Institutional Dynamics in a Re-ordering World

The chapters in this volume point to a profound re-definition of structuring frames for action and of normative and cognitive reference sets. All chapters, individually and as a whole, document in other words significant institutional transformation. The transnationalization of our world, sometimes hastily labeled “globalization”, is not only – and far from it – about flows of goods, capital or people. Nor is transnationalization simply a discourse even though it does have important discursive dimensions. Our transnationalizing world is a re-ordering world, a world where institutional rules of the game are in serious transition. Furthermore, the chapters in this volume clearly suggest – and many mundane contemporary experiences confirm it – that the impact of re-ordering processes is significant and consequential for our everyday lives. [First paragraph

Standardizing and Disseminating Knowledge: The Role of the OECD in Global Governance

If ‘knowledge is power’, it is unsurprising that the production, legitimation, and application of social scientific knowledge, not least that which was designed to harness social organization to economic growth, is a potentially contentious process. Coping with, adapting to, or attempting to shape globalization has emerged as a central concern of policy-makers who are, therefore, interested in knowledge to assist their managerial activities. Thus, an organization that can create, synthesize, legitimate, and dissemination useful knowledge can play a significant role in the emerging global governance system. The OECD operates as one important site for the construction, standardization, and dissemination of transnational policy ideas. OECD staff conducts research and produces a range of background studies and reports, drawing on disciplinary knowledge (typically economics) supplemented by their ‘organizational discourses’. This paper probes the contested nature of knowledge production and attempts to evaluate the impact of the OECD’s efforts to produce globally applicable policy advice. Particular attention is paid to important initiatives in the labour market and social policy fields—the Jobs Study and Babies and Bosses

The translation of management knowledge : challenges, contributions and new directions

Across many sectors, new developments and discourses that emphasize change, collaboration, shifting professional boundaries and increased sharing of knowledge are taking place. One is thus challenged to question and/or develop further understanding of how and to what extent new ideas, scientific developments and technologies are translated within such contexts and thereby extend management and organization studies. To advance understanding about this significant field in the scholarly community, this special issue has assembled a diverse set of papers, which review developments in translation theory and seek to encourage new thinking and frameworks and open up new directions in management and organization studies more generally. By reflecting on these papers, the authors summarize key challenges in translational research and new framings, and point to exciting new research opportunities that can be found in fruitfully comparing, elaborating, expanding, contrasting and blending extant perspectives

Interfacial separation between elastic solids with randomly rough surfaces: comparison between theory and numerical techniques

We study the distribution of interfacial separations P(u) at the contact region between two elastic solids with randomly rough surfaces. An analytical expression is derived for P(u) using Persson's theory of contact mechanics, and is compared to numerical solutions obtained using (a) a half-space method based on the Boussinesq equation, (b) a Green's function molecular dynamics technique and (c) smart-block classical molecular dynamics. Overall, we find good agreement between all the different approaches.Comment: 25 pages, 12 figure

Comprehensive molecular characterization of adenoid cystic carcinoma reveals tumor suppressors as novel drivers and prognostic biomarkers

© 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Adenoid cystic carcinoma (ACC) is a MYB-driven head and neck malignancy with high rates of local recurrence and distant metastasis and poor long-term survival. New effective targeted therapies and clinically useful biomarkers for patient stratification are needed to improve ACC patient survival. Here, we present an integrated copy number and transcriptomic analysis of ACC to identify novel driver genes and prognostic biomarkers. A total of 598 ACCs were studied. Clinical follow-up was available from 366 patients, the largest cohort analyzed to date. Copy number losses of 1p36 (70/492; 14%) and of the tumor suppressor gene PARK2 (6q26) (85/343; 25%) were prognostic biomarkers; patients with concurrent losses (n = 20) had significantly shorter overall survival (OS) than those with one or no deletions (p < 0.0001). Deletion of 1p36 independently predicted short OS in multivariate analysis (p = 0.02). Two pro-apoptotic genes, TP73 and KIF1B, were identified as putative 1p36 tumor suppressor genes whose reduced expression was associated with poor survival and increased resistance to apoptosis. PARK2 expression was markedly reduced in tumors with 6q deletions, and PARK2 knockdown increased spherogenesis and decreased apoptosis, indicating that PARK2 is a tumor suppressor in ACC. Moreover, analysis of the global gene expression pattern in 30 ACCs revealed a transcriptomic signature associated with short OS, multiple copy number alterations including 1p36 deletions, and reduced expression of TP73. Taken together, the results indicate that TP73 and PARK2 are novel putative tumor suppressor genes and potential prognostic biomarkers in ACC. Our studies provide new important insights into the pathogenesis of ACC. The results have important implications for biomarker-driven stratification of patients in clinical trials. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.info:eu-repo/semantics/publishedVersio

