Cultural translation

In every possible sense, translation is necessary but impossible. Melanie Klein, the Viennese psychoanalyst whom the Bloomsbury Group killed with kindness, suggested that the work of translation is an incessant shuttle that is a ‘life’. The human infant grabs on to some one thing and then things. This grabbing (begreifen) of an outside indistinguishable from an inside constitutes an inside, going back and forth and coding everything into a sign-system by the thing(s) grasped. One can call this crude coding a ‘translation’

Cycloserine induced delirium during treatment of multi-drug resistant tuberculosis (MDR-TB)

Objective: To report about delirium related to Cycloserine. Method: Systematic assessment and management of a patient who developed delirium during the course of treatment for MDR-TB. Results: An association was found with the use of Cycloserine and development of delirium. The management of this case is described. Conclusion: Patients with MDR-TB receiving Cycloserine should be closely monitored for neuropsychiatric side effects for early recognition and treatment

Clinical factors associated with lithium treatment response in bipolar disorder patients from India

Background: Bipolar Disorder (BD) is a chronic and disabling psychiatric illness with waxing and waning course. Lithium is the mainstay of treatment for Bipolar disorder (BD). There is limited literature on the clinical markers of Lithium treatment response from south Asia. Methods: Two hundred and ten individuals with BD I and a history of at least 6 months of treatment with Lithium were recruited from the outpatient services of the National Institute of Mental Health and Neurosciences (NIMHANS) after obtaining informed consent. A diagnosis of BD I was made according to the DSM-IV criteria. The characterization of response to lithium prophylaxis was done using NIMH Retrospective Life Chart and “Retrospective Criteria of Long Term Treatment Response in Research Subjects with Bipolar Disorder” scale. Results: There were 132 (62.86%) good responders and 78 (37.14%) non-responders. Good responders were noted to have less number of hospitalizations and more onset episode of depression than non-responders. Using continuous phenotype, Lithium response was inversely correlated with total number of episodes, number of episodes of mania/ depression, number of hospitalisations and presence of suicide attempt. Multivariate analysis only revealed number of episodes and hospitalization to be associated with Lithium response. Conclusion: Our Lithium response rates were higher than what have been reported in the few previous studies. Illness severity was the only factor associated with Lithium response. There is a need to examine this question in larger prospective samples and to focus on biological/ molecular markers of treatment response

557. Pharmacogenetic Association of Lithium Treatment Response with Bcl2 Polymorphism in Bipolar Disorder

Relationship between explained variation by detected eQTLs and Zhenshan97 τ. (PDF 455 kb) (PDF 442 kb