The Impact of HI in Galaxies on 21-cm Intensity Fluctuations During the Reionisation Epoch

We investigate the impact of neutral hydrogen (HI) in galaxies on the statistics of 21-cm fluctuations using analytic and semi-numerical modelling. Following the reionisation of hydrogen the HI content of the Universe is dominated by damped absorption systems (DLAs), with a cosmic density in HI that is observed to be constant at a level equal to ~2% of the cosmic baryon density from z~1 to z~5. We show that extrapolation of this constant fraction into the reionisation epoch results in a reduction of 10-20% in the amplitude of 21-cm fluctuations over a range of spatial scales. The assumption of a different percentage during the reionisation era results in a proportional change in the 21-cm fluctuation amplitude. We find that consideration of HI in galaxies/DLAs reduces the prominence of the HII region induced shoulder in the 21-cm power spectrum (PS), and hence modifies the scale dependence of 21-cm fluctuations. We also estimate the 21cm-galaxy cross PS, and show that the cross PS changes sign on scales corresponding to the HII regions. From consideration of the sensitivity for forthcoming low-frequency arrays we find that the effects of HI in galaxies/DLAs on the statistics of 21-cm fluctuations will be significant with respect to the precision of a PS or cross PS measurement. In addition, since overdense regions are reionised first we demonstrate that the cross-correlation between galaxies and 21-cm emission changes sign at the end of the reionisation era, providing an alternative avenue to pinpoint the end of reionisation. The sum of our analysis indicates that the HI content of the galaxies that reionise the universe will need to be considered in detailed modelling of the 21-cm intensity PS in order to correctly interpret measurements from forthcoming low-frequency arrays.Comment: 11 pages, 6 figures. Submitted to MNRA

Modification of the 21-cm power spectrum by X-rays during the epoch of reionisation

We incorporate a contribution to reionization from X-rays within analytic and semi-numerical simulations of the 21-cm signal arising from neutral hydrogen during the epoch of reionization. We explore the impact that X-ray ionizations have on the power spectrum (PS) of 21-cm fluctuations by varying both the average X-ray MFP and the fractional contribution of X-rays to reionization. In general, prior to the epoch when the intergalactic medium is dominated by ionized regions (H {\sevensize II} regions), X-ray-induced ionization enhances fluctuations on spatial scales smaller than the X-ray MFP, provided that X-ray heating does not strongly supress galaxy formation. Conversely, at later times when \H2 regions dominate, small-scale fluctuations in the 21-cm signal are suppressed by X-ray ionization. Our modelling also shows that the modification of the 21-cm signal due to the presence of X-rays is sensitive to the relative scales of the X-ray MFP, and the characteristic size of \H2 regions. We therefore find that X-rays imprint an epoch and scale-dependent signature on the 21-cm PS, whose prominence depends on fractional X-ray contribution. The degree of X-ray heating of the IGM also determines the extent to which these features can be discerned. We show that the MWA will have sufficient sensitivity to detect this modification of the PS, so long as the X-ray photon MFP falls within the range of scales over which the array is most sensitive ($\sim0.1$ Mpc$^{-1}$). In cases in which this MFP takes a much smaller value, an array with larger collecting area would be required.Comment: 15 pages, 6 figures, Accepted for publication in MNRAS X-ray heating contribution now adde

Modelling high resolution ALMA observations of strongly lensed highly star forming galaxies detected by <i>Herschel</i>

We have modelled ∼ 0.1 arcsec resolution ALMA imaging of six strong gravitationally lensed galaxies detected by the Herschel Space Observatory. Our modelling recovers mass properties of the lensing galaxies and, by determining magnification factors, intrinsic properties of the lensed sub-millimetre sources. We find that the lensed galaxies all have high ratios of star formation rate to dust mass, consistent with or higher than the mean ratio for high redshift sub-millimetre galaxies and low redshift ultra-luminous infra-red galaxies. Source reconstruction reveals that most galaxies exhibit disturbed morphologies. Both the cleaned image plane data and the directly observed interferometric visibilities have been modelled, enabling comparison of both approaches. In the majority of cases, the recovered lens models are consistent between methods, all six having mass density profiles that are close to isothermal. However, one system with poor signal to noise shows mildly significant differences

Analytical Quality by Design-Compliant Development of a Cyclodextrin-Modified Micellar ElectroKinetic Chromatography Method for the Determination of Trimecaine and Its Impurities

In 2022, the International Council for Harmonisation released draft guidelines Q2(R2) and Q14, intending to specify the development and validation activities that should be carried out during the lifespan of an analytical technique addressed to assess the quality of medicinal products. In the present study, these recommendations were implemented in Capillary Electrophoresis method development for the quality control of a drug product containing trimecaine, by applying Analytical Quality by Design. According to the Analytical Target Profile, the procedure should be able to simultaneously quantify trimecaine and its four impurities, with specified analytical performances. The selected operative mode was Micellar ElectroKinetic Chromatography employing sodium dodecyl sulfate micelles supplemented with dimethyl-&amp; beta;-cyclodextrin, in a phosphate-borate buffer. The Knowledge Space was investigated through a screening matrix encompassing the composition of the background electrolyte and the instrumental settings. The Critical Method Attributes were identified as analysis time, efficiency, and critical resolution values. Response Surface Methodology and Monte Carlo Simulations allowed the definition of the Method Operable Design Region: 21-26 mM phosphate-borate buffer pH 9.50-9.77; 65.0 mM sodium dodecyl sulfate; 0.25-1.29% v/v n-butanol; 21-26 mM dimethyl-&amp; beta;-cyclodextrin; temperature, 22 &amp; DEG;C; voltage, 23-29 kV. The method was validated and applied to ampoules drug products

