Reviviscencia

50 p. Recurso Electr?nicoEste trabajo de grado expone una serie de retratos con car?cter rememorativo, en donde se ve plasmada la preocupaci?n por retener en la memoria la imagen del rostro de un ser querido que falleci?. Una manera simb?lica de expresar la relaci?n existente entre imagen y memoria, unida al deseo de preservar metaf?ricamente el recuerdo, tras el da?o que deja el paso del tiempo. Por medio de una foto se hace un proceso de experimentaci?n pict?rica de la imagen, en donde se pinta y se transfiere repetidamente la misma a manera de h?bito contra el desvanecimiento o la p?rdida de la imagen, que conecta la ausencia del ser con la existencia propia. Use la t?cnica enc?ustica que utiliza la cera de abejas y resinas de ?rboles para su preparaci?n. En este proyecto la utilizo como agente protector de la imagen contra los da?os externos, implementada como un ritual relacionado con la protecci?n del difunto en su viaje a lo desconocido. En medio de la b?squeda pict?rica me voy desprendiendo de la imagen veritativa del rostro, reencontr?ndome con la p?rdida y enfrent?ndola con el h?bito de pintar.This degree paper exposes a series of portraits with a reminiscent character, in which is expressed the concern to retain in memory the image of the face of a loved one who died. A symbolic way of expressing the relationship between image and memory, coupled with the desire to preserve metaphorically the memory, after the damage that leaves the passage of time. By means of a photo, a process of pictorial experimentation of the image is done, where it is repeatedly painted and transferred as a habit against the fading or loss of the image, which connects the absence of the being with the existence itself . Use the encaustic technique that uses beeswax and tree resins for preparation. In this project I use it as a protective agent of the image against external damages, implemented as a ritual related to the protection of the deceased in his journey to the unknown. In the middle of the pictorial search, I detach myself from the veritative image of the face, rediscovering myself with loss and confronting it with the habit of painting. Keywords: Memory. Preservation. Paw print. Portrait. Repetition. Habit. Image. Reiteration. Duel. Oblivion

An?lisis de la libertad econ?mica en el contexto del comercio formal peruano

La b?squeda e implementaci?n de pol?ticas y programas que signifiquen alcanzar la prosperidad y mayores niveles de calidad de vida de los individuos, es constante; sin embargo, las medidas que se han planteado en el Per? a nivel estatal que permitan crear riqueza; como podr?a ser la promoci?n o impulso del emprendimiento formal, han sido, infructuosas a corto y a largo plazo. Una clara muestra se evidencia en la mantenci?n del alto ?ndice de informalidad de las empresas en nuestro pa?s; siendo que, de acuerdo a la C?mara de Comercio de Lima, aproximadamente el 75% de empresas dedicadas al sector comercio son informales. Frente a la evidente superioridad del n?mero de unidades productivas informales que operan al margen de la ley, sin los beneficios de la misma; como es la protecci?n jur?dica, acceso al financiamiento y participaci?n para prestar incluso, servicios al estado, se muestra que las pol?ticas, normas o instituciones jur?dicas vigentes, pueden no funcionar; resulta de suma urgencia cuestionar, si los motivos que han llevado hasta la actualidad a la daci?n de dichas normas, son adecuados o no

Increased urinary markers of kidney damage in the institutionalized frail elderly due to recurrent urinary tract infections.

Objective: To characterize the impact on kidney injury of recurrent urinary tract infections (RUTI) in the frail elderly. Methods: Prospective observational study in 200 frail elderly subjects for 1 year. Groups: GA (n = 100): subjects without RUTI, GB (n = 100): subjects with RUTI. Variables: age, concomitant diseases, glomerular filtration rate (GFR), urine neutrophil gelatinase-associated lipocalin (NGAL) at the beginning (NGAL-1) and end (NGAL-2) of the study, urine N-acetyl glucosaminidase (NAG) at the beginning (NAG-1) and the end (NAG-2) of the study, urine transforming growth factor-beta 1 (TGFbeta-1). Descriptive statistics, Mann-Whitney test, Chi-squared test, Fisher's exact test, and multivariate analysis were used. Results: Mean age was 84.33 (65-99) years old, with no difference between GA and GB. Mean NGAL-1 was 1.29 ng/ml (0.04-8). There was lower in GA than in GB. Mean NGAL-2 was 1.41 ng/ml (0.02-9.22). NGAL-2 was lower in GA than in GB. Mean NAG-1 was 0.38 UU.II/ml (0.01-2.63. NAG-1 in GA was lower than in GB. Mean NAG-2 was 0.44 UU.II/ml (0-3.41). NAG-2 was lower in GA compared with GB. Mean TGFbeta-1 was 23.43 pg/ml (0.02-103.76). TGFbeta-1 was lower in GA than GB. There were no differences in the presence of secondary diagnoses between GA and GB. NAG-2 and NGAL-1 were the most determining factors of renal function; in GA it was NGAL-2, followed by NAG-1; in GB it was NGAL-1, followed by NAG-2. Conclusion: Frail elderly with RUTI have higher urinary levels of renal injury markers, specifically NGAL, NAG, and TGFbeta-1, chronically in periods between urinary tract infection (UTI). Urinary markers of renal injury, specifically NGAL, NAG, and TGFbeta-1, identify early deterioration of renal function, compared with serum creatinine, or albuminuria, in frail elderly with recurrent urinary infections

