Kit receptor tyrosine kinase dysregulations in feline splenic mast cell tumours

This study investigated Ki t receptor dysregulations (cytoplasmic immunohistochemical expression and/or c-KIT mutations) in cats a\ufb00ected with splenic mast cell tumours. Twenty-two cats were included. Median survival time was 780 days (range: 1\u20131219). An exclusive splenic involvement was signi\ufb01cantly (P = 0.042) associated with longer survival (807 versus 120 days). Eighteen tumours (85.7%) showed Kit cytoplasmic expression (Kit pattern 2, 3). Mutation analysis was successful in 20 cases. Fourteen missense mutations were detected in 13 out of 20 tumours (65%). Eleven (78.6%) were located in exon 8, and three (21.6%) in exon 9. No mutations were detected in exons 11 and 17. Seven mutations corresponded to the same internal tandem duplication in exon 8 (c.1245_1256dup). Although the association between Kit cytoplasmic expression and mutations was signi\ufb01cant, immunohistochemistry cannot be considered a surrogate marker for mutation analysis. No correlation was observed between c-Kit mutations and tumour di\ufb00erentiation, mitotic activity or survival

Impression Management during Evaluation and Psychological Reactions Post-donation of Living Kidney Donors

Many healthcare providers have been concerned about the extent to which potential kidney donors use impression management or concealment of important information regarding their medical history, current functioning, or other circumstances that could affect whether they are accepted as donors. To date, however, there has been very little empirical examination of these questions. It is also not known whether donors\u27 use of impression management pre-donation is related to their reactions and adjustment post-donation. Methods This study surveyed 76 individuals who had donated a kidney one to six yr previously regarding their use of impression management and their concealing of information during their psychological evaluations. They were also asked about their reactions to the donation and whether they would make the same decision again. In addition, 21 of these donors participated in focus groups that explored these questions in depth. Results Many of the kidney donors reported that they possessed very strong motivation to donate and consequently used impression management in their interactions with medical professionals pre-donation. Very few donors, however, indicated that they concealed information during their pre-donation evaluations. The donors\u27 psychological reactions post-donation were generally positive, and nearly all indicated that they would make the same decision again

"Narratives of America\u27\u27 : The Confrontation with the Unknown

サンパウロ大学, 2008年10月13日-15

Aspectos da biofísica

(1º parágrafo do artigo) Um dos aspectos mais fascinantes dos estudos naturais é o estudo da vida em seus múltiplos e variados aspectos. A natureza e a origem da vida tem sido objeto de atenção da curiosidade humana através dos séculos. Filósofos, teólogos e cientistas tem procurado dar explicações para este fenômeno, sem contudo chegarem a um consenso. Definições para a vida, vão desde as místicas, proferidas pelos santos, até as mais simplórias oriundas do senso comum. Para alguns é o sopro do Criador que dá forma ao pó. Para outros, é um complexo mecanismo bioquímico, cujo objetivo e finalidade ainda não nos é dado a conhecer. Estas idéias sobre a vida, frequentemente se revelam de pouca ou nenhuma utilidade para o pesquisador que se interessa pela natureza e origem da vida

The Relationship Between Students' Flow Experience and Their Behavior Data in Gamified Educational Systems

The number of students using online educational systems is increasing, especially after the growth of the use of this type of system due to the social isolation caused by the Covid-19 pandemic. This situation highlighted the challenge of analyzing the users' experience in this type of system, especially when evaluating more complex experiences, such as the flow experience. One of the most promising innovative alternatives is to use the behavior data logs produced by students in educational systems to analyze their experiences. In this paper, we conducted a study (N = 24) to analyze the relationships between the behavior data logs produced by students when using a gamified educational system and their flow experience during the system usage. Our results contribute to the automatic users' experience analysis in educational systems

Generation of Hprt-disrupted rat through mouse← rat ES chimeras

Isotani, A., Yamagata, K., Okabe, M. et al. Generation of Hprt-disrupted rat through mouse←rat ES chimeras. Sci Rep 6, 24215 (2016). https://doi.org/10.1038/srep2421

The resting microstate networks (RMN): cortical distributions, dynamics, and frequency specific information flow

A brain microstate is characterized by a unique, fixed spatial distribution of electrically active neurons with time varying amplitude. It is hypothesized that a microstate implements a functional/physiological state of the brain during which specific neural computations are performed. Based on this hypothesis, brain electrical activity is modeled as a time sequence of non-overlapping microstates with variable, finite durations (Lehmann and Skrandies 1980, 1984; Lehmann et al 1987). In this study, EEG recordings from 109 participants during eyes closed resting condition are modeled with four microstates. In a first part, a new confirmatory statistics method is introduced for the determination of the cortical distributions of electric neuronal activity that generate each microstate. All microstates have common posterior cingulate generators, while three microstates additionally include activity in the left occipital/parietal, right occipital/parietal, and anterior cingulate cortices. This appears to be a fragmented version of the metabolically (PET/fMRI) computed default mode network (DMN), supporting the notion that these four regions activate sequentially at high time resolution, and that slow metabolic imaging corresponds to a low-pass filtered version. In the second part of this study, the microstate amplitude time series are used as the basis for estimating the strength, directionality, and spectral characteristics (i.e., which oscillations are preferentially transmitted) of the connections that are mediated by the microstate transitions. The results show that the posterior cingulate is an important hub, sending alpha and beta oscillatory information to all other microstate generator regions. Interestingly, beyond alpha, beta oscillations are essential in the maintenance of the brain during resting state.Comment: pre-print, technical report, The KEY Institute for Brain-Mind Research (Zurich), Kansai Medical University (Osaka

The Three-Dimensional Virtual Surgical Simulation and Surgical Assistance for Optimizing Robotic Partial Nephrectomy

Robot-assisted partial nephrectomy (RAPN) has been accepted as the standard treatment recommended for relatively small renal mass or even the T2 renal carcinoma in experienced hospitals as Nephron Sparing Surgery. To obtain better RAPN surgical outcomes, the understanding of surgical anatomies such as the position of intra-renal structure and the positional relationship of each structure should be detailed in a three-dimensional (3D) manner. The 3D virtual surgical simulation for partial nephrectomy based on the image segmentation method with high-resolution CT can provide the 3D anatomical details of the renal tumor focusing on their relationships with the arterial and venous branches as well as with the intrarenal portion of the urinary collecting system. This imaging application is also used as image guidance during the surgery, and it indicated that it provides the improvement of clinical outcomes such as the duration of hospitalization, transfusion, and major postoperative complications as well as conversion to radical nephrectomy or open partial nephrectomy. In this chapter, we describe the basics of the 3D imaging assistance methods for partial nephrectomy and the benefit of 3D virtual surgical simulation in optimizing the outcome of the RAPN

The Relationship Between Students\u27 Flow Experience and Their Behavior Data in Gamified Educational Systems

The number of students using online educational systems is increasing, especially after the growth of the use of this type of system due to the social isolation caused by the Covid-19 pandemic. This situation highlighted the challenge of analyzing the users\u27 experience in this type of system, especially when evaluating more complex experiences, such as the flow experience. One of the most promising innovative alternatives is to use the behavior data logs produced by students in educational systems to analyze their experiences. In this paper, we conducted a study (N = 24) to analyze the relationships between the behavior data logs produced by students when using a gamified educational system and their flow experience during the system usage. Our results contribute to the automatic users\u27 experience analysis in educational systems