con edades comprendidas entre 6 y 21 años. La mayoría de ellos son estudiantes varones (n=108; 61,4%), con edades comprendidas entre 11 y 15 años (n=100; 56,8%). Sin embargo, la solución que se encontró no tenía el mismo significado. Así, se probaron otras soluciones, y se decidió retener cuatro factores, debido al hecho de que parece que uno de los factores se diluyó en el factor "inclusión", porque los ítems presentaron altas correlaciones entre sí. Para el cálculo de las cargas factoriales, se utilizó la técnica de factorización por el eje principal (Principal Axis Factoring), con rotación oblicua Promax, permitiendo verificar que las cargas están mejor distribuidas entre los factores, presentan valores propios mayores o iguales a uno y explican en total el 48% de la varianza total (Factor 1: Participación, Factor 2: Autonomía, Factor 3: Pertenencia y Factor 4: Autodeterminación), todos con alta consistencia interna (α>.88). También se observaron valores satisfactorios en la medición de adecuación de la muestra (KMO=.819) y en la verificación de Bartlett (x2=9327,944, p<,000), indicando que las correlaciones entre los ítems son buenas para realizar el análisis. En cuanto a la confiabilidad de la escala total, tiene una alta consistencia interna (α=.935). Se analizó la distribución de los valores de LVI en su totalidad y para cada uno de los factores, y para ello se realizó la prueba de Kolmogorov-Smirnov, con corrección de Lilliefors. Los valores obtenidos revelan que la distribución es normal para todos los factores (p>.05), por lo que se utilizó la correlación paramétrica, Pearson. Los resultados indican la existencia de correlaciones positivas y estadísticamente significativas entre los factores participación, pertenencia y autonomía, y los factores pertenencia y participación son los que presentan una correlación más alta (r=.687, p<.000). Además, también se realizó un análisis de las diferencias entre las diversas medidas de apoyo al aprendizaje, dependiendo de los factores, y se encontró que existen diferencias estadísticamente significativas en todas ellas. Finalmente, se considera que la versión final de la Lista de Verificación de Inclusión tiene buenas propiedades psicométricas, a pesar de la necesidad de estudios replicativos y confirmatorios de los resultados encontrados. [EN] The lack of an instrument that assesses the Inclusion of students with disabilities or disabilities in Portugal led the ASSOL's Inclusion Resource Center (CRI) team to build an instrument called the Inclusion Checklist (LVI), which is an integral part of the book Belonging and Participating to Learn (Pereira, 2017). In 2021, a first exploratory study was conducted (Saraiva et al, 2022), which concluded that the final version of the scale had good psychometric properties and suggested the need to perform other replicative and confirmatory studies of the results found. Based on the data collected in the application of the LVI, in the 2021-2022 school year a new quantitative, non-experimental, and exploratory study was developed with the objective of confirming the data from the previous study. This work was carried out with a sample of 176 students, from eight to groups of schools in the district of Viseu, aged between 6 and 21 years. Most of them are male students (n=108; 61.4%), aged 11-15 years (n=100; 56.8%). However, the solution that was found did not have the same meaning. Thus, other solutions were tested, and it was decided to retain four factors, because it seems that one of the factors was diluted in the "inclusion" factor, because the items presented high correlations with each other. For the calculation of factor loadings, the technique factoration by the main axis factoring (Main Axis Factoring) was used, with promax oblique rotation, allowing to verify that the loads are better distributed among the factors, present their own values greater than or equal to one and explain in total 48% of the total variance (Factor 1: Participation, Factor 2: Autonomy, Factor 3: Belonging and Factor 4: Self-determination), all with high internal consistency (α>.88). Satisfactory values were also observed in the sample adequacy measurement (KMO=.819) and bartlett's check (x2=9327,944, p<,000), indicating that the correlations between the items are good for performing the analysis. Regarding the reliability of the total scale, it has a high internal consistency (α=.935). The distribution of the LVI values in its entirety and for each of the factors was analyzed, and for this it was performed the Kolmogorov-Smirnov test, with Lilliefors correction. The obtained values reveal that the distribution is normal for all factors (p>.05), so the parametric correlation, Pearson, was used. The results indicate the existence of positive and statistically significant correlations between the factors participation, belonging and autonomy, and the factors belonging, and participation are those that present a stronger correlation (r=.687, p<,000). In addition, an analysis of differences between the various measures to support learning was also performed, depending on the factors, and it was found that there are statistically significant differences in all of them. Finally, it is considered that the final version of the Inclusion Checklist has good psychometric properties, despite the need for replicative and confirmatory studies of the results found

