50 research outputs found
An Exploratory Study of Agression in School-Age Children: Underlying Factors and Implications for Treatment
Aggressive behaviour in school-aged children presents a significant challenge for society. If not managed, it can result in adverse academic, social, emotional, and behavioural outcomes for the child. In addition, it can create stress for families and become a significant burden for the community as these children reach adolescence and adulthood, and engage in antisocial behaviours. Using a three-step exploratory analytical strategy, this study explored parent and child reports of a diverse range of underlying developmental and clinical variables that have been identified in the literature as predictors of aggressive child behaviour, and which could be addressed within an Australian school or community context. A total of 57 children and their parents were recruited from a referral-based Western Australian child mental health service, and the wider community. A group of 31 clinically aggressive children were identified and compared to a group of 26 non-aggressive children. The aggressive group was reported as having a greater prevalence of internalising symptoms, including anxiety and depression, and their aggressive behaviour was more likely to be of the callous/unemotional type, relative to their non-aggressive counterparts. Significant predictors of belonging to the aggressive group included child social problems, thought problems, attention problems, affective problems, narcissism, symptoms of ADHD and PTS, and low maternal self-esteem. Findings are presented and discussed in the context of established theories. Recommendations for principles of treatment for aggressive children and their families are suggested
Cancer risk in socially marginalised women: An exploratory study
Background: Cancer is a leading cause of premature death in women worldwide, and is associated with socio-economic disadvantage. Yet many interventions designed to reduce risk and improve health fail to reach the most marginalised with the greatest needs. Our study focused on socially marginalised women at two women's centres that provide support and training to women in the judicial system or who have experienced domestic abuse. Methods: This qualitative study was framed within a sociological rather than behavioural perspective involving thirty participants in individual interviews and focus groups. It sought to understand perceptions of, and vulnerability to, cancer; decision making (including screening); cancer symptom awareness and views on health promoting activities within the context of the women's social circumstances. Findings: Women's experiences of social adversity profoundly shaped their practices, aspirations and attitudes towards risk, health and healthcare. We found that behaviours, such as unhealthy eating and smoking need to be understood in the context of inherently risky lives. They were a coping mechanism whilst living in extreme adverse circumstances, navigating complex everyday lives and structural failings. Long term experiences of neglect, harm and violence, often by people they should be able to trust, led to low self-esteem and influenced their perceptions of risk and self-care. This was reinforced by negative experiences of navigating state services and a lack of control and agency over their own lives. Conclusion: Women in this study were at high risk of cancer, but it would be better to understand these risk factors as markers of distress and duress. Without appreciating the wider determinants of health and systemic disadvantage of marginalised groups, and addressing these with a structural rather than an individual response, we risk increasing cancer inequities by failing those who are in the greatest nee
The Impact of Intrinsic Alignments: Cosmological Constraints from a Joint Analysis of Cosmic Shear and Galaxy Survey Data
Constraints on cosmology from recent cosmic shear observations are becoming
increasingly sophisticated in their treatment of potential systematic effects.
Here we present cosmological constraints which include modelling of intrinsic
alignments. We demonstrate how the results are changed for three different
intrinsic alignment models, and for two different models of the cosmic shear
galaxy population. We find that intrinsic alignments can either reduce or
increase measurements of the fluctuation amplitude parameter sigma_8 depending
on these decisions, and depending on the cosmic shear survey properties. This
is due to the interplay between the two types of intrinsic alignment, II and
GI. It has been shown that future surveys must make a careful treatment of
intrinsic alignments to avoid significant biases, and that simultaneous
constraints from shear-shear and shear-position correlation functions can
mitigate the effects. For the first time we here combine constraints from
cosmic shear surveys (shear-shear correlations) with those from "GI" intrinsic
alignment data sets (shear-position correlations). We produce updated
constraints on cosmology marginalised over two free parameters in the halo
model for intrinsic alignments. We find that the additional freedom is well
compensated by the additional information, in that the constraints are very
similar indeed to those obtained when intrinsic alignments are ignored, both in
terms of best fit values and uncertainties.Comment: 16 pages, 11 figure
Chiral Structure of F-actin Bundle Formed by Multivalent Counterions?
