1,189 research outputs found
The 6-GHz multibeam maser survey III: comparison between the MMB and HOPS
We have compared the occurrence of 6.7-GHz and 12.2-GHz methanol masers with 22-GHz water masers and 6035-MHz excited-state OH masers in the 100 square degree region of the southern Galactic plane common to the Methanol Multibeam (MMB) and H2O southern Galactic Plane surveys (HOPS). We find the most populous star formation species to be 6.7-GHz methanol, followed by water, then 12.2-GHz and, finally, excited-state OH masers. We present association statistics, flux density (and luminosity where appropriate) and velocity range distributions across the largest, fully surveyed portion of the Galactic plane for four of the most common types of masers found in the vicinity of star formation regions. Comparison of the occurrence of the four maser types with far-infrared dust temperatures shows that sources exhibiting excited-state OH maser emission are warmer than sources showing any of the other three maser types. We further find that sources exhibiting both 6.7-GHz and 12.2-GHz methanol masers are warmer than sources exhibiting just 6.7-GHz methanol maser emission. These findings are consistent with previously made suggestions that both OH and 12.2-GHz methanol masers generally trace a later stage of star formation compared to other common maser types
The effects of supernovae on the dynamical evolution of binary stars and star clusters
In this chapter I review the effects of supernovae explosions on the
dynamical evolution of (1) binary stars and (2) star clusters.
(1) Supernovae in binaries can drastically alter the orbit of the system,
sometimes disrupting it entirely, and are thought to be partially responsible
for `runaway' massive stars - stars in the Galaxy with large peculiar
velocities. The ejection of the lower-mass secondary component of a binary
occurs often in the event of the more massive primary star exploding as a
supernova. The orbital properties of binaries that contain massive stars mean
that the observed velocities of runaway stars (10s - 100s km s) are
consistent with this scenario.
(2) Star formation is an inherently inefficient process, and much of the
potential in young star clusters remains in the form of gas. Supernovae can in
principle expel this gas, which would drastically alter the dynamics of the
cluster by unbinding the stars from the potential. However, recent numerical
simulations, and observational evidence that gas-free clusters are observed to
be bound, suggest that the effects of supernova explosions on the dynamics of
star clusters are likely to be minimal.Comment: 16 pages, to appear in the 'Handbook of Supernovae', eds. Paul Murdin
and Athem Alsabti. This version replaces an earlier version that contained
several typo
Tuning supersymmetric models at the LHC: A comparative analysis at two-loop level
We provide a comparative study of the fine tuning amount (Delta) at the
two-loop leading log level in supersymmetric models commonly used in SUSY
searches at the LHC. These are the constrained MSSM (CMSSM), non-universal
Higgs masses models (NUHM1, NUHM2), non-universal gaugino masses model (NUGM)
and GUT related gaugino masses models (NUGMd). Two definitions of the fine
tuning are used, the first (Delta_{max}) measures maximal fine-tuning wrt
individual parameters while the second (Delta_q) adds their contribution in
"quadrature". As a direct result of two theoretical constraints (the EW minimum
conditions), fine tuning (Delta_q) emerges as a suppressing factor (effective
prior) of the averaged likelihood (under the priors), under the integral of the
global probability of measuring the data (Bayesian evidence p(D)). For each
model, there is little difference between Delta_q, Delta_{max} in the region
allowed by the data, with similar behaviour as functions of the Higgs, gluino,
stop mass or SUSY scale (m_{susy}=(m_{\tilde t_1} m_{\tilde t_2})^{1/2}) or
dark matter and g-2 constraints. The analysis has the advantage that by
replacing any of these mass scales or constraints by their latest bounds one
easily infers for each model the value of Delta_q, Delta_{max} or vice versa.
