8 research outputs found

    Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

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    Kidney size and function in a multi-ethnic population-based cohort of school-age children

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    Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

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    Genetic studies of body mass index yield new insights for obesity biology

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    Note: A full list of authors and affiliations appears at the end of the article. Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p
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