Augmented Reality and Functional Skills Acquisition Among Individuals With Special Needs: A Meta-Analysis of Group Design Studies

Augmented reality (AR) has the potential to support individuals with special needs and to enable their development of daily living skills. This meta-analysis study examined the effect of AR on functional skills acquisition across individuals affected by different disabilities. Group design studies based on a random-effects model alongside the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were used in this study. A total of 119 individuals with different types of disabilities (including intellectual disability, autism spectrum disorder, attention deficit hyperactivity disorder, Down syndrome, hearing disability, and visual disability) were obtained from seven studies. The overall effect size of AR across the seven studies was significant. The results showed that AR can be effective and helpful for individuals with disabilities to help them make daily decisions and guide their actions in society. The implications for practice and research as well as the possible areas that require further investigation are discussed

Fulminant neuroleptic malignant syndrome after perioperative withdrawal of antiParkinsonian medication

Neuroleptic malignant syndrome is a rare complication when using neuroleptic drugs. We report the case of a patient with severe Parkinson's disease who developed neuroleptic malignant syndrome after withdrawal of his antiParkinsonian medication for elective coronary artery bypass grafting. Sodium dantrolene may be a therapeutic option in severe case

Genes in the postgenomic era

We outline three very different concepts of the gene - 'instrumental', 'nominal', and 'postgenomic'. The instrumental gene has a critical role in the construction and interpretation of experiments in which the relationship between genotype and phenotype is explored via hybridization between organisms or directly between nucleic acid molecules. It also plays an important theoretical role in the foundations of disciplines such as quantitative genetics and population genetics. The nominal gene is a critical practical tool, allowing stable communication between bioscientists in a wide range of fields grounded in well-defined sequences of nucleotides, but this concept does not embody major theoretical insights into genome structure or function. The post-genomic gene embodies the continuing project of understanding how genome structure supports genome function, but with a deflationary picture of the gene as a structural unit. This final concept of the gene poses a significant challenge to conventional assumptions about the relationship between genome structure and function, and between genotype and phenotype

Are aberrant cortisol levels prognostic factors for the development of depression in the adult population?

Laut der Weltgesundheitsorganisation (WHO, 2017) litten im Jahr 2015 insgesamt 322 Millionen Menschen an Depressionen; 4,4 Prozent der Weltbevölkerung. Prädiktoren für das Auftreten einer Depression würden helfen Risikopatienten zu identifizieren und die Zeit für eine wirksame Behandlung zu verkürzen. Ziel dieses systematischen Reviews ist es festzustellen, ob der Cortisolspiegel die Entwicklung einer Deprression vorhersagt. In unserer Analyse wurden verschiedene Methoden zur Messung des Cortisolspiegels (Speichel, Urin, Haare und Serum), verschiedene Zeitpunkte und Bedingungen (Awakening Cortisol, Cortisolprofile, DEX-CRH-Test), verschiedene Screening-Instrumente für Depressionen sowie verschiedene Studiendesigns untersucht (prospektive Beobachtungsstudien und interventionelle Kohortenstudien). Die Suche wurde über PubMed, Medline, PsychInfo, Embase, Science direct und Web of Science zwischen März 2015 und April 2015 unter Verwendung geeigneter indizierter Begriffe durchgeführt. Alle beobachtenden und prospektiven Kohortenstudien zwischen 1992 und 2015 wurden ausgewählt, wenn sie alle vordefinierten Einschlusskriterien und keines der Ausschlusskriterien erfüllten. Die Studien wurden gemäß dem PRISMA Vierphasen Flussdiagramm aufgenommen. Die Qualität der Primärstudien wurde mit dem Qualitätsbewertungsinstrument "Newcastle Ottawa Scale" für Beobachtungsstudien und "Jadad Scale" für interventionelle Studien bewertet. Unsere Hauptergebnisvariable war die Inzidenz von Depressionen, definiert nach ICD-10-, DSM-IV oder DSM-V. Standardisierte Eigen- und Frembewertungsinstrumente wurden für die Messung der Ergebnisvariablen akzeptiert. Aus insgesamt 4619 Artikeln in englischer Sprache konnten wir 41 Artikel identifizieren, die unsere Kriterien erfüllten, darunter 17 Beobachtungsstudien und 24 Interventionsstudien. In elf Beobachtungs- und fünf Interventionsstudien wurde die Assoziation von Cortisol und Depression untersucht und berichtet. Die vorliegende Arbeit zeigt, dass bei Frauen erhöhte Cortisolspiegel als Prädiktor für eine Depression dienen könnten. Die aktuelle Forschungssituation bei Männern ist unklar. Speichelcortisol scheint für die Messung am praktikabelsten. Die beste Zeit für eine Probenentnahme ist das Morgencortisol. Messungen der Cortisol ?Aufwachantwort? scheinen ebenfalls vielversprechend, sie sind jedoch häufig nicht geeignet, da diese Art der Messung durch verschiedene Faktoren beeinflusst werden kann. Bestätigende Studien sind jedoch empfohlen, bevor Speichel-Cortisol-Morgenmessungen bei Frauen als klinische Routine für die Vorhersage von Depressionen genutzt werden

