On the galloping instability of two-dimensional bodies having elliptical cross sections.

Galloping, also known as Den Hartog instability, is the large amplitude, low frequency oscillation of a structure in the direction transverse to the mean wind direction. It normally appears in the case of bodies with small stiffness and structural damping, when they are placed in a flow provided the incident velocity is high enough. Galloping depends on the slope of the lift coefficient versus angle of attack curve, which must be negative. Generally speaking this implies that the body is stalled after boundary layer separation, which, as it is known in non-wedged bodies, is a Reynolds number dependent phenomenon. Wind tunnel experiments have been conducted aiming at establishing the characteristics of the galloping motion of elliptical cross-section bodies when subjected to a uniform flow, the angles of attack ranging from 0° to 90°. The results have been summarized in stability maps, both in the angle of attack versus relative thickness and in the angle of attack versus Reynolds number planes, where galloping instability regions are identified

Towards automatic hole detection of a net for fish farms by means of robotic intelligence

In the last decades fish farms became one of the most important sources of seafood. This industry is facing complex and costly problems like net holes, especially due to unexpected situations, such as depredators and storm effects. This is a complex problem because fishes can escape from the fish farms containers or a depredator can enter in the container. To solve this problem divers are needed, but this solution is difficult and sometimes can be dangerous for the diver. The main objective of this work is to present the current state of a system where an underwater robot can detect holes in the net of a fish farm. Once the robot detects the hole it will proceed to manipulate it. This task is bordered using convolutional neural networks and the BlueROV2 platform with the Newton Gripper from BlueRobotics, which will be upgraded in a second stage to perform preliminary net repairs. This work contributes in the area of aquaculture, computer vision, underwater inspection and manipulation.Peer Reviewe

Molecular diagnosis in Allergology: application of the microarray tecnique

Recombinant and purified allergens are currently available for determining specific IgE targeted to different allergenic components. In this way it is possible to diagnose the sensitization profile of each individual patient. The microarray technique makes it possible to determine specific IgE against multiple allergens simultaneously in one same patient, with a minimum amount of serum, and even allows the determination of IgG and IgM against the same allergens in one same serum sample. Microarray procedures are being developed not only for the determination of antibodies but also for cell activation tests. In addition, microarray technology will help explain cross-reactions, and will facilitate the evaluation of subjects in which skin tests cannot be performed. These techniques will allow a great step forward in the development of immunotherapy specifically targeted to the sensitizations found in each individual patient, yielding especially hypoallergenic forms of great immunogenic capacity, and thus improving the safety and efficacy of immunotherapy. Lastly, microarrays will improve our understanding of the physiopathology of allergic diseases

Further teleoperated experiments with an underwater mobile manipulator via acoustic modem: modem characterization

In this study, we conducted preliminary experiments to characterize an acoustic sonar [1][2] for underwater communication. We carried on image transmission experiments and attempted to reduce reflections using insulating cork. Moving the buoy along the surface revealed the central area of the tank to have the best communication with Girona. We plan to conduct further experiments with the acoustic modem in a realistic environment. In addition, we are also testing Visible Light Communication (VLC) [3] optical modems, which yielded better results than the acoustic modem. We aim to develop a multimodal system for improved communication under different environmental conditions.Peer Reviewe

Computational analysis of clinical and molecular markers and new theranostic possibilities in primary open-angle glaucoma

Primary open-angle glaucoma (POAG) is a paramount cause of irreversible visual disability worldwide. We focus on identifying clinical and molecular facts that may help elucidating the pathogenic mechanisms of the disease. By using ophthalmological approaches (biomicroscopy, ocular fundus, optical coherence tomography, and perimetry) and experimental tests (enzyme-linked immunosorbent assay (ELISA), high performance liquid chromatography (HPLC), and Western blot/immunoblotting) directed to evaluate the oxidative stress, inflammation, apoptosis, and neurodegeneration processes, we gather information to build a network of data to perform a computational bioinformatics analysis. Our results showed strong interaction of the above players and its downstream effectors in POAG pathogenesis. In conclusion, specific risk factors were identified, and molecules involved in multiple pathways were found in relation to anterior and posterior eye segment glaucoma changes, pointing to new theranostic challenges for better managing POAG progression

Genetic association study in nasal polyposis.

[EN] Nasal polyposis (NP) is a chronic inflammatory disease of the upper airways with a variable clinical course and unknown pathogenesis that often coexists with other conditions. Considering the possibility of genetic predisposition, we decided to analyze whether polymorphisms in LTC4S, CYSLTR1, PTGDR, and NOS2A were associated with NP. The study population comprised 486 Caucasian individuals. Polyposis and aspirin intolerance were diagnosed following the recommendations of the European Position Paper on Rhinosinusitis and Nasal Polyps. Genotypes were determined using polymerase chain reaction amplification and direct sequencing. The -444A > C LTC4S polymorphism was significantly associated with NP and atopy (P = .033) and with NP and atopic asthma, (P =.012). In addition, a significant association was found when the (CCTTT) repetition of the NOS2A gene was present more than 14 times in patients with NP and asthma (P = .034), in patients with polyposis and intolerance to nonsteroidal anti-inflammatory drugs (P = .009), and in patients with the aspirin triad (P = .005). The PTGDR diplotype CCCT/CCCC (-613CC, -549CC, -441CC and -197TC) was more frequent in patients with NP (P = .043), NP with asthma (P = .013), and the aspirin triad (P = .041). NP was associated with specific polymorphisms only when it occurred with related phenotypes. Our results suggest that this genetic background plays a more relevant role in the development of the associated clinical features of nasal polyposis than in simple polyposis.Junta de Castilla y León; Merck Sharpe Dohme; Mutua Madrileñ

