16 research outputs found

    Meaning in Life as a Mediator of Ethnic Identity and Adjustment Among Adolescents from Latin, Asian, and European American Backgrounds

    Get PDF
    Establishing a sense of life meaning is a primary facet of well-being, yet is understudied in adolescent development. Using data from 579 adolescents (53% female) from Latin American, Asian, and European backgrounds, demographic differences in meaning in life, links with psychological and academic adjustment, and the role of meaning in explaining associations between ethnic identity and adjustment were examined. Although no generational or gender differences were found, Asian Americans reported higher search for meaning than Latin and European Americans. Presence of meaning was positively associated with self-esteem, academic adjustment, daily well-being, and ethnic belonging and exploration, whereas search for meaning was related to lower self-esteem and less stability in daily well-being. Presence of meaning mediated associations between ethnic identity and adjustment, explaining 28–52% of ethnic identity’s protective effect on development. Ethnic identity thus appears to affect adjustment, in part, through its role in fostering a positive sense of meaning in adolescents’ lives

    Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

    Get PDF
    Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

    Association between different anti-Tat antibody isotypes and HIV disease progression: data from an African cohort

    Get PDF
    Background: The presence of IgG and IgM against Tat, an HIV protein important for viral replication and immune dysfunction, is associated with slow disease progression in clade B HIV-infected individuals. However, although Tat activities strictly depend on the viral clade, our knowledge about the importance of anti-Tat antibodies in non-clade B HIV infection is poor. The objective of this study was to investigate the association of different anti-Tat antibody isotypes with disease progression in non-clade B HIV-infected subjects and to study the relationship between anti-Tat humoral responses and immunological abnormalities. Methods: Anti-clade B and - clade C Tat IgG, IgM and IgA titers were assessed in serum samples from 96 cART-naive subjects with chronic HIV infection from Mbeya, Tanzania, and associated with CD4(+) T cell count, plasma viremia and CD4(+) and CD8(+) T cell phenotypes. Results: Anti-Tat IgM were preferentially detected in chronic HIV-infected subjects with low T cell activation (p-value = 0.03) and correlated with higher CD4(+) T cell counts and lower viral loads irrespective of the duration of infection (p-value = 0.019 and p-value = 0.037 respectively). Conversely, anti-Tat IgA were preferentially detected in individuals with low CD4(+) T cell counts and high viral load (p-value = 0.02 and p-value < 0.001 respectively). The simultaneous presence of anti-Tat IgG and IgM protected from fast CD4(+) T cell decline (p-value < 0.01) and accumulation of CD38(+) HLADR(+) CD8(+) T cells (p-value = 0.029). Conclusions: Anti-Tat IgG alone are not protective in non-clade B infected subjects, unless concomitant with IgM, suggesting a protective role of persistent anti-Tat IgM irrespective of the infecting clade

    The revised Multidimensional Model of MAori Identity and Cultural Engagement (MMM-ICE2)

    No full text
    We update and validate the revised Multidimensional Model of Māori Identity and Cultural Engagement (MMM-ICE2) by including a seventh Perceived Appearance subscale. The MMM-ICE2 is designed to assess the subjective experiences, efficacy and evaluation of different facets of identity for Māori (the indigenous peoples of New Zealand). Confirmatory Factor Analysis of an online Māori community sample (N = 276) supported the revised seven-factor model assessing Group Membership Evaluation, Cultural Efficacy and Active Identity Engagement, Interdependent Self-Concept, Spirituality, Socio-Political Consciousness, Authenticity Beliefs, and the new Perceived Appearance subscale. The Perceived Appearance subscale was internally reliable and predicted unique variation in perceived discrimination and mixed ethnic affiliation as both Māori and European when adjusting for the other MMM-ICE2 subscale scores. The MMM-ICE2 is a public domain, quantitative self-report measure for use in statistical models to predict and understand the outcomes and protective function of different aspects of identity for Māori. Keywords: Māori, Psychometric, Identity, Self-report questionnaire, Scale developmen

    Are mixed-ethnic unions more likely to dissolve than co-ethnic unions? New evidence from Britain

    Get PDF
    The increasing proportion of ethnic minorities in Britain has been paralleled by an increase in the occurrence of mixed-ethnic marriages between one White partner and an ethnic minority partner. Such marriages are thought to be at higher risk of divorce, but empirical studies so far have been inconclusive. This paper uses the Office for National Statistics longitudinal study for England and Wales to investigate whether mixed-ethnic unions are more likely to end in divorce than co-ethnic unions. We followed married couples in 1991–2001 and examined their risks of divorce. We found evidence that mixed-ethnic unions have a higher risk of dissolution than co-ethnic unions. However, after controlling for partners’ characteristics, most importantly the younger ages of people in mixed-ethnic unions, the risk of divorce for mixed-ethnic unions was no longer elevated, but lay close to the higher risk found for the two constituent co-ethnic unions.OTB Research Institute for the Built Environmen
    corecore