Discorso, testo e narrazione nella rappresentazione del paesaggio. Il piano paesaggistico sardo

Following a theoretical post-structuralist approach, the paper analyzes the discursive construction of the landscape in the Sardinian legislation from 2006 when it has been approved the first Regional Landscape Plan. The article focuses on the quality of being “built” of the landscape rather than on its technical aspects. The Landscape is a device capable of catalyzing and carrying very different and conflictual discourses, rhetorics and representations as well as an extraordinary tool that shapes reality. The analysis of the discourse on landscape and its protection in legislation can address and problematize the role played by the landscape in relation to broader economic and political interests

A synopsis based approach for XML fast approximate querying

In the last few years, XML has spread in many application fields and today it is used as a format to exchange data on the web, to ensure inter-operability among applications. Due to this success, the W3C has proposed a new query language, XQuery [25], specifically designed to query XML data. XQuery is a well-defined but rather complex language [14]. In this work we propose a new approach to overcome the problem of the high computational costs required by aggregate queries over massive XML data collections. In traditional relational warehouses [11] a similar problem is solved by means of fast approximate queries, that use concise data statistics based on histograms or on other statistical techniques. Their most common application is for aggregate queries in modern decision support systems, where large volumes of data need to be queried, and quick and interactive responses from the DBMS are claimed, e.g., to analyze the data in the warehouse in order to get trend information to evaluate marketing strategies. In such applications, users are often more interested to obtain an approximate answer computed in a short time rather than an exact one obtained in some minutes or, at the worst, hours

Decrease in neutrophil-to-lymphocyte ratio during neoadjuvant chemotherapy as a predictive and prognostic marker in advanced ovarian cancer

Since chronic inflammation is associated with ovarian cancer growth and progression, some clinical studies have assessed the association between the pre-treatment neutrophil-to-lymphocyte ratio (NLR) and the prognosis of ovarian cancer. The purpose of this study was to assess the dynamic behavior of the NLR during the course of neoadjuvant chemotherapy (NACT) in patients with high grade serous (HGS) advanced epithelial ovarian cancer and assess its correlation with clinical response, progression free survival (PFS) and changes in other inflammatory indexes. We performed a prospective observational study on 161 patients who underwent NACT at the Department of Gynecologic Oncology, ARNAS G. Brotzu, Cagliari, between 2009 and 2019. NLR was evaluated before starting and after three cycles of NACT. Based on response after three cycles of NACT, patients were divided into two groups: responsive and non-responsive. The primary endpoint was to assess the predictive role of NLR by comparing the responsive and non-responsive patients at baseline and after three cycles of NACT. Secondary endpoints were (a) to correlate NLR with other inflammation markers (CRP, fibrinogen, ferritin, IL-6), albumin, and modified Glasgow Prognostic Score (mGPS) with NLR at baseline and after NACT; (b) to assess the association between NLR and PFS. We found that the NLR value at baseline was not associated with response to NACT, while a decrease in NLR after three cycles was correlated with a better response to NACT. Also, values of CRP, IL-6, ferritin, and mGPS after three cycles of NACT (but not at baseline) were significantly associated with clinical response. Moreover, we found that patients with a low NLR value after 3 cycles of NACT, but not at baseline, had a significantly higher PFS than patients with high NLR after 3 cycles of NACT. In conclusion, NLR change during treatment could serve as a predictive marker of response to NACT in patients with HGS advanced ovarian cancer. This allows for the early identification of non-responsive patients who will need treatment remodeling

The bovine milk microbiota: insights and perspectives from -omics studies

Recent significant progress in culture-independent techniques, together with the parallel development of -omics technologies and data analysis capabilities, have led to a new perception of the milk microbiota as a complex microbial community with great diversity and multifaceted biological roles, living in an environment that was until recently believed to be sterile. In this review, we summarize and discuss the latest findings on the milk microbiota in dairy cows, with a focus on the role it plays in bovine physiology and health. Following an introduction on microbial communities and the importance of their study, we present an overview of the -omics methods currently available for their characterization, and outline the potential offered by a systems biology approach encompassing metatranscriptomics, metaproteomics, and metametabolomics. Then, we review the recent discoveries on the dairy cow milk microbiome enabled by the application of -omics approaches. Learning from studies in humans and in the mouse model, and after a description of the endogenous route hypothesis, we discuss the role of the milk microbiota in the physiology and health of both the mother and the offspring, and report how it can be changed by farming practices and during infection. In conclusion, we shortly outline the impact of the milk microbiota on the quality of milk and of dairy products