Volumetric study of the maxillary sinus in patients with sinus pathology

OBJECTIVES: The aim of this study is 1) to obtain the area and volumes of the maxillary sinuses in patients affected by clinically unilateral sinus pathology by comparing the results to the contralateral sinus and 2) to determine the importance of the volumetric measures when diagnosing the percentage of sinus obliteration. MATERIALS AND METHODS: A single-centre observational retrospective clinical study was conducted in 214 patients with clinically unilateral sinus pathologies. Linear (mm), area (mm2) and volume (mm3) measurements were taken from Cone Beam Computed Tomography (CBCT) images of the affected sinus as well as from the contralateral ones. Histopathological study was performed using haematoxylin/eosin and PAS or Groccot stains. The lesions were classified into non-specific sinusitis, polyps, inverted papilloma, fungal sinusitis, cysts, mucocele and other lesions. Chi-squared test, ANOVA for independent samples and Pearson test were used for the statistical analysis. RESULTS: A total of 100 sinuses were measured in 50 patients (28 men and 22 women, with an age of 43.6 years (SD = 18.3), 50 pathological and 50 healthy contralateral sinuses. The three-dimensional occupation volume of the affected sinuses was 97.1 mm3 (62.5%) vs. 40.6 mm3 (22.8%) in the healthy ones (p<0.0001). The medial-lateral width of the sinus in the frontal plane was significantly higher in the cysts group (32.4 mm, CI: 23-41.8 mm). CONCLUSION: In medical terms, the global percentage of occupation determined using the classic manual determination method does not differ from the three-dimensional percentage calculated using specific complex software

Plan de negocio para un sistema de intermediaci?n de servicios de belleza en la ciudad de Lima basado en la geolocalizaci?n

El crecimiento sostenido del sector belleza en el Per? y los h?bitos de consumo de los peruanos en sus compras en l?nea han sido factores importantes para comenzar con esta idea de negocio. Esta idea de negocio busca brindar una plataforma de intermediaci?n que permita unir la oferta y la demanda en el sector belleza, modelo de negocio similar a Uber, de tal forma que tanto el profesional o el sal?n de belleza puedan ofrecer y llevar ese servicio hacia la ubicaci?n indicada por el usuario. Esta soluci?n propone llegar a hombres y mujeres entre 18 y 59 a?os que viven o trabajan en la ciudad de Lima, en los distritos de Lima moderna, utilizan la tecnolog?a en sus actividades cotidianas y cuidan su imagen personal. El estudio de mercado realizado demuestra que la idea de negocio es aceptada por el 81% de los encuestados. Asimismo, se realiz? entrevista a un grupo determinado de expertos de distintas ?reas quienes aportaron de gran forma a esta idea de negocio. Esta idea es rentable, esto se sustenta en el plan financiero desarrollado en la tesis, esta viabilidad es atractiva antes los ojos de los inversionistas quienes ser?n nuestros aliados estrat?gicos

Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission: study protocol of a prospective, multicentre, randomized clinical trial

