Radio sources in the Chandra Galactic Bulge Survey

We discuss radio sources in the Chandra Galactic Bulge Survey region. By cross-matching the X-ray sources in this field with the NRAO VLA Sky Survey archival data, we find 12 candidate matches. We present a classification scheme for radio/X-ray matches in surveys taken in or near the Galactic plane, taking into account other multiwavelength data. We show that none of the matches found here is likely to be due to coronal activity from normal stars because the radio to X-ray flux ratios are systematically too high. We show that one of the source could be a radio pulsar, and that one could be a planetary nebula, but that the bulk of the sources are likely to be background active galactic nuclei (AGN), with many confirmed through a variety of approaches. Several of the AGN are bright enough in the near-infrared (and presumably in the optical) to use as probes of the interstellar medium in the inner Galaxy

Plan for the Characterization of HIRF Effects on a Fault-Tolerant Computer Communication System

This report presents the plan for the characterization of the effects of high intensity radiated fields on a prototype implementation of a fault-tolerant data communication system. Various configurations of the communication system will be tested. The prototype system is implemented using off-the-shelf devices. The system will be tested in a closed-loop configuration with extensive real-time monitoring. This test is intended to generate data suitable for the design of avionics health management systems, as well as redundancy management mechanisms and policies for robust distributed processing architectures

Design of Test Articles and Monitoring System for the Characterization of HIRF Effects on a Fault-Tolerant Computer Communication System

This report describes the design of the test articles and monitoring systems developed to characterize the response of a fault-tolerant computer communication system when stressed beyond the theoretical limits for guaranteed correct performance. A high-intensity radiated electromagnetic field (HIRF) environment was selected as the means of injecting faults, as such environments are known to have the potential to cause arbitrary and coincident common-mode fault manifestations that can overwhelm redundancy management mechanisms. The monitors generate stimuli for the systems-under-test (SUTs) and collect data in real-time on the internal state and the response at the external interfaces. A real-time health assessment capability was developed to support the automation of the test. A detailed description of the nature and structure of the collected data is included. The goal of the report is to provide insight into the design and operation of these systems, and to serve as a reference document for use in post-test analyses

Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compounds against breast cancer

[Abstract] The clinical success of cisplatin, carboplatin, and oxaliplatin has sparked the interest of medicinal inorganic chemistry to synthesize and study compounds with non-platinum metal centers. Despite Ru(II)–polypyridyl complexes being widely studied and well established for their antitumor properties, there are not enough in vivo studies to establish the potentiality of this type of compound. Therefore, we report to the best of our knowledge the first in vivo study of Ru(II)–polypyridyl complexes against breast cancer with promising results. In order to conduct our study, we used MCF7 zebrafish xenografts and ruthenium complexes [Ru(bipy)2(C12H8N6-N,N)][CF3SO3]2Ru1 and [{Ru(bipy)2}2(μ-C12H8N6-N,N)][CF3SO3]4Ru2, which were recently developed by our group. Ru1 and Ru2 reduced the tumor size by an average of 30% without causing significant signs of lethality when administered at low doses of 1.25 mg·L−1. Moreover, the in vitro selectivity results were confirmed in vivo against MCF7 breast cancer cells. Surprisingly, this work suggests that both the mono- and the dinuclear Ru(II)–polypyridyl compounds have in vivo potential against breast cancer, since there were no significant differences between both treatments, highlighting Ru1 and Ru2 as promising chemotherapy agents in breast cancer therapy.Xunta de Galicia; ED431C 2018/39Portugal. Fundação para a Ciência e a Tecnologia; PEst 2015-2020Portugal. Fundação para a Ciência e a Tecnologia; UID/Multi/04349/2013Portugal. Fundação para a Ciência e a Tecnologia; RECI/QEQ-QIN/0189/2012Portugal. Fundação para a Ciência e a Tecnologia; UID/QUI/00100/2020Portugal. Fundação para a Ciência e a Tecnologia; UIDP/04378/2020Portugal. Fundação para a Ciência e a Tecnologia; UIDB/04378/2020Portugal. Fundação para a Ciência e a Tecnologia; LA/P/0140/202

Perioperative intensive care in patients with brain tumours

The surgery of brain tumours is not free from complications, above all taking into account that today the patients operated are even older and with multiple comorbidities associated. The multidisciplinary preoperative evaluation aims at minimising the risks; nevertheless this evaluation has not yet been defined and is not based on a strong evidence. The detailed clinical history, the physical examination including functional status and the neuroimaging are the fundamental pillars.The more critical complications occur in the immediate postoperative period: cerebral oedema, postoperative haemorrhage, intracranial hypertension and convulsions; other complications, such as pulmonary thromboembolism or infections, develop lately but are not less severe. Every surgical approach has its own complications in addition to the ones common to the whole neurosurgery

Predictors and moderators of outcome of psychotherapeutic interventions for mental disorders in adolescents and young adults : protocol for systematic reviews

Background: Adolescence and young adulthood is a risk period for the emergence of mental disorders. There is strong evidence that psychotherapeutic interventions are effective for most mental disorders. However, very little is known about which of the different psychotherapeutic treatment modalities are effective for whom. This large systematic review aims to address this critical gap within the literature on non-specific predictors and moderators of the outcomes of psychotherapeutic interventions among adolescents and young adults with mental disorders. Methods: The protocol is being reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) Statement. PubMed and PsycINFO databases will be searched for randomized controlled and quasi-experimental/naturalistic clinical trials. Risk of bias of all included studies will be assessed by the Mixed Methods Appraisal Tool. The quality of predictor and moderator variables will be also assessed. A narrative synthesis will be conducted for all included studies. Discussion: This systematic review will strengthen the evidence base on effective mental health interventions for young people, being the first to explore predictors and moderators of outcome of psychotherapeutic interventions for a wide range of mental disorders in young people.Peer reviewe