Galactic Archeology with 4MOST

4MOST is a new wide-field, high-multiplex spectroscopic survey facility for the VISTA telescope of ESO. Starting in 2022, 4MOST will deploy more than 2400 fibres in a 4.1 square degree field-of-view using a positioner based on the tilting spine principle. In this ontribution we give an outline of the major science goals we wish to achieve with 4MOST in the area of Galactic Archeology. The 4MOST Galactic Archeology surveys have been designed to address long-standing and far-reaching problems in Galactic science. They are focused on our major themes: 1) Near-field cosmology tests, 2) Chemo-dynamical characterisation of the major Milky Way stellar components, 3) The Galactic Halo and beyond, and 4) Discovery and characterisation of extremely metal-poor stars. In addition to a top-level description of the Galactic surveys we provide information about how the community will be able to join 4MOST via a call for Public Spectroscopic Surveys that ESO will launch.Comment: To be published in "Rediscovering our Galaxy", IAU Symposium 334, Eds. C. Chiappini, I. Minchev, E. Starkenburg, M. Valentin

The Pristine survey II: a sample of bright stars observed with FEROS

Extremely metal-poor (EMP) stars are old objects formed in the first Gyr of the Universe. They are rare and, to select them, the most successful strategy has been to build on large and low-resolution spectroscopic surveys. The combination of narrow- and broad band photometry provides a powerful and cheaper alternative to select metal-poor stars. The on-going Pristine Survey is adopting this strategy, conducting photometry with the CFHT MegaCam wide field imager and a narrow-band filter centred at 395.2 nm on the CaII-H and -K lines. In this paper we present the results of the spectroscopic follow-up conducted on a sample of 26 stars at the bright end of the magnitude range of the Survey (g<=15), using FEROS at the MPG/ESO 2.2 m telescope. From our chemical investigation on the sample, we conclude that this magnitude range is too bright to use the SDSS gri bands, which are typically saturated. Instead the Pristine photometry can be usefully combined with the APASS gri photometry to provide reliable metallicity estimates.Comment: AN accepte

Constraints on mass loss and self-enrichment scenarios for the globular clusters of the Fornax dSph

Recently, high-dispersion spectroscopy has demonstrated conclusively that four of the five globular clusters (GCs) in the Fornax dwarf spheroidal galaxy are very metal-poor with [Fe/H]<-2. The remaining cluster, Fornax 4, has [Fe/H]=-1.4. This is in stark contrast to the field star metallicity distribution which shows a broad peak around [Fe/H]=-1 with only a few percent of the stars having [Fe/H]<-2. If we only consider stars and clusters with [Fe/H]<-2 we thus find an extremely high GC specific frequency, SN=400, implying by far the highest ratio of GCs to field stars known anywhere. We estimate that about 1/5-1/4 of all stars in the Fornax dSph with [Fe/H]<-2 belong to the four most metal-poor GCs. These GCs could, therefore, at most have been a factor of 4-5 more massive initially. Yet, the Fornax GCs appear to share the same anomalous chemical abundance patterns known from Milky Way GCs, commonly attributed to the presence of multiple stellar generations within the clusters. The extreme ratio of metal-poor GC- versus field stars in the Fornax dSph is difficult to reconcile with scenarios for self-enrichment and early evolution of GCs in which a large fraction (90%-95%) of the first-generation stars have been lost. It also suggests that the GCs may not have formed as part of a larger population of now disrupted clusters with an initial power-law mass distribution. The Fornax dSph may be a rosetta stone for constraining theories of the formation, self-enrichment and early dynamical evolution of star clusters.Comment: 4 pages, 2 figures, accepted for A&A Letter

Draft Nuclear Genome, Complete Chloroplast Genome, and Complete Mitochondrial Genome for the Biofuel/ Bioproduct Feedstock Species Scenedesmus obliquus Strain DOE0152z

The green alga Scenedesmus obliquus is an emerging platform species for the industrial production of biofuels. Here, we report the draft assembly and annotation for the nuclear, plastid, and mitochondrial genomes of S. obliquus strain DOE0152z

The Rest-Frame Optical Luminosity Density, Color, and Stellar Mass Density of the Universe from z=0 to z=3

We present the evolution of the rest-frame optical luminosity density, of the integrated rest-frame optical color, and of the stellar mass density for a sample of Ks-band selected galaxies in the HDF-S. We derived the luminosity density in the rest-frame U, B, and V-bands and found that the luminosity density increases by a factor of 1.9+-0.4, 2.9+-0.6, and 4.9+-1.0 in the V, B, and U rest-frame bands respectively between a redshift of 0.1 and 3.2. We derived the luminosity weighted mean cosmic (U-B)_rest and (B-V)_rest colors as a function of redshift. The colors bluen almost monotonically with increasing redshift; at z=0.1, the (U-B)_rest and (B-V)_rest colors are 0.16 and 0.75 respectively, while at z=2.8 they are -0.39 and 0.29 respectively. We derived the luminosity weighted mean M/LV using the correlation between (U-V)_rest and log_{10} M/LV which exists for a range in smooth SFHs and moderate extinctions. We have shown that the mean of individual M/LV estimates can overpredict the true value by ~70% while our method overpredicts the true values by only ~35%. We find that the universe at z~3 had ~10 times lower stellar mass density than it does today in galaxies with LV>1.4 \times 10^{10} h_{70}^-2 Lsol. 50% of the stellar mass of the universe was formed by $z~1-1.5. The rate of increase in the stellar mass density with decreasing redshift is similar to but above that for independent estimates from the HDF-N, but is slightly less than that predicted by the integral of the SFR(z) curve.Comment: 19 pages, 12 figures, Accepted for Publication in the Dec. 20, 2003 edition of the Astrophysical Journal. Minor changes made to match the accepted version including short discussions on the effects of clustering and on possible systematic effects resulting from photometric redshift error

