Caddoan Reburial

On February 7, 1993 in eastern Texas, the remains of a prehistoric Caddoan Indian were reburied in the original grave. A small ceremony was held to mark the occasion. Representatives of the Caddo Tribe from Oklahoma and Louisiana were in attendance, as were members of the Nonheast Texas Archeological Society (NETAS). This report deals with one case of recently excavated human remains

Archaeological Investigation at the Marshall Powder Mill (41HS17), Confederate States of America 1863-1865, Harrison County, Texas: 1994 Season

The Northeast Texas Archeological Society, in conjunction with the East Texas, Dallas, and Tarrant County archeological societies, reinstated archaeological investigations at the Marshall Powder Mill (41HS17) in 1994 following several years of delicate negotiations with the landowner about the value of preserving this archaeological site. The Marshall Powder Mill manufactured gunpowder, small arms and cannon, and refurbished weaponry, and was one of several arsenals that served the Trans-Mississippi Department of the Confederate States of America from 1863 to 1865. None have been thoroughly investigated archaeologically, however, thereby ignoring a major aspect of the Confederacy\u27s war effort, and an important industrial enterprise. Building foundations, earthworks, roads, and an artificial channel race remain essentially undisturbed within the Loop 390 corridor and the privately-owned portions of the site; the eastern one-third of the site has been destroyed by a modern lumber mill. Although the site is listed on the National Register of Historic Places, there is no concerted plan for preservation of this Civil War military-industrial complex. Little historical documentation exists as to the number and types of buildings, their locations, or the activities that were conducted at the Marshall Powder Mill. The single map in the National Archives was captured by Federal troops in 1864, and only indicates a few of the buildings and none of the earthworks. Apparently the Confederates were concerned with security, and the commander, Major George D. Alexander, destroyed or removed all records prior to Federal occupation of the site in 1865. Therefore, the archaeological remains speak the clearest about the Marshall Powder Mill\u27s buildings and their functions, and may be the only sure means of reconstructing the layout and design of the arsenal, as well as ancillary fortifications, buildings, and structures around Marshall that date to the Civil War period

Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin

International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L. pneumophila is thought to induce apoptosis during egress from macrophages. The bacterial effector protein, SidF, has been shown to control host cell survival and death by inhibiting pro-apoptotic BNIP3 and BCL-RAMBO signaling. Using live-cell imaging to follow the L. pneumophila-macrophage interaction, we now demonstrate that L. pneumophila evades host cell apoptosis independent of SidF. In the absence of SidF, L. pneumophila was able to replicate, cause loss of mitochondria membrane potential, kill macrophages, and establish infections in lungs of mice. Consistent with this, deletion of BNIP3 and BCL-RAMBO did not affect intracellular L. pneumophila replication, macrophage death rates, and in vivo bacterial virulence. Abrogating mitochondrial cell death by genetic deletion of the effectors of intrinsic apoptosis, BAX, and BAK, or the regulator of mitochondrial permeability transition pore formation, cyclophilin-D, did not affect bacterial growth or the initial killing of macrophages. Loss of BAX and BAK only marginally limited the ability of L. pneumophila to efficiently kill all macrophages over extended periods. L. pneumophila induced killing of macrophages was delayed in the absence of capsase-11 mediated pyroptosis. Together, our data demonstrate that L. pneumophila evades host cell death responses independently of SidF during replication and can induce pyroptosis to kill macrophages in a timely manner

Possible Archaeological Sites within the City Limits of Jefferson, Texas

In 1992, the author accompanied a longtime resident of Jefferson on a tour of the city to examine historic and prehistoric sites within the city limits that might be of archaeological interest. He became aware of many of these sites over 20 years ago while growing up in the area. The condition of the sites has, of course, changed radically since that time. Enough information about the sites was revealed to indicate where it might be worthwhile in the future to do more extensive archaeological and historical research. We began our tour at 12:00 noon on July 24, 1992. My host drove, allowing the author to take notes on the sites. The first stops on the tour were in North Jefferson, while later in the day some possible sites in South and East Jefferson were looked at. Each site was numbered chronologically as they were shown to the author; the sites were also plotted on a map of Marion County and Jefferson. The same numerical system will be used in this report