"Invisible burials" and fragmentation practices in Iron Age Europe:Excavations at the Monte Bernorio Necropolis (Northern Spain)

The scarcity of burial remains in large parts of Iron Age Europe, particularly in the Atlantic regions, has often led scholars to discuss the apparent “invisibility” of graves. This paper presents the results from several excavation campaigns at Monte Bernorio, one of the most important sites of the 1st millennium b.c. on the Iberian Peninsula. The fieldwork and post-excavation work carried out in the area of the necropolis have identified numerous burial pits, with complex ritual activities characterized by fragmentation and the practice of the pars pro toto. In addition, evidence for later rituals in some of the graves can be linked to ancestor worship. The results provide important insights into funerary practices in Late Iron Age Europe, leading us to rethink the very meaning of cemeteries in the study area and beyond.- Burial Traditions in Iron Age Europe - The Monte Bernorio Archaeological Zone - The 2007–2008 Necropolis Excavations - The 2015–2016 Necropolis Excavations - Post-Excavation Work and Interpretation: The Faunal and Human Remains - Structure and Chronology of Monte Bernorio Area 7 - Destruction of the Body, Commemoration in the Absence of a Corpse, and Visibility of the Mortuary Rite

Is Energy Expenditure or Physical Activity Considered When Energy Intake Is Measured? A Scoping Review 1975-2015

Support from the Spanish Nutrition Society (SEN) is highly acknowledged.The following are available online at https://www.mdpi.com/article/10 .3390/nu13093262/s1, Excel data review results.The health-transitions humans have delivered during the 20th Century associated with the nutrition is that from undernutrition to obesity, which perseveres in the current years of the 21st Century. Energy intake (EI) is a contributing factor and therefore a fascination in nutritional sciences. However, energy expenditure (EE) has not been usually considered as a conjoint factor. Thus, this study aimed to review if studies on adults consider data on dietary intake, specifically EI, and included data on EE and physical activity (PA). A search of MEDLINE from 1975 to December 2015 was managed. Our scoping review consisted of keywords related to EI, dietary allowances, and nutritional requirements. From 2229 acknowledged articles, 698 articles were finally taken fulfilling inclusion and quality criteria. A total of 2,081,824 adults (53.7% females) were involved, and most studies had been conducted in EEUU (241), Canada (42), Australia (30), Japan (32), and Brazil (14). In Europe, apart from UK (64), the Netherlands (31) and France (26) led the classification, followed by Sweden (18), Denmark (17), and France (26). Mediterranean countries are represented with 27 studies. A total of 76.4% did not include EE and 93.1% did not include PA. Only 23.6% of the studies contained both EI and EE. A large methodological diversity was perceived, with more than 14 different methods regarding EI, and more than 10 for EE. PA was only analyzed in scarce articles, and scarcely considered for interpretation of data and conclusions. Moreover, PA was often measured by subjective questionnaires. Dietary surveys show a large diversity regarding methodology, which makes comparability of studies difficult. EE and PA are missing in around 80% of studies or are not included in the interpretation of results. Conclusions regarding EI or diet adequacy in adults should not be taken without analyzing EE and PA.Spanish Nutrition Society (SEN

Real-time incidence of travel-related symptoms through a smartphone-based app remote monitoring system: a pilot study

Trip Doctor(R), a Smartphone-based app monitoring system, was developed to detect infections among travelers in real-time. For testing, 106 participants were recruited (62.2% male, mean age 36 years (SD = 11)). Majority of trips were for tourism and main destinations were in South East Asia. Mean travel duration was 14 days (SD = 10). Diarrhea was the most frequently reported symptom (15.5%). The system demonstrated adequate usability and is ready to be used on a larger scale

Clinical and Molecular-Genetic Insights into the Role of Oxidative Stress in Diabetic Retinopathy: Antioxidant Strategies and Future Avenues

Reactive oxygen species (ROS) overproduction and ROS-signaling pathways activation attack the eyes. We evaluated the oxidative stress (OS) and the effects of a daily, core nutritional supplement regimen containing antioxidants and omega 3 fatty acids (A/ω3) in type 2 diabetics (T2DM). A case-control study was carried out in 480 participants [287 T2DM patients with (+)/without (−) diabetic retinopathy (DR) and 193 healthy controls (CG)], randomly assigned to a daily pill of A/ω3. Periodic evaluation through 38 months allowed to outline patient characteristics, DR features, and classic/OS blood parameters. Statistics were performed by the SPSS 24.0 program. Diabetics displayed significantly higher circulating pro-oxidants (p = 0.001) and lower antioxidants (p = 0.0001) than the controls. Significantly higher plasma malondialdehyde/thiobarbituric acid reactive substances (MDA/TBARS; p = 0.006) and lower plasma total antioxidant capacity (TAC; p = 0.042) and vitamin C (0.020) was found in T2DM + DR versus T2DM-DR. The differential expression profile of solute carrier family 23 member 2 (SLC23A2) gene was seen in diabetics versus the CG (p = 0.001), and in T2DM + DR versus T2DM − DR (p < 0.05). The A/ω3 regime significantly reduced the pro-oxidants (p < 0.05) and augmented the antioxidants (p < 0.05). This follow-up study supports that a regular A/ω3 supplementation reduces the oxidative load and may serve as a dietary prophylaxis/adjunctive intervention for patients at risk of diabetic blindness