Host pathogen interactions in relation to management of light leaf spot disease (caused by Pyrenopeziza brassicae) on Brassica species

Light leaf spot, caused by Pyrenopeziza brassicae, is currently the most damaging disease problem in oilseed rape in the UK. According to recent survey data, the severity of epidemics has increased progressively across the UK, with current yield losses of up to £160M per annum in England and more severe epidemics in Scotland. Light leaf spot is a polycyclic disease with primary inoculum consisting of air-borne ascospores produced on diseased debris from the previous cropping season. Splash-dispersed conidia produced on diseased leaves are the main component of the secondary inoculum. P. brassicae is also able to infect and cause considerable yield losses on vegetable brassicas, especially Brussels sprouts. There may be spread of light leaf spot among different brassica species. Since they have a wide host range, Pyrenopeziza brassicae populations are likely to have considerable genetic diversity and there is evidence suggesting population variations between different regions, which need further study. Available disease-management tools are not sufficient to provide adequate control of the disease. There is a need to identify new sources of resistance, which can be integrated with fungicide applications to achieve sustainable management of light leaf spot. Several major resistance genes and quantitative trait loci have been identified in previous studies, but rapid improvements in the understanding of molecular mechanisms underpinning B. napus – P. brassicae interactions can be expected through exploitation of novel genetic and genomic information for brassicas and extracellular fungal pathogens.Peer reviewe

Franck-Condon Effect in Central Spin System

We study the quantum transitions of a central spin surrounded by a collective-spin environment. It is found that the influence of the environmental spins on the absorption spectrum of the central spin can be explained with the analog of the Franck-Condon (FC) effect in conventional electron-phonon interaction system. Here, the collective spins of the environment behave as the vibrational mode, which makes the electron to be transitioned mainly with the so-called "vertical transitions" in the conventional FC effect. The "vertical transition" for the central spin in the spin environment manifests as, the certain collective spin states of the environment is favored, which corresponds to the minimal change in the average of the total spin angular momentum.Comment: 8 pages, 8 figure

Determinants of the voltage dependence of G protein modulation within calcium channel β subunits

CaVβ subunits of voltage-gated calcium channels contain two conserved domains, a src-homology-3 (SH3) domain and a guanylate kinase-like (GK) domain with an intervening HOOK domain. We have shown in a previous study that, although Gβγ-mediated inhibitory modulation of CaV2.2 channels did not require the interaction of a CaVβ subunit with the CaVα1 subunit, when such interaction was prevented by a mutation in the α1 subunit, G protein modulation could not be removed by a large depolarization and showed voltage-independent properties (Leroy et al., J Neurosci 25:6984–6996, 2005). In this study, we have investigated the ability of mutant and truncated CaVβ subunits to support voltage-dependent G protein modulation in order to determine the minimal domain of the CaVβ subunit that is required for this process. We have coexpressed the CaVβ subunit constructs with CaV2.2 and α2δ-2, studied modulation by the activation of the dopamine D2 receptor, and also examined basal tonic modulation. Our main finding is that the CaVβ subunit GK domains, from either β1b or β2, are sufficient to restore voltage dependence to G protein modulation. We also found that the removal of the variable HOOK region from β2a promotes tonic voltage-dependent G protein modulation. We propose that the absence of the HOOK region enhances Gβγ binding affinity, leading to greater tonic modulation by basal levels of Gβγ. This tonic modulation requires the presence of an SH3 domain, as tonic modulation is not supported by any of the CaVβ subunit GK domains alone