The Minimization of the Number of Stops Problem

In this paper two optimum models to study the transport of passengers and goods through the VIPA (Automatic individual Public Vehicle) are proposed. The objective is to minimize the number of times the vehicles stop. Since those are autonomous vehicles (they have no driver), the operations of deceleration, acceleration, stopping, opening and closing doors and going out of the circuit to go to the station implies a loss of reliability. Therefore, minimizing the number of times the vehicles stop is crucial to ensure their fleet works efficiently. Moreover, doing this we will achieve less energy expense, the minimization of the total time and the maximization of the number of served clients

Interference of the T cell and antigen-presenting cell costimulatory pathway using CTLA4-Ig (abatacept) prevents Staphylococcal enterotoxin B pathology

Abstract Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that binds the receptors in the APC/T cell synapse and causes increased proliferation of T cells and a cytokine storm syndrome in vivo. Exposure to the toxin can be lethal and cause significant pathology in humans. The lack of effective therapies for SEB exposure remains an area of concern, particularly in scenarios of acute mass casualties. We hypothesized that blockade of the T cell costimulatory signal by the CTLA4-Ig synthetic protein (abatacept) could prevent SEB-dependent pathology. In this article, we demonstrate mice treated with a single dose of abatacept 8 h post SEB exposure had reduced pathology compared with control SEB-exposed mice. SEB-exposed mice showed significant reductions in body weight between days 4 and 9, whereas mice exposed to SEB and also treated with abatacept showed no weight loss for the duration of the study, suggesting therapeutic mitigation of SEB-induced morbidity. Histopathology and magnetic resonance imaging demonstrated that SEB mediated lung damage and edema, which were absent after treatment with abatacept. Analysis of plasma and lung tissues from SEB-exposed mice treated with abatacept demonstrated significantly lower levels of IL-6 and IFN-γ (p &amp;lt; 0.0001), which is likely to have resulted in less pathology. In addition, exposure of human and mouse PBMCs to SEB in vitro showed a significant reduction in levels of IL-2 (p &amp;lt; 0.0001) after treatment with abatacept, indicating that T cell proliferation is the main target for intervention. Our findings demonstrate that abatacept is a robust and potentially credible drug to prevent toxic effects from SEB exposure.</jats:p

Capote´s Emotion – Reinventando e inovando o capote tradicional alentejano

Criada em 2014 para oferecer ao mercado feminino um modelo de capote alentejano moderno, a Capote´s Emotion, Lda. evidencia desde sempre a sua ambição e vontade de crescer de forma sustentada e progressiva, apostando na qualidade da produção e utilizando exclusivamente materiais nacionais em peças únicas personalizadas. Para a sua gestão diária escolheu aplicar os pensamentos estratégicos da Gestão pela Qualidade Total (TQM), de modo a incrementar uma maior credibilidade face ao mercado, visando a melhoria contínua e a satisfação do cliente

The Potential of Cistus salviifolius L. to Phytostabilize Gossan Mine Wastes Amended with Ash and Organic Residues