Background: Patients with inflammatory bowel disease who achieve remission with anti-tumour necrosis factor (anti-TNF) drugs may have treatment withdrawn due to safety concerns and cost considerations, but there is a lack of prospective, controlled data investigating this strategy. The primary study aim is to compare the rates of clinical remission at 1?year in patients who discontinue anti-TNF treatment versus those who continue treatment. Methods: This is an ongoing, prospective, double-blind, multicentre, randomized, placebo-controlled study in patients with Crohn?s disease or ulcerative colitis who have achieved clinical remission for ?6?months with an anti-TNF treatment and an immunosuppressant. Patients are being randomized 1:1 to discontinue anti-TNF therapy or continue therapy. Randomization stratifies patients by the type of inflammatory bowel disease and drug (infliximab versus adalimumab) at study inclusion. The primary endpoint of the study is sustained clinical remission at 1?year. Other endpoints include endoscopic and radiological activity, patient-reported outcomes (quality of life, work productivity), safety and predictive factors for relapse. The required sample size is 194 patients. In addition to the main analysis (discontinuation versus continuation), subanalyses will include stratification by type of inflammatory bowel disease, phenotype and previous treatment. Biological samples will be obtained to identify factors predictive of relapse after treatment withdrawal. Results: Enrolment began in 2016, and the study is expected to end in 2020. Conclusions: This study will contribute prospective, controlled data on outcomes and predictors of relapse in patients with inflammatory bowel disease after withdrawal of anti-TNF agents following achievement of clinical remission. Clinical trial reference number: EudraCT 2015-001410-1

Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology

Background: Emerging evidence indicates a potential role for monocytes in COVID-19 immunopathology. We investigated two soluble markers of monocyte activation, sCD14 and sCD163, in COVID-19 patients, with the aim of characterizing their potential role in monocyte-macrophage disease immunopathology. To the best of our knowledge, this is the first study of its kind. Methods: Fifty-nine SARS-Cov-2 positive hospitalized patients, classified according to ICU or non-ICU admission requirement, were prospectively recruited and analyzed by ELISA for levels of sCD14 and sCD163, along with other laboratory parameters, and compared to a healthy control group. Results: sCD14 and sCD163 levels were significantly higher among COVID-19 patients, independently of ICU admission requirement, compared to the control group. We found a significant correlation between sCD14 levels and other inflammatory markers, particularly Interleukin-6, in the non-ICU patients group. sCD163 showed a moderate positive correlation with the time lapsed from admission to sampling, independently of severity group. Treatment with corticoids showed an interference with sCD14 levels, whereas hydroxychloroquine and tocilizumab did not. Conclusions: Monocyte-macrophage activation markers are increased and correlate with other inflammatory markers in SARS-Cov-2 infection, in association to hospital admission. These data suggest a preponderant role for monocyte-macrophage activation in the development of immunopathology of COVID-19 patients

Real Wage Responsiveness to Unemployment in Spain: Asymmetries Along the Business Cycle

We estimate real wage cyclicality in the period compressed between 1987 and 2013 using a large administrative dataset of workers in Spain. Real wages are weakly procyclical in Spain and focusing on differences in different phases of the business cycle, we find that differences across expansions and recessions are significant, with an even lower real wage cyclicality in recessions. Furthermore, higher levels of unemployment do not translate into additional real wages adjustments when the economy is contracting, while lower levels of unemployment during expansions have incremental effects on wage elasticity. This general result holds after accounting for differences in tenure, type of contract and age categories. Nevertheless, wages of newly-hired workers are the most sensitive to the business cycle and exhibit the lowest asymmetric pattern between expansions and recessions. At the other end, wages of workers with more than six years of tenure can be characterized as the most protected against economic downturns. The same is true for fixed-term vs. permanent workers, as well as for young vs. older workers

The simple and rapid detection of specific PCR products from bacterial genomes using Zn finger proteins

A novel method of rapid and specific detection of polymerase chain reaction (PCR) products from bacterial genomes using Zn finger proteins was developed. Zn finger proteins are DNA-binding proteins that can sequence specifically recognize PCR products. Since Zn finger proteins can directly detect PCR products without undergoing dehybridization, unlike probe DNA, and can double check the specific PCR amplification and sequence specificity of the PCR products, this novel method would be quick and highly accurate. In this study, we tried to detect Legionella pneumophila using Sp1. It was found that a 49 bp L. pneumophila-specific region containing the Sp1 recognition site is located on the flhA gene of the L. pneumophila genome. We succeeded in specifically detecting PCR products amplified from L. pneumophila in the presence of other bacterial genomes by ELISA, and demonstrated that Sp1 enables the discrimination of L. pneumophila-specific PCR products from others. By fluorescence depolarization measurement, these specific PCR products could be detected within 1 min. These results indicate that the rapid and simple detection of PCR products specific to L. pneumophila using a Zn finger protein was achieved. This methodology can be applied to the detection of other bacteria using various Zn finger proteins that have already been reported