Climate Change in Mediterranean and Caribbean Seas: Research Experiences and New Scientific Challenges

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Merging bio-optical data from Biogeochemical-Argo floats and models in marine biogeochemistry

In numerical models for marine biogeochemistry, bio-optical data, such as measurements of the light field, may be important descriptors of the dynamics of primary producers and ultimately of oceanic carbon fluxes. However, the paucity of field observations has limited the integration of bio-optical data in such models so far. New autonomous robotic platforms for observing the ocean, i.e., Biogeochemical-Argo floats, have drastically increased the number of vertical profiles of irradiance, photosynthetically available radiation (PAR) and algal chlorophyll concentrations around the globe independently of the season. Such data may be therefore a fruitful resource to improve performances of numerical models for marine biogeochemistry. Here we present a work that integrates into a 1-dimensional model 1314 vertical profiles of PAR acquired by 31 BGC-Argo floats operated in the Mediterranean Sea between 2012 and 2016 to simulate the vertical and temporal variability of algal chlorophyll concentrations. In addition to PAR as input, alternative light and vertical mixing models were considered. We evaluated the models\u2019 skill to reproduce the spatial and temporal variability of deep chlorophyll maxima as observed by BGC-Argo floats. The assumptions used to set up the 1-D model are validated by the high number of co-located in-situ measurements. Our results illustrate the key role of PAR and vertical mixing in shaping the vertical dynamics of primary produces in the Mediterranean Sea. Moreover, we demonstrate the importance of modeling the diel cycle to simulate chlorophyll concentrations in stratified waters at the surface

Future projections of Mediterranean cyclone characteristics using the Med-CORDEX ensemble of coupled regional climate system models

Here, we analyze future projections of cyclone activity in the Mediterranean region at the end of the twenty-first century based on an ensemble of state-of-the-art fully-coupled Regional Climate System Models (RCSMs) from the Med-CORDEX initiative under the Representative Concentration Pathway (RCP) 8.5. Despite some noticeable biases, all the RCSMs capture spatial patterns and cyclone activity key characteristics in the region and thus all of them can be considered as plausible representations of the future evolution of Mediterranean cyclones. In general, the RCSMs show at the end of the twenty-first century a decrease in the number and an overall weakening of cyclones moving across the Mediterranean. Five out of seven RCSMs simulate also a decrease of the mean size of the systems. Moreover, in agreement with what already observed in CMIP5 projections for the area, the models suggest an increase in the Central part of the Mediterranean region and a decrease in the South-eastern part of the region in the cyclone-related wind speed and precipitation rate. These rather two opposite tendencies observed in the precipitation should compensate and amplify, respectively, the effect of the overall reduction of the frequency of cyclones on the water budget over the Central and South-eastern part of the region. A pronounced inter-model spread among the RCSMs emerges for the projected changes in the cyclone adjusted deepening rate, seasonal cycle occurrence and associated precipitation and wind patterns over some areas of the basin such as Ionian Sea and Iberian Peninsula. The differences observed appear to be determined by the driving Global Circulation Model (GCM) and influenced by the RCSM physics and internal variability. These results point to the importance of (1) better characterizing the range of plausible futures by relying on ensembles of models that explore well the existing diversity of GCMs and RCSMs as well as the climate natural variability and (2) better understanding the driving mechanisms of the future evolution of Mediterranean cyclones properties

The Copernicus Marine Service ocean forecasting system for the Mediterranean Sea

The Mediterranean Monitoring and Forecasting Center (MED-MFC) is part of the Copernicus Marine Environment and Monitoring Service (CMEMS) and provides regular and systematic information on the time-evolving Mediterranean Sea physical (including waves) and biogeochemical state. The systems consist of 3 components: 1) Med-Physics, a numerical ocean prediction systems, based on NEMO model, that operationally produces analyses, reanalysis and short term forecasts of the main physical parameters; 2) Med-Biogeochemistry, a biogeochemical analysis, reanalysis and forecasting system based on the Biogeochemical Flux Model (BFM) which provides information on chlorophyll, phosphate, nitrate, primary productivity, oxygen, phytoplankton biomass, pH and pCO2; 3) Med-Waves based on WAM model and providing analysis, forecast and reanalysis products for waves. The systems have been recently upgraded at a resolution of 1/24 degree in the horizontal and 141 vertical levels. The Med-Physics analysis and forecasting system is composed by the hydrodynamic model NEMO 2-way coupled with the third-generation wave model WaveWatchIII and forced by ECMWF atmospheric fields. The model solutions are corrected by the 3DVAR data assimilation system (3D variational scheme adapted to the oceanic assimilation problem) with a daily assimilation cycle of sea level anomaly and vertical profiles of temperature and salinity. The model has a non-linear explicit free surface and it is forced by surface pressure, interactive heat, momentum and water fluxes at the air-sea interface. The biogeochemical analysis and forecasts are produced by means of the MedBFM v2.1 modeling system (i.e. the physical-biogeochemical OGSTM-BFM model coupled with the 3DVARBIO assimilation scheme) forced by the outputs of the Med-Physics product. Seven days of analysis/hindcast and ten days of forecast are bi-weekly produced on Wednesday and on Saturday, with the assimilation of surface chlorophyll concentration from satellite observations. In-situ data are mainly used to estimate model uncertainty at different spatial scales. The Med-Waves modelling system is based on the WAM Cycle 4.5.4 wave model code. It consists of a wave model grid covering the Mediterranean Sea at a 1/24° horizontal resolution, nested to a North Atlantic grid at a 1/6° resolution. The system is forced by ECMWF winds at 1/8°. Refraction due to surface currents is accounted by the system which assimilates altimeter along-track significant wave height observations. On a daily basis, it provides 1-day analysis and 5-day forecast hourly wave parameters. Currently, wave buoy observations of significant wave height and mean wave period along with satellite observations are used to calibrate and validate the Med-waves modelling system.PublishedHalifax, Nova Scotia, Canada4A. Oceanografia e clim