For all models, minimal fine tuning is achieved for M_{higgs} near 115 GeV with
a Delta_q\approx Delta_{max}\approx 10 to 100 depending on the model, and in
the CMSSM this is actually a global minimum. Due to a strong (
exponential) dependence of Delta on M_{higgs}, for a Higgs mass near 125 GeV,
the above values of Delta_q\approx Delta_{max} increase to between 500 and
1000. Possible corrections to these values are briefly discussed.Comment: 23 pages, 46 figures; references added; some clarifications (section
2
Enhanced thylakoid photoprotection can increase yield and canopy radiation use efficiency in rice
High sunlight can raise plant growth rates but can potentially cause cellular damage. The likelihood of deleterious effects is lowered by a sophisticated set of photoprotective mechanisms, one of the most important being the controlled dissipation of energy from chlorophyll within photosystem II (PSII) measured as non-photochemical quenching (NPQ). Although ubiquitous, the role of NPQ in plant productivity remains uncertain because it momentarily reduces the quantum efficiency of photosynthesis. Here we used plants overexpressing the gene encoding a central regulator of NPQ, the protein PsbS, within a major crop species (rice) to assess the effect of photoprotection at the whole canopy scale. We accounted for canopy light interception, to our knowledge for the first time in this context. We show that in comparison to wild-type plants, psbS overexpressors increased canopy radiation use efficiency and grain yield in fluctuating light, demonstrating that photoprotective mechanisms should be altered to improve rice crop productivity
Screening of DUB activity and specificity by MALDI-TOF mass spectrometry
Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive and fast assay to quantify in vitro DUB enzyme activity using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Unlike other current assays, this method uses unmodified substrates, such as diubiquitin topoisomers. By analyzing 42 human DUBs against all diubiquitin topoisomers we provide an extensive characterization of DUB activity and specificity. Our results confirm the high specificity of many members of the OTU and JAMM DUB families and highlight that all USPs tested display low linkage selectivity. We also demonstrate that this assay can be deployed to assess the potency and specificity of DUB inhibitors by profiling 11 compounds against a panel of 32 DUBs
Genome wide association mapping of grain arsenic, copper, molybdenum and zinc in rice (Oryza sativa L.) grown at four international field sites
Peer reviewedPublisher PD
Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR)
Bacterial populations co-ordinate gene expression collectively through quorum sensing (QS), a cell-to-cell communication mechanism employing diffusible signal molecules. The LysR-type transcriptional regulator (LTTR) protein PqsR (MvfR) is a key component of alkyl-quinolone (AQ)-dependent QS in Pseudomonas aeruginosa. PqsR is activated by 2-alkyl-4-quinolones including the Pseudomonas quinolone signal (PQS; 2-heptyl-3-hydroxy-4(1H)-quinolone), its precursor 2-heptyl-4- hydroxyquinoline (HHQ) and their C9 congeners, 2-nonyl-3-hydroxy-4(1H)-quinolone (C9-PQS) and 2-nonyl-4-hydroxyquinoline (NHQ). These drive the autoinduction of AQ biosynthesis and the up-regulation of key virulence determinants as a function of bacterial population density. Consequently, PqsR constitutes a potential target for novel antibacterial agents which attenuate infection through the blockade of virulence. Here we present the crystal structures of the PqsR co-inducer binding domain (CBD) and a complex with the native agonist NHQ. We show that the structure of the PqsR CBD has an unusually large ligand-binding pocket in which a native AQ agonist is stabilized entirely by hydrophobic interactions. Through a ligand-based design strategy we synthesized and evaluated a series of 50 AQ and novel quinazolinone (QZN) analogues and measured the impact on AQ biosynthesis, virulence gene expression and biofilm development. The simple exchange of two isosteres (OH for NH2) switches a QZN agonist to an antagonist with a concomitant impact on the induction of bacterial virulence factor production. We also determined the complex crystal structure of a QZN antagonist bound to PqsR revealing a similar orientation in the ligand binding pocket to the native agonist NHQ. This structure represents the first description of an LTTR-antagonist complex. Overall these studies present novel insights into LTTR ligand binding and ligand-based drug design and provide a chemical scaffold for further anti-P. aeruginosa virulence drug development by targeting the AQ receptor PqsR
