91 research outputs found

    Experimental evaluation of the wake characteristics of cross flow turbine arrays

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    One key factor in the exploitation of tidal energy is the study of interactions of turbines when working in tidal turbine farms. The Momentum Reversal and Lift (MRL) turbine is a novel cross flow turbine. The three blades rotate around a common central horizontal axis which is parallel to their own axis and perpendicular to the flow. The novelty of the MRL turbine is that it relies on the combination of both lift and momentum reversal (drag) for energy extraction. Scaled MRL turbine models of 0.164 m in diameter were used to characterise the flow in three different tidal array settings. Detailed maps of axial velocity profiles and velocity deficits downstream of the turbine are presented, enabling the visualisation of characteristic flow patterns. The results show that the MRL generates lower velocity deficits and turbulence intensities in the near wake than those associated with horizontal axis turbines. The downstream wake was not completely symmetrical which was related to the geometry of the device but also due to the flow developed in the flume. Amongst the three array configurations studied, a fence of turbines with the lowest separation provided the highest power output

    Design and manufacture of a bed supported tidal turbine model for blade and shaft load measurement in turbulent flow and waves

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    Laboratory testing of tidal turbine models is an essential tool to investigate hydrodynamic interactions between turbines and the flow. Such tests can be used to calibrate numerical models and to estimate rotor loading and wake development to inform the design of full scale machines and array layout. The details of the design and manufacturing techniques used to develop a highly instrumented turbine model are presented. The model has a 1.2 m diameter, three bladed horizontal axis rotor and is bottom mounted. Particular attention is given to the instrumentation which can measure streamwise root bending moment for each blade and torque and thrust for the overall rotor. The model is mainly designed to investigate blade and shaft loads due to both turbulence and waves. Initial results from tests in a 2 m deep by 4 m wide flume are also presented

    Toward the clinical application of time-domain fluorescence lifetime imaging

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    High-speed (video-rate) fluorescence lifetime imaging (FLIM) through a flexible endoscope is reported based on gated optical image intensifier technology. The optimization and potential application of FLIM to tissue autofluorescence for clinical applications are discussed. (c) 2005 Society of Photo-Optical Instrumentation Engineers

    The effects of oblique waves and currents on the loadings and performance of tidal turbines

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    Tidal energy exploitation is at an early deployment stage and costs need to be reduced to improve the long term economic viability of the sector. High costs of tidal turbines are, in part, the result of load uncertainties, which lead to the use of high factors of safety in the design to ensure survival. One of the most important causes of uncertainty is hydrodynamic loadings. To date, most of the scaled model experiments with horizontal axis turbines investigating this issue have been carried out with collinear wave and current directions. To the authors’ knowledge, the work presented herein is the first experimental investigation of a horizontal axis turbine model subjected to combined oblique waves and current. Turbine performance and loading are measured for a 1:15 scale model tested in the FloWave circular, combined wave and current basin at the University of Edinburgh (UK). Three different flow directions were tested and each of them were also combined with regular waves in three different directions non-collinear with the flow. Fifteen physical quantities were measured including flow velocity, rotor and foundation loads and turbine speed. Characterisation of loads and turbine performance in those oblique current and wave conditions are presented. Waves affect means and standard deviation of rotor power and thrust, but off-axis waves are associated with lower thrust loads than head-on waves. Compared to current only, rotor torque and thrust standard deviations are higher in the presence of waves and almost twice as high when the wave crest is parallel to the rotor plan

    Epidermal Transglutaminase (TGase 3) Is Required for Proper Hair Development, but Not the Formation of the Epidermal Barrier

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    Transglutaminases (TGase), a family of cross-linking enzymes present in most cell types, are important in events as diverse as cell-signaling and matrix stabilization. Transglutaminase 1 is crucial in developing the epidermal barrier, however the skin also contains other family members, in particular TGase 3. This isoform is highly expressed in the cornified layer, where it is believed to stabilize the epidermis and its reduction is implicated in psoriasis. To understand the importance of TGase 3 in vivo we have generated and analyzed mice lacking this protein. Surprisingly, these animals display no obvious defect in skin development, no overt changes in barrier function or ability to heal wounds. In contrast, hair lacking TGase 3 is thinner, has major alterations in the cuticle cells and hair protein cross-linking is markedly decreased. Apparently, while TGase 3 is of unique functional importance in hair, in the epidermis loss of TGase 3 can be compensated for by other family members

    Reviewing the integration of patient data: how systems are evolving in practice to meet patient needs

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    <p>Abstract</p> <p>Background</p> <p>The integration of Information Systems (IS) is essential to support shared care and to provide consistent care to individuals – patient-centred care. This paper identifies, appraises and summarises studies examining different approaches to integrate patient data from heterogeneous IS.</p> <p>Methods</p> <p>The literature was systematically reviewed between 1995–2005 to identify articles mentioning patient records, computers and data integration or sharing.</p> <p>Results</p> <p>Of 3124 articles, 84 were included describing 56 distinct projects. Most of the projects were on a regional scale. Integration was most commonly accomplished by messaging with pre-defined templates and middleware solutions. HL7 was the most widely used messaging standard. Direct database access and web services were the most common communication methods. The user interface for most systems was a Web browser. Regarding the type of medical data shared, 77% of projects integrated diagnosis and problems, 67% medical images and 65% lab results. More recently significantly more IS are extending to primary care and integrating referral letters.</p> <p>Conclusion</p> <p>It is clear that Information Systems are evolving to meet people's needs by implementing regional networks, allowing patient access and integration of ever more items of patient data. Many distinct technological solutions coexist to integrate patient data, using differing standards and data architectures which may difficult further interoperability.</p

    Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis

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    Current concepts and future of noninvasive procedures for diagnosing oral squamous cell carcinoma - a systematic review

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