Tye7 regulates yeast Ty1 retrotransposon sense and antisense transcription in response to adenylic nucleotides stress

Transposable elements play a fundamental role in genome evolution. It is proposed that their mobility, activated under stress, induces mutations that could confer advantages to the host organism. Transcription of the Ty1 LTR-retrotransposon of Saccharomyces cerevisiae is activated in response to a severe deficiency in adenylic nucleotides. Here, we show that Ty2 and Ty3 are also stimulated under these stress conditions, revealing the simultaneous activation of three active Ty retrotransposon families. We demonstrate that Ty1 activation in response to adenylic nucleotide depletion requires the DNA-binding transcription factor Tye7. Ty1 is transcribed in both sense and antisense directions. We identify three Tye7 potential binding sites in the region of Ty1 DNA sequence where antisense transcription starts. We show that Tye7 binds to Ty1 DNA and regulates Ty1 antisense transcription. Altogether, our data suggest that, in response to adenylic nucleotide reduction, TYE7 is induced and activates Ty1 mRNA transcription, possibly by controlling Ty1 antisense transcription. We also provide the first evidence that Ty1 antisense transcription can be regulated by environmental stress conditions, pointing to a new level of control of Ty1 activity by stress, as Ty1 antisense RNAs play an important role in regulating Ty1 mobility at both the transcriptional and post-transcriptional stages

Science with the space-based interferometer eLISA. II: gravitational waves from cosmological phase transitions

We investigate the potential for the eLISA space-based interferometer to detect the stochastic gravitational wave background produced by strong first-order cosmological phase transitions. We discuss the resulting contributions from bubble collisions, magnetohydrodynamic turbulence, and sound waves to the stochastic background, and estimate the total corresponding signal predicted in gravitational waves. The projected sensitivity of eLISA to cosmological phase transitions is computed in a model-independent way for various detector designs and configurations. By applying these results to several specific models, we demonstrate that eLISA is able to probe many well-motivated scenarios beyond the Standard Model of particle physics predicting strong first-order cosmological phase transitions in the early Universe

Comment les patients insuffisants respiratoires chroniques trachéotomisés évaluent-ils leur qualité de vie et leur prise en charge au CHU d Angers ?

ANGERS-BU Médecine-Pharmacie (490072105) / SudocSudocFranceF

D.D. Francisci Amostazo ... Alvearensis ... De causis piis in genere, et in specie libri VIII... : tomus secundus...

3 ej. de la misma obraMarca tip. en port.: "Papillon f."Texto a dos col.El ej. El ej. BHR/B-049-190 (2) enc. junto: "D.D. Francisci Amostazo ... Alvearensis ... De causis piis in genere, et in specie libri VIII... : tomus primus", formando un vol. facticioCCPB000139150-XBHR/A-010-101 (2)BHR/A-016-057BHR/A-016-057BHR/B-049-190 (2).BHR/B-049-190 (2).PielPerg.Piel0890406624FDH/1721-13-57E-18 T-5 N-426-1-4Hª Derecho/N-97 (2)*6, A-Z6, Aa-Ll6, Mm

Diversité génétique des erythrovirus humains

CHATENAY M.-PARIS 11-BU Pharma. (920192101) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF

D. Ioannis Gutierrez J.C. hispani ... Opera omnia : in XV partes et X tomos distributa ... : tomus primus seu Practicarum quaestionum civilium super quinque prioribus libris primae partis legum novae collectionis regiae hispaniae libri duo priores...

Tít. en antep.: "D. Joannis Gutierrez ... Opera omnia civilia, canonica et criminalia, in XV partes et X tomos distributa cum repertorio generali"Port. con marca tip. calc.: "V.L.S", de los hermanos TournesTexto a dos col.CCPB000180634-3IT\ICCU\UBOE\053679BHR/B-049-193.Perg.FDH 38484N-96 (1){u03EF}4, {u03EF}{u03EF}2, a6, A-Z6, Aa-Mm

D. Ioannis Gutierrez J.C. hispani ... Operum tomus septimus seu Tractatus de tutelis et curis minorum deque officio, obligatione & mercede tutorum ac curatorum...

Port. con marca tip. calc.: "V.L.S.", de los hermanos TournesTexto a dos col.Enc. junto con: "D. Joannis Gutierrez J.C. hispani ... Operum tomus sextus seu Tractatus tripartitus de juramento confirmatorio & aliis in jure variis resolutionibus...", formando un vol. facticioCCPB000180947-4BHR/B-049-011 (2).Perg.FDH 38474Hª Derecho/N-96 (6-7)4, A-Z6, Aa-Bb6, Cc

D. Ioannis Gutierrez J.C. hispani ... Operum tomus sextus seu Tractatus tripartitus de juramento confirmatorio & aliis in jure variis resolutionibus...

Port. con marca tip. calc.: "V.L.S.", de los hermanos TournesTexto a dos col.Enc. junto con: "D. Joannis Gutierrez J.C. hispani ... Operum tomus septimus seu Tractatus de tutelis et curis minorum deque officio, obligatione & mercede tutorum ac curatorum...", formando un vol. facticioCCPB000180956-3BHR/B-049-011 (1).Perg.FDH 38474Hª Derecho/N-96 (6-7)a4, A-Z6, Aa-Hh

Robust Seriation and Applications to Cancer Genomics

The seriation problem seeks to reorder a set of elements given pairwise similarity information, so that elements with higher similarity are closer in the resulting sequence. When a global ordering consistent with the similarity information exists, an exact spectral solution recovers it in the noiseless case and seriation is equivalent to the combinatorial 2-SUM problem over permutations, for which several relaxations have been derived. However, in applications such as DNA assembly, similarity values are often heavily corrupted, and the solution of 2-SUM may no longer yield an approximate serial structure on the elements. We introduce the robust seriation problem and show that it is equivalent to a modified 2-SUM problem for a class of similarity matrices modeling those observed in DNA assembly. We explore several relaxations of this modified 2-SUM problem and compare them empirically on both synthetic matrices and real DNA data. We then introduce the problem of seriation with duplications, which is a generalization of Seriation motivated by applications to cancer genome reconstruction. We propose an algorithm involving robust seriation to solve it, and present preliminary results on synthetic data sets

Título: Variae resolutiones juris civilis, communis et regii.

Tit. en antep. : "Opera omnia aucta, indice generali adornata, et duobus tomis distincta"Datos de ed. preceden al indice.Sign. : a\p4\s, A-Z\p6\s, 2A-2Y\p6\s, 2Z\p5\s.Multiples errores tip. de sign.Texto a dos col.Port. a dos tintas.Port. con grab. xil. : "Papillon. f.", representa escena alegórica con la flor de lis en el centro