The mechanism of multivalent counterion-induced bundle formation by
filamentous actin (F-actin) is studied using a coarse-grained model and
molecular dynamics simulation. Real diameter size, helically ordered charge
distribution and twist rigidity of F-actin are taken into account in our model.
The attraction between parallel F-actins induced by multivalent counterions is
studied in detail and it is found that the maximum attraction occurs between
their closest charged domains. The model F-actins aggregate due to the
like-charge attraction and form closely packed bundles. Counterions are mostly
distributed in the narrowest gaps between neighboring F-actins inside the
bundles and the channels between three adjacent F-actins correspond to low
density of the counterions. Density of the counterions varies periodically with
a wave length comparable to the separation between consecutive G-actin monomers
along the actin polymers. Long-lived defects in the hexagonal order of F-actins
in the bundles are observed that their number increases with increasing the
bundles size. Combination of electrostatic interactions and twist rigidity has
been found not to change the symmetry of F-actin helical conformation from the
native 13/6 symmetry. Calculation of zero-temperature energy of hexagonally
ordered model F-actins with the charge of the counterions distributed as
columns of charge domains representing counterion charge density waves has
shown that helical symmetries commensurate with the hexagonal lattice
correspond to local minima of the energy of the system. The global minimum of
energy corresponds to 24/11 symmetry with the columns of charge domains
arranged in the narrowest gaps between the neighboring F-actins.Comment: 9 pages, 10 figures, Published online in Soft Matter journal:
http://pubs.rsc.org/en/content/articlelanding/2012/sm/c2sm07104
The WiggleZ Dark Energy Survey: Direct constraints on blue galaxy intrinsic alignments at intermediate redshifts
Correlations between the intrinsic shapes of galaxy pairs, and between the
intrinsic shapes of galaxies and the large-scale density field, may be induced
by tidal fields. These correlations, which have been detected at low redshifts
(z<0.35) for bright red galaxies in the Sloan Digital Sky Survey (SDSS), and
for which upper limits exist for blue galaxies at z~0.1, provide a window into
galaxy formation and evolution, and are also an important contaminant for
current and future weak lensing surveys. Measurements of these alignments at
intermediate redshifts (z~0.6) that are more relevant for cosmic shear
observations are very important for understanding the origin and redshift
evolution of these alignments, and for minimising their impact on weak lensing
measurements. We present the first such intermediate-redshift measurement for
blue galaxies, using galaxy shape measurements from SDSS and spectroscopic
redshifts from the WiggleZ Dark Energy Survey. Our null detection allows us to
place upper limits on the contamination of weak lensing measurements by blue
galaxy intrinsic alignments that, for the first time, do not require
significant model-dependent extrapolation from the z~0.1 SDSS observations.
Also, combining the SDSS and WiggleZ constraints gives us a long redshift
baseline with which to constrain intrinsic alignment models and contamination
of the cosmic shear power spectrum. Assuming that the alignments can be
explained by linear alignment with the smoothed local density field, we find
that a measurement of \sigma_8 in a blue-galaxy dominated, CFHTLS-like survey
would be contaminated by at most +/-0.02 (95% confidence level, SDSS and
WiggleZ) or +/-0.03 (WiggleZ alone) due to intrinsic alignments. [Abridged]Comment: 18 pages, 12 figures, accepted to MNRAS; v2 has correction to one
author's name, NO other changes; v3 has minor changes in explanation and
calculations, no significant difference in results or conclusions; v4 has an
additional footnote about model interpretation, no changes to
data/calculations/result
The WiggleZ Dark Energy Survey: the transition to large-scale cosmic homogeneity
We have made the largest-volume measurement to date of the transition to
large-scale homogeneity in the distribution of galaxies. We use the WiggleZ
survey, a spectroscopic survey of over 200,000 blue galaxies in a cosmic volume
of ~1 (Gpc/h)^3. A new method of defining the 'homogeneity scale' is presented,
which is more robust than methods previously used in the literature, and which
can be easily compared between different surveys. Due to the large cosmic depth
of WiggleZ (up to z=1) we are able to make the first measurement of the
transition to homogeneity over a range of cosmic epochs. The mean number of
galaxies N(<r) in spheres of comoving radius r is proportional to r^3 within
1%, or equivalently the fractal dimension of the sample is within 1% of D_2=3,
at radii larger than 71 \pm 8 Mpc/h at z~0.2, 70 \pm 5 Mpc/h at z~0.4, 81 \pm 5
Mpc/h at z~0.6, and 75 \pm 4 Mpc/h at z~0.8. We demonstrate the robustness of