A precision study of the fine tuning in the DiracNMSSM
Recently the DiracNMSSM has been proposed as a possible solution to reduce
the fine tuning in supersymmetry. We determine the degree of fine tuning needed
in the DiracNMSSM with and without non-universal gaugino masses and compare it
with the fine tuning in the GNMSSM. To apply reasonable cuts on the allowed
parameter regions we perform a precise calculation of the Higgs mass. In
addition, we include the limits from direct SUSY searches and dark matter
abundance. We find that both models are comparable in terms of fine tuning,
with the minimal fine tuning in the GNMSSM slightly smaller.Comment: 20 pages + appendices, 10 figure
A free weekly iron-folic acid supplementation and regular deworming program is associated with improved hemoglobin and iron status indicators in Vietnamese women
Background Anemia due to iron deficiency is recognized as one of the major nutritional deficiencies in women and children in developing countries. Daily iron supplementation for pregnant women is recommended in many countries although there are few reports of these programs working efficiently or effectively. Weekly iron-folic acid supplementation (WIFS) and regular deworming treatment is recommended for non-pregnant women living in areas with high rates of anemia. Following a baseline survey to assess the prevalence of anemia, iron deficiency and soil transmitted helminth infections, we implemented a program to make WIFS and regular deworming treatment freely and universally available for all women of reproductive age in two districts of a province in northern Vietnam over a 12 month period. The impact of the program at the population level was assessed in terms of: i) change in mean hemoglobin and iron status indicators, and ii) change in the prevalence of anemia, iron deficiency and hookworm infections. Method Distribution of WIFS and deworming were integrated with routine health services and made available to 52,000 women. Demographic data and blood and stool samples were collected in baseline, and three and 12-month post-implementation surveys using a population-based, stratified multi-stage cluster sampling design. Results The mean Hb increased by 9.6 g/L (95% CI, 5.7, 13.5, p < 0.001) during the study period. Anemia (Hb<120 g/L) was present in 131/349 (37.5%, 95% CI 31.3, 44.8) subjects at baseline, and in 70/363 (19.3%, 95% CI 14.0, 24.6) after twelve months. Iron deficiency reduced from 75/329 (22.8%, 95% CI 16.9, 28.6) to 33/353 (9.3%, 95% CI 5.7, 13.0) by the 12-mnth survey, and hookworm infection from 279/366 (76.2%,, 95% CI 68.6, 83.8) to 66/287 (23.0%, 95% CI 17.5, 28.5) over the same period. Conclusion A free, universal WIFS program with regular deworming was associated with reduced prevalence and severity of anemia, iron deficiency and h
The environmental impact of fertilizer embodied in a wheat-to-bread supply chain
Food production and consumption cause approximately one-third of total greenhouse gas emissions, and therefore delivering food security challenges not only the capacity of our
agricultural system, but also its environmental sustainability. Knowing where and at what level environmental impacts
occur within particular food supply chains is necessary if
farmers, agri-food industries and consumers are to share
responsibility to mitigate these impacts. Here we present
an analysis of a complete supply chain for a staple of the
global diet, a loaf of bread. We obtained primary data for all
the processes involved in the farming, production and transport
systems that lead to the manufacture of a particular brand of
800 g loaf. The data were analysed using an advanced life
cycle assessment (LCA) tool, yielding metrics of environmental
impact, including greenhouse gas emissions. We show
that more than half of the environmental impact of producing
the loaf of bread arises directly from wheat cultivation, with
the use of ammonium nitrate fertilizer alone accounting for
around 40%. These findings reveal the dependency of bread
production on the unsustainable use of fertilizer and illustrate
the detail needed if the actors in the supply chain are to
assume shared responsibility for achieving sustainable
food production
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