1969-1976: el doble sentido de la noción de democracia en las revistas de la nueva izquierda intelectual e independiente argentina (NIIA) : el caso de Pasado y Presente Nueva Serie

Fil: Sabattini, Virginia. Universidad Nacional de Villa Marí

Kit receptor tyrosine kinase dysregulations in feline splenic mast cell tumours

This study investigated Ki t receptor dysregulations (cytoplasmic immunohistochemical expression and/or c-KIT mutations) in cats a\ufb00ected with splenic mast cell tumours. Twenty-two cats were included. Median survival time was 780 days (range: 1\u20131219). An exclusive splenic involvement was signi\ufb01cantly (P = 0.042) associated with longer survival (807 versus 120 days). Eighteen tumours (85.7%) showed Kit cytoplasmic expression (Kit pattern 2, 3). Mutation analysis was successful in 20 cases. Fourteen missense mutations were detected in 13 out of 20 tumours (65%). Eleven (78.6%) were located in exon 8, and three (21.6%) in exon 9. No mutations were detected in exons 11 and 17. Seven mutations corresponded to the same internal tandem duplication in exon 8 (c.1245_1256dup). Although the association between Kit cytoplasmic expression and mutations was signi\ufb01cant, immunohistochemistry cannot be considered a surrogate marker for mutation analysis. No correlation was observed between c-Kit mutations and tumour di\ufb00erentiation, mitotic activity or survival

Sophocles’ Electra lines 1050-1057

Este trabajo pretende tomar posición sobre la atribución de los vv. 1050-1051 de Electra de Sófocles a la obra fragmentaria Fedra, teniendo en cuenta la presencia y función teatrales del verbo ἄπειμι en la tragedia griega antigua. De esta manera, sostendremos que existen motivos convincentes, aunque no suficientes, para atribuir los vv. 1050-1057 a Electra y no a Fedra.This paper seeks to take a position on the attribution of Sophocles’ Electra 1050-1051 to the fragmentary play Phaedra, taking into consideration the theatrical presence and function of the verb ἄπειμι in ancient Greek tragedy. Thus, we will claim that there are convincing –though not sufficient– reasons to attribute lines 1050-1057 to Electraand not to Phaedra.Fil: Sabattini, Luciano Adrián. Universidad Nacional del Sur. Departamento de Humanidades; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentin

Totoralia, a new conical-shaped mollusk from the Middle Cambrian of western Argentina

The new genus Totoralia from the Late Middle Cambrian of El Totoral (Mendoza Province, western Argentina) is described herein. It is a delicate, high, bilaterally symmetrical cone with a sub-central apex and five to seven prominent comarginal corrugations. In addition, its surface shows numerous fine comarginal lines, as well as thin, closely spaced radial lirae. Totoralia gen. nov., in most respects, resembles the Cambrian helcionellids Scenella BILLINGS and Palaeacmaea HALL and Whitfield. Although Scenella has been considered as a chondrophorine cnidarian by some authors in the past, now the predominant view is that it is a mollusk. Likewise, several aspects of Totoralia gen. nov. morphology indicate closer affinities with mollusks. The specimens studied constitute elevated cones that are rather consistent in height, implying that they were not flexible structures like those of the chondrophorines. The presence of a short concave slope immediately in front of the apex can also be interpreted as a mollusk feature. In addition, the numerous comarginal lines of the cone are uniform in prominence and constant in spacing, and are only represented on the dorsal surface of the shell; thus, they are most similar to the incremental growth lines of shells of mollusks. The morphology of Totoralia gen. nov. is regarded as primitive in the Helcionelloida because the ancestor of the class is likely to have had a minute, untorted limpet-shaped shell. Although the new genus herein described seems to be endemic to Argentina, the Cambrian occurrences of related scenellid genera suggest affinities with Laurentia

Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall

Benign TdT-positive cells have been documented in a variety of non-hematopoietic tissues. Scant data are however available on their presence in non-neoplastic lymph nodes. This study is aimed to: (i) characterize the presence/distribution of benign TdT-positive cells in pediatric and adult reactive lymph nodes; (ii) define the phenotype and nature of such elements. This retrospective study considered 141 reactive lymph nodes from pediatric and adult patients without history of neoplastic disease. TdT-positive cells were characterized by immunohistochemical and morphometric analyses and their presence was correlated with the clinical-pathological features. The nature of TdT-positive cells was investigated by: (i) double immunostaining for early lymphoid cell markers; and (ii) assessment of TdT expression in fetal lymph nodes. Sparse TdT-positive cells were documented in all pediatric cases and in most (76%) adult lymph nodes. TdT-positive cell density was higher in children than adults (15.9/mm2 versus 8.6/mm2; P<.05). TdT positivity did not correlate with any clinical and histological parameter and double immunostaining disclosed a phenotype compatible with early lymphoid precursors (positivity for CD34, CD10 and variable expression of CD7). A very high TdT-positive cell density (802.4/mm2) was reported in all fetal lymph nodes. In conclusion, TdT-positive cells are a common finding in pediatric and adult lymph nodes. The interstitial distribution and low number of such cells allows for the differential diagnosis with precursor lymphoid neoplasms. The high density in fetal lymph nodes and the phenotype of such cells suggest their belonging to an immature lymphoid subset gradually decreasing with age

A Quadratic Programming approach for coordinating multi-AGV systems

This paper presents an optimization strategy to coordinate multiple Autonomous Guided Vehicles (AGVs) on ad-hoc pre-defined roadmaps used in logistic operations in industrial applications. Specifically, the objective is to maximize traffic throughput of AGVs navigating in an automated warehouse by minimizing the time AGVs spend negotiating complex traffic patterns to avoid collisions with other AGVs. In this work, the coordination problem is posed as a Quadratic Programming (QP) problem where the optimization is performed in a centralized manner. The optimality of the coordination strategy is established and the feasibility of the strategy is validated in simulation for different scenarios and for real industrial environments. The performance of the proposed strategy is then compared with a decentralized coordination strategy which relies on local negotiations for shared resources. The results show that the proposed coordination strategy successfully maximizes vehicle throughout and significantly minimizes the time vehicles spend negotiating traffic under different scenarios

Features and prognostic impact of distant metastases in 45 dogs with de novo stage IV cutaneous mast cell tumours: A prospective study

BACKGROUND: Distant metastases in dogs with cutaneous mast cell tumors (cMCT) are rare and incurable. The aims of this prospective study were to clarify the clinico-pathological features of stage IV cMCTs and to identify possible prognostic factors for progression-free interval (PFI) and survival time (ST). MATERIAL AND METHODS: Dogs were eligible for recruitment if they had a previously untreated, histologically confirmed cMCT and if they underwent complete staging demonstrating stage IV disease. Dogs were uniformly followed-up, whereas treatment was not standardized and included no therapy, surgery, radiation therapy, chemotherapy, tyrosine-kinase inhibitors or a combination of these. RESULTS: 45 dogs with stage IV cMCT were enrolled. All dogs had distant metastatic disease, and 41 (91.1%) dogs had also metastasis in the regional lymph node. Histopathological grade and mutational status greatly varied among dogs. Median ST was 110 days. Notably, PFI and ST were independent of well-known prognostic factors, including anatomic site, histological grade, and mutational status. Conversely, tumor diameter >3\u2009cm, more than 2 metastatic sites, bone marrow infiltration, and lack of tumor control at the primary site were confirmed to be negative prognostic factors by multivariate analysis. CONCLUSION: Currently, there is no satisfactory treatment for stage IV cMCT. Asymptomatic dogs with tumor diameter <3\u2009cm and a low tumor burden, without bone marrow infiltration may be candidates for multimodal treatment. Stage IV dogs without lymph node metastasis may enjoy a surprisingly prolonged survival. The achievement of local tumor control seems to predict a better outcome in dogs with stage IV cMCT

STUDIARE, DOCUMENTARSI, INCONTRARSI: indagine sull'utenza delle biblioteche universitarie nei Poli della Romagna Indagine sul gradimento da parte dell'utenza (studentesca e non) della qualità dei servizi delle biblioteche dei Poli scientifico-didattici di Cesena, Forlì, Ravenna e Rimini

La nuova indagine sul gradimento da parte dell’utenza dei servizi delle biblioteche dei Poli scientifico-didattici della Romagna è stata realizzata nelle ultime due settimane di maggio 2010. Per questa nuova rilevazione sono state recepite le criticità della precedente indagine, con l’adozione di un questionario online e dalla struttura più snella, che permettesse di condurre l’indagine in tempi brevi e coinvolgesse maggiormente il personale docente e Ricercatore, senza comunque trascurare valutazioni dei servizi e desiderata di miglioramento degli studenti