Blended E85-diesel fuel droplet heating and evaporation

The multidimensional quasi-discrete (MDQD) model is applied to the analysis of heating and evaporation of mixtures of E85 (85 vol % ethanol and 15 vol % gasoline) with diesel fuel, commonly known as “E85–diesel” blends, using the universal quasi-chemical functional group activity coefficients model for the calculation of vapor pressure. The contribution of 119 components of E85–diesel fuel blends is taken into account, but replaced with smaller number of components/quasi-components, under conditions representative of diesel engines. Our results show that high fractions of E85–diesel fuel blends have a significant impact on the evolutions of droplet radii and surface temperatures. For instance, droplet lifetime and surface temperature for a blend of 50 vol % E85 and 50 vol % diesel are 23.2% and up to 3.4% less than those of pure diesel fuel, respectively. The application of the MDQD model has improved the computational efficiency significantly with minimal sacrifice to accuracy. This approach leads to a saving of up to 86.4% of CPU time when reducing the 119 components to 16 components/quasi-components without a sacrifice to the main features of the model

The Asia Minor Greek adpositional cycle: a tale of multiple causation

This paper examines the interplay of language-internal continuity and external influence in the cyclical development of the Asia Minor Greek adpositional system. The Modern Greek dialects of Asia Minor inherited an adpositional system of the Late Medieval Greek type whereby secondary adpositions regularly combined with primary adpositions to encode spatial region. Secondary adpositions could originally precede simple adpositions ([PREPOSITION + PREPOSITION + NPACC]) or follow the adpositional complement ([PREPOSITION + NPACC + POSTPOSITION]). Asia Minor Greek replicated the structure of Ottoman Turkish postpositional phrases to resolve this variability, fixing the position of secondary adpositions after the complement and thus developing circumpositions of the type [PREPOSITION + NPACC + POSTPOSITION]. Later, some varieties dropped the primary preposition SE from circumpositional phrases, leaving (secondary) postpositions as the only overt relator ([NPACC + POSTPOSITION]) in some environments. In addition, a number of Turkish postpositions were borrowed wholesale, thus enriching the Greek adpositional inventory

Models for automotive fuel droplets heating and evaporation

[EN] The paper presents recent approaches to the modelling of heating and evaporation of automotive fuel droplets with application to biodiesel, diesel, gasoline, and blended fuels in conditions representative of internal combustion engines. The evolutions of droplet radii and temperatures for gasoline, diesel, and a broad range of biodiesel fuels and their selective diesel fuel blends have been predicted using the Discrete Component model (DCM). These mixtures combine up to 112 components of hydrocarbons and methyl esters. The results are compared with the predictions of the case when blended diesel-biodiesel fuel are represented by pure fossil and biodiesel fuels. In contrast to previous studies, it is shown that droplet evaporation time and surface temperature predicted for 100% biodiesel (B100) are not always close to those predicted for pure diesel fuel. Also, the previously introduced MultiDimensional Quasi-Discrete model and its application to these fuels and their mixtures are discussed. The previous application of this model has resulted in up to 96% reduction in CPU time compared to the case when all fuel components are considered using the DCM.The authors are grateful to the Centre for Mobility and Transport – Coventry University for financial support.Al Qubeissi, M.; Sazhin, S.; Al-Esawi, N. (2017). Models for automotive fuel droplets heating and evaporation. En Ilass Europe. 28th european conference on Liquid Atomization and Spray Systems. Editorial Universitat Politècnica de València. 1044-4051. https://doi.org/10.4995/ILASS2017.2017.4754OCS1044405

SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck.

BACKGROUND:Programmed cell death ligand-1 (PD-L1) expression on tumor cells (TCs) is associated with improved survival in patients with head and neck squamous cell carcinoma (HNSCC) treated with immunotherapy, although its role as a prognostic factor is controversial. This study investigates whether tumoral expression of PD-L1 is a prognostic marker in patients with recurrent and/or metastatic (R/M) HNSCC treated with standard chemotherapy. METHODS:This retrospective, multicenter, noninterventional study assessed PD-L1 expression on archival R/M HNSCC tissue samples using the VENTANA PD-L1 (SP263) Assay. PD-L1 high was defined as PD-L1 staining of ≥ 25% TC, with exploratory scoring at TC ≥ 10% and TC ≥ 50%. The primary objective of this study was to estimate the prognostic value of PD-L1 status in terms of overall survival (OS) in patients with R/M HNSCC. RESULTS:412 patients (median age, 62.0 years; 79.9% male; 88.2% Caucasian) were included from 19 sites in seven countries. 132 patients (32.0%) had TC ≥ 25% PD-L1 expression; 199 patients (48.3%) and 85 patients (20.6%) had TC ≥ 10% and ≥ 50%, respectively. OS did not differ significantly across PD-L1 expression (at TC ≥ 25% cutoff median OS: 8.2 months vs TC < 25%, 10.1 months, P = 0.55) or the ≥ 10% and ≥ 50% cutoffs (at TC ≥ 10%, median OS: 9.6 months vs TC < 10%, 9.4 months, P = 0.32, and at TC ≥ 50%, median OS 7.9 vs TC < 50%, 10.0 months, P = 0.39, respectively). CONCLUSIONS:PD-L1 expression, assessed using the VENTANA PD-L1 (SP263) Assay, was not prognostic of OS in patients with R/M HNSCC treated with standard of care chemotherapies. Trial registration ClinicalTrials.gov, NCT02543476. Registered September 4, 2015