Navigating institutional complexity: The production of risk culture in the financial sector

Earlier versions of this paper were presented at the EGOS 2014 Colloquium, at research seminars at Copenhagen Business School and HEC Lausanne, and, under the title ‘Searching for Risk Culture’, as a keynote address at the SAMS/JMS annual conference on Managing Complexity Within and Across Organizational Boundaries at Cambridge University, March 2014. The authors are grateful for the helpful comments of Mats Alvesson, Roger Friedland, Matthew Hall, Silvia Jordan, Steve Maguire and Iain Munro, as well as the editors of the special issue of JMS on Managing Complexity. The authors gratefully acknowledge the financial support of the Economic and Social Research Council (ESRC), the Chartered Insurance Institute (CII), the Chartered Institute of Management Accountants (CIMA) and the Lighthill Risk Network

Standardization as Institutional Work: The Regulatory Power of a Responsible Investment Standard

This paper conceptualizes standardization as institutional work to study the emergence of a standard and the deployment of its regulatory power. We rely on unique access to longitudinal archival data for exploring how the FTSE4Good index, a responsible investment index, emerged as a standard for socially responsible corporate behavior. Our results show how three types of standardization work - calculative framing, engaging and valorizing - support the design, legitimation and monitoring processes whereby a standard acquires its regulatory power. Our findings reveal new facets in the dynamics of standardization by approaching standardization as a product of institutional work and in showing how unintended consequences of that work can be recaptured to strengthen the regulatory power of the standard

Evidence-based design strategies to produce health promoting landscapes

Outdoor Environments for Health and Well-being is an international master’s program offered at the Swedish University of Agricultural Sciences (SLU) at Alnarp¸ leading to a Master of Science degree with a specialization in Environmental Psychology. The course Nature-Based Interventions LK0306 focuses on how different types of natural outdoor settings can be used for interventions as part of treatment, rehabilitation and programs for the prevention and promotion of healthy everyday habits in different user groups. This factsheet is the final product of the students’ work within the course during the autumn term of 2019. This year, Associate Professor John Rayner, contributed to this factsheet with his thoughts on the findings from the different groups’ work

Development of a new mechano-chemical model in boundary lubrication

A newly developed tribochemical model based on thermodynamics of interfaces and kinetics of tribochemical reactions is implemented in a contact mechanics simulation and the results are validated against experimental results. The model considers both mechanical and thermal activation of tribochemical reactions instead of former thermal activation theories. The model considers tribofilm removal and is able to capture the tribofilm behaviour during the experiment. The aim of this work is to implement tribochemistry into deterministic modelling of boundary lubrication and study the effect of tribofilms in reducing friction or wear. A new contact mechanics model considering normal and tangential forces in boundary lubrication is developed for two real rough steel surfaces. The model is developed for real tribological systems and is flexible to different laboratory experiments. Tribochemistry (e.g. tribofilm formation and removal) and also mechanical properties are considered in this model. The amount of wear is calculated using a modified Archard’s wear equation accounting for local tribofilm thickness and its mechanical properties. This model can be used for monitoring the tribofilm growth on rough surfaces and also the real time surface roughness as well as changes in the λ ratio. This model enables the observation of in-situ tribofilm thickness and surface coverage and helps in better understanding the real mechanisms of wear