638 research outputs found

    Book review of 'the people make the place: dynamic linkages between individuals and organizations edited by D. Brent Smith'

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    The People Make the Place is a festschrift celebrating the work of industrial/organizational psychologist Benjamin Schneider. It contains 11 specially written chapters each addressing a different element of Schneider’s work. The twelfth chapter, written by the honored scholar, summarizes the contributions and uses the opportunity to clarify many of the ideas surrounding attraction-selection-attrition (ASA) theory

    Farmland Prices: Is This Time Different?

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    The historical behavior of farmland prices, rental rates, and rates of return are examined by treating farmland as an asset with an infinitely long life. It is found that high (low) farmland prices relative to rents have historically preceded extended periods of low (high) net rates of return, rather than greater (smaller) growth in rents. Our analysis shows that this attribute is shared with stocks and housing, and the financial literature provides ample evidence that other assets feature it as well. The long-run relationship linking farmland prices, rents, and rates of return is analyzed. Based on this relationship, we conclude that recent trends are unlikely to be sustainable. The study explores the expected paths that farmland prices and rates of return might follow if they were to eventually conform to the average values observed in the historical sample, and concludes with a discussion of the policy implications. Recommendations for policy makers include close monitoring of farmland lending practices and institutions to allow early identification of potential problems, and identifying in advance appropriate interventions in case recent farmland market trends were to suddenly change

    Overcoming challenges to data quality in the ASPREE clinical trial

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    Š 2019 The Author(s). Background: Large-scale studies risk generating inaccurate and missing data due to the complexity of data collection. Technology has the potential to improve data quality by providing operational support to data collectors. However, this potential is under-explored in community-based trials. The Aspirin in reducing events in the elderly (ASPREE) trial developed a data suite that was specifically designed to support data collectors: the ASPREE Web Accessible Relational Database (AWARD). This paper describes AWARD and the impact of system design on data quality. Methods: AWARD's operational requirements, conceptual design, key challenges and design solutions for data quality are presented. Impact of design features is assessed through comparison of baseline data collected prior to implementation of key functionality (n = 1000) with data collected post implementation (n = 18,114). Overall data quality is assessed according to data category. Results: At baseline, implementation of user-driven functionality reduced staff error (from 0.3% to 0.01%), out-of-range data entry (from 0.14% to 0.04%) and protocol deviations (from 0.4% to 0.08%). In the longitudinal data set, which contained more than 39 million data values collected within AWARD, 96.6% of data values were entered within specified query range or found to be accurate upon querying. The remaining data were missing (3.4%). Participant non-attendance at scheduled study activity was the most common cause of missing data. Costs associated with cleaning data in ASPREE were lower than expected compared with reports from other trials. Conclusions: Clinical trials undertake complex operational activity in order to collect data, but technology rarely provides sufficient support. We find the AWARD suite provides proof of principle that designing technology to support data collectors can mitigate known causes of poor data quality and produce higher-quality data. Health information technology (IT) products that support the conduct of scheduled activity in addition to traditional data entry will enhance community-based clinical trials. A standardised framework for reporting data quality would aid comparisons across clinical trials

    Corrigendum to “Developmental synergy between thalamic structure and interhemispheric connectivity in the visual system of preterm infants” [NeuroImage: Clinical 8 (2015) 462–472]

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    Why preserve bamboos? Bamboos are a natural material and under natural conditions will gradually decay. If they are used as structural components they will need to be replaced after a period of time. The costs of this may prove prohibitive and the status of the bamboo will need constant monitoring to determine when it needs to be replaced. Preserving bamboos extends their life, reduces costs in the long run and improves safety of the structures they are used to form. What are sap displacement preservation methods? Sap displacement methods replace the sap in the vessels of a fresh bamboo culm with preservative. The culms are then left to stand for two weeks in order that the preservative can diffuse into the surrounding tissues and the preserving salts can be fixed in the cells. Sap displacement can be done by using natural capillary action or by one of a small range of simple pressurised techniques. What is the role of a sap displacement preservation unit in rural development? The unit itself offers employment opportunities to its employees and to many people in its forward and backward linkages. The unit can only treat freshly harvested bamboos and so a source of bamboos near to the unit is required. Local bamboo plantations can be established to supply the unit and create further income generating opportunities. Bamboos can be intercropped with food plants and the plantations can thereby increase the food security of the rural people that manage them. How do I establish a sap displacement unit? A sap displacement preservation unit can be established very cheaply. The only requirements are a supply of freshly harvested bamboos, labour and information from the secondary processors of their requirements. If a pressurised unit is to be established then a source of energy for the compressor will be needed. A pressurised unit capable of treating 50 bamboos per day can be established for USD $500, including a compressor, and non-pressurised units can be established for considerably less.Preserving bamboos extends their life, reduces costs in the long run and improves safety of the structures they are used to for

