710 research outputs found
Cost-effectiveness Analysis of Hospital Infection Control Response to an Epidemic Respiratory Virus Threat
Pandemic (H1N1) 2009 can be contained with less expensive measures than some other viruses
Development of an Electrogenerated Chemiluminescence Biosensor using Carboxylic acid-functionalized MWCNT and Au Nanoparticles
A COOH-F-MWCNT-Nafion-Ru(bpy)32+-Au-ADH electrogenerated chemiluminescence (ECL) electrode using COOH-functionalized MWCNT (COOH-F-MWCNT) and Au nanoparticles synthesized by the radiation method was fabricated for ethanol sensing. A higher sensing efficiency for ethanol for the ECL biosensor prepared by PAAc-g-MWCNT was measured compared to that of the ECL biosensor prepared by PMAc-g-MWCNT, and purified MWCNT. Experimental parameters affecting ethanol detection were also examined in terms of pH and the content of PAAc-g-MWCNT in Nafion. Little interference of other compounds was observed for the assay of ethanol. Results suggest this ECL biosensor could be applied for ethanol detection in real samples
A Portable Luminometer with a Disposable Electrochemiluminescent Biosensor for Lactate Determination
A hand-held luminometer for measuring electrochemiluminescence (ECL) for lactate determination and based on one-shot biosensors fabricated using screen-printed electrodes is described. The lactate recognition system is based on lactate oxidase and the transduction system consists of electro-oxidation of luminol, with all the reagents immobilized in a Methocel membrane. The membrane composition and reaction conditions have been optimized to obtain adequate sensitivity. The luminometer is based on a large silicon photodiode as detector and includes a programmable potentiostat to initialize the chemical reaction and signal processing circuitry, designed to acquire a low level photocurrent with offset cancelation, low pass filtering for noise attenuation and adjustable gain up to 1012 V/A. The one-shot biosensor responds to lactate rapidly, with an acquisition time of 2.5 min, obtaining a linear dependence from 8 Ă 10â6 to 2 Ă 10â4 M, a detection limit of 2.4 Ă 10â6 M and a sensor-to-sensor reproducibility (relative standard deviation, RSD) of around 7â10 % at the medium level of the range
Longitudinal seroepidemiologic study of the 2009 pandemic influenza A (H1N1) infection among health care workers in a children's hospital
<p>Abstract</p> <p>Background</p> <p>To probe seroepidemiology of the 2009 pandemic influenza A (H1N1) among health care workers (HCWs) in a children's hospital.</p> <p>Methods</p> <p>From August 2009 to March 2010, serum samples were drawn from 150 HCWs in a children's hospital in Taipei before the 2009 influenza A (H1N1) pandemic, before H1N1 vaccination, and after the pandemic. HCWs who had come into direct contact with 2009 influenza A (H1N1) patients or their clinical respiratory samples during their daily work were designated as a high-risk group. Antibody levels were determined by hemagglutination inhibition (HAI) assay. A four-fold or greater increase in HAI titers between any successive paired sera was defined as seroconversion, and factors associated with seroconversion were analyzed.</p> <p>Results</p> <p>Among the 150 HCWs, 18 (12.0%) showed either virological or serological evidence of 2009 pandemic influenza A (H1N1) infection. Of the 90 unvaccinated HCWs, baseline and post-pandemic seroprotective rates were 5.6% and 20.0%. Seroconversion rates among unvaccinated HCWs were 14.4% (13/90), 22.5% (9/40), and 8.0% (4/50) for total, high-risk group, and low-risk group, respectively. Multivariate analysis revealed being in the high-risk group is an independent risk factor associated with seroconversion.</p> <p>Conclusion</p> <p>The infection rate of 2009 pandemic influenza A (H1N1) in HCWs was moderate and not higher than that for the general population. The majority of unvaccinated HCWs remained susceptible. Direct contact of influenza patients and their respiratory samples increased the risk of infection.</p
Association of serum lipid levels and prostate cancer severity among Hispanic Puerto Rican men
Induced polarization of {\Lambda}(1116) in kaon electroproduction
We have measured the induced polarization of the in the
reaction , detecting the scattered and
in the final state along with the proton from the decay .The present study used the CEBAF Large Acceptance Spectrometer (CLAS),