The satellites of the Milky Way – insights from semi-analytic modelling in a ΛCDM cosmology

We combine the six high-resolution Aquarius dark matter simulations with a semi-analytic galaxy formation model to investigate the properties of the satellites of Milky Way-like galaxies. We find good correspondence with the observed luminosity function, luminosity–metallicity relation and radial distribution of the Milky Way satellites. The star formation histories of the dwarf galaxies in our model vary widely, in accordance with what is seen observationally. Some systems are dominated by old populations, whereas others are dominated by intermediate populations; star formation histories can either be continuous or more bursty. Ram-pressure stripping of hot gas from the satellites leaves a clear imprint of the environment on the characteristics of a dwarf galaxy. We find that the fraction of satellites dominated by old populations of stars matches observations well. However, the internal metallicity distributions of the model satellites appear to be narrower than observed. This may indicate limitations in our treatment of chemical enrichment, which is based on the instantaneous recycling approximation. We find a strong correlation between the number of satellites and the dark matter mass of the host halo. Our model works best if the dark matter halo of the Milky Way has a mass of ∼8 × 1011 M⊙, in agreement with the lower estimates from observations, but about a factor of 2 lower than estimates based on the Local Group timing argument or abundance matching techniques. The galaxy that resembles the Milky Way the most also has the best-matching satellite luminosity function, although it does not contain an object as bright as the Large or Small Magellanic Cloud. Compared to other semi-analytic models and abundance matching relations we find that central galaxies reside in less massive haloes, but the halo mass–stellar mass relation in our model is consistent both with hydrodynamical simulations and with recent observations

The size evolution of galaxies since z~3: combining SDSS, GEMS and FIRES

We present the evolution of the luminosity-size and stellar mass-size relations of luminous (L_V>3.4x10^10h_70^-2L_sun) and of massive (M_*>3x10^10h_70^-2M_sun) galaxies in the last ~11 Gyr. We use very deep near-infrared images of the Hubble Deep Field-South and the MS1054-03 field in the J_s, H and K_s bands from FIRES to retrieve the sizes in the optical rest-frame for galaxies with z>1. We combine our results with those from GEMS at 0.2<z<1 and SDSS at z~0.1 to achieve a comprehensive picture of the optical rest-frame size evolution from z=0 to z=3. Galaxies are differentiated according to their light concentration using the Sersic index n. For less concentrated objects, the galaxies at a given luminosity were typically ~3+-0.5 (+-2 sigma) times smaller at z~2.5 than those we see today. The stellar mass-size relation has evolved less: the mean size at a given stellar mass was \~2+-0.5 times smaller at z~2.5, evolving proportional to (1+z)^{-0.40+-0.06}. Simple scaling relations between dark matter halos and baryons in a hierarchical cosmogony predict a stronger (although consistent within the error bars) than observed evolution of the stellar mass-size relation. The observed luminosity-size evolution out to z~2.5 matches well recent infall model predictions for Milky-Way type objects. For low-n galaxies, the evolution of the stellar mass-size relation would follow naturally if the individual galaxies grow inside-out. For highly concentrated objects, the situation is as follows: at a given luminosity, these galaxies were ~2.7+-1.1 times smaller at z~2.5 (or put differently, were typically ~2.2+-0.7 mag brighter at a given size than they are today), and at a given stellar mass the size has evolved proportional to (1+z)^{-0.45+-0.10}.Comment: Accepted for publication in ApJ. The new version includes several improvements: much accurate size estimations and a better completeness and robustness analysis. Tables of data are included. 29 pages and 14 figures (one low resolution

A Substantial Population of Red Galaxies at z > 2: Modeling of the Spectral Energy Distributions of an Extended Sample

