THE MAGNETIC FIELD AND POLARIZATION PROPERTIES OF RADIO GALAXIES IN DIFFERENT ACCRETION STATES

We use the integrated polarized radio emission at 1.4 GHz (P1.4 GHz) from a large sample of active galactic nuclei (AGN; 796 sources at redshifts z < 0.7) to study the large-scale magnetic field properties of radio galaxies in relation to the host galaxy accretion state. We find a fundamental difference in P1.4 GHz between radiative-mode AGN (i.e., high-excitation radio galaxies (HERGs) and radio-loud QSOs) and jet-mode AGN (i.e., low-excitation radio galaxies (LERGs)). While LERGs can achieve a wide range of P1.4 GHz (up to ∼30%), the HERGs and radioloud QSOs are limited to P1.4 GHz 15%. A difference in P1.4 GHz is also seen when the sample is divided at 0.5% of the total Eddington-scaled accretion rate, where the weakly accreting sources can attain higher values of P1.4 GHz. We do not find any clear evidence that this is driven by intrinsic magnetic field differences of the different radio morphological classes. Instead, we attribute the differences in P1.4 GHz to the local environments of the radio sources, in terms of both the ambient gas density and the magnetoionic properties of this gas. Thus, not only are different large-scale gaseous environments potentially responsible for the different accretion states of HERGs and LERGs, we argue that the large-scale magnetized environments may also be important for the formation of powerful AGN jets. Upcoming high angular resolution and broadband radio polarization surveys will provide the high-precision Faraday rotation measure and depolarization data required to robustly test this claim

Osmium isotope evidence for two pulses of increased continental weathering linked to Early Jurassic volcanism and climate change

Large igneous provinces (LIPs) are proposed to have caused a number of episodes of abrupt environmental change by increasing atmospheric CO2 levels, which were subsequently alleviated by drawdown of CO2 via enhanced continental weathering and burial of organic matter. Here the sedimentary records of two such episodes of environmental change, the Toarcian oceanic anoxic event (T-OAE) and preceding Pliensbachian–Toarcian (Pl-To) event (both possibly linked to the Karoo-Ferrar LIP), are investigated using a new suite of geochemical proxies that have not been previously compared. Stratigraphic variations in osmium isotope (187Os/188Os) records are compared with those of mercury (Hg) and carbon isotopes (d13C) in samples from the Mochras core, Llanbedr Farm, Cardigan Bay Basin, Wales. These sedimentary rocks are confirmed as recording an open-marine setting by analysis of molybdenum/uranium enrichment trends, indicating that the Os isotope record in these samples reflects the isotopic composition of the global ocean. The Os isotope data include the first results across the Pl-To boundary, when seawater 187Os/188Os increased from ~0.40 to ~0.53, in addition to new data that show elevated 187Os/188Os (from ~0.42 to ~0.68) during the T-OAE. Both increases in 187Os/188Os correlate with negative carbon isotope excursions and increased mercury concentrations, supporting an interplay between terrestrial volcanism, weathering, and climate that was instrumental in driving these distinct episodes of global environmental change. These observations also indicate that the environmental impact of the Karoo-Ferrar LIP was not limited solely to the T-OAE

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.

Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature GWAS in 44,042 individuals of Caucasian and Asian with replication in 88,218 UK Biobank data. We identified 47 loci (of which 26 are novel), with population-specific signals as well as shared signals across ethnicities. Some identified variants showed precise scaling in corneal curvature and eye elongation (i.e. axial length) to maintain eyes in emmetropia (i.e. HDAC11/FBLN2 rs2630445, RBP3 rs11204213); others exhibited association with myopia with little pleiotropic effects on eye elongation. Implicated genes are involved in extracellular matrix organization, developmental process for body and eye, connective tissue cartilage and glycosylation protein activities. Our study provides insights into population-specific novel genes for corneal curvature, and their pleiotropic effect in regulating eye size or conferring susceptibility to myopia

Multi-trait genome-wide association study identifies new loci associated with optic disc parameters