which allowed for a large kinematic acceptance in invariant energy
( GeV) and covered the full range of the kaon production
angle at an average momentum transfer GeV.In this experiment a
5.50 GeV electron beam was incident upon an unpolarized liquid-hydrogen target.
We have mapped out the and kaon production angle dependencies of the
induced polarization and found striking differences from photoproduction data
over most of the kinematic range studied. However, we also found that the
induced polarization is essentially independent in our kinematic domain,
suggesting that somewhere below the covered here there must be a strong
dependence. Along with previously published photo- and electroproduction
cross sections and polarization observables, these data are needed for the
development of models, such as effective field theories, and as input to
coupled-channel analyses that can provide evidence of previously unobserved
-channel resonances.Comment: 13 figure
Demonstration of a novel technique to measure two-photon exchange effects in elastic scattering
The discrepancy between proton electromagnetic form factors extracted using
unpolarized and polarized scattering data is believed to be a consequence of
two-photon exchange (TPE) effects. However, the calculations of TPE corrections
have significant model dependence, and there is limited direct experimental
evidence for such corrections. We present the results of a new experimental
technique for making direct comparisons, which has the potential to
make precise measurements over a broad range in and scattering angles. We
use the Jefferson Lab electron beam and the Hall B photon tagger to generate a
clean but untagged photon beam. The photon beam impinges on a converter foil to
generate a mixed beam of electrons, positrons, and photons. A chicane is used
to separate and recombine the electron and positron beams while the photon beam
is stopped by a photon blocker. This provides a combined electron and positron
beam, with energies from 0.5 to 3.2 GeV, which impinges on a liquid hydrogen
target. The large acceptance CLAS detector is used to identify and reconstruct
elastic scattering events, determining both the initial lepton energy and the
sign of the scattered lepton. The data were collected in two days with a
primary electron beam energy of only 3.3 GeV, limiting the data from this run
to smaller values of and scattering angle. Nonetheless, this measurement
yields a data sample for with statistics comparable to those of the
best previous measurements. We have shown that we can cleanly identify elastic
scattering events and correct for the difference in acceptance for electron and
positron scattering. The final ratio of positron to electron scattering:
for GeV and
Cross sections for the ÎłpâK*+Î and ÎłpâK*+ÎŁ0 reactions measured at CLAS
The first high-statistics cross sections for the reactions ÎłpâK*+Î and ÎłpâK*+ÎŁ0 were measured using the CLAS detector at photon energies between threshold and 3.9 GeV at the Thomas Jefferson National Accelerator Facility. Differential cross sections are presented over the full range of the center-of-mass angles, and then fitted to Legendre polynomials to extract the total cross section. Results for the K*+Î final state are compared with two different calculations in an isobar and a Regge model, respectively. Theoretical calculations significantly underestimate the K*+Î total cross sections between 2.1 and 2.6 GeV, but are in better agreement with present data at higher photon energies
Quantifying the Impact of Immune History and Variant on SARS-CoV-2 Viral Kinetics and Infection Rebound: A Retrospective Cohort Study
BACKGROUND: The combined impact of immunity and SARS-CoV-2 variants on viral kinetics during infections has been unclear.
METHODS: We characterized 1,280 infections from the National Basketball Association occupational health cohort identified between June 2020 and January 2022 using serial RT-qPCR testing. Logistic regression and semi-mechanistic viral RNA kinetics models were used to quantify the effect of age, variant, symptom status, infection history, vaccination status and antibody titer to the founder SARS-CoV-2 strain on the duration of potential infectiousness and overall viral kinetics. The frequency of viral rebounds was quantified under multiple cycle threshold (Ct) value-based definitions.
RESULTS: Among individuals detected partway through their infection, 51.0% (95% credible interval [CrI]: 48.3-53.6%) remained potentially infectious (Ct
CONCLUSIONS: SARS-CoV-2 viral kinetics are partly determined by immunity and variant but dominated by individual-level variation. Since booster vaccination protects against infection, longer clearance times for BA.1-infected, boosted individuals may reflect a less effective immune response, more common in older individuals, that increases infection risk and reduces viral RNA clearance rate. The shifting landscape of viral kinetics underscores the need for continued monitoring to optimize isolation policies and to contextualize the health impacts of therapeutics and vaccines.
FUNDING: Supported in part by CDC contract #200-2016-91779, a sponsored research agreement to Yale University from the National Basketball Association contract #21-003529, and the National Basketball Players Association
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