The São Domingos mine is within the Iberian Pyrite Belt, a mining district with large concentrations of polymetallic massive sulfide deposits. Mine waste heaps are considered extreme environments, since they contain high total concentrations of potentially hazardous elements (PHE), which contribute to inhibiting the development of most plants. Autochthonous plant species, such as Cistus salviifolius L., are able to grow naturally in this degraded environment, and may contribute to minimizing the negative chemical impacts and improving the landscape quality. However, the environmental rehabilitation processes associated with the development of these plants (phytostabilization) are very slow, so the use of materials/wastes to improve some physicochemical properties of the matrix is necessary in order to speed up the process. This work studied the effectiveness of the phytostabilization with C. salviifolius of gossan mine wastes from the mine of São Domingos amended with organic and inorganic wastes in order to construct Technosols. The mine wastes have an acid pH ( 3.5), high total concentrations of PHE and low concentrations of organic C and available nutrients. The best vegetative development occurred without visible signs of toxicity in the Technosols containing a mixture of agriculture residues. These treatments allowed the improvement of the soil-plant system providing a better plant cover and improved several chemical properties of mine wastes, helping to speed up the environmental rehabilitationinfo:eu-repo/semantics/publishedVersio

Is it possible to identify physical-motor profiles of preschool children on their association with selected biosocial factors?

Biosocial factors play a crucial role in the physical-motor development (PMD) of children during the preschool age. The present study aims to identify physical-motor profiles throughout preschool age (3–6 years) and explore associations between profiles and selected biosocial factors such as age, sex, prematurity, weight, height, BMI, and participation in extracurricular physical activities. Data from 412 typically developing children (46.6% girls and 53.4% boys), aged 35–71 months (M = 51.21, SD = 10.47) was collected using the Psychomotor Activities Checklist and specifically the scale of Psycho-Motor Aspects. Cluster analysis made it possible to define four different childhood PMD profiles. High PMD; High PMD except left laterality; medium-low PMD; and low PMD. High PMD profile includes older children, with anthropometric measurements closer to the WHO recommendations, fewer preterm children, and greater participation in extracurricular physical activities. Low PMD profile includes younger children, with weight slightly above and height slightly below the WHO recommendations and low participation in extracurricular physical activities. This study allows us to identify specific trends that may be decisive for the motor development of children throughout preschool age, highlighting selected biological variables and participation in extracurricular physical activities

Perfil social e clínico de crianças e adolescentes com diabetes mellitus tipo 1

Objective: to identify the social and clinical profile of children and adolescents with type 1 diabetes mellitus. Method: quantitative, cross-sectional and descriptive research, developed with 81 guardians of children and adolescents with type 1 diabetes mellitus between March and September/2021, in two reference centers in Paraiba. The descriptive analysis was performed using the Statistical Package for the Social Science software, version 18. Results: predominantly, the companions of the children and adolescents were the mothers themselves, 90.1%, and about 40% lived with family income lower than a minimum wage. Among the children and adolescents, 54% had high glycated hemoglobin values, even though they were undergoing treatment; 65.4% indicated ignorance of the correct form of insulin storage, and 77.6% had lipohypertrophy. Conclusion: socioeconomic vulnerability and ineffective clinical management of type 1 diabetes mellitus in children and adolescents were predominant.Objetivo: identificar el perfil social y clínico de niños y adolescentes con diabetes mellitus tipo 1. Método: investigación cuantitativa, transversal y descriptiva, realizada con 81 cuidadores de niños y adolescentes con diabetes mellitus tipo 1 entre marzo y septiembre/2021, en dos centros de referencia en Paraíba. El análisis descriptivo fue realizado mediante el software Statistical Package for Social Science, versión 18. Resultados: predominantemente, los acompañantes de los niños y adolescentes eran sus madres, el 90,1%, y cerca del 40% vivían con renta familiar inferior a un salario mínimo. Entre los niños y adolescentes, el 54% presentaba niveles elevados de hemoglobina glucosilada, a pesar de estar en tratamiento; El 65,4% indicó desconocer la forma correcta de almacenar la insulina y el 77,6% presentaba lipohipertrofia. Conclusión: predominó la vulnerabilidad socioeconómica y el manejo clínico ineficaz de la diabetes mellitus tipo 1 en niños y adolescentes.Objetivo: identificar o perfil social e clínico de crianças e adolescentes com diabetes mellitus tipo 1. Método: pesquisa quantitativa, transversal e descritiva, desenvolvida com 81 responsáveis de crianças e adolescentes com diabetes mellitus tipo 1 entre março e setembro/2021, em dois centros de referência da Paraíba.  A análise descritiva foi realizada com auxílio do software Statistical Package for the Social Science, versão 18. Resultados: predominantemente, os acompanhantes das crianças e adolescentes eram as próprias mães, 90,1%, e cerca de 40% viviam com renda familiar menor que um salário mínimo.  Entre as crianças e adolescentes, 54% apresentaram valores elevados de hemoglobina glicada, mesmo estando em tratamento; 65,4% indicaram desconhecimento na forma correta de armazenamento da insulina, e 77,6% possuía lipohipertrofia. Conclusão: foram preponderantes a vulnerabilidade socioeconômica e o manejo clínico ineficaz do diabetes mellitus tipo 1 em crianças e adolescentes