A new avenue of mining published genome-wide association studies includes the joint analysis of related traits. The power of this approach depends on the genetic correlation of traits, which reflects the number of pleiotropic loci, i.e. genetic loci influencing multiple traits. Here, we applied new meta-analyses of optic nerve head (ONH) related traits implicated in primary open-angle glaucoma (POAG); intraocular pressure and central corneal thickness using Haplotype reference consortium imputations. We performed a multi-trait analysis of ONH parameters cup area, disc area and vertical cup-disc ratio. We uncover new variants; rs11158547 in PPP1R36-PLEKHG3 and rs1028727 near SERPINE3 at genome-wide significance that replicate in independent Asian cohorts imputed to 1000 Genomes. At this point, validation of these variants in POAG cohorts is hampered by the high degree of heterogeneity. Our results show that multi-trait analysis is a valid approach to identify novel pleiotropic variants for ONH

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

The environments of radio-loud AGN from the LOFAR Two-Metre Sky Survey (LoTSS)

An understanding of the relationship between radio-loud active galaxies and their large-scale environments is essential for realistic modelling of radio-galaxy evolution and environmental impact, for understanding AGN triggering and life cycles, and for calibrating galaxy feedback in cosmological models. We use the LOFAR Two-Metre Sky Survey (LoTSS) Data Release 1 catalogues to investigate this relationship. We cross-matched a sample of 8,745 radio-loud AGN with 0.08 14 M⊙. We find that the probability of a cluster association, and the richness of the associated cluster, is correlated with AGN radio luminosity, and we also find that, for the cluster population, the number of associated AGN and the radio luminosity of the brightest associated AGN is richness-dependent. We demonstrate that these relations are not driven solely by host-galaxy stellar mass, supporting models in which large-scale environment is influential in driving AGN jet activity in the local Universe. At the lowest radio luminosities we find that the minority of objects with a cluster association are located at larger mean cluster-centre distances than more luminous AGN, an effect that appears to be driven primarily by host-galaxy mass. Finally, we also find that FRI radio galaxies inhabit systematically richer environments than FRIIs, consistent with previous work. The work presented here demonstrates the potential of LoTSS for AGN environmental studies. In future, the full northern-sky LoTSS catalogue, together with the use of deeper optical/IR imaging data and spectroscopic follow-up with WEAVE-LOFAR, will provide opportunities to extend this type of work to much larger samples and higher redshifts

Possible discovery of Calvera's supernova remnant

We report the discovery of a ring of low surface brightness radio emission around the Calvera pulsar, a high Galactic latitude, isolated neutron star, in the LOFAR Two-metre Sky Survey (LoTSS). It is centered at α = 14h11m12s.6, δ = +79°23'15", has inner and outer radii of 14'.2 and 28'.4, and has an integrated flux density at 144 MHz of 1.08 ± 0.15 Jy. The ring center is offset by 4'.9 from the location of the Calvera pulsar. Observations with the Isaac Newton Telescope in the Hα band show no coincident optical emission, but they do show a small (20") optical structure internal to the ring. We consider three possible interpretations for the ring: that it is an H II region, a supernova remnant (SNR), or an odd radio circle (ORC). The positional coincidence of the ring, the pulsar, and an X-ray-emitting non-equilibrium ionization plasma previously detected lead us to prefer the SNR interpretation. If the source is indeed a SNR and if its association with the Calvera pulsar is confirmed, then Calveraas SNR, or G118.4+37.0, will be one of few SNRs in the Galactic halo

Possible discovery of Calvera's supernova remnant

We report the discovery of a ring of low surface brightness radio emission around the Calvera pulsar, a high Galactic latitude, isolated neutron star, in the LOFAR Two-metre Sky Survey (LoTSS). It is centered at α = 14h11m12s.6, δ = +79°23'15", has inner and outer radii of 14'.2 and 28'.4, and has an integrated flux density at 144 MHz of 1.08 ± 0.15 Jy. The ring center is offset by 4'.9 from the location of the Calvera pulsar. Observations with the Isaac Newton Telescope in the Hα band show no coincident optical emission, but they do show a small (20") optical structure internal to the ring. We consider three possible interpretations for the ring: that it is an H II region, a supernova remnant (SNR), or an odd radio circle (ORC). The positional coincidence of the ring, the pulsar, and an X-ray-emitting non-equilibrium ionization plasma previously detected lead us to prefer the SNR interpretation. If the source is indeed a SNR and if its association with the Calvera pulsar is confirmed, then Calveraas SNR, or G118.4+37.0, will be one of few SNRs in the Galactic halo