Mediterranean monitoring and forecasting operational system for Copernicus Marine Service

The MEDiterranean Monitoring and Forecasting Center (Med-MFC) is part of the Copernicus Marine Environment Monitoring Service (CMEMS, http://marine.copernicus.eu/), provided on an operational mode by Mercator Ocean in agreement with the European Commission. Specifically, Med MFC system provides regular and systematic information about the physical state of the ocean and marine ecosystems for the Mediterranean Sea. The Med-MFC service started in May 2015 from the pre-operational system developed during the MyOcean projects, consolidating the understanding of regional Mediterranean Sea dynamics, from currents to biogeochemistry to waves, interfacing with local data collection networks and guaranteeing an efficient link with other Centers in Copernicus network. The Med-MFC products include analyses, 10 days forecasts and reanalysis, describing currents, temperature, salinity, sea level and pelagic biogeochemistry. Waves products will be available in MED-MFC version in 2017. The consortium, composed of INGV (Italy), HCMR (Greece) and OGS (Italy) and coordinated by the Euro-Mediterranean Centre on Climate Change (CMCC, Italy), performs advanced R&D activities and manages the service delivery. The Med-MFC infrastructure consists of 3 Production Units (PU), for Physics, Biogechemistry and Waves, a unique Dissemination Unit (DU) and Archiving Unit (AU) and Backup Units (BU) for all principal components, guaranteeing a resilient configuration of the service and providing and efficient and robust solution for the maintenance of the service and delivery. The Med-MFC includes also an evolution plan, both in terms of research and operational activities, oriented to increase the spatial resolution of products, to start wave products dissemination, to increase temporal extent of the reanalysis products and improving ocean physical modeling for delivering new products. The scientific activities carried out in 2015 concerned some improvements in the physical, biogeochemical and wave components of the system. Regarding the currents, new grid-point EOFs have been implemented in the Med-MFC assimilation system; the climatological CMAP precipitation was replaced by the ECMWF daily precipitation; reanalysis time-series have been increased by one year. Regarding the biogeochemistry, the main scientific achievement is related to the implementation of the carbon system in the Med-MFC biogeochemistry model system already available. The new model is able to reproduce the principal spatial patterns of the carbonate system variables in the Mediterranean Sea. Further, a key result consists of the calibration of the new variables (DIC and alkalinity), which serves to the estimation of the accuracy of the new products to be released in the next version of the system (i.e. pH and pCO2 at surface). Regarding the waves, the system has been validated against in-situ and satellite observations. For example, a very good agreement between model output and in-situ observations has been obtained at offshore and/or well-exposed wave buoys in the Mediterranean Sea.PublishedVienna3SR. AMBIENTE - Servizi e ricerca per la Societ

Proteomics identifies neddylation as a potential therapy target in small intestinal neuroendocrine tumors.

Patients with small intestinal neuroendocrine tumors (SI-NETs) frequently develop spread disease; however, the underlying molecular mechanisms of disease progression are not known and effective preventive treatment strategies are lacking. Here, protein expression profiling was performed by HiRIEF-LC-MS in 14 primary SI-NETs from patients with and without liver metastases detected at the time of surgery and initial treatment. Among differentially expressed proteins, overexpression of the ubiquitin-like protein NEDD8 was identified in samples from patients with liver metastasis. Further, NEDD8 correlation analysis indicated co-expression with RBX1, a key component in cullin-RING ubiquitin ligases (CRLs). In vitro inhibition of neddylation with the therapeutic agent pevonedistat (MLN4924) resulted in a dramatic decrease of proliferation in SI-NET cell lines. Subsequent mass spectrometry-based proteomics analysis of pevonedistat effects and effects of the proteasome inhibitor bortezomib revealed stabilization of multiple targets of CRLs including p27, an established tumor suppressor in SI-NET. Silencing of NEDD8 and RBX1 using siRNA resulted in a stabilization of p27, suggesting that the cellular levels of NEDD8 and RBX1 affect CRL activity. Inhibition of CRL activity, by either NEDD8/RBX1 silencing or pevonedistat treatment of cells resulted in induction of apoptosis that could be partially rescued by siRNA-based silencing of p27. Differential expression of both p27 and NEDD8 was confirmed in a second cohort of SI-NET using immunohistochemistry. Collectively, these findings suggest a role for CRLs and the ubiquitin proteasome system in suppression of p27 in SI-NET, and inhibition of neddylation as a putative therapeutic strategy in SI-NET

Competence Centre ICDI per Open Science, FAIR, ed EOSC - Mission, Strategia e piano d'azione

This document presents the mission and strategy of the Italian Competence Centre on Open Science, FAIR, and EOSC. The Competence Centre is an initiative born within the Italian Computing and Data Infrastructure (ICDI), a forum created by representatives of major Italian Research Infrastructures and e-Infrastructures, with the aim of promoting sinergies at the national level, and optimising the Italian participation to European and global challenges in this field, including the European Open Science Cloud (EOSC), the European Data Infrastructure (EDI) and HPC. This working paper depicts the mission and objectives of the ICDI Competence Centre, a network of experts with various skills and competences that are supporting the national stakeholders on topics related to Open Science, FAIR principles application and participation to the EOSC. The different actors and roles are described in the document as well as the activities and services offered, and the added value each stakeholder can find the in Competence Centre. The tools and services provided, in particular the concept for the portal, though which the Centre will connect to the national landscape and users, are also presented