We investigate the nature of the substantial population of high-z galaxies with Js-Ks>2.3 discovered as part of our FIRES survey. This colour cut efficiently isolates z>2 galaxies with red rest-frame optical colors ("Distant Red Galaxies" or DRGs). We select objects in the 2.5'x2.5' HDF-South (HDF-S) and 5'x5' field around the MS1054-03 cluster; the surface densities at Ks<21 are 1.6+-0.6 and 1.0+-0.2 arcmin^-2. We discuss the 34 DRGs at 2<z<3.5: 11 at Ks<22.5 in HDF-S and 23 at Ks<21.7 in the MS1054-03 field. We analyze the SEDs constructed from our deep near-infrared (NIR) and optical imaging from the ESO VLT and HST. We develop diagnostics involving I-Js, Js-H, and H-Ks to argue that the red NIR colors of DRGs cannot be attributed solely to extinction and require for many an evolved stellar population with prominent Balmer/4000A break. In the rest-frame, the optical colours of DRGs fall within the envelope of normal nearby galaxies and the UV colours suggest a wide range in star formation activity and/or extinction. This contrasts with the much bluer and more uniform SEDs of Lyman break galaxies (LBGs). From evolutionary synthesis models with constant star formation, solar metallicity, Salpeter IMF, and Calzetti et al. extinction law, we derive for the HDF-S (MS1054-03 field) DRGs median ages of 1.7(2.0) Gyr, A_V = 2.7(2.4) mag, stellar masses 0.8(1.6)x10^11 Msun, M/L_V = 1.2(2.3) Msun/LVsun, and SFR = 120(170) Msun/yr. Models assuming declining SFRs with e-folding timescales of 10Myr-1Gyr generally imply younger ages, lower A_V's and SFRs, but similar stellar masses within a factor of two. Compared to LBGs at similar redshifts and rest-frame L_V's, DRGs are older, more massive, and more obscured for any given star formation history. [ABRIDGED]Comment: Accepted for publication in the Astrophysical Journal. 27 pages, 14 b/w figure

Cost-effectiveness of tipranavir versus comparator protease inhibitor regimens in HIV infected patients previously exposed to antiretroviral therapy in the Netherlands

<p>Abstract</p> <p>Background</p> <p>This study compares the costs and effects of a regimen with ritonavir-boosted tipranavir (TPV/r) to a physician-selected genotypically-defined standard-of-care comparator protease inhibitor regimen boosted with ritonavir (CPI/r) in HIV infected patients that were previously exposed to antiretroviral therapy in the Netherlands.</p> <p>Methods</p> <p>We compared the projected lifetime costs and effects of two theoretical groups of 1000 patients, one receiving a standard of care regimen with TPV/r as a component and the other receiving a standard of care regimen with CPI/r. A 3-stage Markov model was formulated to represent three different consecutive HAART regimens. The model uses 12 health states based on viral load and CD4+ count to simulate disease progression. The transition probabilities for the Markov model were derived from a United States cohort of treatment experienced HIV patients. Furthermore, the study design was based on 48-week data from the RESIST-2 clinical trial and local Dutch costing data. Cost and health effects were discounted at 4% and 1.5% respectively according to the Dutch guideline. The analysis was conducted from the Dutch healthcare perspective using 2006 unit cost prices.</p> <p>Results</p> <p>Our model projects an accumulated discounted cost to the Dutch healthcare system per patient receiving the TPV/r regimen of €167,200 compared to €145,400 for the CPI/r regimen. This results in an incremental cost of €21,800 per patient. The accumulated discounted effect is 7.43 life years or 6.31 quality adjusted life years (QALYs) per patient receiving TPV/r, compared to 6.91 life years or 5.80 QALYs per patient receiving CPI/r. This translates into an incremental effect of TPV/r over CPI/r of 0.52 life years gained (LYG) or 0.51 QALYs gained. The corresponding incremental cost effectiveness ratios (iCERs) are €41,600 per LYG and €42,500 per QALY.</p> <p>Conclusion</p> <p>We estimated the iCER for TPV/r compared to CPI/r at approximately €40,000 in treatment experienced HIV-1 infected patients in the Netherlands. This ratio may well be in range of what is acceptable and warrants reimbursement for new drug treatments in the Netherlands, in particular in therapeutic areas as end-stage oncology and HIV and other last-resort health-care interventions.</p

Code Comparison in Galaxy Scale Simulations with Resolved Supernova Feedback: Lagrangian vs. Eulerian Methods

We present a suite of high-resolution simulations of an isolated dwarf galaxy using four different hydrodynamical codes: {\sc Gizmo}, {\sc Arepo}, {\sc Gadget}, and {\sc Ramses}. All codes adopt the same physical model which includes radiative cooling, photoelectric heating, star formation, and supernova (SN) feedback. Individual SN explosions are directly resolved without resorting to sub-grid models, eliminating one of the major uncertainties in cosmological simulations. We find reasonable agreement on the time-averaged star formation rates as well as the joint density-temperature distributions between all codes. However, the Lagrangian codes show significantly burstier star formation, larger supernova-driven bubbles, and stronger galactic outflows compared to the Eulerian code. This is caused by the behavior in the dense, collapsing gas clouds when the Jeans length becomes unresolved: gas in Lagrangian codes collapses to much higher densities than in Eulerian codes, as the latter is stabilized by the minimal cell size. Therefore, more of the gas cloud is converted to stars and SNe are much more clustered in the Lagrangian models, amplifying their dynamical impact. The differences between Lagrangian and Eulerian codes can be reduced by adopting a higher star formation efficiency in Eulerian codes, which significantly enhances SN clustering in the latter. Adopting a zero SN delay time reduces burstiness in all codes, resulting in vanishing outflows as SN clustering is suppressed.Comment: accepted version by ApJ (including a new simulation in Appendix B suggested by the referee