Planet Hunters. VI: An Independent Characterization of KOI-351 and Several Long Period Planet Candidates from the Kepler Archival Data

We report the discovery of 14 new transiting planet candidates in the Kepler field from the Planet Hunters citizen science program. None of these candidates overlapped with Kepler Objects of Interest (KOIs) at the time of submission. We report the discovery of one more addition to the six planet candidate system around KOI-351, making it the only seven planet candidate system from Kepler. Additionally, KOI-351 bears some resemblance to our own solar system, with the inner five planets ranging from Earth to mini-Neptune radii and the outer planets being gas giants; however, this system is very compact, with all seven planet candidates orbiting $\lesssim 1$ AU from their host star. A Hill stability test and an orbital integration of the system shows that the system is stable. Furthermore, we significantly add to the population of long period transiting planets; periods range from 124-904 days, eight of them more than one Earth year long. Seven of these 14 candidates reside in their host star's habitable zone.Comment: 27 pages, 6 figures, 5 tables, Accepted to AJ (in press) (updated title from original astro-ph submission

High Rate of Microbleed Formation Following Primary Intracerebral Hemorrhage

Background We sought to investigate the frequency of microbleed development following intracerebral hemorrhage in a predominantly African-American population and to identify predictors of new microbleed formation. Aims and/or hypothesis To investigate the frequency and predictors of new microbleeds following intracerebral hemorrhage. Methods The DECIPHER study was a prospective, longitudinal, magnetic resonance-based cohort study designed to evaluate racial/ethnic differences in risk factors for microbleeds and to evaluate the prognostic impact of microbleeds in this intracerebral hemorrhage population. We evaluated new microbleed formation in two time periods: from baseline to 30 days and from 30 days to year 1. Results Of 200 subjects enrolled in DECIPHER, 84 had magnetic resonance imaging at all required time points to meet criteria for this analysis. In the baseline to day 30 analysis, 11 (13·1%) had new microbleeds, compared with 25 (29·8%) in the day 30 to year 1 analysis. Logistic regression analysis demonstrated that baseline number of microbleeds [odds ratio 1·05 (95% confidence interval 1·01, 1·08), P = 0·01] was associated with new microbleed formation at 30 days. A logistic regression model predicting new microbleed at one-year included baseline number of microbleeds [odds ratio 1·05 (1·00, 1·11), P = 0·046], baseline age [odds ratio 1·05 (1·00, 1·10), P = 0·04], and white matter disease score [odds ratio 1·18 (0·96, 1·45). P = 0·115]. Overall, 28 of 84 (33·3%) intracerebral hemorrhage subjects formed new microbleeds at some point in the first year post-intracerebral hemorrhage. Conclusions We found that one-third of intracerebral hemorrhage subjects in this cohort surviving one-year developed new microbleeds, which suggests a dynamic and rapidly progressive vasculopathy. Future studies are needed to examine the impact of new microbleed formation on patient outcomes

Extraction of cocoa butter by supercritical carbon dioxide: optimization of operating conditions and effect of particle size.

The optimum operating conditions for the extraction of cocoa butter from cocoa liquor using supercritical carbon dioxide and the effect of sample particle size on cocoa butter extraction under optimized operating conditions were investigated. The optimization was conducted at 10–45 MPa and 35–75C, with extraction times of 1–12 h by response surface methodology. The effect of particle size was studied using cocoa liquor, ground cocoa nibs and crushed cocoa nibs with particle sizes of approximately 74 µm, 0.85–1 mm and 4–6 mm, respectively. The yield was analyzed for total fat content by gravimetric method and triacylglycerol (TAG) profile by high-performance liquid chromatography. The results showed higher yield of cocoa butter with higher values of pressure, temperature and extraction time. The optimum conditions for cocoa butter extraction were 45 MPa, 75C and 12 h. The smaller particle size produced a higher yield of cocoa butter. 1,3-Dipalmitoyl-2-oleoyl-glycerol (POP), 1-palmitoyl-2-oleoyl-3-stearoyl-glycerol (POS) and 1,3-distearoyl-2-oleoyl-glycerol (SOS) were the major TAGs present in the extracted cocoa butter, with POS being the highest (>30%) for all treatments studied