Parque Estadual da Ilha Grande ameaças ambientais e diretrizes para conservação

O Parque Estadual da Ilha Grande é somente uma parte (5.594 hectares) de toda a ilha (19.300 hectares) localizada na costa sul do Estado do Rio de Janeiro, entre as cidades de Mangaratiba e Angra dos Reis. Aproximadamente a metade da área do Parque (47%) é coberta por floresta densa, ombrófila, de Mata Atlântica. A mata secundária, em processo de regeneração por sucessão ecológica, está perto da maturidade (43%) e o restante (10%) é composto por áreas antropizadas (1%), afloramentos rochosos com vegetação herbácea (7%), restingas, manguezais e praias (2%). A fauna está bem representada, mas já mostra sinais de degradação com a presença de espécies introduzidas. A análise conduzida sobre o grau de ameaças mostrou que a floresta ombrófila densa está relativamente bem conservada, enquanto a mata secundária, as restingas e mangues e a vegetação herbácea dos terrenos rochosos (e suas respectivas faunas) estão categorizadas como vulneráveis. A área onde há ocupação humana é categorizada como ameaçada. Contraditoriamente, a maior ameaça à biodiversidade local em suas unidades de paisagens é o turismo. Uma vez que a costa onde se localiza a Ilha Grande tem alto valor cênico (conhecida como costa verde pelo constraste entre o mar e o verde da Mata Atlântica que cobre a Serra do Mar), o turismo tem alto potencial para se tornar o meio de atingir a sustentabilidade econômica para conservação. No entanto, por causa do turismo desorganizado e sem controle hoje em prática, com visitantes em número superior à capacidade de suporte na alta estação, a proliferação de hotéis, pousadas e acampamentos e o conseqüente esgoto a céu aberto, depósito de lixo e outras atividades prejudiciais à biodiversidade são as principais ameaças. _______________________________________________________________________________ ABSTRACTThe State Park of Ilha Grande is only a part (5,594 hectares) of the entire island (19,300 hectares) which is located off the south coast of Rio de Janeiro state, between the cities of Mangaratiba and Angra dos Reis. Approximately half of the Park area (47%) is covered by dense Atlantic forest. The secondary forest growth is in a process of ecological succession close to attaining maturity (43%) and the remaining part (10%) is composed of human-altered areas (1%), rocky outcrops with herbaceous vegetation (7%), mangroves and beaches (2%). The fauna is well represented but already shows signs of degradation with introduced species. The analysis of the degree of threat has shown that the dense forest habitat has a relatively stable status of conservation while the secondary forest, the mangrove and the herbaceous vegetation on rocky outcrops (and their fauna) are categorized as vulnerable. The area altered by human occupation is considered threatened. Since the coastal area where Ilha Grande is located is well known for its beautiful scenery (known as the green coast, because of the contrast between the ocean and the Atlantic forest covering the Serra do Mar mountain chain). There is a strong possibility for tourism to become the means in which to achieve economic sustainability for conservation. Contradictorily, tourism is also the major threat to local biodiversity and its landscape units. Because tourism is not organized and controlled, during high season the numbers grow above local capacity, giving rise to a proliferation of hotels, guesthouses and camping grounds. The resulting untreated open sewage, random garbage disposal and other harmful activities form the major threats to biodiversity

Avalanche amplification of a single exciton in a semiconductor nanowire

Interfacing single photons and electrons is a crucial ingredient for sharing quantum information between remote solid-state qubits. Semiconductor nanowires offer the unique possibility to combine optical quantum dots with avalanche photodiodes, thus enabling the conversion of an incoming single photon into a macroscopic current for efficient electrical detection. Currently, millions of excitation events are required to perform electrical read-out of an exciton qubit state. Here we demonstrate multiplication of carriers from only a single exciton generated in a quantum dot after tunneling into a nanowire avalanche photodiode. Due to the large amplification of both electrons and holes (> 10^4), we reduce by four orders of magnitude the number of excitation events required to electrically detect a single exciton generated in a quantum dot. This work represents a significant step towards single-shot electrical read-out and offers a new functionality for on-chip quantum information circuits