our results against selection function effects, using a LCDM N-body simulation
and a suite of inhomogeneous fractal distributions. The results are in
excellent agreement with both the LCDM N-body simulation and an analytical LCDM
prediction. We can exclude a fractal distribution with fractal dimension below
D_2=2.97 on scales from ~80 Mpc/h up to the largest scales probed by our
measurement, ~300 Mpc/h, at 99.99% confidence.Comment: 21 pages, 16 figures, accepted for publication in MNRA
Crowdsourcing hypothesis tests: Making transparent how design choices shape research results
To what extent are research results influenced by subjective decisions that scientists make as they design studies? Fifteen research teams independently designed studies to answer fiveoriginal research questions related to moral judgments, negotiations, and implicit cognition. Participants from two separate large samples (total N > 15,000) were then randomly assigned to complete one version of each study. Effect sizes varied dramatically across different sets of materials designed to test the same hypothesis: materials from different teams renderedstatistically significant effects in opposite directions for four out of five hypotheses, with the narrowest range in estimates being d = -0.37 to +0.26. Meta-analysis and a Bayesian perspective on the results revealed overall support for two hypotheses, and a lack of support for three hypotheses. Overall, practically none of the variability in effect sizes was attributable to the skill of the research team in designing materials, while considerable variability was attributable to the hypothesis being tested. In a forecasting survey, predictions of other scientists were significantly correlated with study results, both across and within hypotheses. Crowdsourced testing of research hypotheses helps reveal the true consistency of empirical support for a scientific claim.</div
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Proceedings of the 3rd Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2015: advancing efficient methodologies through community partnerships and team science
It is well documented that the majority of adults, children and families in need of evidence-based behavioral health interventionsi do not receive them [1, 2] and that few robust empirically supported methods for implementing evidence-based practices (EBPs) exist. The Society for Implementation Research Collaboration (SIRC) represents a burgeoning effort to advance the innovation and rigor of implementation research and is uniquely focused on bringing together researchers and stakeholders committed to evaluating the implementation of complex evidence-based behavioral health interventions. Through its diverse activities and membership, SIRC aims to foster the promise of implementation research to better serve the behavioral health needs of the population by identifying rigorous, relevant, and efficient strategies that successfully transfer scientific evidence to clinical knowledge for use in real world settings [3]. SIRC began as a National Institute of Mental Health (NIMH)-funded conference series in 2010 (previously titled the “Seattle Implementation Research Conference”; $150,000 USD for 3 conferences in 2011, 2013, and 2015) with the recognition that there were multiple researchers and stakeholdersi working in parallel on innovative implementation science projects in behavioral health, but that formal channels for communicating and collaborating with one another were relatively unavailable. There was a significant need for a forum within which implementation researchers and stakeholders could learn from one another, refine approaches to science and practice, and develop an implementation research agenda using common measures, methods, and research principles to improve both the frequency and quality with which behavioral health treatment implementation is evaluated. SIRC’s membership growth is a testament to this identified need with more than 1000 members from 2011 to the present.ii SIRC’s primary objectives are to: (1) foster communication and collaboration across diverse groups, including implementation researchers, intermediariesi, as well as community stakeholders (SIRC uses the term “EBP champions” for these groups) – and to do so across multiple career levels (e.g., students, early career faculty, established investigators); and (2) enhance and disseminate rigorous measures and methodologies for implementing EBPs and evaluating EBP implementation efforts. These objectives are well aligned with Glasgow and colleagues’ [4] five core tenets deemed critical for advancing implementation science: collaboration, efficiency and speed, rigor and relevance, improved capacity, and cumulative knowledge. SIRC advances these objectives and tenets through in-person conferences, which bring together multidisciplinary implementation researchers and those implementing evidence-based behavioral health interventions in the community to share their work and create professional connections and collaborations