Progesterone in breast cancer angiogenesis

The involvement of steroid hormones in breast carcinogenesis is well established. Recent evidence suggests that angiogenesis can be regulated by hormones. Both oestrogen and progesterone have been implicated in the angiogenic process of hormone-dependent cancers, such as breast cancer. Vascular Endothelial Growth Factor (VEGF) is a growth factor involved in angiogenesis in breast cancer that is up-regulated by estrogens. In our study we evaluated the role of progesterone in the expression of this angiogenic growth factor commonly up-regulated in breast cancer. Our findings indicate that progesterone activates an angiogenic pathway involving VEGF stimulation. The elucidation of specific angiogenic pathways promoted by progesterone can raise new therapeutic targets at least in a subset of breast cancers responsive to progesterone

The Sub-Surface Structure of a Large Sample of Active Regions

We employ ring-diagram analysis to study the sub-surface thermal structure of active regions. We present results using a large number of active regions over the course of Solar Cycle 23. We present both traditional inversions of ring-diagram frequency differences, with a total sample size of 264, and a statistical study using Principal Component Analysis. We confirm earlier results on smaller samples that sound speed and adiabatic index are changed below regions of strong magnetic field. We find that sound speed is decreased in the region between approximately r=0.99R_sun and r=0.995R_sun (depths of 3Mm to 7Mm), and increased in the region between r=0.97R_sun and r=0.985R_sun (depths of 11Mm to 21Mm). The adiabatic index is enhanced in the same deeper layers that sound-speed enhancement is seen. A weak decrease in adiabatic index is seen in the shallower layers in many active regions. We find that the magnitudes of these perturbations depend on the strength of the surface magnetic field, but we find a great deal of scatter in this relation, implying other factors may be relevant.Comment: 16 pages, 11 figures, accepted for publication in Solar Physic

Pathways of estrogen metabolism underlying the association between Schistosoma haematobium and bladder cancer

Squamous cell carcinoma (SCC) is a malignant, poorly differentiated neuroendocrine neoplasm. SCC is the common form of bladder cancer in rural Africa where S. haematobium is prevalent. In contrast, the majority of bladder cancer in developing countries and regions not endemic for urogenital schistosomiasis is transitional cell carcinoma (TCC) that arises from the transitional epithelium lining of the bladder. The parasite eggs trapped in the bladder wall release antigens and other metabolites (presumably evolved to expedite egress to the urine, and hence to the external environment). However, the phenomenon leads to haematuria and to chronic inflammation, in turn increasing risk of SCC of the bladder. In addition to the hormone- -like effects of the parasite estradiol-related molecules on the endocrine and immune system of the host, in relation to cancer initiation metabolites of estrogens can be also considered as carcinogenic chemicals.info:eu-repo/semantics/publishedVersio

Results of the First Exchange on Pouting Otoliths 2015

El documento muestra los resultados obtenidos en el primer intercambio ibérico de lectura de otolitos de faneca (Trisopterus luscus

Spatially Variable Reaction In The Formation Of Anodically Grown Porous Silicon Structures

In porous silicon formations there is an increase of dissolution rate at the fluorine-covered sites of the silicon surface due to the presence of excess electrons coming from oxidation of molecular hydrogen at the passivated (hydrogen-covered) sites. The dissolution rate increase in the presence of excess charge at the fluorine-covered sites is experimentally measured and a theoretical investigation is carried out by a semiempirical Hartree-Fock calculation. This spatially variable dissolution generates the porous silicon surface. © 1995 American Institute of Physics.78159059

Prototype implementation of a smart locker

Smart lockers are intelligent storage units that are increasingly being adopted to help solving the last mile problem. This paper focuses on the concept of an individual smart locker that can be installed at the entrance of a residential house. First, the operational principle and advantages of this concept are discussed. Then, the design, development and implementation of a functional prototype is demonstrated. The prototype was submitted to tests and can be used as a proof of concept.info:eu-repo/semantics/publishedVersio

Expression of angiogenic and inflammation markers in murine schistosomiasis mansoni

Aim: to study angiogenesis in the livers of mice infected with S. mansoni.N/

Comparison of engine power correction factors for varying atmospheric conditions

This work evaluates proposed methods to correct engine power output as a function of atmospheric conditions. The analysis was made through experiments carried out in a vehicle on the road, under different temperature, pressure and air humidity conditions. The vehicle had a four-cylinder gasoline-fuelled engine, with multi-point fuel injection system, variable intake pipe length and variable intake valve camshaft position. The vehicle was tested at sea level and at 827 m above sea level, corresponding to atmospheric pressures between 1027 and 926 mbar. Air temperature varied from 22.8 to 33.8°C at the test locations. The measured performance parameter in the tests was the vehicle acceleration time. The acceleration times from 0 to 400 m, 0 to 1000 m, 40 to 100 km/h and 80 to 120 km/h were all recorded, leaving from an initial vehicle speed of 40 km/h. The engine power curve obtained in laboratory under a standard ambient condition was corrected to the conditions of the road tests by the correction factors proposed by the methods under evaluation, and the corresponding acceleration times were calculated and compared with the measurements from the road tests. The evaluated methods for power correction were the following: DIN 70020, SAE J 1349, JIS D 1001 and ISO 1585. The SAE J 1349 method provided the best approach between the experimental and calculated acceleration times