Transcending hunter gatherer pursuits while balancing customary cultural ideals with market forces of advanced western societies: Extending the traditional boundaries of indigenous Yolngu people of the Northern Territory of Australia

As large multinationals move their operations into remote regions of the world, imperatives of social responsibility and sound business pragmatism compel engagement of the marginalized local Indigenous people. This notion is particularly relevant for the mining industry in Australia, which is undertaken in remote regions, where the local Indigenous communities are significantly socio-economically disadvantaged compared to other Australians. This article reports the job-related outcomes of Indigenous Yolngu people of East Arnhem Land in the Northern Territory of Australia who were participants in a unique vocational-educational programme set up by the multinational mining company Rio Tinto Alcan. These mainline job-related outcomes are in two main areas: (1) employment in mainline work at the Nhulunbuy refinery or the mine site and (2) entrepreneurial timber-related business (milling timber, house construction, furniture manufacture). Both streams are inaugural achievements for these Indigenous Australians. The concluding sections present challenges for multinational corporations when anchoring institutional processes, structures and the contemporary technologies of the workplace with the contextuality of rural Australian communities

Learning from the History of Language Oppression: Educators as Agents of Language Justice

There is a long history in this country of language oppression that has led to policies currently in place that affect the way educators are asked to teach. Therefore, educators must understand national and local language policy to know how it affects their students and how they can perform their duties as educators. Even though the U.S. does not have an official language, states have enacted language policies through court decisions and legislation. These policies have led to students being denied access to English as a Second Language (ESL) and bilingual education programs, resources, and accommodations, all of which lead to the silencing of entire communities from languages and backgrounds that are not “the norm.” However, with the help of policy makers and scholars, educators have reversed some of these decisions. Their examples show us that when communities work together, they can enact changes. In this paper, we explore the history of language oppression in the United States and how it affects educators, their students, and their communities. We also propose ways that educators can reverse the harmful effects of language oppression in their students’ lives in order to achieve “language justice.

A mixed-methods exploration of the factors affecting bike riding participation in Victoria, Australia

Participation rates in Australia remain low compared to other international settings, and gross inequities exist in participation, including for women and people living in low socioeconomic areas [1]. In recognition of the health and environmental benefits of increasing cycling participation, governments in Australia are increasing investment in initiatives to increase bicycling [2]. Recent research found that 78% of people in Greater Melbourne (a major Australian metropolitan region) are interested in riding a bike [3]. This demonstrates an opportunity for considerable modal shift to bike riding. There is, however, insufficient knowledge of the barriers to, and enablers of cycling for transport in this context. Research of barriers and enablers in Australia is very limited, however the majority of what has been conducted bas been quantitative research in groups whom are already cyclists. Existing research explores factors affecting cycling for all purposes, potentially overlooking differences in barriers and enablers reported for either riding a bike for transport, or recreational purposes. Further, quantitative studies often present the prevalence of a particular barrier or enabler, without consideration of the strength of how preventative, or encouraging the factor may be. This has resulted in cycling strategies being largely uninformed by the needs of people who are not current cyclists, and without consideration of the needs of people who ride a bike for transport, compared to recreational ri.ders. To increase cycling participation, it is essential to understand the barriers and enablers of cycling for all people of all ages and abilities, and to understand the nuances of their perception of safety. This requires a mixed-methods approach, with a robust sampling approach, to consider the prevalence and strength of the varying factors that influence people's decision to ride a bike or not. We conducted an online survey and semi-structured interviews with people living in nine selected local government areas across Greater Melbourne. [From: Introduction

Indigenous Australians Overcoming Vulnerability to Employability by Creating a Viable Labour Market for Local Challenges

Australian Indigenous people experience severe labour market disadvantage due to constraints embedded in technology inclination to work formal education lack of job experience as well as geographic factors Indigenous precarious employment grows in prominence when there is an absence of jobs and particularly in remote regions of Australia where intergenerational unemployment is the norm In the remote Gove Peninsula of the Northern Territory of Australia many English illiterate and innumerate people without previous employment have overcome vulnerability to employment by engaging with an educational vocational scheme in a networking arrangement with government agencies and the resident mining corporation Rio Tinto This paper voices the Indigenous work relevant accomplishments during the two and one half years after installment of the programme that is grounded in the interests and sensitivity to cultural continuities of the local Yolngu peopl