Searching for the earliest galaxies in the 21 cm forest

We use a model developed by Xu et al. (2010) to compute the 21 cm line absorption signatures imprinted by star-forming dwarf galaxies (DGs) and starless minihalos (MHs). The method, based on a statistical comparison of the equivalent width (W_\nu) distribution and flux correlation function, allows us to derive a simple selection criteria for candidate DGs at very high (z >= 8) redshift. We find that ~ 18% of the total number of DGs along a line of sight to a target radio source (GRB or quasar) can be identified by the condition W_\nu < 0; these objects correspond to the high-mass tail of the DG distribution at high redshift, and are embedded in large HII regions. The criterion W_\nu > 0.37 kHz instead selects ~ 11% of MHs. Selected candidate DGs could later be re-observed in the near-IR by the JWST with high efficiency, thus providing a direct probe of the most likely reionization sources.Comment: 8 pages, 3 figures. Accepted for publication in Science in China Series

21-cm cosmology

Imaging the Universe during the first hundreds of millions of years remains one of the exciting challenges facing modern cosmology. Observations of the redshifted 21 cm line of atomic hydrogen offer the potential of opening a new window into this epoch. This would transform our understanding of the formation of the first stars and galaxies and of the thermal history of the Universe. A new generation of radio telescopes is being constructed for this purpose with the first results starting to trickle in. In this review, we detail the physics that governs the 21 cm signal and describe what might be learnt from upcoming observations. We also generalize our discussion to intensity mapping of other atomic and molecular lines.Comment: 64 pages, 20 figures, submitted to Reports on Progress in Physics, comments welcom

Observational Manifestations of the First Protogalaxies in the 21 cm Line

The absorption properties of the first low-mass protogalaxies (mini-halos) forming at high redshifts in the 21-cm line of atomic hydrogen are considered. The absorption properties of these protogalaxies are shown to depend strongly on both their mass and evolutionary status. The optical depths in the line reach $\sim$0.1-0.2 for small impact parameters of the line of sight. When a protogalaxy being compressed, the influence of gas accretion can be seen manifested in a non-monotonic frequency dependence of the optical depth. The absorption characteristics in the 21-cm line are determined by the thermal and dynamical evolution of the gas in protogalaxies. Since the theoretical line width in the observer's reference frame is 1-6 kHz and the expected separation between lines 8.4 kHz, the lines from low mass protogalaxies can be resolved using ongoing and future low frequency interferometers.Comment: 12 pages, 5 figure

The Energy Cascade from Warm Dark Matter Decays

We use a set of Monte Carlo simulations to follow the cascade produced by a primary electron of energy E_in in the intergalactic medium. We choose E_in=3-10 keV as expected from the decay of one of the most popular Warm Dark Matter (WDM) candidates, sterile neutrinos. Our simulation takes into account processes previously neglected such as free-free interactions with ions and recombinations and uses the best available cross sections for collisional ionizations and excitations with H and He and for electron-electron collisions. We precisely derive the fraction of the primary electron energy that heats the gas, ionizes atoms and produces line and continuum photons as a function of the ionization fraction. Handy fitting formulae for all the above energy depositions are provided. By keeping track of the individual photons we can distinguish between photons in the Ly-alpha resonance and those with energy E < 10.2 eV that do not interact further with gas. This separation is important because a Ly-alpha background can heat or cool the gas depending on the nature of the photons, and can have effects on the 21 cm radiation emitted by neutral H, which will probably become detectable at z > 6 in the near future by the next generation radio interferometers.Comment: Accepted for publication in MNRAS Letters, 5 pages, 2 figures, 1 tabl

Scale-dependent Galaxy Bias

We present a simple heuristic model to demonstrate how feedback related to the galaxy formation process can result in a scale-dependent bias of mass versus light, even on very large scales. The model invokes the idea that galaxies form initially in locations determined by the local density field, but the subsequent formation of galaxies is also influenced by the presence of nearby galaxies that have already formed. The form of bias that results possesses some features that are usually described in terms of stochastic effects, but our model is entirely deterministic once the density field is specified. Features in the large-scale galaxy power spectrum (such as wiggles that might in an extreme case mimic the effect of baryons on the primordial transfer function) could, at least in principle, arise from spatial modulations of the galaxy formation process that arise naturally in our model. We also show how this fully deterministic model gives rise to apparently stochasticity in the galaxy distribution.Comment: 14 pages, 2 figures, typos corrected, discussion added and references corrected; matches version accepted by JCA

In Situ Probes of the First Galaxies and Reionization: Gamma-ray Bursts

The first structures in the Universe formed at z>7, at higher redshift than all currently known galaxies. Since GRBs are brighter than other cosmological sources at high redshift and exhibit simple power-law afterglow spectra that is ideal for absorption studies, they serve as powerful tools for studying the early universe. New facilities planned for the coming decade will be able to obtain a large sample of high-redshift GRBs. Such a sample would constrain the nature of the first stars, galaxies, and the reionization history of the Universe.Comment: 8 pages, 3 figures, science white paper submitted to the US Astro2010 Decadal Surve