Archaeological Investigations at the Marshall Powdermill and Arsenal (41HS17), Confederate States of America 1864-1865, Harrison County, Texas

The Northeast Texas Archeological Society (NETAS), in conjunction with the East Texas, Dallas, and Tarrant County Archeological Societies has completed a year-long project at the Marshall Powder Mill, 41HS17, Harrison County, Texas. The Marshall Powder Mill manufactured gunpowder, small arms and cannon, and refurbished weaponry. It is one of several arsenals that served the Trans-Mississippi Department of the Confederate States of America, and was among the last in operation from 1864 to 1865. None have been thoroughly investigated archaeologically, thereby ignoring a major aspect of the Confederacy\u27s war effort and an important industrial enterprise

Архетип свобода у контексті французької політичної теорії та історії

Розглянуто сучасні підходи щодо аналізу політичної ментальності. У межах політологічного аналізу окреслено коло проблем, які потребують вирішення з використанням підходів психології. Зроблено висновок про те, що архетип “свобода” становить важливий елемент політичної ментальності французів.Modern approaches of analysis of political mentality are considered. Within the limits of political science analysis outlined circle of problems which need decision with the use of approaches of psychology. A conclusion is done that archetype freedom makes the important element of political mentality of French’s

SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation

Synchronization of mitochondrial and cytoplasmic translation rates is critical for the maintenance of cellular fitness, with cancer cells being especially vulnerable to translational uncoupling. Although alterations of cytosolic protein synthesis are common in human cancer, compensating mechanisms in mitochondrial translation remain elusive. Here we show that the malignant long non-coding RNA (lncRNA) SAMMSON promotes a balanced increase in ribosomal RNA (rRNA) maturation and protein synthesis in the cytosol and mitochondria by modulating the localization of CARF, an RNA-binding protein that sequesters the exo-ribonuclease XRN2 in the nucleoplasm, which under normal circumstances limits nucleolar rRNA maturation. SAMMSON interferes with XRN2 binding to CARF in the nucleus by favoring the formation of an aberrant cytoplasmic RNA-protein complex containing CARF and p32, a mitochondrial protein required for the processing of the mitochondrial rRNAs. These data highlight how a single oncogenic lncRNA can simultaneously modulate RNA-protein complex formation in two distinct cellular compartments to promote cell growth

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

BACKGROUND:DNA methylation is affected by the activities of the key enzymes and intermediate metabolites of the one-carbon pathway, one of which involves homocysteine. We investigated the effect of the well-known genetic variant associated with mildly elevated homocysteine: MTHFR 677C>T independently and in combination with other homocysteine-associated variants, on genome-wide leukocyte DNA-methylation. METHODS:Methylation levels were assessed using Illumina 450k arrays on 9,894 individuals of European ancestry from 12 cohort studies. Linear-mixed-models were used to study the association of additive MTHFR 677C>T and genetic-risk score (GRS) based on 18 homocysteine-associated SNPs, with genome-wide methylation. RESULTS:Meta-analysis revealed that the MTHFR 677C>T variant was associated with 35 CpG sites in cis, and the GRS showed association with 113 CpG sites near the homocysteine-associated variants. Genome-wide analysis revealed that the MTHFR 677C>T variant was associated with 1 trans-CpG (nearest gene ZNF184), while the GRS model showed association with 5 significant trans-CpGs annotated to nearest genes PTF1A, MRPL55, CTDSP2, CRYM and FKBP5. CONCLUSIONS:Our results do not show widespread changes in DNA-methylation across the genome, and therefore do not support the hypothesis that mildly elevated homocysteine is associated with widespread methylation changes in leukocytes

Conceptual design for a receiving station for the nondestructive assay of PuO/sub 2/ at the fuels and materials examination facility

We propose a conceptual design for a receiving station for input accountability measurements on PuO/sub 2/ received at the Fuels and Materials Examination Facility at the Hanford Engineering Development Laboratory. Nondestructive assay techniques are proposed, including neutron coincidence counting, calorimetry, and isotopic determination by gamma-ray spectroscopy, in a versatile data acquisition system to perform input accountability measurements with precisions better than 1% at throughputs of up to 2 M.T./yr of PuO/sub 2/