Polyphenon E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells

This is the author's accepted manuscript. The final published article is available from the link below. Note: In this manuscript as well as in the original published version of this article the word "Polyphenon" was incorrectly spelled in the title as "Polyphenol."Purpose: Neuroblastoma is a rare childhood cancer whose high risk, metastatic form has a dismal outcome in spite of aggressive therapeutic interventions. The toxicity of drug treatments is a major problem in this pediatric setting. In this study, we investigated whether Polyphenon E, a clinical grade mixture of green tea catechins under evaluation in multiple clinical cancer trials run by the National Cancer Institute (Bethesda, MD), has anticancer activity in mouse models of neuroblastoma. Experimental Design: We used three neuroblastoma models: (i) transgenic TH-MYCN mouse developing spontaneous neuroblastomas; (ii) nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice xenotransplanted with human SHSY5Y cells; and (iii) A/J mice transplanted with syngeneic Neuro 2A cells. Mice were randomized in control and Polyphenon E–drinking groups. Blood from patients with neuroblastoma and normal controls was used to assess the phenotype and function of myeloid cells. Results: Polyphenon E reduced the number of tumor-infiltrating myeloid cells, and inhibited the development of spontaneous neuroblastomas in TH-MYCN transgenic mice. In therapeutic models of neuroblastoma in A/J, but not in immunodeficient NOD/SCID mice, Polyphenon E inhibited tumor growth by acting on myeloid-derived suppressor cells (MDSC) and CD8 T cells. In vitro, Polyphenon E impaired the development and motility of MDSCs and promoted differentiation to more neutrophilic forms through the 67 kDa laminin receptor signaling and induction of granulocyte colony-stimulating factor. The proliferation of T cells infiltrating a patient metastasis was reactivated by Polyphenon E. Conclusions: These findings suggest that the neuroblastoma-promoting activity of MDSCs can be manipulated pharmacologically in vivo and that green tea catechins operate, at least in part, through this mechanism.SPARKS, Research in Childhood Cancer, the CGD Research Trust, and the Wellcome Trust

Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes

This work was funded by the Chief Scientists Office of the Scottish Government by a joint grant to the University of the Highland and Islands, Grampian Health Board, Biomathematics and Statistics Scotland and the Rowett Institute of Nutrition and Health, University of Aberdeen. Additional support was provided by Provexis plc.Peer reviewedPublisher PD

Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype

The antidiabetic drug gliclazide is partly metabolized by CYP2C19, the main enzyme involved in omeprazole metabolism. The aim of the study was to explore the interaction between omeprazole and gliclazide in relation to CYP2C19 phenotype using physiologically based pharmacokinetic (PBPK) modeling approach. Developed PBPK models were verified using in vivo pharmacokinetic profiles obtained from a clinical trial on omeprazole-gliclazide interaction in healthy volunteers, CYP2C19 normal/rapid/ultrarapid metabolizers (NM/RM/UM). In addition, the association of omeprazole cotreatment with gliclazide-induced hypoglycemia was explored in 267 patients with type 2 diabetes (T2D) from the GoDARTS cohort, Scotland. The PBPK simulations predicted 1.4–1.6-fold higher gliclazide area under the curve (AUC) after 5-day treatment with 20 mg omeprazole in all CYP2C19 phenotype groups except in poor metabolizers. The predicted gliclazide AUC increased 2.1 and 2.5-fold in intermediate metabolizers, and 2.6-and 3.8-fold in NM/RM/UM group, after simulated 20-day dosing with 40 mg omeprazole once and twice daily, respectively. The predicted results were corroborated by findings in patients with T2D which demonstrated 3.3-fold higher odds of severe gliclazide-induced hypoglycemia in NM/RM/UM patients concomitantly treated with omeprazole. Our results indicate that omeprazole may increase exposure to gliclazide and thus increase the risk of gliclazide-associated hypoglycemia in the majority of patients