Control of Milk Allergenicity

UID/SEM/04077/2013. P0C1-01-0145- FEDER-007728.Food allergies are classified among the largest problems of human health by World Health Organization (WHO), with 2-10% of the world's population (children and adults) being confronted with it. Milk protein allergy is one of the most common types of allergies. But milk and dairy products are widely consumed and represent not only an inexpensive and easily accessible source of protein, calcium and vitamin D, but also an important share in the world food industry economy. Here, it is presented an overview of the different approaches, tested and developed to help the dairy industry in controlling the allergenicity of these products. Special emphasis is given to protein cross linking by transglutaminase, a recent technique that has attracted increasing attention in the scientific and industrial community. In fact, it does not involve the use of chemicals, it is easy to control and it is not necessary to remove the allergenic protein after the treatment, leading to a final non-allergenic product with equivalent protein content to the original product.publishe

Phenolic compounds of Galega Vulgar and Cobrançosa olive oils along early ripening stages

In this study, the lipophilic and hydrophilic phenol composition of virgin olive oils (VOO) obtained from olives from two of the most important Portuguese cultivars (‘Galega Vulgar’ and ‘Cobrançosa’), harvested at different ripening stages and under two irrigation schemes (rain fed and irrigated), was evaluated. Phenolic alcohols (hydroxytyrosol and tyrosol), phenolic acids and derivatives and flavonoids (luteolin and apigenin), as well as tocopherols were quantified. Lipophilic (>300 mg kg 1) and hydrophilic phenols (>600 mg kg 1) were present in high contents in both VOO, for early ripening stages. Gamma-tocopherol content is higher in ‘Galega Vulgar’ VOO. Total phenols showed a decrease between ripening index 2.5 and 3.5. The dialdehydic form of elenolic acid linked to hydroxytyrosol (3,4-DHPEA-EDA), also known as oleacein, was the major phenolic compound identified in both oils. The concentration of free hydroxytyrosol and tyrosol in both VOO is very low while their esterified derivatives, like 3,4-DHPEA-EDA and p- HPEA-EDA, are much more abundantinfo:eu-repo/semantics/publishedVersio

Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production

Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis isolates from cases with mild disease consistently induce robust cytokine responses in macrophages across multiple donors. By contrast, bacteria from patients with severe TB do not do so. Secretion of IL-1β is a good surrogate of the differences observed, and thus to classify strains as probable drivers of different TB severities. Furthermore, we demonstrate that M. tuberculosis isolates that induce low levels of IL-1β production can evade macrophage cytosolic surveillance systems, including cGAS and the inflammasome. Isolates exhibiting this evasion strategy carry candidate mutations, generating sigA recognition boxes or affecting components of the ESX-1 secretion system. Therefore, we provide evidence that M. tuberculosis strains manipulate host-pathogen interactions to drive variable TB severities