    3D-HST+CANDELS : the evolution of the galaxy size-mass distribution since z=3

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    Spectroscopic+photometric redshifts, stellar mass estimates, and rest-frame colors from the 3D-HST survey are combined with structural parameter measurements from CANDELS imaging to determine the galaxy size-mass distribution over the redshift range 0 < z < 3. Separating early- and late-type galaxies on the basis of star-formation activity, we confirm that early-type galaxies are on average smaller than late-type galaxies at all redshifts, and we find a significantly different rate of average size evolution at fixed galaxy mass, with fast evolution for the early-type population, R eff∝(1 + z)–1.48, and moderate evolution for the late-type population, R eff∝(1 + z)-0.75Peer reviewedFinal Accepted Versio

    A multistate model of health transitions in older people: a secondary analysis of ASPREE clinical trial data

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    Background: Understanding the nature of transitions from a healthy state to chronic diseases and death is important for planning health-care system requirements and interventions. We aimed to quantify the trajectories of disease and disability in a population of healthy older people. Methods: We conducted a secondary analysis of data from the ASPREE trial, which was done in 50 sites in Australia and the USA and recruited community-dwelling, healthy individuals who were aged 70 years or older (≥65 years for Black and Hispanic people in the USA) between March 10, 2010, and Dec 24, 2014. Participants were followed up with annual face-to-face visits, biennial assessments of cognitive function, and biannual visits for physical function until death or June 12, 2017, whichever occurred first. We used multistate models to examine transitions from a healthy state to first intermediate disease events (ie, cancer events, stroke events, cardiac events, and physical disability or dementia) and, ultimately, to death. We also examined the effects of age and sex on transition rates using Cox proportional hazards regression models. Findings: 19 114 participants with a median age of 74·0 years (IQR 71·6–77·7) were included in our analyses. During a median follow-up of 4·7 years (IQR 3·6–5·7), 1933 (10·1%) of 19 114 participants had an incident cancer event, 487 (2·5%) had an incident cardiac event, 398 (2·1%) had an incident stroke event, 924 (4·8%) developed persistent physical disability or dementia, and 1052 (5·5%) died. 15 398 (80·6%) individuals did not have any of these events during follow-up. The highest proportion of deaths followed incident cancer (501 [47·6%] of 1052) and 129 (12·3%) participants transitioned from disability or dementia to death. Among 12 postulated transitions, transitions from the intermediate states to death had much higher rates than transitions from a healthy state to death. The progression rates to death were 158 events per 1000 person-years (95% CI 144–172) from cancer, 112 events per 1000 person-years (86–145) from stroke, 88 events per 1000 person-years (68–111) from cardiac disease, 69 events per 1000 person-years (58–82) from disability or dementia, and four events per 1000 person-years (4–5) from a healthy state. Age was significantly associated with an accelerated rate for most transitions. Male sex (vs female sex) was significantly associated with an accelerate rate for five of 12 transitions. Interpretation: We describe a multistate model in a healthy older population in whom the most common transition was from a healthy state to cancer. Our findings provide unique insights into the frequency of events, their transition rates, and the impact of age and sex. These results have implications for preventive health interventions and planning for appropriate levels of residential care in healthy ageing populations. Funding: The National Institutes of Health

    Adaptation to life on land at high O-2 via transition from ferredoxin-to NADH-dependent redox balance

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    Pyruvate : ferredoxin oxidoreductase (PFO) and iron only hydrogenase ([Fe]-HYD) are common enzymes among eukaryotic microbes that inhabit anaerobic niches. Their function is to maintain redox balance by donating electrons from food oxidation via ferredoxin (Fd) to protons, generating H2 as a waste product. Operating in series, they constitute a soluble electron transport chain of one-electron transfers between FeS clusters. They fulfil the same function—redox balance—served by two electron-transfers in the NADH- and O2-dependent respiratory chains of mitochondria. Although they possess O2-sensitive FeS clusters, PFO, Fd and [Fe]-HYD are also present among numerous algae that produce O2. The evolutionary persistence of these enzymes among eukaryotic aerobes is traditionally explained as adaptation to facultative anaerobic growth. Here, we show that algae express enzymes of anaerobic energy metabolism at ambient O2 levels (21% v/v), Chlamydomonas reinhardtii expresses them with diurnal regulation. High O2 environments arose on Earth only approximately 450 million years ago. Gene presence/absence and gene expression data indicate that during the transition to high O2 environments and terrestrialization, diverse algal lineages retained enzymes of Fd-dependent one-electron-based redox balance, while the land plant and land animal lineages underwent irreversible specialization to redox balance involving the O2-insensitive two-electron carrier NADH

    On the SUSY Accompanied Neutrino Exchange Mechanism of Neutrinoless Double Beta Decay

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    The neutrinoless double beta decay (\znbb) induced by light Majorana neutrino exchange between decaying nucleons, accompanied by the squark exchange inside one nucleon, recently discussed by Babu and Mohapatra, is carefully analyzed both from the particle and nuclear physics sides. New nuclear matrix elements relevant to this mechanism are calculated. We extend the analysis to include mixing of light neutrinos with heavy and "sterile" neutrinos. It introduces another supersymmetric (SUSY) contribution to \znbb. We discuss constraints on the \rp MSSM parameters imposed by the current experimental limit on \znbb decay half-life of 76^{76}Ge.Comment: LATEX, 10 pages + 2 (uuencoded) figures appende
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