Increased Heat Resilience of Intraspecific Outbred Compared to Inbred Lineages in the Kelp Laminaria digitata: Physiology and Transcriptomics

Marine forests and kelps as their foundation species are threatened by ocean warming especially at the warm distributional edges. Previously identified genetic divergence and ecotypic differentiation within kelp species may allow to produce more resilient lineages by intraspecific outbreeding among populations. In a mechanistic investigation of heat stress, heterosis (hybrid vigour), and underlying gene expression patterns, we assessed the thermal performance of inbred (selfings) and outbred (reciprocal crosses) sporophytes of the N-Atlantic kelp Laminaria digitata among clonal isolates from two divergent populations; one from the temperate North Sea (Helgoland) and one from the Arctic (Spitsbergen). First, we investigated the upper thermal tolerance of microscopic sporophytes in a 14-day experiment applying sublethal to lethal 20–23°C. The upper survival temperature of microscopic sporophytes was lower for the inbred Arctic selfing (21°C) than for the temperate selfing and the reciprocal crosses (22°C). Only in the temperate selfing, 4.5% of sporophytes survived 23°C. We then subjected 4–7 cm long sporophytes to a control temperature (10°C), moderate (19°C) and sublethal to lethal heat stress (20.5°C) for 18 days to assess gene expression in addition to physiological parameters. Growth and optimum quantum yield decreased similarly in the reciprocal crosses and the temperate selfing at 19 and 20.5°C, while inbred Arctic sporophytes died within seven days at both 19 and 20.5°C. In response to 20.5°C, 252 genes were constitutively regulated across all surviving lineages, which we use to describe metabolic regulation patterns in response to heat stress in kelp. At sublethal 20.5°C, ca. 150 genes were differentially expressed by either crossed lineage in comparison to the temperate selfing, indicating that they maintained a growth response similar to the temperate selfing with differential metabolic regulation during sublethal heat stress. Subtle differences in physiology and the differential expression of nine genes between the reciprocal crosses at 20.5°C indicate that female and male gametophytes may contribute differently to offspring traits. We consider potential inbreeding depression in the Spitsbergen selfing and quantify the better performance of both crosses using heterosis-related parameters. We discuss the potential and risks of outbreeding to produce more resilient crops for mariculture and marine forest restoration

Quantifying Dynamics in Tropical Peat Swamp Forest Biomass with Multi- Temporal LiDAR Datasets

Tropical peat swamp forests in Indonesia store huge amounts of carbon and are responsible for enormous carbon emissions every year due to forest degradation and deforestation. These forest areas are in the focus of REDD+ (reducing emissions from deforestation, forest degradation, and the role of conservation, sustainable management of forests and enhancement of forest carbon stocks) projects, which require an accurate monitoring of their carbon stocks or aboveground biomass (AGB). Our study objective was to evaluate multi-temporal LiDAR measurements of a tropical forested peatland area in Central Kalimantan on Borneo. Canopy height and AGB dynamics were quantified with a special focus on unaffected, selective logged and burned forests. More than 11,000 ha were surveyed with airborne LiDAR in 2007 and 2011. In a first step, the comparability of these datasets was examined and canopy height models were created. Novel AGB regression models were developed on the basis of field inventory measurements and LiDAR derived height histograms for 2007 (r(2) = 0.77, n = 79) and 2011 (r(2) = 0.81, n = 53), taking the different point densities into account. Changes in peat swamp forests were identified by analyzing multispectral imagery. Unaffected forests accumulated on average 20 t/ha AGB with a canopy height increase of 2.3 m over the four year time period. Selective logged forests experienced an average AGB loss of 55 t/ha within 30 m and 42 t/ha within 50 m of detected logging trails, although the mean canopy height increased by 0.5 m and 1.0 m, respectively. Burned forests lost 92% of the initial biomass. These results demonstrate the great potential of repetitive airborne LiDAR surveys to precisely quantify even small scale AGB and canopy height dynamics in remote tropical forests, thereby featuring the needs of REDD+