Chemistry research in Catalonia : 1996-2002

The seven-year period studied here differs very little from the sixyear period described in the previous Report (1990-1995) [1]. Sustained growth was observed in almost all the indicators used to evaluate the resources invested and the scientific results obtained

Evolución de las poblaciones y aspectos de conservación del endemismo valenciano en peligro de extinción Limonium perplexum

Limonium perplexum Sáez & Rosselló (Plumbaginaceae) es un endemismo exclusivo de la Comunidad Valenciana (Sáez & Rosselló, 1999), únicamente presente en los acantilados de la Sierra de Irta (Peñíscola, Castellón) (Gómez-Serrano et al., 2005), donde se localiza la única población nativa conocida hasta la fecha, dentro de la microrreserva de flora denominada "Torre de la Badum"

Homeostatic control of polyamine levels under long-term salt stress in Arabidopsis

Salt stress has been frequently studied in its first osmotic phase. Very often, data regarding the second ionic phase is missing. It has also been suggested that Putrescine or/and Spermine could be responsible for salt resistance. In order to test this hypothesis under long-term salt stress, we obtained Arabidopsis thaliana transgenic plants harboring pRD29A::oatADC or pRD29A::GUS construction. Although Putrescine was the only polyamine significantly increased after salt acclimation in pRD29A::oatADC transgenic lines, this rendered in no advantage to this kind of stress. The higher Spermine levels found in WT and transgenic lines when compared to control conditions along with no increment on Putrescine levels in WT plants under salt acclimation, leads us to analyze Spermine effect on pADC1 and pADC2 expression. Increasing levels of this polyamine inhibits these promoters expression while enhances pRD29A expression, making Spermine the polyamine responsible for salt acclimation, and the transgenic lines developed in this work suitable for studying Putrescine roles in conditions where its biosynthesis would be inhibited in the WT genotype

Novel Immune Features of the Systemic Inflammation Associated with Primary Hypercholesterolemia: Changes in Cytokine/Chemokine Profile, Increased Platelet and Leukocyte Activation

Primary hypercholesterolemia (PH) is associated with a low grade systemic inflammation that is likely the main driver of premature atherosclerosis. Accordingly, we characterized the immune cell behaviour in PH and its potential consequences. Whole blood from 22 PH patients and 21 age-matched controls was analysed by flow cytometry to determine the percentage of leukocyte immunophenotypes, activation, and platelet-leukocyte aggregates. Plasma markers were determined by Enzyme-Linked ImmunoSorbent Assay (ELISA). The adhesion of platelet-leukocyte aggregates to tumor necrosis factor-α (TNFα)-stimulated arterial endothelium was investigated using the dynamic model of the parallel-plate flow chamber. PH patients presented greater percentage of Mon 3 monocytes, Th2 and Th17 lymphocytes, activated platelets, and leukocytes than controls. The higher percentages of circulating platelet-neutrophil, monocyte and lymphocyte aggregates in patients caused increased platelet-leukocyte adhesion to dysfunctional arterial endothelium. Circulating CXCL8, CCL2, CX3CL1, and IL-6 levels positively correlated with key lipid features of PH, whereas negative correlations were found for IL-4 and IL-10. We provide the first evidence that increased platelet and leukocyte activation leads to elevated platelet-leukocyte aggregates in PH and augmented arterial leukocyte adhesiveness, a key event in atherogenesis. Accordingly, modulation of immune system behavior might be a powerful target in the control of further cardiovascular disease in PH

Motion of CMS detector and mechanical structures during Magnet Cycles and Stability Periods from 2008 to 2013 as observed by the Link Alignment System

Magnet Cycles and Stability Periods of the CMS Experiment are studied with the Alignment Link System data recorded along the 2008-2013 years of operation. The motions of the mechanical structures due to the magnetic field forces are studied and the mechanical stability of the detector during the physics data taking periods is verified.Peer Reviewe

EChemTest: sistema de evaluación de la Calidad en Química

Este proyecto plantea la herramienta EChemTest como mecanismo de evaluación de la Calidad de un Grado relacionado con la Química. También presenta la oportunidad de evaluar cómo ha influido la docencia online en la adquisición de conocimientos, comparando con cursos anteriores

Recurrent presence of the PLCG1 S345F mutation in nodal peripheral T-cell lymphomas

This work was supported by grants from Asociación Española contra el Cancer (AECC), Ministerio de Economía y Competitividad (MINECO) (SAF2013-47416-R), Instituto Salud Carlos III (ISCIII) – Fondos FEDER, MINECO-AES(RD012/0036/0060, PI10/00621, CP11/00018). RM is supported by the Fundación Conchita Rábago de la Fundación Jiménez Díaz, Madrid (Spain). JG-R is supported by a predoctoral grant from the Fundacion Investigacion Biomedica Puerta de Hierro. Salary support to SG is provided by ISCIII-FEDER (CP11/00018). MS-B is supported by a Miguel Servet contract from ISCIII-FEDER (CP11/00018). The Instituto de Investigación Marqués de Valdecilla (IDIVAL) is partly funded by the Sociedad para el Desarrollo Regional de Cantabria (SODERCAN)

Bases per al desenvolupament del model organitzatiu d’atenció integral a la població adulta amb necessitats pal·liatives i en situació de final de la vida

Atenció integral; Població adulta; Cures pal·liatives; Malalties limitantsComprehensive care; Adult population; Palliative care; Limiting illnessesAtención integral; Población adulta; Cuidados paliativos; Enfermedades limitantesAquest document, emmarcat en el Pla de salut 2016-2020, pretén considerar i alinear les directrius en l’atenció al final de la vida i cures pal·liatives derivades del Pla director sociosanitari, així com les impulsades pel Programa de prevenció i atenció a la cronicitat en matèria de cronicitat avançada. Recull les bases per al desenvolupament del model d’atenció al final de la vida a Catalunya, entenent l’etapa de final de vida amb una mirada àmplia, que va des de la fase avançada de la malaltia fins a la mort, i fins i tot més enllà, amb el procés de dol dels familiars i persones de l’entorn